Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serpin B13

Gene

Serpinb13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the proliferation or differentiation of keratinocytes.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei354 – 3552Reactive bondBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B13
Gene namesi
Name:Serpinb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3042250. Serpinb13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Serpin B13PRO_0000094122Add
BLAST

Proteomic databases

PaxDbiQ8CDC0.
PeptideAtlasiQ8CDC0.
PRIDEiQ8CDC0.

PTM databases

iPTMnetiQ8CDC0.
PhosphoSiteiQ8CDC0.

Expressioni

Gene expression databases

BgeeiQ8CDC0.
ExpressionAtlasiQ8CDC0. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027564.

Structurei

3D structure databases

ProteinModelPortaliQ8CDC0.
SMRiQ8CDC0. Positions 2-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ8CDC0.
KOiK13963.
OMAiRHNESNS.
OrthoDBiEOG7327PB.
PhylomeDBiQ8CDC0.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CDC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLGTAATQ FLFDLFKELN KTNDGNVFFS PVGISTAIGM IILGTRGATA
60 70 80 90 100
SELQKVLYTE QGTESSRIKS EEEEIEKREE IHHQLQMLLT EISKFSNDYD
110 120 130 140 150
LIISNRLFGE KTYLFLQKYI DYVEKYYHAS LEPVDFVNAA DESRKKINSW
160 170 180 190 200
VESQTNVKVK DLFPEGSLNS STKLVLINTV YFKGLWDREF KKEHTKEEDF
210 220 230 240 250
WLNKNLSKPV QMMALCSSFN FTFLEDLQAK IVGIPYKNND ISMFVLLPND
260 270 280 290 300
IDGLEKIMDK MSPEKLVEWT SPGHLEQRRV DLRLPRLQVE ETYDLEPVLE
310 320 330 340 350
AVGIHSAFSE HADYSGMSAR SGLHAQNFLH RSFLVVTEEG VEATAGTGVG
360 370 380
LKVSSAASCE LVHCNHPFLF FIRHRESDSI LFFGKFSSP
Length:389
Mass (Da):44,316
Last modified:October 5, 2010 - v2
Checksum:iB2960B949EA5EFD9
GO
Isoform 2 (identifier: Q8CDC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):19,935
Checksum:iF1A3912EABAA4B93
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951L → Q in BAC27072 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 211211Missing in isoform 2. 1 PublicationVSP_039855Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030670 mRNA. Translation: BAC27072.1.
CH466520 Genomic DNA. Translation: EDL39854.1.
BC117990 mRNA. Translation: AAI17991.1.
BC117991 mRNA. Translation: AAI17992.1.
CCDSiCCDS15213.1. [Q8CDC0-1]
RefSeqiNP_766440.2. NM_172852.3. [Q8CDC0-1]
UniGeneiMm.110886.

Genome annotation databases

EnsembliENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775. [Q8CDC0-1]
GeneIDi241196.
KEGGimmu:241196.
UCSCiuc007chf.1. mouse. [Q8CDC0-1]
uc011wqd.1. mouse. [Q8CDC0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030670 mRNA. Translation: BAC27072.1.
CH466520 Genomic DNA. Translation: EDL39854.1.
BC117990 mRNA. Translation: AAI17991.1.
BC117991 mRNA. Translation: AAI17992.1.
CCDSiCCDS15213.1. [Q8CDC0-1]
RefSeqiNP_766440.2. NM_172852.3. [Q8CDC0-1]
UniGeneiMm.110886.

3D structure databases

ProteinModelPortaliQ8CDC0.
SMRiQ8CDC0. Positions 2-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027564.

Protein family/group databases

MEROPSiI04.017.

PTM databases

iPTMnetiQ8CDC0.
PhosphoSiteiQ8CDC0.

Proteomic databases

PaxDbiQ8CDC0.
PeptideAtlasiQ8CDC0.
PRIDEiQ8CDC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775. [Q8CDC0-1]
GeneIDi241196.
KEGGimmu:241196.
UCSCiuc007chf.1. mouse. [Q8CDC0-1]
uc011wqd.1. mouse. [Q8CDC0-2]

Organism-specific databases

CTDi5275.
MGIiMGI:3042250. Serpinb13.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ8CDC0.
KOiK13963.
OMAiRHNESNS.
OrthoDBiEOG7327PB.
PhylomeDBiQ8CDC0.
TreeFamiTF352619.

Miscellaneous databases

ChiTaRSiSerpinb13. mouse.
PROiQ8CDC0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CDC0.
ExpressionAtlasiQ8CDC0. baseline.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiSPB13_MOUSE
AccessioniPrimary (citable) accession number: Q8CDC0
Secondary accession number(s): Q148S5, Q148S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 5, 2010
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.