Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serpin B13

Gene

Serpinb13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the proliferation or differentiation of keratinocytes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei354 – 355Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-8939242. RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.

Protein family/group databases

MEROPSiI04.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B13
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3042250. Serpinb13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941221 – 389Serpin B13Add BLAST389

Proteomic databases

PaxDbiQ8CDC0.
PeptideAtlasiQ8CDC0.
PRIDEiQ8CDC0.

PTM databases

iPTMnetiQ8CDC0.
PhosphoSitePlusiQ8CDC0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048775.
ExpressionAtlasiQ8CDC0. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027564.

Structurei

3D structure databases

ProteinModelPortaliQ8CDC0.
SMRiQ8CDC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ8CDC0.
KOiK13963.
OMAiFKGQWDR.
OrthoDBiEOG091G0ION.
PhylomeDBiQ8CDC0.
TreeFamiTF352619.

Family and domain databases

InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
IPR036186. Serpin_sf.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CDC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLGTAATQ FLFDLFKELN KTNDGNVFFS PVGISTAIGM IILGTRGATA
60 70 80 90 100
SELQKVLYTE QGTESSRIKS EEEEIEKREE IHHQLQMLLT EISKFSNDYD
110 120 130 140 150
LIISNRLFGE KTYLFLQKYI DYVEKYYHAS LEPVDFVNAA DESRKKINSW
160 170 180 190 200
VESQTNVKVK DLFPEGSLNS STKLVLINTV YFKGLWDREF KKEHTKEEDF
210 220 230 240 250
WLNKNLSKPV QMMALCSSFN FTFLEDLQAK IVGIPYKNND ISMFVLLPND
260 270 280 290 300
IDGLEKIMDK MSPEKLVEWT SPGHLEQRRV DLRLPRLQVE ETYDLEPVLE
310 320 330 340 350
AVGIHSAFSE HADYSGMSAR SGLHAQNFLH RSFLVVTEEG VEATAGTGVG
360 370 380
LKVSSAASCE LVHCNHPFLF FIRHRESDSI LFFGKFSSP
Length:389
Mass (Da):44,316
Last modified:October 5, 2010 - v2
Checksum:iB2960B949EA5EFD9
GO
Isoform 2 (identifier: Q8CDC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):19,935
Checksum:iF1A3912EABAA4B93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295L → Q in BAC27072 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398551 – 211Missing in isoform 2. 1 PublicationAdd BLAST211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030670 mRNA. Translation: BAC27072.1.
CH466520 Genomic DNA. Translation: EDL39854.1.
BC117990 mRNA. Translation: AAI17991.1.
BC117991 mRNA. Translation: AAI17992.1.
CCDSiCCDS15213.1. [Q8CDC0-1]
RefSeqiNP_766440.2. NM_172852.3. [Q8CDC0-1]
UniGeneiMm.110886.

Genome annotation databases

EnsembliENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775. [Q8CDC0-1]
GeneIDi241196.
KEGGimmu:241196.
UCSCiuc007chf.1. mouse. [Q8CDC0-1]
uc011wqd.1. mouse. [Q8CDC0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSPB13_MOUSE
AccessioniPrimary (citable) accession number: Q8CDC0
Secondary accession number(s): Q148S5, Q148S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 5, 2010
Last modified: October 25, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families