Unreviewed, UniProtKB/TrEMBL Q8CDB3 (Q8CDB3_MOUSE)

Names and origin

Protein names

Submitted name:
    Putative uncharacterized protein EMBL BAC27143.1

Gene names

Name:

Cd28 MGI 88327

Organism

Mus musculus (Mouse) EMBL BAC27143.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	T cell costimulation Inferred from direct assay. Source: MGI immune response Inferred from electronic annotation. Source: InterPro induction of apoptosis by extracellular signals Inferred from direct assay. Source: MGI negative thymic T cell selection Inferred from mutant phenotype. Source: MGI positive regulation of alpha-beta T cell proliferation Inferred from direct assay. Source: MGI positive regulation of inflammatory response to antigenic stimulus Inferred from mutant phenotype. Source: MGI positive regulation of interleukin-2 biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of isotype switching to IgG isotypes Inferred from mutant phenotype. Source: MGI positive regulation of mitosis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	external side of plasma membrane Inferred from direct assay. Source: MGI membrane raft Inferred from electronic annotation. Source: Compara
Molecular function	protein homodimerization activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8CDB3-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: C55A859DD7ED1486	FASTA	218	25,244
	10 20 30 40 50 60 MTLRLLFLAL NFFSVQVTEN KILVKQSPLL VVDSNEVSLS CRYSYNLLAK EFRASLYKGV 70 80 90 100 110 120 NSDVEVCVGN GNFTYQPQFR SNAEFNCDGD FDNETVTFRL WNLHVNHTDI YFCKIEFMYP 130 140 150 160 170 180 PPYLDNERSN GTIIHIKEKH LCHTQSSPEL FWALVVVAGV LFCYGLLVTV ALCVIWTNSR 190 200 210 RNRLLQSDYM NMTPRRPGLT RKPYQPYAPA RDFAAYRP

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J EMBL BAC27143.1. Tissue: Thymus EMBL BAC27143.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK030812 mRNA. Translation: BAC27143.1.
IPI	IPI00387437.
RefSeq	NP_031668.3.
UniGene	Mm.255003
3D structure databases
HSSP	HSSP built from PDB template 1I85 based on UniProtKB P16410.
SMR	Q8CDB3. Positions 20-137.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CDB3.
Genome annotation databases
Ensembl	ENSMUST00000027165; ENSMUSP00000027165; ENSMUSG00000026012; Mus musculus. [Genome view]
GeneID	12487.
KEGG	mmu:12487.
Organism-specific databases
CTD	12487.
MGI	MGI:88327. Cd28.
Phylogenomic databases
HOVERGEN	Q8CDB3.
InParanoid	Q8CDB3.
Gene expression databases
ArrayExpress	Q8CDB3.
Bgee	Q8CDB3.
Genevestigator	Q8CDB3.
Family and domain databases
InterPro	IPR008093. CD28. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
PRINTS	PR01717. CD28ANTIGEN.
SMART	SM00409. IG. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q8CDB3_MOUSE

Accession

Primary (citable) accession number: Q8CDB3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 19, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)