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Q8CDB3

- Q8CDB3_MOUSE

UniProt

Q8CDB3 - Q8CDB3_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Cd28

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. apoptotic signaling pathway Source: MGI
  2. immune response Source: InterPro
  3. negative thymic T cell selection Source: MGI
  4. positive regulation of alpha-beta T cell proliferation Source: MGI
  5. positive regulation of inflammatory response to antigenic stimulus Source: MGI
  6. positive regulation of interleukin-2 biosynthetic process Source: UniProtKB
  7. positive regulation of isotype switching to IgG isotypes Source: MGI
  8. positive regulation of mitosis Source: UniProtKB
  9. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  10. positive regulation of protein kinase B signaling Source: MGI
  11. positive regulation of T cell proliferation Source: UniProtKB
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. T cell costimulation Source: MGI
  14. T cell receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Cd28Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88327. Cd28.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. immunological synapse Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8CDB3.

Structurei

3D structure databases

ProteinModelPortaliQ8CDB3.
SMRiQ8CDB3. Positions 20-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG004094.
KOiK06470.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008093. CD28.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01717. CD28ANTIGEN.
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CDB3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTLRLLFLAL NFFSVQVTEN KILVKQSPLL VVDSNEVSLS CRYSYNLLAK
60 70 80 90 100
EFRASLYKGV NSDVEVCVGN GNFTYQPQFR SNAEFNCDGD FDNETVTFRL
110 120 130 140 150
WNLHVNHTDI YFCKIEFMYP PPYLDNERSN GTIIHIKEKH LCHTQSSPEL
160 170 180 190 200
FWALVVVAGV LFCYGLLVTV ALCVIWTNSR RNRLLQSDYM NMTPRRPGLT
210
RKPYQPYAPA RDFAAYRP
Length:218
Mass (Da):25,244
Last modified:March 1, 2003 - v1
Checksum:iC55A859DD7ED1486
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030812 mRNA. Translation: BAC27143.1.
RefSeqiNP_031668.3. NM_007642.4.
UniGeneiMm.255003.

Genome annotation databases

GeneIDi12487.
KEGGimmu:12487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030812 mRNA. Translation: BAC27143.1 .
RefSeqi NP_031668.3. NM_007642.4.
UniGenei Mm.255003.

3D structure databases

ProteinModelPortali Q8CDB3.
SMRi Q8CDB3. Positions 20-137.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12487.
KEGGi mmu:12487.

Organism-specific databases

CTDi 940.
MGIi MGI:88327. Cd28.

Phylogenomic databases

HOVERGENi HBG004094.
KOi K06470.

Miscellaneous databases

NextBioi 281396.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8CDB3.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR008093. CD28.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR01717. CD28ANTIGEN.
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ8CDB3_MOUSE
AccessioniPrimary (citable) accession number: Q8CDB3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)