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Q8CDB3

- Q8CDB3_MOUSE

UniProt

Q8CDB3 - Q8CDB3_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Cd28

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. apoptotic signaling pathway Source: MGI
    2. immune response Source: InterPro
    3. negative thymic T cell selection Source: MGI
    4. positive regulation of alpha-beta T cell proliferation Source: MGI
    5. positive regulation of inflammatory response to antigenic stimulus Source: MGI
    6. positive regulation of interleukin-2 biosynthetic process Source: UniProtKB
    7. positive regulation of isotype switching to IgG isotypes Source: MGI
    8. positive regulation of mitosis Source: UniProtKB
    9. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
    10. positive regulation of protein kinase B signaling Source: MGI
    11. positive regulation of T cell proliferation Source: UniProtKB
    12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    13. T cell costimulation Source: MGI
    14. T cell receptor signaling pathway Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Cd28Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88327. Cd28.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. immunological synapse Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ8CDB3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CDB3.
    SMRiQ8CDB3. Positions 20-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG004094.
    InParanoidiQ8CDB3.
    KOiK06470.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR008093. CD28.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    PRINTSiPR01717. CD28ANTIGEN.
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CDB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLRLLFLAL NFFSVQVTEN KILVKQSPLL VVDSNEVSLS CRYSYNLLAK    50
    EFRASLYKGV NSDVEVCVGN GNFTYQPQFR SNAEFNCDGD FDNETVTFRL 100
    WNLHVNHTDI YFCKIEFMYP PPYLDNERSN GTIIHIKEKH LCHTQSSPEL 150
    FWALVVVAGV LFCYGLLVTV ALCVIWTNSR RNRLLQSDYM NMTPRRPGLT 200
    RKPYQPYAPA RDFAAYRP 218
    Length:218
    Mass (Da):25,244
    Last modified:March 1, 2003 - v1
    Checksum:iC55A859DD7ED1486
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030812 mRNA. Translation: BAC27143.1.
    RefSeqiNP_031668.3. NM_007642.4.
    UniGeneiMm.255003.

    Genome annotation databases

    GeneIDi12487.
    KEGGimmu:12487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030812 mRNA. Translation: BAC27143.1 .
    RefSeqi NP_031668.3. NM_007642.4.
    UniGenei Mm.255003.

    3D structure databases

    ProteinModelPortali Q8CDB3.
    SMRi Q8CDB3. Positions 20-137.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12487.
    KEGGi mmu:12487.

    Organism-specific databases

    CTDi 940.
    MGIi MGI:88327. Cd28.

    Phylogenomic databases

    HOVERGENi HBG004094.
    InParanoidi Q8CDB3.
    KOi K06470.

    Miscellaneous databases

    NextBioi 281396.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8CDB3.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR008093. CD28.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    PRINTSi PR01717. CD28ANTIGEN.
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.

    Entry informationi

    Entry nameiQ8CDB3_MOUSE
    AccessioniPrimary (citable) accession number: Q8CDB3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)