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Q8CDB3 (Q8CDB3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Cd28 MGI 88327
OrganismMus musculus (Mouse) EMBL BAC27143.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processT cell costimulation

Inferred from direct assay PubMed 10429671PubMed 12925852PubMed 15240667PubMed 8125140PubMed 9368605. Source: MGI

T cell receptor signaling pathway

Inferred from mutant phenotype PubMed 23793062. Source: MGI

apoptotic signaling pathway

Inferred from direct assay PubMed 10429671. Source: MGI

immune response

Inferred from electronic annotation. Source: InterPro

negative thymic T cell selection

Inferred from mutant phenotype PubMed 10429671. Source: MGI

positive regulation of T cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of alpha-beta T cell proliferation

Inferred from direct assay PubMed 14973438PubMed 8125140PubMed 9368605. Source: MGI

positive regulation of inflammatory response to antigenic stimulus

Inferred from mutant phenotype PubMed 10791997. Source: MGI

positive regulation of interleukin-2 biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of isotype switching to IgG isotypes

Inferred from mutant phenotype PubMed 7688139. Source: MGI

positive regulation of mitosis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 16809611. Source: MGI

   Cellular_componentexternal side of plasma membrane

Inferred from direct assay PubMed 12874832PubMed 23793062PubMed 7790813PubMed 8125140. Source: MGI

immunological synapse

Inferred from direct assay PubMed 23793062. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8CDB3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C55A859DD7ED1486

FASTA21825,244
        10         20         30         40         50         60 
MTLRLLFLAL NFFSVQVTEN KILVKQSPLL VVDSNEVSLS CRYSYNLLAK EFRASLYKGV 

        70         80         90        100        110        120 
NSDVEVCVGN GNFTYQPQFR SNAEFNCDGD FDNETVTFRL WNLHVNHTDI YFCKIEFMYP 

       130        140        150        160        170        180 
PPYLDNERSN GTIIHIKEKH LCHTQSSPEL FWALVVVAGV LFCYGLLVTV ALCVIWTNSR 

       190        200        210 
RNRLLQSDYM NMTPRRPGLT RKPYQPYAPA RDFAAYRP 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC27143.1.
Tissue: Thymus EMBL BAC27143.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC27143.1.
Tissue: Thymus EMBL BAC27143.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC27143.1.
Tissue: Thymus EMBL BAC27143.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC27143.1.
Tissue: Thymus EMBL BAC27143.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC27143.1.
Tissue: Thymus EMBL BAC27143.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC27143.1.
Tissue: Thymus EMBL BAC27143.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC27143.1.
Tissue: Thymus EMBL BAC27143.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC27143.1.
Tissue: Thymus EMBL BAC27143.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK030812 mRNA. Translation: BAC27143.1.
RefSeqNP_031668.3. NM_007642.4.
UniGeneMm.255003.

3D structure databases

ProteinModelPortalQ8CDB3.
SMRQ8CDB3. Positions 20-137.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12487.
KEGGmmu:12487.

Organism-specific databases

CTD940.
MGIMGI:88327. Cd28.

Phylogenomic databases

HOVERGENHBG004094.
InParanoidQ8CDB3.
KOK06470.

Gene expression databases

GenevestigatorQ8CDB3.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR008093. CD28.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01717. CD28ANTIGEN.
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281396.
SOURCESearch...

Entry information

Entry nameQ8CDB3_MOUSE
AccessionPrimary (citable) accession number: Q8CDB3
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)