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Q8CD76

- Q8CD76_MOUSE

UniProt

Q8CD76 - Q8CD76_MOUSE

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Protein
Submitted name:

Kinesin light chain 1

Gene

Klc1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. microtubule motor activity Source: InterPro

GO - Biological processi

  1. axon cargo transport Source: MGI
  2. intracellular protein transport Source: Ensembl
  3. protein localization to synapse Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Names & Taxonomyi

Protein namesi
Submitted name:
Kinesin light chain 1Imported
Gene namesi
Name:Klc1Imported
Synonyms:Kns2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:107978. Klc1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. ciliary rootlet Source: MGI
  3. cytoplasm Source: MGI
  4. cytoplasmic vesicle Source: MGI
  5. growth cone Source: Ensembl
  6. kinesin complex Source: Ensembl
  7. membrane Source: Ensembl
  8. membrane-bounded organelle Source: MGI
  9. neuronal cell body Source: Ensembl
  10. neuron projection Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8CD76.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLSTN1O949857EBI-6271950,EBI-522075From a different organism.
Clstn1Q9EPL23EBI-6271950,EBI-2013142

Protein-protein interaction databases

MINTiMINT-4544192.

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, TPR repeatUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
KOiK10407.
OMAiEDHFQER.
OrthoDBiEOG7TXKGD.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR015390. Rabaptin_Rab5-bd_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF09311. Rab5-bind. 1 hit.
PF00515. TPR_1. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
PROSITEiPS01160. KINESIN_LIGHT. 4 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CD76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYDNMSTMVY IKEEKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL
60 70 80 90 100
ETLKCLKKDD ESNLVEEKSS MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE
110 120 130 140 150
SEKQKLRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF
160 170 180 190 200
MNQLKKYDDD ISPSEDKDSD SSKEPLDDLF PNDEDEPGQG IQQQHSSAAA
210 220 230 240 250
AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL EDLEKTSGHD
260 270 280 290 300
HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG RDHPAVAATL
310 320 330 340 350
NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ
360 370 380 390 400
NQGKYEEVEY YYQRALGIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA
410 420 430 440 450
ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGSAFGEYG
460 470 480 490 500
GWYKACKVDS PTVTTTLKNL GALYRRQGKF EAAETLEEAA MRSRKQGLDN
510 520 530 540 550
VHKQRVAEVL NDPESMEKRR SRESLNMDVV KYESGPDGGE EVSMSVEWNG
560 570 580 590 600
DGTGSLKRSG SFSKLRASIR RSSEKLVRKL KGGSSRDSEP RNPGASPAEP
610
LCVENDSSSL EDASTN
Length:616
Mass (Da):69,495
Last modified:March 1, 2003 - v1
Checksum:iDE32E541E4F7178B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152065 Genomic DNA. No translation available.
AK031309 mRNA. Translation: BAC27341.1.
RefSeqiNP_001020531.2. NM_001025360.2.
NP_001075428.1. NM_001081959.1.
UniGeneiMm.278357.

Genome annotation databases

EnsembliENSMUST00000084941; ENSMUSP00000082004; ENSMUSG00000021288.
GeneIDi16593.
KEGGimmu:16593.
UCSCiuc007pdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152065 Genomic DNA. No translation available.
AK031309 mRNA. Translation: BAC27341.1 .
RefSeqi NP_001020531.2. NM_001025360.2.
NP_001075428.1. NM_001081959.1.
UniGenei Mm.278357.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4544192.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084941 ; ENSMUSP00000082004 ; ENSMUSG00000021288 .
GeneIDi 16593.
KEGGi mmu:16593.
UCSCi uc007pdx.1. mouse.

Organism-specific databases

CTDi 3831.
MGIi MGI:107978. Klc1.

Phylogenomic databases

GeneTreei ENSGT00390000006393.
HOGENOMi HOG000261663.
HOVERGENi HBG006217.
KOi K10407.
OMAi EDHFQER.
OrthoDBi EOG7TXKGD.
TreeFami TF314010.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Miscellaneous databases

ChiTaRSi Klc1. mouse.
NextBioi 290149.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8CD76.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR015390. Rabaptin_Rab5-bd_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF09311. Rab5-bind. 1 hit.
PF00515. TPR_1. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view ]
PRINTSi PR00381. KINESINLIGHT.
SMARTi SM00028. TPR. 5 hits.
[Graphical view ]
PROSITEi PS01160. KINESIN_LIGHT. 4 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  9. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8CD76_MOUSE
AccessioniPrimary (citable) accession number: Q8CD76
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3