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Q8CD76

- Q8CD76_MOUSE

UniProt

Q8CD76 - Q8CD76_MOUSE

Protein
Submitted name:

Kinesin light chain 1

Gene

Klc1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. microtubule motor activity Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. axon cargo transport Source: MGI
    2. intracellular protein transport Source: Ensembl
    3. protein localization to synapse Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Kinesin light chain 1Imported
    Gene namesi
    Name:Klc1Imported
    Synonyms:Kns2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:107978. Klc1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. ciliary rootlet Source: MGI
    3. cytoplasm Source: MGI
    4. cytoplasmic vesicle Source: MGI
    5. kinesin complex Source: Ensembl
    6. membrane Source: Ensembl
    7. membrane-bounded organelle Source: MGI
    8. neuronal cell body Source: Ensembl
    9. neuron projection Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ8CD76.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CLSTN1O949857EBI-6271950,EBI-522075From a different organism.
    Clstn1Q9EPL23EBI-6271950,EBI-2013142

    Protein-protein interaction databases

    MINTiMINT-4544192.

    Family & Domainsi

    Keywords - Domaini

    RepeatUniRule annotation, TPR repeatUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000006393.
    HOGENOMiHOG000261663.
    HOVERGENiHBG006217.
    KOiK10407.
    OMAiEDHFQER.
    OrthoDBiEOG7TXKGD.
    TreeFamiTF314010.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR002151. Kinesin_light.
    IPR015792. Kinesin_light_repeat.
    IPR015390. Rabaptin_Rab5-bd_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF09311. Rab5-bind. 1 hit.
    PF00515. TPR_1. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    PRINTSiPR00381. KINESINLIGHT.
    SMARTiSM00028. TPR. 5 hits.
    [Graphical view]
    PROSITEiPS01160. KINESIN_LIGHT. 4 hits.
    PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CD76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYDNMSTMVY IKEEKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL    50
    ETLKCLKKDD ESNLVEEKSS MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE 100
    SEKQKLRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF 150
    MNQLKKYDDD ISPSEDKDSD SSKEPLDDLF PNDEDEPGQG IQQQHSSAAA 200
    AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL EDLEKTSGHD 250
    HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG RDHPAVAATL 300
    NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ 350
    NQGKYEEVEY YYQRALGIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA 400
    ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGSAFGEYG 450
    GWYKACKVDS PTVTTTLKNL GALYRRQGKF EAAETLEEAA MRSRKQGLDN 500
    VHKQRVAEVL NDPESMEKRR SRESLNMDVV KYESGPDGGE EVSMSVEWNG 550
    DGTGSLKRSG SFSKLRASIR RSSEKLVRKL KGGSSRDSEP RNPGASPAEP 600
    LCVENDSSSL EDASTN 616
    Length:616
    Mass (Da):69,495
    Last modified:March 1, 2003 - v1
    Checksum:iDE32E541E4F7178B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC152065 Genomic DNA. No translation available.
    AK031309 mRNA. Translation: BAC27341.1.
    RefSeqiNP_001020531.2. NM_001025360.2.
    NP_001075428.1. NM_001081959.1.
    UniGeneiMm.278357.

    Genome annotation databases

    EnsembliENSMUST00000084941; ENSMUSP00000082004; ENSMUSG00000021288.
    GeneIDi16593.
    KEGGimmu:16593.
    UCSCiuc007pdx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC152065 Genomic DNA. No translation available.
    AK031309 mRNA. Translation: BAC27341.1 .
    RefSeqi NP_001020531.2. NM_001025360.2.
    NP_001075428.1. NM_001081959.1.
    UniGenei Mm.278357.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4544192.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084941 ; ENSMUSP00000082004 ; ENSMUSG00000021288 .
    GeneIDi 16593.
    KEGGi mmu:16593.
    UCSCi uc007pdx.1. mouse.

    Organism-specific databases

    CTDi 3831.
    MGIi MGI:107978. Klc1.

    Phylogenomic databases

    GeneTreei ENSGT00390000006393.
    HOGENOMi HOG000261663.
    HOVERGENi HBG006217.
    KOi K10407.
    OMAi EDHFQER.
    OrthoDBi EOG7TXKGD.
    TreeFami TF314010.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Miscellaneous databases

    ChiTaRSi KLC1. mouse.
    NextBioi 290149.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8CD76.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR002151. Kinesin_light.
    IPR015792. Kinesin_light_repeat.
    IPR015390. Rabaptin_Rab5-bd_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF09311. Rab5-bind. 1 hit.
    PF00515. TPR_1. 1 hit.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00381. KINESINLIGHT.
    SMARTi SM00028. TPR. 5 hits.
    [Graphical view ]
    PROSITEi PS01160. KINESIN_LIGHT. 4 hits.
    PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    9. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    11. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8CD76_MOUSE
    AccessioniPrimary (citable) accession number: Q8CD76
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3