ID   Q8CD56_MOUSE            Unreviewed;       635 AA.
AC   Q8CD56;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 84.
DE   RecName: Full=Hermansky-Pudlak syndrome 1 protein homolog {ECO:0008006|Google:ProtNLM};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC27385.1};
RN   [1] {ECO:0000313|EMBL:BAC27385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27385.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC27385.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAC27385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27385.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC27385.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAC27385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27385.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC27385.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAC27385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27385.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC27385.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAC27385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27385.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC27385.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:BAC27385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27385.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC27385.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [7] {ECO:0000313|EMBL:BAC27385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27385.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC27385.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAC27385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27385.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC27385.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK031397; BAC27385.1; -; mRNA.
DR   AlphaFoldDB; Q8CD56; -.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR026053; HPS1.
DR   PANTHER; PTHR12761:SF1; HERMANSKY-PUDLAK SYNDROME 1 PROTEIN; 1.
DR   PANTHER; PTHR12761; HERMANSKY-PUDLAK SYNDROME PROTEIN 1; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          2..159
FT                   /note="FUZ/MON1/HPS1 first Longin"
FT                   /evidence="ECO:0000259|Pfam:PF19036"
FT   DOMAIN          206..415
FT                   /note="FUZ/MON1/HPS1 second Longin"
FT                   /evidence="ECO:0000259|Pfam:PF19037"
FT   REGION          246..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   635 AA;  71612 MW;  B276D193E75F5183 CRC64;
     MKCVLVATEG AEVLFYWTDE EFAESLRLKL QQSEDEEEEL PVLEDQLSTL LAPVIISSMT
     MMEKLSDTYT CFSTENDNHL YVLHLFGEYL FVAINGDHSE SEGDLRRKLC VLKYLFEVHF
     GLVTVDGQLI RKELRPPDLE ERARVWKHFQ RLLGTYSYLR DREQSFAVEA VERLIHPQLC
     EQSIETLERH VVQAINASPE RGGEEDLHAF LLVHCKLLAF YSGHGASTLR PADLLALILL
     VQDLQPSPGT TEEEEEEEDS DSPQVPEHKG NRRRPKSSQN IPVQQARSQS TSVPTRSSRE
     TDTDSISLPE EYFTPAPSPG DQSSGSLVWL DGGTPPSDAL QMAEDTPEGL ASHSPELPSP
     RRIFLDANIK ENYCPLVPHT MYCLPLWPGI NMVLLAKSPS TPLALILYQL LDGFSLLEKK
     LKEGQEAGSA LRSQPFVADL RQKMDKFIKN RVGQEIQNTW LEFKSKAFSR SEPGSSWELL
     QVCGKLKRQL CVIYRLSFLV TAPSRGGPHL PQHLQDRAQK LMKERLLDWK DFLLVKSRRN
     VTMVSYLEDF PGLVHFIYVD RTTGQMVAPS LSPNEKMSSE LGKGPLAAFV KAKVWSPRTR
     VLRQHSALSL SCSHTPAEWT GVVSTQEASF SALLI
//