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Q8CD15

- MINA_MOUSE

UniProt

Q8CD15 - MINA_MOUSE

Protein

Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA

Gene

Mina

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' By similarity. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.By similarity1 Publication

    Catalytic activityi

    L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO2.

    Cofactori

    Binds 1 Fe2+ ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi179 – 1791Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi181 – 1811Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi240 – 2401Iron; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dioxygenase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: MGI

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: GOC
    2. regulation of cell proliferation Source: MGI
    3. ribosome biogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Ribosome biogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (EC:1.14.11.-)
    Alternative name(s):
    Histone lysine demethylase MINA
    MYC-induced nuclear antigen
    Gene namesi
    Name:MinaImported
    Synonyms:Mina531 Publication
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1914264. Mina.

    Subcellular locationi

    Nucleus 1 Publication. Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. nucleolus Source: MGI
    3. nucleus Source: MGI
    4. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINAPRO_0000308378Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei309 – 3091PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8CD15.
    PaxDbiQ8CD15.
    PRIDEiQ8CD15.

    PTM databases

    PhosphoSiteiQ8CD15.

    Expressioni

    Tissue specificityi

    Predominantly expressed in testis. Expressed at high levels in spleen, thymus, and colon, but barely detectable in brain, skeletal muscle, and seminal vesicle (at protein level).1 Publication

    Developmental stagei

    In testis, expressed in the nuclei of spermatogonia at all stages of the seminiferous epithelial cycle, and in meiotic prophase cells such as preleptotene, leptotene and zygotene, and weakly in early pachytene spermatocytes, but is absent in late pachytene spermatocytes, spermatids and mature sperm (at protein level).1 Publication

    Inductioni

    Up-regulated in experimentally-induced cryptorchid testis.1 Publication

    Gene expression databases

    BgeeiQ8CD15.
    CleanExiMM_MINA.
    GenevestigatoriQ8CD15.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8CD15. 1 interaction.
    MINTiMINT-4115257.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CD15.
    SMRiQ8CD15. Positions 31-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini139 – 271133JmjCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MINA53/NO66 family.Curated
    Contains 1 JmjC domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG83808.
    GeneTreeiENSGT00390000000083.
    HOGENOMiHOG000007965.
    HOVERGENiHBG055265.
    InParanoidiQ8CD15.
    OMAiSTYQNNS.
    OrthoDBiEOG7T1RBJ.
    PhylomeDBiQ8CD15.
    TreeFamiTF318659.

    Family and domain databases

    InterProiIPR003347. JmjC_dom.
    [Graphical view]
    PfamiPF08007. Cupin_4. 1 hit.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CD15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKKVQPTGD ENEEASVPCK RVKEELPETL SVLNFDSPSS FFESLISPIK    50
    VETFFKEFWE QKPLLIQRDD PVLAKYYQSL FSLSDLKRLC KKGVYYGRDV 100
    NVCRSISGKK KVLNKDGRAH FLQLRKDFDQ KRATIQFHQP QRYKDELWRI 150
    QEKLECYFGS LVGSNVYMTP AGSQGLPPHY DDVEVFILQL EGTKHWRLYS 200
    PTVPLAHEYS VESEDRIGTP THDFLLKPGD LLYFPRGTIH QAETPSGLAY 250
    SIHLTISTYQ NNSWGDCLLD SISGFVFDIA KEDVALRSGM PRRMLLNVET 300
    PADVTRKLSG FLRTLADQLE GREELLSSDM KKDFVKHRLP PFFEGNGTET 350
    MDPGKQLPRL DNIIRLQFKD HIVLTVGPDK NPFDEAQQKV VYIYHSLKNV 400
    RQMHMIGEEE ESEIFGLRFP LSHVDALKQI WCGSPIRVKD LKLDTDEEKE 450
    NLALSLWSES LIQVL 465
    Length:465
    Mass (Da):53,517
    Last modified:October 23, 2007 - v2
    Checksum:iE0504FE459FFC47A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151A → E in AAH25109. (PubMed:15489334)Curated
    Sequence conflicti15 – 151A → E in AAH23462. (PubMed:15489334)Curated
    Sequence conflicti107 – 1071S → N in BAC27503. (PubMed:16141072)Curated
    Sequence conflicti440 – 4401D → E in AAH25109. (PubMed:15489334)Curated
    Sequence conflicti440 – 4401D → E in AAH23462. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB177385 mRNA. Translation: BAD60965.1.
    AK007810 mRNA. Translation: BAB25275.1.
    AK013451 mRNA. Translation: BAB28860.1.
    AK031671 mRNA. Translation: BAC27503.1.
    BC023462 mRNA. Translation: AAH23462.1.
    BC025109 mRNA. Translation: AAH25109.1.
    BC058242 mRNA. Translation: AAH58242.1.
    CCDSiCCDS28257.1.
    RefSeqiNP_080186.3. NM_025910.3.
    XP_006522542.1. XM_006522479.1.
    UniGeneiMm.289150.

    Genome annotation databases

    EnsembliENSMUST00000023407; ENSMUSP00000023407; ENSMUSG00000022724.
    ENSMUST00000160571; ENSMUSP00000125297; ENSMUSG00000022724.
    GeneIDi67014.
    KEGGimmu:67014.
    UCSCiuc007zph.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB177385 mRNA. Translation: BAD60965.1 .
    AK007810 mRNA. Translation: BAB25275.1 .
    AK013451 mRNA. Translation: BAB28860.1 .
    AK031671 mRNA. Translation: BAC27503.1 .
    BC023462 mRNA. Translation: AAH23462.1 .
    BC025109 mRNA. Translation: AAH25109.1 .
    BC058242 mRNA. Translation: AAH58242.1 .
    CCDSi CCDS28257.1.
    RefSeqi NP_080186.3. NM_025910.3.
    XP_006522542.1. XM_006522479.1.
    UniGenei Mm.289150.

    3D structure databases

    ProteinModelPortali Q8CD15.
    SMRi Q8CD15. Positions 31-465.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CD15. 1 interaction.
    MINTi MINT-4115257.

    PTM databases

    PhosphoSitei Q8CD15.

    Proteomic databases

    MaxQBi Q8CD15.
    PaxDbi Q8CD15.
    PRIDEi Q8CD15.

    Protocols and materials databases

    DNASUi 67014.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023407 ; ENSMUSP00000023407 ; ENSMUSG00000022724 .
    ENSMUST00000160571 ; ENSMUSP00000125297 ; ENSMUSG00000022724 .
    GeneIDi 67014.
    KEGGi mmu:67014.
    UCSCi uc007zph.2. mouse.

    Organism-specific databases

    CTDi 84864.
    MGIi MGI:1914264. Mina.

    Phylogenomic databases

    eggNOGi NOG83808.
    GeneTreei ENSGT00390000000083.
    HOGENOMi HOG000007965.
    HOVERGENi HBG055265.
    InParanoidi Q8CD15.
    OMAi STYQNNS.
    OrthoDBi EOG7T1RBJ.
    PhylomeDBi Q8CD15.
    TreeFami TF318659.

    Miscellaneous databases

    ChiTaRSi MINA. mouse.
    NextBioi 323310.
    PROi Q8CD15.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CD15.
    CleanExi MM_MINA.
    Genevestigatori Q8CD15.

    Family and domain databases

    InterProi IPR003347. JmjC_dom.
    [Graphical view ]
    Pfami PF08007. Cupin_4. 1 hit.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of Mina53, a product of a Myc target gene in mouse testis."
      Tsuneoka M., Nishimune Y., Ohta K., Teye K., Tanaka H., Soejima M., Iida H., Inokuchi T., Kimura H., Koda Y.
      Int. J. Androl. 29:323-330(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
      Tissue: StomachImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: EmbryoImported, Embryonic testisImported and PancreasImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported and FVB/NImported.
      Tissue: KidneyImported and Olfactory epitheliumImported.

    Entry informationi

    Entry nameiMINA_MOUSE
    AccessioniPrimary (citable) accession number: Q8CD15
    Secondary accession number(s): Q8QZX1, Q9CQ03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3