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Q8CD15 (MINA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA

EC=1.14.11.-
Alternative name(s):
Histone lysine demethylase MINA
MYC-induced nuclear antigen
Gene names
Name:Mina
Synonyms:Mina53
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' By similarity. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. Ref.1

Catalytic activity

L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO2.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Subcellular location

Nucleus. Nucleusnucleolus Ref.1.

Tissue specificity

Predominantly expressed in testis. Expressed at high levels in spleen, thymus, and colon, but barely detectable in brain, skeletal muscle, and seminal vesicle (at protein level). Ref.1

Developmental stage

In testis, expressed in the nuclei of spermatogonia at all stages of the seminiferous epithelial cycle, and in meiotic prophase cells such as preleptotene, leptotene and zygotene, and weakly in early pachytene spermatocytes, but is absent in late pachytene spermatocytes, spermatids and mature sperm (at protein level). Ref.1

Induction

Up-regulated in experimentally-induced cryptorchid testis. Ref.1

Sequence similarities

Belongs to the MINA53/NO66 family.

Contains 1 JmjC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
PRO_0000308378

Regions

Domain139 – 271133JmjC

Sites

Metal binding1791Iron; catalytic By similarity
Metal binding1811Iron; catalytic By similarity
Metal binding2401Iron; catalytic By similarity

Amino acid modifications

Modified residue3091Phosphoserine By similarity

Experimental info

Sequence conflict151A → E in AAH25109. Ref.3
Sequence conflict151A → E in AAH23462. Ref.3
Sequence conflict1071S → N in BAC27503. Ref.2
Sequence conflict4401D → E in AAH25109. Ref.3
Sequence conflict4401D → E in AAH23462. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8CD15 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: E0504FE459FFC47A

FASTA46553,517
        10         20         30         40         50         60 
MPKKVQPTGD ENEEASVPCK RVKEELPETL SVLNFDSPSS FFESLISPIK VETFFKEFWE 

        70         80         90        100        110        120 
QKPLLIQRDD PVLAKYYQSL FSLSDLKRLC KKGVYYGRDV NVCRSISGKK KVLNKDGRAH 

       130        140        150        160        170        180 
FLQLRKDFDQ KRATIQFHQP QRYKDELWRI QEKLECYFGS LVGSNVYMTP AGSQGLPPHY 

       190        200        210        220        230        240 
DDVEVFILQL EGTKHWRLYS PTVPLAHEYS VESEDRIGTP THDFLLKPGD LLYFPRGTIH 

       250        260        270        280        290        300 
QAETPSGLAY SIHLTISTYQ NNSWGDCLLD SISGFVFDIA KEDVALRSGM PRRMLLNVET 

       310        320        330        340        350        360 
PADVTRKLSG FLRTLADQLE GREELLSSDM KKDFVKHRLP PFFEGNGTET MDPGKQLPRL 

       370        380        390        400        410        420 
DNIIRLQFKD HIVLTVGPDK NPFDEAQQKV VYIYHSLKNV RQMHMIGEEE ESEIFGLRFP 

       430        440        450        460 
LSHVDALKQI WCGSPIRVKD LKLDTDEEKE NLALSLWSES LIQVL 

« Hide

References

« Hide 'large scale' references
[1]"Expression of Mina53, a product of a Myc target gene in mouse testis."
Tsuneoka M., Nishimune Y., Ohta K., Teye K., Tanaka H., Soejima M., Iida H., Inokuchi T., Kimura H., Koda Y.
Int. J. Androl. 29:323-330(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
Tissue: Stomach.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Embryonic testis and Pancreas.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Kidney and Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB177385 mRNA. Translation: BAD60965.1.
AK007810 mRNA. Translation: BAB25275.1.
AK013451 mRNA. Translation: BAB28860.1.
AK031671 mRNA. Translation: BAC27503.1.
BC023462 mRNA. Translation: AAH23462.1.
BC025109 mRNA. Translation: AAH25109.1.
BC058242 mRNA. Translation: AAH58242.1.
CCDSCCDS28257.1.
RefSeqNP_080186.3. NM_025910.3.
XP_006522542.1. XM_006522479.1.
UniGeneMm.289150.

3D structure databases

ProteinModelPortalQ8CD15.
SMRQ8CD15. Positions 31-465.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8CD15. 1 interaction.
MINTMINT-4115257.

PTM databases

PhosphoSiteQ8CD15.

Proteomic databases

MaxQBQ8CD15.
PaxDbQ8CD15.
PRIDEQ8CD15.

Protocols and materials databases

DNASU67014.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023407; ENSMUSP00000023407; ENSMUSG00000022724.
ENSMUST00000160571; ENSMUSP00000125297; ENSMUSG00000022724.
GeneID67014.
KEGGmmu:67014.
UCSCuc007zph.2. mouse.

Organism-specific databases

CTD84864.
MGIMGI:1914264. Mina.

Phylogenomic databases

eggNOGNOG83808.
GeneTreeENSGT00390000000083.
HOGENOMHOG000007965.
HOVERGENHBG055265.
InParanoidQ8CD15.
OMASTYQNNS.
OrthoDBEOG7T1RBJ.
PhylomeDBQ8CD15.
TreeFamTF318659.

Gene expression databases

BgeeQ8CD15.
CleanExMM_MINA.
GenevestigatorQ8CD15.

Family and domain databases

InterProIPR003347. JmjC_dom.
[Graphical view]
PfamPF08007. Cupin_4. 1 hit.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMINA. mouse.
NextBio323310.
PROQ8CD15.
SOURCESearch...

Entry information

Entry nameMINA_MOUSE
AccessionPrimary (citable) accession number: Q8CD15
Secondary accession number(s): Q8QZX1, Q9CQ03
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot