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Q8CD15

- MINA_MOUSE

UniProt

Q8CD15 - MINA_MOUSE

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Protein

Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA

Gene

Mina

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' By similarity. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.By similarity1 Publication

Catalytic activityi

L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO2.

Cofactori

Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi179 – 1791Iron; catalyticPROSITE-ProRule annotation
Metal bindingi181 – 1811Iron; catalyticPROSITE-ProRule annotation
Metal bindingi240 – 2401Iron; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. dioxygenase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: MGI

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: GOC
  2. regulation of cell proliferation Source: MGI
  3. ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Ribosome biogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (EC:1.14.11.-)
Alternative name(s):
Histone lysine demethylase MINA
MYC-induced nuclear antigen
Gene namesi
Name:MinaImported
Synonyms:Mina531 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1914264. Mina.

Subcellular locationi

Nucleus 1 Publication. Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. cytosol Source: MGI
  2. nucleolus Source: MGI
  3. nucleus Source: MGI
  4. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINAPRO_0000308378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CD15.
PaxDbiQ8CD15.
PRIDEiQ8CD15.

PTM databases

PhosphoSiteiQ8CD15.

Expressioni

Tissue specificityi

Predominantly expressed in testis. Expressed at high levels in spleen, thymus, and colon, but barely detectable in brain, skeletal muscle, and seminal vesicle (at protein level).1 Publication

Developmental stagei

In testis, expressed in the nuclei of spermatogonia at all stages of the seminiferous epithelial cycle, and in meiotic prophase cells such as preleptotene, leptotene and zygotene, and weakly in early pachytene spermatocytes, but is absent in late pachytene spermatocytes, spermatids and mature sperm (at protein level).1 Publication

Inductioni

Up-regulated in experimentally-induced cryptorchid testis.1 Publication

Gene expression databases

BgeeiQ8CD15.
CleanExiMM_MINA.
ExpressionAtlasiQ8CD15. baseline and differential.
GenevestigatoriQ8CD15.

Interactioni

Protein-protein interaction databases

IntActiQ8CD15. 1 interaction.
MINTiMINT-4115257.

Structurei

3D structure databases

ProteinModelPortaliQ8CD15.
SMRiQ8CD15. Positions 31-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 271133JmjCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MINA53/NO66 family.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG83808.
GeneTreeiENSGT00390000000083.
HOGENOMiHOG000007965.
HOVERGENiHBG055265.
InParanoidiQ8CD15.
OMAiSTYQNNS.
OrthoDBiEOG7T1RBJ.
PhylomeDBiQ8CD15.
TreeFamiTF318659.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF08007. Cupin_4. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CD15-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKKVQPTGD ENEEASVPCK RVKEELPETL SVLNFDSPSS FFESLISPIK
60 70 80 90 100
VETFFKEFWE QKPLLIQRDD PVLAKYYQSL FSLSDLKRLC KKGVYYGRDV
110 120 130 140 150
NVCRSISGKK KVLNKDGRAH FLQLRKDFDQ KRATIQFHQP QRYKDELWRI
160 170 180 190 200
QEKLECYFGS LVGSNVYMTP AGSQGLPPHY DDVEVFILQL EGTKHWRLYS
210 220 230 240 250
PTVPLAHEYS VESEDRIGTP THDFLLKPGD LLYFPRGTIH QAETPSGLAY
260 270 280 290 300
SIHLTISTYQ NNSWGDCLLD SISGFVFDIA KEDVALRSGM PRRMLLNVET
310 320 330 340 350
PADVTRKLSG FLRTLADQLE GREELLSSDM KKDFVKHRLP PFFEGNGTET
360 370 380 390 400
MDPGKQLPRL DNIIRLQFKD HIVLTVGPDK NPFDEAQQKV VYIYHSLKNV
410 420 430 440 450
RQMHMIGEEE ESEIFGLRFP LSHVDALKQI WCGSPIRVKD LKLDTDEEKE
460
NLALSLWSES LIQVL
Length:465
Mass (Da):53,517
Last modified:October 23, 2007 - v2
Checksum:iE0504FE459FFC47A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151A → E in AAH25109. (PubMed:15489334)Curated
Sequence conflicti15 – 151A → E in AAH23462. (PubMed:15489334)Curated
Sequence conflicti107 – 1071S → N in BAC27503. (PubMed:16141072)Curated
Sequence conflicti440 – 4401D → E in AAH25109. (PubMed:15489334)Curated
Sequence conflicti440 – 4401D → E in AAH23462. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB177385 mRNA. Translation: BAD60965.1.
AK007810 mRNA. Translation: BAB25275.1.
AK013451 mRNA. Translation: BAB28860.1.
AK031671 mRNA. Translation: BAC27503.1.
BC023462 mRNA. Translation: AAH23462.1.
BC025109 mRNA. Translation: AAH25109.1.
BC058242 mRNA. Translation: AAH58242.1.
CCDSiCCDS28257.1.
RefSeqiNP_080186.3. NM_025910.3.
XP_006522542.1. XM_006522479.1.
UniGeneiMm.289150.

Genome annotation databases

EnsembliENSMUST00000023407; ENSMUSP00000023407; ENSMUSG00000022724.
ENSMUST00000160571; ENSMUSP00000125297; ENSMUSG00000022724.
GeneIDi67014.
KEGGimmu:67014.
UCSCiuc007zph.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB177385 mRNA. Translation: BAD60965.1 .
AK007810 mRNA. Translation: BAB25275.1 .
AK013451 mRNA. Translation: BAB28860.1 .
AK031671 mRNA. Translation: BAC27503.1 .
BC023462 mRNA. Translation: AAH23462.1 .
BC025109 mRNA. Translation: AAH25109.1 .
BC058242 mRNA. Translation: AAH58242.1 .
CCDSi CCDS28257.1.
RefSeqi NP_080186.3. NM_025910.3.
XP_006522542.1. XM_006522479.1.
UniGenei Mm.289150.

3D structure databases

ProteinModelPortali Q8CD15.
SMRi Q8CD15. Positions 31-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CD15. 1 interaction.
MINTi MINT-4115257.

PTM databases

PhosphoSitei Q8CD15.

Proteomic databases

MaxQBi Q8CD15.
PaxDbi Q8CD15.
PRIDEi Q8CD15.

Protocols and materials databases

DNASUi 67014.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023407 ; ENSMUSP00000023407 ; ENSMUSG00000022724 .
ENSMUST00000160571 ; ENSMUSP00000125297 ; ENSMUSG00000022724 .
GeneIDi 67014.
KEGGi mmu:67014.
UCSCi uc007zph.2. mouse.

Organism-specific databases

CTDi 84864.
MGIi MGI:1914264. Mina.

Phylogenomic databases

eggNOGi NOG83808.
GeneTreei ENSGT00390000000083.
HOGENOMi HOG000007965.
HOVERGENi HBG055265.
InParanoidi Q8CD15.
OMAi STYQNNS.
OrthoDBi EOG7T1RBJ.
PhylomeDBi Q8CD15.
TreeFami TF318659.

Miscellaneous databases

ChiTaRSi MINA. mouse.
NextBioi 323310.
PROi Q8CD15.
SOURCEi Search...

Gene expression databases

Bgeei Q8CD15.
CleanExi MM_MINA.
ExpressionAtlasi Q8CD15. baseline and differential.
Genevestigatori Q8CD15.

Family and domain databases

InterProi IPR003347. JmjC_dom.
[Graphical view ]
Pfami PF08007. Cupin_4. 1 hit.
[Graphical view ]
SMARTi SM00558. JmjC. 1 hit.
[Graphical view ]
PROSITEi PS51184. JMJC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of Mina53, a product of a Myc target gene in mouse testis."
    Tsuneoka M., Nishimune Y., Ohta K., Teye K., Tanaka H., Soejima M., Iida H., Inokuchi T., Kimura H., Koda Y.
    Int. J. Androl. 29:323-330(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Tissue: StomachImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: EmbryoImported, Embryonic testisImported and PancreasImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported and FVB/NImported.
    Tissue: KidneyImported and Olfactory epitheliumImported.

Entry informationi

Entry nameiMINA_MOUSE
AccessioniPrimary (citable) accession number: Q8CD15
Secondary accession number(s): Q8QZX1, Q9CQ03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3