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Protein

NACHT, LRR and PYD domains-containing protein 10

Gene

Nlrp10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1768ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • defense response to fungus Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • dendritic cell migration Source: UniProtKB
  • helper T cell enhancement of adaptive immune response Source: UniProtKB
  • innate immune response Source: UniProtKB-KW
  • positive regulation of interleukin-6 secretion Source: UniProtKB
  • positive regulation of interleukin-8 secretion Source: UniProtKB
  • positive regulation of T-helper 17 type immune response Source: UniProtKB
  • positive regulation of T-helper 1 type immune response Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 10
Gene namesi
Name:Nlrp10
Synonyms:Nalp10, Pynod
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2444084. Nlrp10.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired adaptive immunity due to inability of dendritic cells to transport antigen from inflamed tissue to the lymph nodes. High susceptibility to systemic infection by C.albicans with 100% mortality by day 16 post-infection.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673NACHT, LRR and PYD domains-containing protein 10PRO_0000080897Add
BLAST

Proteomic databases

PaxDbiQ8CCN1.
PRIDEiQ8CCN1.

PTM databases

iPTMnetiQ8CCN1.
PhosphoSiteiQ8CCN1.

Expressioni

Tissue specificityi

Expressed in skin, tongue, heart, colon and several cell lines of hematopoietic and myocytic origin but not in kidney, skeletal muscle, spleen, liver, lung, thymus, brain or small intestine (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000049709.
CleanExiMM_NLRP10.
ExpressionAtlasiQ8CCN1. baseline and differential.
GenevisibleiQ8CCN1. MM.

Interactioni

Subunit structurei

Oligomerizes. Interacts with PYCARD, CASP1 and IL1B. Also interacts with NOD1 and components of the NOD1 signaling pathway including RIPK2, NR2C2/TAK1 and IKBKG/NEMO (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050252.

Structurei

Secondary structure

1
673
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 1911
Helixi22 – 3615
Beta strandi42 – 443
Turni45 – 473
Helixi52 – 609
Helixi63 – 7715
Helixi80 – 889
Beta strandi97 – 993

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DO9NMR-A1-102[»]
ProteinModelPortaliQ8CCN1.
SMRiQ8CCN1. Positions 1-102, 159-185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CCN1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292PyrinPROSITE-ProRule annotationAdd
BLAST
Domaini163 – 469307NACHTPROSITE-ProRule annotationAdd
BLAST

Domaini

The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection.By similarity
The NACHT domain is required for inhibition of CASP1 autoprocessing.By similarity

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGPF. Eukaryota.
ENOG410Y19A. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000113728.
HOVERGENiHBG052572.
InParanoidiQ8CCN1.
OMAiDIFMAYV.
OrthoDBiEOG091G01CG.
PhylomeDBiQ8CCN1.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CCN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALARANSPQ EALLWALNDL EENSFKTLKF HLRDVTQFHL ARGELESLSQ
60 70 80 90 100
VDLASKLISM YGAQEAVRVV SRSLLAMNLM ELVDYLNQVC LNDYREIYRE
110 120 130 140 150
HVRCLEERQD WGVNSSHNKL LLMATSSSGG RRSPSCSDLE QELDPVDVET
160 170 180 190 200
LFAPEAESYS TPPIVVMQGS AGTGKTTLVK KLVQDWSKGK LYPGQFDYVF
210 220 230 240 250
YVSCREVVLL PKCDLPNLIC WCCGDDQAPV TEILRQPGRL LFILDGYDEL
260 270 280 290 300
QKSSRAECVL HILMRRREVP CSLLITTRPP ALQSLEPMLG ERRHVLVLGF
310 320 330 340 350
SEEERETYFS SCFTDKEQLK NALEFVQNNA VLYKACQVPG ICWVVCSWLK
360 370 380 390 400
KKMARGQEVS ETPSNSTDIF TAYVSTFLPT DGNGDSSELT RHKVLKSLCS
410 420 430 440 450
LAAEGMRHQR LLFEEEVLRK HGLDGPSLTA FLNCIDYRAG LGIKKFYSFR
460 470 480 490 500
HISFQEFFYA MSFLVKEDQS QQGEATHKEV AKLVDPENHE EVTLSLQFLF
510 520 530 540 550
DMLKTEGTLS LGLKFCFRIA PSVRQDLKHF KEQIEAIKYK RSWDLEFSLY
560 570 580 590 600
DSKIKKLTQG IQMKDVILNV QHLDEKKSDK KKSVSVTSSF SSGKVQSPFL
610 620 630 640 650
GNDKSTRKQK KASNGKSRGA EEPAPGVRNR RLASREKGHM EMNDKEDGGV
660 670
EEQEDEEGQT LKKDGEMIDK MNG
Length:673
Mass (Da):76,367
Last modified:March 1, 2003 - v1
Checksum:iEE773C592BEC7054
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032446 mRNA. Translation: BAC27872.1.
CCDSiCCDS21730.1.
RefSeqiNP_780741.1. NM_175532.3.
UniGeneiMm.37991.

Genome annotation databases

EnsembliENSMUST00000055745; ENSMUSP00000050252; ENSMUSG00000049709.
GeneIDi244202.
KEGGimmu:244202.
UCSCiuc009jdb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032446 mRNA. Translation: BAC27872.1.
CCDSiCCDS21730.1.
RefSeqiNP_780741.1. NM_175532.3.
UniGeneiMm.37991.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DO9NMR-A1-102[»]
ProteinModelPortaliQ8CCN1.
SMRiQ8CCN1. Positions 1-102, 159-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050252.

PTM databases

iPTMnetiQ8CCN1.
PhosphoSiteiQ8CCN1.

Proteomic databases

PaxDbiQ8CCN1.
PRIDEiQ8CCN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055745; ENSMUSP00000050252; ENSMUSG00000049709.
GeneIDi244202.
KEGGimmu:244202.
UCSCiuc009jdb.1. mouse.

Organism-specific databases

CTDi338322.
MGIiMGI:2444084. Nlrp10.

Phylogenomic databases

eggNOGiENOG410IGPF. Eukaryota.
ENOG410Y19A. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000113728.
HOVERGENiHBG052572.
InParanoidiQ8CCN1.
OMAiDIFMAYV.
OrthoDBiEOG091G01CG.
PhylomeDBiQ8CCN1.

Miscellaneous databases

EvolutionaryTraceiQ8CCN1.
PROiQ8CCN1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049709.
CleanExiMM_NLRP10.
ExpressionAtlasiQ8CCN1. baseline and differential.
GenevisibleiQ8CCN1. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAL10_MOUSE
AccessioniPrimary (citable) accession number: Q8CCN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Despite its official name, does not contain LRR repeats.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.