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Q8CCK0

- H2AW_MOUSE

UniProt

Q8CCK0 - H2AW_MOUSE

Protein

Core histone macro-H2A.2

Gene

H2afy2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. dosage compensation Source: MGI
    3. nucleosome assembly Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198626. Meiotic synapsis.
    REACT_200667. NoRC negatively regulates rRNA expression.
    REACT_214440. NoRC negatively regulates rRNA expression.
    REACT_27235. Meiotic Recombination.
    REACT_75800. Meiotic Synapsis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Core histone macro-H2A.2
    Short name:
    Histone macroH2A2
    Short name:
    mH2A2
    Gene namesi
    Name:H2afy2
    Synonyms:H2afy3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:3037658. H2afy2.

    Subcellular locationi

    Nucleus 1 Publication. Chromosome 1 Publication
    Note: Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

    GO - Cellular componenti

    1. Barr body Source: MGI
    2. nucleosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Chromosome, Nucleosome core, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Core histone macro-H2A.2PRO_0000227906Add
    BLAST

    Proteomic databases

    MaxQBiQ8CCK0.
    PaxDbiQ8CCK0.
    PRIDEiQ8CCK0.

    PTM databases

    PhosphoSiteiQ8CCK0.

    Expressioni

    Tissue specificityi

    Present in liver, kidney and adrenal gland (at protein level). In the liver, present in cells of the bile ducts and parenchymal cells, but not in hepatocytes. In the kidney, present in proximal and distal convoluted tubules and in glomeruli. Present at highest levels in the parietal layer of Bowman capsule. In the adrenal gland, present in the outer cells of the capsule.1 Publication

    Gene expression databases

    ArrayExpressiQ8CCK0.
    BgeeiQ8CCK0.
    CleanExiMM_H2AFY2.
    GenevestigatoriQ8CCK0.

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CCK0.
    SMRiQ8CCK0. Positions 12-117, 177-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 117116Histone H2AAdd
    BLAST
    Domaini184 – 370187MacroPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 histone H2A domain.Curated
    Contains 1 Macro domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2110.
    GeneTreeiENSGT00740000115281.
    HOGENOMiHOG000234653.
    HOVERGENiHBG009342.
    InParanoidiA0JP36.
    KOiK11251.
    OMAiKVEGIVH.
    OrthoDBiEOG71G9VP.
    PhylomeDBiQ8CCK0.
    TreeFamiTF332276.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR021171. Core_histone_macro-H2A.
    IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR002119. Histone_H2A.
    IPR002589. Macro_dom.
    [Graphical view]
    PfamiPF00125. Histone. 1 hit.
    PF01661. Macro. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037942. Core_histone_macro-H2A. 1 hit.
    PRINTSiPR00620. HISTONEH2A.
    SMARTiSM00414. H2A. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    PROSITEiPS51154. MACRO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CCK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGRSGKKKM SKLSRSARAG VIFPVGRLMR YLKKGTFKYR ISVGAPVYMA    50
    AVIEYLAAEI LELAGNAARD NKKARIAPRH ILLAVANDEE LNQLLKGVTI 100
    ASGGVLPRIH PELLAKKRGT KGKSETILSP PPEKRGRKAA SGKKGGKKSK 150
    ATKPRTSKKS KAKDSDKEGT SNSTSEDGPG DGFTILSSKS LVLGQKLSLT 200
    QSDISHIGSM RVEGIVHPTT AEIDLKEEIG KALEKAGGKE FLETVKELRK 250
    SQGPLEVAEA AVSQSSGLAA KFVIHCHIPQ WGSDKCEEQL EETIKNCLSA 300
    AEDKKLKSVA FPPFPSGRNC FPKQTAAQVT LKAISAHFDD SSSSSLKNVY 350
    FLLFDSESIG IYVQEMAKLD TK 372
    Length:372
    Mass (Da):40,092
    Last modified:January 23, 2007 - v3
    Checksum:i471E3CDCE28F4A1D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901E → D in BAC27963. (PubMed:16141072)Curated
    Sequence conflicti239 – 2391K → E in BAE38003. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF336305 mRNA. Translation: AAK52472.1.
    AK032636 mRNA. Translation: BAC27963.1.
    AK165020 mRNA. Translation: BAE38003.1.
    BC045140 mRNA. Translation: AAH45140.1.
    BC046794 mRNA. Translation: AAH46794.1.
    BC107279 mRNA. Translation: AAI07280.1.
    BC107280 mRNA. Translation: AAI07281.1.
    BC127144 mRNA. Translation: AAI27145.1.
    CCDSiCCDS23885.1.
    RefSeqiNP_996883.1. NM_207000.2.
    UniGeneiMm.272870.

    Genome annotation databases

    EnsembliENSMUST00000020283; ENSMUSP00000020283; ENSMUSG00000020086.
    GeneIDi404634.
    KEGGimmu:404634.
    UCSCiuc007fgm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF336305 mRNA. Translation: AAK52472.1 .
    AK032636 mRNA. Translation: BAC27963.1 .
    AK165020 mRNA. Translation: BAE38003.1 .
    BC045140 mRNA. Translation: AAH45140.1 .
    BC046794 mRNA. Translation: AAH46794.1 .
    BC107279 mRNA. Translation: AAI07280.1 .
    BC107280 mRNA. Translation: AAI07281.1 .
    BC127144 mRNA. Translation: AAI27145.1 .
    CCDSi CCDS23885.1.
    RefSeqi NP_996883.1. NM_207000.2.
    UniGenei Mm.272870.

    3D structure databases

    ProteinModelPortali Q8CCK0.
    SMRi Q8CCK0. Positions 12-117, 177-369.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8CCK0.

    Proteomic databases

    MaxQBi Q8CCK0.
    PaxDbi Q8CCK0.
    PRIDEi Q8CCK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020283 ; ENSMUSP00000020283 ; ENSMUSG00000020086 .
    GeneIDi 404634.
    KEGGi mmu:404634.
    UCSCi uc007fgm.1. mouse.

    Organism-specific databases

    CTDi 55506.
    MGIi MGI:3037658. H2afy2.

    Phylogenomic databases

    eggNOGi COG2110.
    GeneTreei ENSGT00740000115281.
    HOGENOMi HOG000234653.
    HOVERGENi HBG009342.
    InParanoidi A0JP36.
    KOi K11251.
    OMAi KVEGIVH.
    OrthoDBi EOG71G9VP.
    PhylomeDBi Q8CCK0.
    TreeFami TF332276.

    Enzyme and pathway databases

    Reactomei REACT_198626. Meiotic synapsis.
    REACT_200667. NoRC negatively regulates rRNA expression.
    REACT_214440. NoRC negatively regulates rRNA expression.
    REACT_27235. Meiotic Recombination.
    REACT_75800. Meiotic Synapsis.

    Miscellaneous databases

    NextBioi 407104.
    PROi Q8CCK0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CCK0.
    Bgeei Q8CCK0.
    CleanExi MM_H2AFY2.
    Genevestigatori Q8CCK0.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR021171. Core_histone_macro-H2A.
    IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR002119. Histone_H2A.
    IPR002589. Macro_dom.
    [Graphical view ]
    Pfami PF00125. Histone. 1 hit.
    PF01661. Macro. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037942. Core_histone_macro-H2A. 1 hit.
    PRINTSi PR00620. HISTONEH2A.
    SMARTi SM00414. H2A. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    PROSITEi PS51154. MACRO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant."
      Chadwick B.P., Willard H.F.
      Hum. Mol. Genet. 10:1101-1113(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Olfactory epithelium.
    4. "MACROH2A2, a new member of the MACROH2A core histone family."
      Costanzi C., Pehrson J.R.
      J. Biol. Chem. 276:21776-21784(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiH2AW_MOUSE
    AccessioniPrimary (citable) accession number: Q8CCK0
    Secondary accession number(s): A0JP36, Q3TNT4, Q925I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3