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Protein

APC membrane recruitment protein 2

Gene

Amer2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
APC membrane recruitment protein 2
Short name:
Amer2
Alternative name(s):
Protein FAM123A
Gene namesi
Name:Amer2
Synonyms:Fam123a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919375 Amer2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818861 – 672APC membrane recruitment protein 2Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CCJ4
PeptideAtlasiQ8CCJ4
PRIDEiQ8CCJ4

PTM databases

iPTMnetiQ8CCJ4
PhosphoSitePlusiQ8CCJ4

Interactioni

Subunit structurei

Interacts with APC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CCJ4, 2 interactors
MINTiQ8CCJ4
STRINGi10090.ENSMUSP00000022561

Structurei

3D structure databases

ProteinModelPortaliQ8CCJ4
SMRiQ8CCJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi204 – 207Poly-Glu4

Sequence similaritiesi

Belongs to the Amer family.Curated

Phylogenomic databases

eggNOGiENOG410IM10 Eukaryota
ENOG410ZHFV LUCA
HOGENOMiHOG000168235
HOVERGENiHBG107862
InParanoidiQ8CCJ4
PhylomeDBiQ8CCJ4
TreeFamiTF333006

Family and domain databases

InterProiView protein in InterPro
IPR019003 AMER
PANTHERiPTHR22237 PTHR22237, 1 hit
PfamiView protein in Pfam
PF09422 WTX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CCJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METGRSRGGG AAVSERGGGA RAGVCGRQEQ AGALAADMDS HCECAAETPA
60 70 80 90 100
AEPPSGKINK AAFKLFKKRK SGGTMPSIFG VKNKGDGKSS GPTGMVRSRT
110 120 130 140 150
HDGLAEVLVL EGSKKEEPPG GSDHSGARPI PGPPKPSGPG LGSLASSSVA
160 170 180 190 200
KSHSFFSLLK KNGRSETGKG DHAEASKAGG KQKRGLKGIF SSMRWHRRDK
210 220 230 240 250
RGKEEEEKAV RAAGPGNLVL PGSLTASLEC VKEEPPRAAR RPDSPGQDAS
260 270 280 290 300
RHAAGEPAGG EQAPASAESA PERICLEAGS PTGSGDQSSR GEDAEGHRRE
310 320 330 340 350
EKPGAALESG AGEVQAAEDA SKTGDVPIKT VPLVDSEGGS GRASAVPDPS
360 370 380 390 400
SVDPPSDPSA DRICLMFSDV TSLKSFDSLT GCGDIIADPE EEAGPSCDKH
410 420 430 440 450
VPGPGKPVLS KKNASVVAYQ GGGEEMASPD QVDDTYLPEF WDMLSQTEDQ
460 470 480 490 500
GQGTQEGAAK AATASDIKLA PETSSDTRCG EAAKDMSSVK RRRLHRIPIE
510 520 530 540 550
SQQKEEPKHP EKEHQEGVPN SDEGYWDSTT PGPEEESISN SSSSKKVVIP
560 570 580 590 600
RDSDSGDALC DLYVEPEASP ATLPATEDPP CLSRLKPVSP GTITCPLRTP
610 620 630 640 650
GSLLKDSKIP ISIKHLSNLP SSHPVVHQQP ARSEVPRTKI PVSKVLVRRV
660 670
SNRGLAGTTI RAAACHDSAK KL
Length:672
Mass (Da):69,933
Last modified:April 3, 2007 - v2
Checksum:i5CE3FFDF4FFE1348
GO
Isoform 2 (identifier: Q8CCJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-380: Missing.

Show »
Length:546
Mass (Da):57,354
Checksum:iFA5F5882B0409627
GO

Sequence cautioni

The sequence AAH30356 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH56350 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB27452 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC27972 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE23912 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024090255 – 380Missing in isoform 2. 2 PublicationsAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103355 Genomic DNA No translation available.
AK032651 mRNA Translation: BAC27972.1 Different initiation.
AK011185 mRNA Translation: BAB27452.1 Different initiation.
AK139177 mRNA Translation: BAE23912.1 Different initiation.
BC030356 mRNA Translation: AAH30356.1 Different initiation.
BC056350 mRNA Translation: AAH56350.1 Different initiation.
RefSeqiNP_001158177.1, NM_001164705.1
NP_082389.1, NM_028113.3
XP_006519653.1, XM_006519590.3 [Q8CCJ4-1]
UniGeneiMm.275499

Genome annotation databases

GeneIDi72125
KEGGimmu:72125
UCSCiuc007ufb.2 mouse [Q8CCJ4-2]
uc011zmz.1 mouse [Q8CCJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAMER2_MOUSE
AccessioniPrimary (citable) accession number: Q8CCJ4
Secondary accession number(s): Q7TNC5, Q8K0U9, Q9D0Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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