Q8CCH9 (Q8CCH9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAC28164.1

Gene names

Name:

Bdnf MGI 88145

Organism

Mus musculus (Mouse) EMBL BAC28164.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the NGF-beta family. RuleBase RU003917

Ontologies

Keywords
Molecular function	Growth factor RuleBase RU003917 SAAS SAAS019846
Gene Ontology (GO)
Biological_process	axon guidance Inferred from mutant phenotype PubMed 15014133. Source: MGI axon target recognition Inferred from mutant phenotype PubMed 15464571. Source: MGI behavioral fear response Inferred from mutant phenotype PubMed 15249684. Source: MGI dendrite development Inferred from mutant phenotype PubMed 12890780. Source: MGI feeding behavior Inferred from mutant phenotype PubMed 12796784. Source: MGI glutamate secretion Inferred from physical interaction PubMed 16819522. Source: MGI inner ear development Inferred from mutant phenotype PubMed 7605630. Source: MGI learning or memory Inferred from mutant phenotype PubMed 15249684. Source: MGI mechanoreceptor differentiation Inferred from genetic interaction PubMed 15376326. Source: MGI negative regulation of neuroblast proliferation Inferred from direct assay PubMed 12798291. Source: MGI negative regulation of neuron apoptotic process Inferred from mutant phenotype PubMed 15869495PubMed 8861722. Source: MGI nerve development Inferred from mutant phenotype PubMed 7605630. Source: MGI neuron recognition Inferred from mutant phenotype PubMed 15844198. Source: MGI positive regulation of neuron differentiation Inferred from direct assay PubMed 12798291. Source: MGI regulation of metabolic process Inferred from mutant phenotype PubMed 12106019. Source: MGI regulation of retinal cell programmed cell death Inferred from direct assay PubMed 11747369. Source: MGI regulation of synaptic plasticity Inferred from direct assay PubMed 16819522PubMed 17442827. Source: MGI response to drug Inferred from mutant phenotype PubMed 15249684. Source: MGI ureteric bud development Inferred from direct assay PubMed 16018995. Source: MGI
Cellular_component	cytoplasmic membrane-bounded vesicle Inferred from direct assay PubMed 14715936PubMed 15242649. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8CCH9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 90C37276BB235C97	FASTA	249	28,089
	10 20 30 40 50 60 MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR AGSRGLTTTS 70 80 90 100 110 120 LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD 130 140 150 160 170 180 AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK 190 200 210 220 230 240 QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RLIRIDTSCV CTLTIKRGR

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC28164.1. Tissue: Testis EMBL BAC28164.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC28164.1. Tissue: Testis EMBL BAC28164.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC28164.1. Tissue: Testis EMBL BAC28164.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC28164.1. Tissue: Testis EMBL BAC28164.1.
[5]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC28164.1. Tissue: Testis EMBL BAC28164.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC28164.1. Tissue: Testis EMBL BAC28164.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC28164.1. Tissue: Testis EMBL BAC28164.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC28164.1. Tissue: Testis EMBL BAC28164.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK033127 mRNA. Translation: BAC28164.1.
IPI	IPI00121215.
UniGene	Mm.1442.
3D structure databases
ProteinModelPortal	Q8CCH9.
SMR	Q8CCH9. Positions 138-246.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:88145. Bdnf.
Phylogenomic databases
HOVERGEN	HBG006494.
InParanoid	Q8CCH9.
Gene expression databases
Genevestigator	Q8CCH9.
Family and domain databases
InterPro	IPR020430. Brain-der_neurotrophic_factor. IPR020408. Nerve_growth_factor-like. IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. [Graphical view]
PANTHER	PTHR11589. PTHR11589. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR01912. BDNFACTOR. PR00268. NGF.
ProDom	PD002052. Nerve_growth_factor-rel. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q8CCH9_MOUSE

Accession

Primary (citable) accession number: Q8CCH9

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)