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Q8CCH7

- FOG2_MOUSE

UniProt

Q8CCH7 - FOG2_MOUSE

Protein

Zinc finger protein ZFPM2

Gene

Zfpm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.6 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri250 – 27324C2HC-type 1Add
    BLAST
    Zinc fingeri296 – 32025C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri335 – 35723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri363 – 38523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri548 – 57124C2HC-type 2Add
    BLAST
    Zinc fingeri687 – 71024C2HC-type 3Add
    BLAST
    Zinc fingeri854 – 87724C2HC-type 4Add
    BLAST
    Zinc fingeri1119 – 114224C2HC-type 5Add
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. nucleic acid binding transcription factor activity Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. transcription corepressor activity Source: MGI
    6. transcription factor binding Source: MGI

    GO - Biological processi

    1. atrioventricular valve morphogenesis Source: BHF-UCL
    2. cardiac muscle tissue development Source: MGI
    3. cardiac muscle tissue morphogenesis Source: BHF-UCL
    4. embryonic organ development Source: MGI
    5. heart development Source: MGI
    6. in utero embryonic development Source: MGI
    7. lung development Source: MGI
    8. mitral valve formation Source: BHF-UCL
    9. negative regulation of cell death Source: UniProtKB
    10. negative regulation of fat cell differentiation Source: BHF-UCL
    11. negative regulation of female gonad development Source: UniProtKB
    12. negative regulation of transcription, DNA-templated Source: DFLAT
    13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    14. outflow tract morphogenesis Source: BHF-UCL
    15. outflow tract septum morphogenesis Source: Ensembl
    16. positive regulation of male gonad development Source: UniProtKB
    17. positive regulation of transcription, DNA-templated Source: UniProtKB
    18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    19. right ventricular cardiac muscle tissue morphogenesis Source: Ensembl
    20. transcription, DNA-templated Source: UniProtKB-KW
    21. tricuspid valve formation Source: BHF-UCL
    22. vasculogenesis Source: MGI
    23. vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT
    24. ventricular septum morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein ZFPM2
    Alternative name(s):
    Friend of GATA protein 2
    Short name:
    FOG-2
    Short name:
    Friend of GATA 2
    Short name:
    mFOG-2
    Zinc finger protein multitype 2
    Gene namesi
    Name:Zfpm2
    Synonyms:Fog2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1334444. Zfpm2.

    Subcellular locationi

    Nucleus 3 Publications

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice die of congestive heart failure at E13 with a syndrome of tricuspid atresia that includes an absent tricuspid valve, a large atrial and ventricular spetal defects, an elongated left ventricular outflow tract, rightward displacement of the aortic valve and pulmonic stenosis. These mice also display hypoplasia of the compact zone of the left ventricle.1 Publication

    Keywords - Diseasei

    Cardiomyopathy

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11511151Zinc finger protein ZFPM2PRO_0000221044Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki324 – 324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
    Cross-linki471 – 471Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
    Cross-linki915 – 915Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
    Cross-linki955 – 955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

    Post-translational modificationi

    Sumoylation reduces transcriptional repression activity.By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ8CCH7.
    PRIDEiQ8CCH7.

    PTM databases

    PhosphoSiteiQ8CCH7.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain and testis. Weakly expressed in lung and liver. First expressed at approximately E8.5 in the developing ventral heart tube and septum transversum. Cardiac expression persists throughout the remainder of embryonic development in the atria as well as in all layers of the ventricles (endocardium, myocardium, and pericardium). Expressed in the neuroepithelium of the developing midbrain and hindbrain from E11.5 and increased in intensity between E12 and E16.5. Also expressed in the urogenital ridge beginning at E11.5 and subsequently localized to the gonads by E16.5. Colocalizes with GATA4 GATA5 and GATA6 in the developing heart, GATA3 in the brain, and GATA4 in the gonads.3 Publications

    Gene expression databases

    ArrayExpressiQ8CCH7.
    BgeeiQ8CCH7.
    CleanExiMM_ZFPM2.
    GenevestigatoriQ8CCH7.

    Interactioni

    Subunit structurei

    Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Interacts with NR2F2 and NR2F6.6 Publications

    Protein-protein interaction databases

    BioGridi204688. 1 interaction.
    STRINGi10090.ENSMUSP00000051335.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CCH7.
    SMRiQ8CCH7. Positions 186-224, 250-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni829 – 8357Interaction with CTBP2Curated

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi736 – 7405Nuclear localization signal

    Domaini

    The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is probably essential for the interaction with GATA-type zinc fingers.1 Publication

    Sequence similaritiesi

    Belongs to the FOG (Friend of GATA) family.Curated
    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 5 C2HC-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri250 – 27324C2HC-type 1Add
    BLAST
    Zinc fingeri296 – 32025C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri335 – 35723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri363 – 38523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri548 – 57124C2HC-type 2Add
    BLAST
    Zinc fingeri687 – 71024C2HC-type 3Add
    BLAST
    Zinc fingeri854 – 87724C2HC-type 4Add
    BLAST
    Zinc fingeri1119 – 114224C2HC-type 5Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG146797.
    GeneTreeiENSGT00530000063823.
    HOGENOMiHOG000057275.
    HOVERGENiHBG048953.
    InParanoidiQ8CCH7.
    KOiK17442.
    OMAiDPNKTTC.
    OrthoDBiEOG74TWXR.
    PhylomeDBiQ8CCH7.
    TreeFamiTF331342.

    Family and domain databases

    Gene3Di3.30.160.60. 1 hit.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CCH7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRRKQSKPR QIKRPLEDAI DDEEEECPVE EAEVISKGDF PLEGSFPAGF     50
    EPENLSCEDV EFFCNKGDDE GIQEPAESDG DSHSDKPGQP GVETDDWDGP 100
    GELEVFQRDG ERKIQSRQQL PVGTTWGPFA GKMDLNNNSL KTKAQVPMVL 150
    TAGPKWLLDV TWQGVEDSKN NCIVYSKGGQ LWCTTTKAIS EGEELVAFVV 200
    DFDSRLQAAS HMTLTEGMYP ARLLDSIQLL PQQAAMASIL PTAIVNKDIF 250
    PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDN SHQVSSLCPF 300
    PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF 350
    HQHLFSHLTQ AAFRCNHCHF GFQTQRELLQ HQELHVPSGK LPRESDMEHS 400
    PSGTEDSLQP ATDLLARSDL SQSQKAMPTK DASSDTELDK CEKKTQLFLT 450
    NQRPEIQPAA NKQNFSYTKI KSEPSSPRLA SSPVQPNIGP SFPVGPFLSQ 500
    FAFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY SPLMPKGATC 550
    FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK MPEAVSPNTG 600
    QTSINLLNPA AHSSDPENPL LQTSCINSST VLDLIGPNGK GHEKDFSTQV 650
    KKLPTSNSSD DKINGKPVDV KNPSGPLVDG ESDPNKTTCE ACNITFSRHE 700
    TYMVHKQYYC ATRHDPPLKR SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE 750
    QRPPLVQQRF LDVANLSNPC SSTQEPTEGL GECYHPRCDI FPGIVSKHLE 800
    TSLAMNKCVP VPKCDTTHSN VSCLEMDVPI DLSKKCLSQS ERTTASPKRL 850
    LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES 900
    ERSSPEVSFE RNMIKCEKNG NPKQPSPNGN LFSSHLATLQ GLKVFSEAAQ 950
    LIATKEENKH LFLPQCLYPG AIKKTKGADQ LSPYYGIKPS DYIASSLVIH 1000
    NTDVEQSTNT ENESPKGQAS SNGCAVPKKD SLPLLPKNRG MVIVNGGLKQ 1050
    DERPTANPQQ ENISQNTQHE DGHKSPSWIS ENPLAANENV SPGIPCAEEQ 1100
    LSSIAKGVNG ASQAPSSGKY CRLCDIQFNN LSNFITHKKF YCSSHAAEHV 1150
    K 1151
    Length:1,151
    Mass (Da):127,692
    Last modified:March 15, 2004 - v2
    Checksum:i2759B0AA65D84F9E
    GO
    Isoform 2 (identifier: Q8CCH7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         102-111: ELEVFQRDGE → RTESTAFNPL
         112-1151: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:111
    Mass (Da):12,273
    Checksum:iB4E98DF3567B913C
    GO
    Isoform 3 (identifier: Q8CCH7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         381-398: Missing.

    Note: Splicing donor site between exon 3 and 4 is not canonical. No experimental confirmation available.

    Show »
    Length:1,133
    Mass (Da):125,621
    Checksum:i1E4D25871E61ED2D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei102 – 11110ELEVFQRDGE → RTESTAFNPL in isoform 2. 1 PublicationVSP_009703
    Alternative sequencei112 – 11511040Missing in isoform 2. 1 PublicationVSP_009704Add
    BLAST
    Alternative sequencei381 – 39818Missing in isoform 3. 1 PublicationVSP_009705Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118845 mRNA. Translation: AAD17251.1.
    AF107306 mRNA. Translation: AAD12182.1.
    AF125166 mRNA. Translation: AAD33250.1.
    AK033131 mRNA. Translation: BAC28166.1.
    BC059241 mRNA. Translation: AAH59241.1.
    CCDSiCCDS27447.1. [Q8CCH7-1]
    PIRiT18297.
    RefSeqiNP_035896.1. NM_011766.5. [Q8CCH7-1]
    UniGeneiMm.39496.

    Genome annotation databases

    EnsembliENSMUST00000053467; ENSMUSP00000051335; ENSMUSG00000022306. [Q8CCH7-1]
    GeneIDi22762.
    KEGGimmu:22762.
    UCSCiuc007voq.1. mouse. [Q8CCH7-2]
    uc007vos.1. mouse. [Q8CCH7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118845 mRNA. Translation: AAD17251.1 .
    AF107306 mRNA. Translation: AAD12182.1 .
    AF125166 mRNA. Translation: AAD33250.1 .
    AK033131 mRNA. Translation: BAC28166.1 .
    BC059241 mRNA. Translation: AAH59241.1 .
    CCDSi CCDS27447.1. [Q8CCH7-1 ]
    PIRi T18297.
    RefSeqi NP_035896.1. NM_011766.5. [Q8CCH7-1 ]
    UniGenei Mm.39496.

    3D structure databases

    ProteinModelPortali Q8CCH7.
    SMRi Q8CCH7. Positions 186-224, 250-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204688. 1 interaction.
    STRINGi 10090.ENSMUSP00000051335.

    PTM databases

    PhosphoSitei Q8CCH7.

    Proteomic databases

    PaxDbi Q8CCH7.
    PRIDEi Q8CCH7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053467 ; ENSMUSP00000051335 ; ENSMUSG00000022306 . [Q8CCH7-1 ]
    GeneIDi 22762.
    KEGGi mmu:22762.
    UCSCi uc007voq.1. mouse. [Q8CCH7-2 ]
    uc007vos.1. mouse. [Q8CCH7-1 ]

    Organism-specific databases

    CTDi 23414.
    MGIi MGI:1334444. Zfpm2.

    Phylogenomic databases

    eggNOGi NOG146797.
    GeneTreei ENSGT00530000063823.
    HOGENOMi HOG000057275.
    HOVERGENi HBG048953.
    InParanoidi Q8CCH7.
    KOi K17442.
    OMAi DPNKTTC.
    OrthoDBi EOG74TWXR.
    PhylomeDBi Q8CCH7.
    TreeFami TF331342.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 303281.
    PROi Q8CCH7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CCH7.
    Bgeei Q8CCH7.
    CleanExi MM_ZFPM2.
    Genevestigatori Q8CCH7.

    Family and domain databases

    Gene3Di 3.30.160.60. 1 hit.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes."
      Svensson E.C., Tufts R.L., Polk C.E., Leiden J.M.
      Proc. Natl. Acad. Sci. U.S.A. 96:956-961(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH GATA4.
      Tissue: Heart.
    2. "FOG-2: a novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped."
      Tevosian S.G., Deconinck A.E., Cantor A.B., Rieff H.I., Fujiwara Y., Corfas G., Orkin S.H.
      Proc. Natl. Acad. Sci. U.S.A. 96:950-955(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH GATA4.
      Tissue: Embryo.
    3. "FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors."
      Lu J.-R., McKinsey T.A., Xu H., Wang D.-Z., Richardson J.A., Olson E.N.
      Mol. Cell. Biol. 19:4495-4502(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH GATA4 AND GATA5.
      Tissue: Embryonic heart.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6.
      Tissue: Brain.
    6. "Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers."
      Fox A.H., Liew C., Holmes M., Kowalski K., Mackay J., Crossley M.
      EMBO J. 18:2812-2822(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN.
    7. "A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription."
      Svensson E.C., Huggins G.S., Dardik F.B., Polk C.E., Leiden J.M.
      J. Biol. Chem. 275:20762-20769(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTBP2.
    8. "FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium."
      Tevosian S.G., Deconinck A.E., Tanaka M., Schinke M., Litovsky S.H., Izumo S., Fujiwara Y., Orkin S.H.
      Cell 101:729-739(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2."
      Svensson E.C., Huggins G.S., Lin H., Clendenin C., Jiang F., Tufts R., Dardik F.B., Leiden J.M.
      Nat. Genet. 25:353-356(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    10. "Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter."
      Huggins G.S., Bacani C.J., Boltax J., Aikawa R., Leiden J.M.
      J. Biol. Chem. 276:28029-28036(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NR2F1; NR2F2 AND NR2F6.
    11. "Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2."
      Tevosian S.G., Albrecht K.H., Crispino J.D., Fujiwara Y., Eicher E.M., Orkin S.H.
      Development 129:4627-4634(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Transcription factors GATA-4 and GATA-6 and a GATA family cofactor, FOG-2, are expressed in human ovary and sex cord-derived ovarian tumors."
      Laitinen M.P., Anttonen M., Ketola I., Wilson D.B., Ritvos O., Butzow R., Heikinheimo M.
      J. Clin. Endocrinol. Metab. 85:3476-3483(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RXRA.

    Entry informationi

    Entry nameiFOG2_MOUSE
    AccessioniPrimary (citable) accession number: Q8CCH7
    Secondary accession number(s): Q9Z0F2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3