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Q8CCH7

- FOG2_MOUSE

UniProt

Q8CCH7 - FOG2_MOUSE

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Protein

Zinc finger protein ZFPM2

Gene

Zfpm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri250 – 27324C2HC-type 1Add
BLAST
Zinc fingeri296 – 32025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57124C2HC-type 2Add
BLAST
Zinc fingeri687 – 71024C2HC-type 3Add
BLAST
Zinc fingeri854 – 87724C2HC-type 4Add
BLAST
Zinc fingeri1119 – 114224C2HC-type 5Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. transcription corepressor activity Source: MGI
  4. transcription factor binding Source: MGI

GO - Biological processi

  1. atrioventricular valve morphogenesis Source: BHF-UCL
  2. cardiac muscle tissue development Source: MGI
  3. cardiac muscle tissue morphogenesis Source: BHF-UCL
  4. embryonic organ development Source: MGI
  5. heart development Source: MGI
  6. in utero embryonic development Source: MGI
  7. lung development Source: MGI
  8. mitral valve formation Source: BHF-UCL
  9. negative regulation of cell death Source: UniProtKB
  10. negative regulation of fat cell differentiation Source: BHF-UCL
  11. negative regulation of female gonad development Source: UniProtKB
  12. negative regulation of transcription, DNA-templated Source: DFLAT
  13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  14. outflow tract morphogenesis Source: BHF-UCL
  15. outflow tract septum morphogenesis Source: Ensembl
  16. positive regulation of male gonad development Source: UniProtKB
  17. positive regulation of transcription, DNA-templated Source: UniProtKB
  18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  19. right ventricular cardiac muscle tissue morphogenesis Source: Ensembl
  20. transcription, DNA-templated Source: UniProtKB-KW
  21. tricuspid valve formation Source: BHF-UCL
  22. vasculogenesis Source: MGI
  23. vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT
  24. ventricular septum morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM2
Alternative name(s):
Friend of GATA protein 2
Short name:
FOG-2
Short name:
Friend of GATA 2
Short name:
mFOG-2
Zinc finger protein multitype 2
Gene namesi
Name:Zfpm2
Synonyms:Fog2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1334444. Zfpm2.

Subcellular locationi

Nucleus 3 Publications

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice die of congestive heart failure at E13 with a syndrome of tricuspid atresia that includes an absent tricuspid valve, a large atrial and ventricular spetal defects, an elongated left ventricular outflow tract, rightward displacement of the aortic valve and pulmonic stenosis. These mice also display hypoplasia of the compact zone of the left ventricle.1 Publication

Keywords - Diseasei

Cardiomyopathy

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11511151Zinc finger protein ZFPM2PRO_0000221044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki324 – 324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki471 – 471Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki915 – 915Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki955 – 955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Post-translational modificationi

Sumoylation reduces transcriptional repression activity.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8CCH7.
PRIDEiQ8CCH7.

PTM databases

PhosphoSiteiQ8CCH7.

Expressioni

Tissue specificityi

Expressed in heart, brain and testis. Weakly expressed in lung and liver. First expressed at approximately E8.5 in the developing ventral heart tube and septum transversum. Cardiac expression persists throughout the remainder of embryonic development in the atria as well as in all layers of the ventricles (endocardium, myocardium, and pericardium). Expressed in the neuroepithelium of the developing midbrain and hindbrain from E11.5 and increased in intensity between E12 and E16.5. Also expressed in the urogenital ridge beginning at E11.5 and subsequently localized to the gonads by E16.5. Colocalizes with GATA4 GATA5 and GATA6 in the developing heart, GATA3 in the brain, and GATA4 in the gonads.3 Publications

Gene expression databases

BgeeiQ8CCH7.
CleanExiMM_ZFPM2.
ExpressionAtlasiQ8CCH7. baseline and differential.
GenevestigatoriQ8CCH7.

Interactioni

Subunit structurei

Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Interacts with NR2F2 and NR2F6.6 Publications

Protein-protein interaction databases

BioGridi204688. 1 interaction.
STRINGi10090.ENSMUSP00000051335.

Structurei

3D structure databases

ProteinModelPortaliQ8CCH7.
SMRiQ8CCH7. Positions 186-224, 290-324, 353-386, 546-573, 685-713, 1113-1145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni829 – 8357Interaction with CTBP2Curated

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi736 – 7405Nuclear localization signal

Domaini

The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is probably essential for the interaction with GATA-type zinc fingers.1 Publication

Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.Curated
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 5 C2HC-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri250 – 27324C2HC-type 1Add
BLAST
Zinc fingeri296 – 32025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57124C2HC-type 2Add
BLAST
Zinc fingeri687 – 71024C2HC-type 3Add
BLAST
Zinc fingeri854 – 87724C2HC-type 4Add
BLAST
Zinc fingeri1119 – 114224C2HC-type 5Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG146797.
GeneTreeiENSGT00530000063823.
HOGENOMiHOG000057275.
HOVERGENiHBG048953.
InParanoidiQ8CCH7.
KOiK17442.
OMAiDPNKTTC.
OrthoDBiEOG74TWXR.
PhylomeDBiQ8CCH7.
TreeFamiTF331342.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CCH7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRKQSKPR QIKRPLEDAI DDEEEECPVE EAEVISKGDF PLEGSFPAGF
60 70 80 90 100
EPENLSCEDV EFFCNKGDDE GIQEPAESDG DSHSDKPGQP GVETDDWDGP
110 120 130 140 150
GELEVFQRDG ERKIQSRQQL PVGTTWGPFA GKMDLNNNSL KTKAQVPMVL
160 170 180 190 200
TAGPKWLLDV TWQGVEDSKN NCIVYSKGGQ LWCTTTKAIS EGEELVAFVV
210 220 230 240 250
DFDSRLQAAS HMTLTEGMYP ARLLDSIQLL PQQAAMASIL PTAIVNKDIF
260 270 280 290 300
PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDN SHQVSSLCPF
310 320 330 340 350
PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF
360 370 380 390 400
HQHLFSHLTQ AAFRCNHCHF GFQTQRELLQ HQELHVPSGK LPRESDMEHS
410 420 430 440 450
PSGTEDSLQP ATDLLARSDL SQSQKAMPTK DASSDTELDK CEKKTQLFLT
460 470 480 490 500
NQRPEIQPAA NKQNFSYTKI KSEPSSPRLA SSPVQPNIGP SFPVGPFLSQ
510 520 530 540 550
FAFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY SPLMPKGATC
560 570 580 590 600
FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK MPEAVSPNTG
610 620 630 640 650
QTSINLLNPA AHSSDPENPL LQTSCINSST VLDLIGPNGK GHEKDFSTQV
660 670 680 690 700
KKLPTSNSSD DKINGKPVDV KNPSGPLVDG ESDPNKTTCE ACNITFSRHE
710 720 730 740 750
TYMVHKQYYC ATRHDPPLKR SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE
760 770 780 790 800
QRPPLVQQRF LDVANLSNPC SSTQEPTEGL GECYHPRCDI FPGIVSKHLE
810 820 830 840 850
TSLAMNKCVP VPKCDTTHSN VSCLEMDVPI DLSKKCLSQS ERTTASPKRL
860 870 880 890 900
LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES
910 920 930 940 950
ERSSPEVSFE RNMIKCEKNG NPKQPSPNGN LFSSHLATLQ GLKVFSEAAQ
960 970 980 990 1000
LIATKEENKH LFLPQCLYPG AIKKTKGADQ LSPYYGIKPS DYIASSLVIH
1010 1020 1030 1040 1050
NTDVEQSTNT ENESPKGQAS SNGCAVPKKD SLPLLPKNRG MVIVNGGLKQ
1060 1070 1080 1090 1100
DERPTANPQQ ENISQNTQHE DGHKSPSWIS ENPLAANENV SPGIPCAEEQ
1110 1120 1130 1140 1150
LSSIAKGVNG ASQAPSSGKY CRLCDIQFNN LSNFITHKKF YCSSHAAEHV

K
Length:1,151
Mass (Da):127,692
Last modified:March 15, 2004 - v2
Checksum:i2759B0AA65D84F9E
GO
Isoform 2 (identifier: Q8CCH7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-111: ELEVFQRDGE → RTESTAFNPL
     112-1151: Missing.

Note: No experimental confirmation available.

Show »
Length:111
Mass (Da):12,273
Checksum:iB4E98DF3567B913C
GO
Isoform 3 (identifier: Q8CCH7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-398: Missing.

Note: Splicing donor site between exon 3 and 4 is not canonical. No experimental confirmation available.

Show »
Length:1,133
Mass (Da):125,621
Checksum:i1E4D25871E61ED2D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei102 – 11110ELEVFQRDGE → RTESTAFNPL in isoform 2. 1 PublicationVSP_009703
Alternative sequencei112 – 11511040Missing in isoform 2. 1 PublicationVSP_009704Add
BLAST
Alternative sequencei381 – 39818Missing in isoform 3. 1 PublicationVSP_009705Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF118845 mRNA. Translation: AAD17251.1.
AF107306 mRNA. Translation: AAD12182.1.
AF125166 mRNA. Translation: AAD33250.1.
AK033131 mRNA. Translation: BAC28166.1.
BC059241 mRNA. Translation: AAH59241.1.
CCDSiCCDS27447.1. [Q8CCH7-1]
PIRiT18297.
RefSeqiNP_035896.1. NM_011766.5. [Q8CCH7-1]
UniGeneiMm.39496.

Genome annotation databases

EnsembliENSMUST00000053467; ENSMUSP00000051335; ENSMUSG00000022306. [Q8CCH7-1]
GeneIDi22762.
KEGGimmu:22762.
UCSCiuc007voq.1. mouse. [Q8CCH7-2]
uc007vos.1. mouse. [Q8CCH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF118845 mRNA. Translation: AAD17251.1 .
AF107306 mRNA. Translation: AAD12182.1 .
AF125166 mRNA. Translation: AAD33250.1 .
AK033131 mRNA. Translation: BAC28166.1 .
BC059241 mRNA. Translation: AAH59241.1 .
CCDSi CCDS27447.1. [Q8CCH7-1 ]
PIRi T18297.
RefSeqi NP_035896.1. NM_011766.5. [Q8CCH7-1 ]
UniGenei Mm.39496.

3D structure databases

ProteinModelPortali Q8CCH7.
SMRi Q8CCH7. Positions 186-224, 290-324, 353-386, 546-573, 685-713, 1113-1145.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204688. 1 interaction.
STRINGi 10090.ENSMUSP00000051335.

PTM databases

PhosphoSitei Q8CCH7.

Proteomic databases

PaxDbi Q8CCH7.
PRIDEi Q8CCH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053467 ; ENSMUSP00000051335 ; ENSMUSG00000022306 . [Q8CCH7-1 ]
GeneIDi 22762.
KEGGi mmu:22762.
UCSCi uc007voq.1. mouse. [Q8CCH7-2 ]
uc007vos.1. mouse. [Q8CCH7-1 ]

Organism-specific databases

CTDi 23414.
MGIi MGI:1334444. Zfpm2.

Phylogenomic databases

eggNOGi NOG146797.
GeneTreei ENSGT00530000063823.
HOGENOMi HOG000057275.
HOVERGENi HBG048953.
InParanoidi Q8CCH7.
KOi K17442.
OMAi DPNKTTC.
OrthoDBi EOG74TWXR.
PhylomeDBi Q8CCH7.
TreeFami TF331342.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi 303281.
PROi Q8CCH7.
SOURCEi Search...

Gene expression databases

Bgeei Q8CCH7.
CleanExi MM_ZFPM2.
ExpressionAtlasi Q8CCH7. baseline and differential.
Genevestigatori Q8CCH7.

Family and domain databases

Gene3Di 3.30.160.60. 1 hit.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes."
    Svensson E.C., Tufts R.L., Polk C.E., Leiden J.M.
    Proc. Natl. Acad. Sci. U.S.A. 96:956-961(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH GATA4.
    Tissue: Heart.
  2. "FOG-2: a novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped."
    Tevosian S.G., Deconinck A.E., Cantor A.B., Rieff H.I., Fujiwara Y., Corfas G., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 96:950-955(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH GATA4.
    Tissue: Embryo.
  3. "FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors."
    Lu J.-R., McKinsey T.A., Xu H., Wang D.-Z., Richardson J.A., Olson E.N.
    Mol. Cell. Biol. 19:4495-4502(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH GATA4 AND GATA5.
    Tissue: Embryonic heart.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers."
    Fox A.H., Liew C., Holmes M., Kowalski K., Mackay J., Crossley M.
    EMBO J. 18:2812-2822(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  7. "A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription."
    Svensson E.C., Huggins G.S., Dardik F.B., Polk C.E., Leiden J.M.
    J. Biol. Chem. 275:20762-20769(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTBP2.
  8. "FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium."
    Tevosian S.G., Deconinck A.E., Tanaka M., Schinke M., Litovsky S.H., Izumo S., Fujiwara Y., Orkin S.H.
    Cell 101:729-739(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2."
    Svensson E.C., Huggins G.S., Lin H., Clendenin C., Jiang F., Tufts R., Dardik F.B., Leiden J.M.
    Nat. Genet. 25:353-356(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  10. "Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter."
    Huggins G.S., Bacani C.J., Boltax J., Aikawa R., Leiden J.M.
    J. Biol. Chem. 276:28029-28036(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NR2F1; NR2F2 AND NR2F6.
  11. "Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2."
    Tevosian S.G., Albrecht K.H., Crispino J.D., Fujiwara Y., Eicher E.M., Orkin S.H.
    Development 129:4627-4634(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Transcription factors GATA-4 and GATA-6 and a GATA family cofactor, FOG-2, are expressed in human ovary and sex cord-derived ovarian tumors."
    Laitinen M.P., Anttonen M., Ketola I., Wilson D.B., Ritvos O., Butzow R., Heikinheimo M.
    J. Clin. Endocrinol. Metab. 85:3476-3483(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RXRA.

Entry informationi

Entry nameiFOG2_MOUSE
AccessioniPrimary (citable) accession number: Q8CCH7
Secondary accession number(s): Q9Z0F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3