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Protein

Developmental pluripotency-associated protein 4

Gene

Dppa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic stem (ES) cells into a primitive ectoderm lineage.2 Publications

GO - Biological processi

  • lung-associated mesenchyme development Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 4
Alternative name(s):
Embryonic stem cell-associated transcript 15-1 protein
Short name:
ECAT15-1
Gene namesi
Name:Dppa4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2157525. Dppa4.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

The mortality of mutant animals is increased at birth and most die within 3 days. The few surviving neonates show growth retardation, but they catch up with wild-type mice by 20 weeks of age.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Developmental pluripotency-associated protein 4PRO_0000239269Add
BLAST

Proteomic databases

MaxQBiQ8CCG4.
PaxDbiQ8CCG4.
PeptideAtlasiQ8CCG4.
PRIDEiQ8CCG4.

PTM databases

iPTMnetiQ8CCG4.
PhosphoSiteiQ8CCG4.

Expressioni

Tissue specificityi

Expressed in pluripotent embryonic cells, but not in differentiated somatic tissues.3 Publications

Developmental stagei

Expressed in 4-cell embryo, morula and blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc, expressed in the primordial germ cells and at 12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is restricted to testis. 6 days after birth, still detected in primitive type A spermatogonia. Expressed in undifferentiated embryonic stem cells, but expression decreases upon differentiation (at protein level).3 Publications

Gene expression databases

BgeeiENSMUSG00000058550.
CleanExiMM_DPPA4.
ExpressionAtlasiQ8CCG4. baseline and differential.
GenevisibleiQ8CCG4. MM.

Interactioni

Subunit structurei

Interacts with DPPA2 (PubMed:21896782). Interacts with PCGF1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093749.

Structurei

3D structure databases

ProteinModelPortaliQ8CCG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IG5K. Eukaryota.
ENOG41118PS. LUCA.
GeneTreeiENSGT00390000004871.
HOGENOMiHOG000060113.
HOVERGENiHBG066898.
InParanoidiQ8CCG4.
OMAiMWCVVHG.
OrthoDBiEOG091G0QL3.
PhylomeDBiQ8CCG4.
TreeFamiTF338129.

Family and domain databases

InterProiIPR025891. Dppa2/4_C_dom.
IPR025892. Dppa2/4_central_dom.
[Graphical view]
PfamiPF14047. DCR. 1 hit.
PF14049. Dppa2_A. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CCG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAGDKKWS AEEPKEEVEL QMSSQPSTAP AKAKATGKKQ KKSETDNGCK
60 70 80 90 100
PKEGKPQDTE TPGQTRRKVP IPPIPEYLPP VNLIHRDVLR AWCQKKRVSS
110 120 130 140 150
KGQKLDAYKR LLARAFPEQM LELRNVPDSA KDARLKTAHK KMKTEPGEES
160 170 180 190 200
EVTVPLEMVP VPEEQIPALI DPPMLYEEVS TTVVTTPATE AVLASWARIA
210 220 230 240 250
SNAKKYEAVP ADASSSSEVK GEMWCVVHGT SLPGNSRGWV RLQFHAGQAW
260 270 280 290
VPDKKGKAIA LFLLPACTFP PPHLEDNMLC PKCVHKNKIL TKSLEG
Length:296
Mass (Da):32,699
Last modified:May 30, 2006 - v2
Checksum:i31CADF37547975B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271S → G in AAH64754 (PubMed:15489334).Curated
Sequence conflicti55 – 551K → R in AAH64754 (PubMed:15489334).Curated
Sequence conflicti99 – 991S → R in AAO84506 (PubMed:12620990).Curated
Sequence conflicti120 – 1201M → L in AAO84506 (PubMed:12620990).Curated
Sequence conflicti128 – 1281D → Y in AAO84506 (PubMed:12620990).Curated
Sequence conflicti142 – 1421M → L in AAO84506 (PubMed:12620990).Curated
Sequence conflicti295 – 2951E → K in BAC28194 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490348 mRNA. Translation: AAO84506.1.
AK033197 mRNA. Translation: BAC28194.1.
BC064754 mRNA. Translation: AAH64754.1.
CCDSiCCDS28209.1.
RefSeqiNP_001018002.1. NM_001018002.1.
NP_082886.2. NM_028610.2.
UniGeneiMm.35597.

Genome annotation databases

EnsembliENSMUST00000096045; ENSMUSP00000093749; ENSMUSG00000058550.
GeneIDi73693.
KEGGimmu:73693.
UCSCiuc007zjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490348 mRNA. Translation: AAO84506.1.
AK033197 mRNA. Translation: BAC28194.1.
BC064754 mRNA. Translation: AAH64754.1.
CCDSiCCDS28209.1.
RefSeqiNP_001018002.1. NM_001018002.1.
NP_082886.2. NM_028610.2.
UniGeneiMm.35597.

3D structure databases

ProteinModelPortaliQ8CCG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093749.

PTM databases

iPTMnetiQ8CCG4.
PhosphoSiteiQ8CCG4.

Proteomic databases

MaxQBiQ8CCG4.
PaxDbiQ8CCG4.
PeptideAtlasiQ8CCG4.
PRIDEiQ8CCG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096045; ENSMUSP00000093749; ENSMUSG00000058550.
GeneIDi73693.
KEGGimmu:73693.
UCSCiuc007zjl.1. mouse.

Organism-specific databases

CTDi55211.
MGIiMGI:2157525. Dppa4.

Phylogenomic databases

eggNOGiENOG410IG5K. Eukaryota.
ENOG41118PS. LUCA.
GeneTreeiENSGT00390000004871.
HOGENOMiHOG000060113.
HOVERGENiHBG066898.
InParanoidiQ8CCG4.
OMAiMWCVVHG.
OrthoDBiEOG091G0QL3.
PhylomeDBiQ8CCG4.
TreeFamiTF338129.

Miscellaneous databases

PROiQ8CCG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058550.
CleanExiMM_DPPA4.
ExpressionAtlasiQ8CCG4. baseline and differential.
GenevisibleiQ8CCG4. MM.

Family and domain databases

InterProiIPR025891. Dppa2/4_C_dom.
IPR025892. Dppa2/4_central_dom.
[Graphical view]
PfamiPF14047. DCR. 1 hit.
PF14049. Dppa2_A. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPPA4_MOUSE
AccessioniPrimary (citable) accession number: Q8CCG4
Secondary accession number(s): Q6P228, Q810Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.