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Q8CC86

- PNCB_MOUSE

UniProt

Q8CC86 - PNCB_MOUSE

Protein

Nicotinate phosphoribosyltransferase

Gene

Naprt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells By similarity.By similarity
    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide salvage Source: InterPro
    3. response to oxidative stress Source: UniProtKB

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_211619. Nicotinamide salvaging.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
    Short name:
    NAPRTase
    Alternative name(s):
    Nicotinate phosphoribosyltransferase domain-containing protein 1
    Gene namesi
    Name:Naprt
    Synonyms:Naprt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2442664. Naprt1.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. Golgi apparatus Source: Ensembl
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Nicotinate phosphoribosyltransferasePRO_0000315682Add
    BLAST

    Proteomic databases

    MaxQBiQ8CC86.
    PaxDbiQ8CC86.
    PRIDEiQ8CC86.

    PTM databases

    PhosphoSiteiQ8CC86.

    Expressioni

    Tissue specificityi

    Abundantly expressed in the small intestine, liver and kidney.1 Publication

    Gene expression databases

    BgeeiQ8CC86.
    GenevestigatoriQ8CC86.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8CC86. 3 interactions.
    MINTiMINT-1855495.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CC86.
    SMRiQ8CC86. Positions 16-522.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    eggNOGiCOG1488.
    GeneTreeiENSGT00390000002664.
    HOGENOMiHOG000001111.
    HOVERGENiHBG062439.
    InParanoidiQ8CC86.
    KOiK00763.
    OMAiMQVYFNQ.
    OrthoDBiEOG7N63MH.
    PhylomeDBiQ8CC86.
    TreeFamiTF314732.

    Family and domain databases

    InterProiIPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CC86-1 [UniParc]FASTAAdd to Basket

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    MEMELDSEGR MVVRPLLTDL YQATMALGYW RAGRACEAAE FELFFRHCPF    50
    GGSFALSAGL QDCMRFLRAF RLRDADVQFL ASVLPPDTDP AFFEHLRALD 100
    CSGVTVRALP EGSLAFPGVP LLQVSGPLLL VQLLETPLLC LVSYASLVAT 150
    NAARLRLIAG PDKKLLEMGL RRAQGPDGGF TASIYSYLGG FDSSSNTLAG 200
    QLRGVPVAGT LAHSFVTSFS GSEVPPDPML APASSEGPTV DLPARVNLWL 250
    KRVCLYLGLE EQEPHPGERA AFVAYALAFP RAFQGLLDSY SVRRSGLPNF 300
    LAVALALGEL GYRAVGVRLD SGDLLQQAKE IRGIFRTAGA QFQMPWLESV 350
    PIAVSNNIDE SELMRLAQKG SEVNVIGIGT SVVTCPKQPS MGCVYKLVSV 400
    GGQPRIKLTE DPEKQTLPGS KAAFRFLGPD GSLLLDLLQL AEEPPPKAGQ 450
    ELRVWPRGTQ EPCTVKPAQV EPLLRLYLQQ GQLCEPLPSL DESRRFAQQS 500
    LSLLRPAHKQ LQSPAVYPVA LSEKLRALVD SLSARGPL 538
    Length:538
    Mass (Da):58,265
    Last modified:March 1, 2003 - v1
    Checksum:iDFD3BC809E860A9E
    GO

    Sequence cautioni

    The sequence BAC33575.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC33575.1 differs from that shown. Reason: Erroneous termination at position 517. Translated as Tyr.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti518 – 5181P → T in BAC33575. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY214331 mRNA. Translation: AAP69609.1.
    AK033661 mRNA. Translation: BAC28414.1.
    AK049157 mRNA. Translation: BAC33575.1. Sequence problems.
    AK159127 mRNA. Translation: BAE34841.1.
    AK170518 mRNA. Translation: BAE41854.1.
    BC058800 mRNA. Translation: AAH58800.1.
    CCDSiCCDS27552.1.
    RefSeqiNP_766195.2. NM_172607.3.
    UniGeneiMm.288368.

    Genome annotation databases

    EnsembliENSMUST00000023237; ENSMUSP00000023237; ENSMUSG00000022574.
    GeneIDi223646.
    KEGGimmu:223646.
    UCSCiuc007whi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY214331 mRNA. Translation: AAP69609.1 .
    AK033661 mRNA. Translation: BAC28414.1 .
    AK049157 mRNA. Translation: BAC33575.1 . Sequence problems.
    AK159127 mRNA. Translation: BAE34841.1 .
    AK170518 mRNA. Translation: BAE41854.1 .
    BC058800 mRNA. Translation: AAH58800.1 .
    CCDSi CCDS27552.1.
    RefSeqi NP_766195.2. NM_172607.3.
    UniGenei Mm.288368.

    3D structure databases

    ProteinModelPortali Q8CC86.
    SMRi Q8CC86. Positions 16-522.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CC86. 3 interactions.
    MINTi MINT-1855495.

    PTM databases

    PhosphoSitei Q8CC86.

    Proteomic databases

    MaxQBi Q8CC86.
    PaxDbi Q8CC86.
    PRIDEi Q8CC86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023237 ; ENSMUSP00000023237 ; ENSMUSG00000022574 .
    GeneIDi 223646.
    KEGGi mmu:223646.
    UCSCi uc007whi.1. mouse.

    Organism-specific databases

    CTDi 223646.
    MGIi MGI:2442664. Naprt1.

    Phylogenomic databases

    eggNOGi COG1488.
    GeneTreei ENSGT00390000002664.
    HOGENOMi HOG000001111.
    HOVERGENi HBG062439.
    InParanoidi Q8CC86.
    KOi K00763.
    OMAi MQVYFNQ.
    OrthoDBi EOG7N63MH.
    PhylomeDBi Q8CC86.
    TreeFami TF314732.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    Reactomei REACT_211619. Nicotinamide salvaging.

    Miscellaneous databases

    NextBioi 376772.
    PROi Q8CC86.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CC86.
    Genevestigatori Q8CC86.

    Family and domain databases

    InterProi IPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
      Huang C.-H., Peng J., Chen Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Cecum.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    4. "Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells."
      Hara N., Yamada K., Shibata T., Osago H., Hashimoto T., Tsuchiya M.
      J. Biol. Chem. 282:24574-24582(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPNCB_MOUSE
    AccessioniPrimary (citable) accession number: Q8CC86
    Secondary accession number(s): Q8C7W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3