ID   CDNF_MOUSE              Reviewed;         187 AA.
AC   Q8CC36;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   14-DEC-2011, entry version 62.
DE   RecName: Full=Cerebral dopamine neurotrophic factor;
DE   AltName: Full=ARMET-like protein 1;
DE   AltName: Full=Conserved dopamine neurotrophic factor;
DE   Flags: Precursor;
GN   Name=Cdnf; Synonyms=Armetl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=17611540; DOI=10.1038/nature05957;
RA   Lindholm P., Voutilainen M.H., Lauren J., Peraenen J.,
RA   Leppaenen V.-M., Andressoo J.-O., Lindahl M., Janhunen S.,
RA   Kalkkinen N., Timmusk T., Tuominen R.K., Saarma M.;
RT   "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine
RT   neurons in vivo.";
RL   Nature 448:73-77(2007).
CC   -!- FUNCTION: Trophic factor for dopamine neurons. Prevents the 6-
CC       hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic
CC       neurons. When administered after 6-OHDA-lesioning, restores the
CC       dopaminergic function and prevents the degeneration of
CC       dopaminergic neurons in substantia nigra (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in the heart,
CC       skeletal muscle, testis and brain (at protein level). In the
CC       brain, detected in the cerebral cortex neurons through layers II
CC       to VI. In the hippocampus, detected in the CA1 to CA3 pyramidal
CC       regions and in the granule and polymorph layers of dentate gyrus.
CC       Weak expression in the striatum. In substantia nigra, detected in
CC       solitary cells that did not express tyrosine hydroxylase, a marker
CC       for dopaminergic neurons. Relatively high expression in the
CC       Purkinje cells of the cerebellum and in regions of the brain stem,
CC       including the locus coeruleus.
CC   -!- DEVELOPMENTAL STAGE: At postnatal stage P1 and P10, expressed in
CC       the brain, including the hippocampus, thalamus, striatum and
CC       substantia nigra. Highest levels in the hippocampus and thalamus.
CC   -!- SIMILARITY: Belongs to the ARMET family.
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DR   EMBL; AK034009; BAC28545.1; -; mRNA.
DR   EMBL; AL732620; CAM16050.1; -; Genomic_DNA.
DR   EMBL; AL929080; CAM16050.1; JOINED; Genomic_DNA.
DR   EMBL; AL929080; CAM27637.1; -; Genomic_DNA.
DR   EMBL; AL732620; CAM27637.1; JOINED; Genomic_DNA.
DR   EMBL; BC110560; AAI10561.1; -; mRNA.
DR   IPI; IPI00228432; -.
DR   RefSeq; NP_808315.1; NM_177647.4.
DR   UniGene; Mm.211455; -.
DR   ProteinModelPortal; Q8CC36; -.
DR   SMR; Q8CC36; 35-168.
DR   STRING; Q8CC36; -.
DR   PhosphoSite; Q8CC36; -.
DR   PRIDE; Q8CC36; -.
DR   Ensembl; ENSMUST00000036350; ENSMUSP00000046297; ENSMUSG00000039496.
DR   GeneID; 227526; -.
DR   KEGG; mmu:227526; -.
DR   UCSC; uc008iej.1; mouse.
DR   CTD; 441549; -.
DR   MGI; MGI:3606576; Cdnf.
DR   eggNOG; roNOG09397; -.
DR   GeneTree; ENSGT00390000007160; -.
DR   InParanoid; Q8CC36; -.
DR   OMA; DCEVCKE; -.
DR   OrthoDB; EOG4QZ7MZ; -.
DR   PhylomeDB; Q8CC36; -.
DR   NextBio; 378625; -.
DR   ArrayExpress; Q8CC36; -.
DR   Bgee; Q8CC36; -.
DR   Genevestigator; Q8CC36; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019345; Armet_prot.
DR   Pfam; PF10208; Armet; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Disulfide bond; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    187       Cerebral dopamine neurotrophic factor.
FT                                /FTId=PRO_0000281138.
FT   DISULFID     37    124       By similarity.
FT   DISULFID     40    113       By similarity.
FT   DISULFID     71     82       By similarity.
SQ   SEQUENCE   187 AA;  21032 MW;  24DFFE42026A7971 CRC64;
     MRCISPTALV TFCAGFCISN PVLAQGLEAG VGPRADCEVC KEFLDRFYNS LLSRGIDFSA
     DTIEKELLNF CSDAKGKENR LCYYLGATTD AATKILGEVT RPMSVHIPAV KICEKLKKMD
     SQICELKYGK KLDLASVDLW KMRVAELKQI LQRWGEECRA CAEKSDYVNL IRELAPKYVE
     IYPQTEL
//