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Protein

Cerebral dopamine neurotrophic factor

Gene

Cdnf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).By similarity

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebral dopamine neurotrophic factor
Alternative name(s):
ARMET-like protein 1
Conserved dopamine neurotrophic factor
Gene namesi
Name:Cdnf
Synonyms:Armetl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3606576. Cdnf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 187163Cerebral dopamine neurotrophic factorPRO_0000281138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 124By similarity
Disulfide bondi40 ↔ 113By similarity
Disulfide bondi71 ↔ 82By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8CC36.
PaxDbiQ8CC36.
PeptideAtlasiQ8CC36.
PRIDEiQ8CC36.

PTM databases

PhosphoSiteiQ8CC36.

Expressioni

Tissue specificityi

Expressed at high levels in the heart, skeletal muscle, testis and brain (at protein level). In the brain, detected in the cerebral cortex neurons through layers II to VI. In the hippocampus, detected in the CA1 to CA3 pyramidal regions and in the granule and polymorph layers of dentate gyrus. Weak expression in the striatum. In substantia nigra, detected in solitary cells that did not express tyrosine hydroxylase, a marker for dopaminergic neurons. Relatively high expression in the Purkinje cells of the cerebellum and in regions of the brain stem, including the locus coeruleus.1 Publication

Developmental stagei

At postnatal stage P1 and P10, expressed in the brain, including the hippocampus, thalamus, striatum and substantia nigra. Highest levels in the hippocampus and thalamus.1 Publication

Gene expression databases

BgeeiENSMUSG00000039496.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046297.

Structurei

3D structure databases

ProteinModelPortaliQ8CC36.
SMRiQ8CC36. Positions 28-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMET family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4154. Eukaryota.
ENOG4111QMZ. LUCA.
GeneTreeiENSGT00390000007160.
HOGENOMiHOG000264245.
InParanoidiQ8CC36.
OMAiCLDVKGK.
OrthoDBiEOG091G0P3O.
PhylomeDBiQ8CC36.
TreeFamiTF314252.

Family and domain databases

InterProiIPR019345. Armet_prot.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CC36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCISPTALV TFCAGFCISN PVLAQGLEAG VGPRADCEVC KEFLDRFYNS
60 70 80 90 100
LLSRGIDFSA DTIEKELLNF CSDAKGKENR LCYYLGATTD AATKILGEVT
110 120 130 140 150
RPMSVHIPAV KICEKLKKMD SQICELKYGK KLDLASVDLW KMRVAELKQI
160 170 180
LQRWGEECRA CAEKSDYVNL IRELAPKYVE IYPQTEL
Length:187
Mass (Da):21,032
Last modified:March 1, 2003 - v1
Checksum:i24DFFE42026A7971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034009 mRNA. Translation: BAC28545.1.
AL732620, AL929080 Genomic DNA. Translation: CAM16050.1.
AL929080, AL732620 Genomic DNA. Translation: CAM27637.1.
BC110560 mRNA. Translation: AAI10561.1.
CCDSiCCDS15654.1.
RefSeqiNP_808315.1. NM_177647.4.
UniGeneiMm.211455.

Genome annotation databases

EnsembliENSMUST00000036350; ENSMUSP00000046297; ENSMUSG00000039496.
GeneIDi227526.
KEGGimmu:227526.
UCSCiuc008iej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034009 mRNA. Translation: BAC28545.1.
AL732620, AL929080 Genomic DNA. Translation: CAM16050.1.
AL929080, AL732620 Genomic DNA. Translation: CAM27637.1.
BC110560 mRNA. Translation: AAI10561.1.
CCDSiCCDS15654.1.
RefSeqiNP_808315.1. NM_177647.4.
UniGeneiMm.211455.

3D structure databases

ProteinModelPortaliQ8CC36.
SMRiQ8CC36. Positions 28-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046297.

PTM databases

PhosphoSiteiQ8CC36.

Proteomic databases

MaxQBiQ8CC36.
PaxDbiQ8CC36.
PeptideAtlasiQ8CC36.
PRIDEiQ8CC36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036350; ENSMUSP00000046297; ENSMUSG00000039496.
GeneIDi227526.
KEGGimmu:227526.
UCSCiuc008iej.1. mouse.

Organism-specific databases

CTDi441549.
MGIiMGI:3606576. Cdnf.

Phylogenomic databases

eggNOGiKOG4154. Eukaryota.
ENOG4111QMZ. LUCA.
GeneTreeiENSGT00390000007160.
HOGENOMiHOG000264245.
InParanoidiQ8CC36.
OMAiCLDVKGK.
OrthoDBiEOG091G0P3O.
PhylomeDBiQ8CC36.
TreeFamiTF314252.

Miscellaneous databases

PROiQ8CC36.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039496.

Family and domain databases

InterProiIPR019345. Armet_prot.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDNF_MOUSE
AccessioniPrimary (citable) accession number: Q8CC36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.