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Protein

Tetratricopeptide repeat protein 19, mitochondrial

Gene

Ttc19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial protein required for formation of the mitochondrial complex III.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 19, mitochondrial
Short name:
TPR repeat protein 19
Gene namesi
Name:Ttc19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920045. Ttc19.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000010640853 – 365Tetratricopeptide repeat protein 19, mitochondrialAdd BLAST313

Proteomic databases

PaxDbiQ8CC21.
PeptideAtlasiQ8CC21.
PRIDEiQ8CC21.

PTM databases

iPTMnetiQ8CC21.
PhosphoSitePlusiQ8CC21.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042298.
CleanExiMM_TTC19.
ExpressionAtlasiQ8CC21. baseline and differential.
GenevisibleiQ8CC21. MM.

Interactioni

Subunit structurei

Interacts with UQCRC1 and UQCRFS1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054367.

Structurei

3D structure databases

ProteinModelPortaliQ8CC21.
SMRiQ8CC21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati127 – 160TPR 1Add BLAST34
Repeati220 – 260TPR 2Add BLAST41
Repeati269 – 302TPR 3Add BLAST34
Repeati308 – 341TPR 4Add BLAST34

Sequence similaritiesi

Belongs to the TTC19 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000009194.
HOGENOMiHOG000015406.
HOVERGENiHBG056672.
InParanoidiQ8CC21.
KOiK18169.
OMAiGRGGSMY.
OrthoDBiEOG091G0AH0.
PhylomeDBiQ8CC21.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CC21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRLLRWRLG RTLLRAAGRR CGGCTARLLP ERTGDAGTGA ERLRTRGAPA
60 70 80 90 100
RGHGVLPLLA ALAWFSRPAA TAEQPGEDAS DEAEAEIIQL LKQAKLSIMK
110 120 130 140 150
DEPEAAELIL HDALRLAYES DNRKAITYTY DLMANLAFIR GQLENAEQLF
160 170 180 190 200
KATMSYLLGG GMKQEDNAII EISLKLANIY AAQNKQEFAL AGYEFCISTL
210 220 230 240 250
EGKIEREKEL AEDIMSEETA NTYLLLGMCL DSCARYLLFS KQLSQAQRMY
260 270 280 290 300
EKALQICQEI QGERHPQTIV LMSDLATTLD AQGHFDDAYI YMQRASDLAR
310 320 330 340 350
EINHPELHMV LSNLAAILIH RERYTQAKEI YQEALKRAEL KRDEVSVQHI
360
REELAELSRK SRRLT
Length:365
Mass (Da):41,234
Last modified:March 1, 2003 - v1
Checksum:i2C1AD6DCD91C3B69
GO
Isoform 2 (identifier: Q8CC21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-145: Missing.

Show »
Length:352
Mass (Da):39,776
Checksum:iD8E433AFFE28BB33
GO

Sequence cautioni

The sequence AAH37111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB28813 differs from that shown. Reason: Frameshift at positions 21 and 42.Curated
The sequence EDL10340 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43L → V in BAB28813 (PubMed:16141072).Curated1
Sequence conflicti220A → S in BAB28813 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041051133 – 145Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013368 mRNA. Translation: BAB28813.2. Frameshift.
AK034075 mRNA. Translation: BAC28572.1.
AL596110 Genomic DNA. Translation: CAI35326.1.
AL596110 Genomic DNA. Translation: CAI35327.1.
CH466601 Genomic DNA. Translation: EDL10340.1. Sequence problems.
BC026866 mRNA. Translation: AAH26866.1.
BC037111 mRNA. Translation: AAH37111.1. Different initiation.
CCDSiCCDS36177.1. [Q8CC21-1]
CCDS48817.1. [Q8CC21-2]
RefSeqiNP_082636.3. NM_028360.2. [Q8CC21-1]
NP_083980.2. NM_029704.2. [Q8CC21-2]
UniGeneiMm.489722.

Genome annotation databases

EnsembliENSMUST00000050646; ENSMUSP00000054367; ENSMUSG00000042298. [Q8CC21-1]
ENSMUST00000101075; ENSMUSP00000098636; ENSMUSG00000042298. [Q8CC21-2]
GeneIDi72795.
KEGGimmu:72795.
UCSCiuc007jir.2. mouse. [Q8CC21-1]
uc007jis.2. mouse. [Q8CC21-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013368 mRNA. Translation: BAB28813.2. Frameshift.
AK034075 mRNA. Translation: BAC28572.1.
AL596110 Genomic DNA. Translation: CAI35326.1.
AL596110 Genomic DNA. Translation: CAI35327.1.
CH466601 Genomic DNA. Translation: EDL10340.1. Sequence problems.
BC026866 mRNA. Translation: AAH26866.1.
BC037111 mRNA. Translation: AAH37111.1. Different initiation.
CCDSiCCDS36177.1. [Q8CC21-1]
CCDS48817.1. [Q8CC21-2]
RefSeqiNP_082636.3. NM_028360.2. [Q8CC21-1]
NP_083980.2. NM_029704.2. [Q8CC21-2]
UniGeneiMm.489722.

3D structure databases

ProteinModelPortaliQ8CC21.
SMRiQ8CC21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054367.

PTM databases

iPTMnetiQ8CC21.
PhosphoSitePlusiQ8CC21.

Proteomic databases

PaxDbiQ8CC21.
PeptideAtlasiQ8CC21.
PRIDEiQ8CC21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050646; ENSMUSP00000054367; ENSMUSG00000042298. [Q8CC21-1]
ENSMUST00000101075; ENSMUSP00000098636; ENSMUSG00000042298. [Q8CC21-2]
GeneIDi72795.
KEGGimmu:72795.
UCSCiuc007jir.2. mouse. [Q8CC21-1]
uc007jis.2. mouse. [Q8CC21-2]

Organism-specific databases

CTDi54902.
MGIiMGI:1920045. Ttc19.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000009194.
HOGENOMiHOG000015406.
HOVERGENiHBG056672.
InParanoidiQ8CC21.
KOiK18169.
OMAiGRGGSMY.
OrthoDBiEOG091G0AH0.
PhylomeDBiQ8CC21.
TreeFamiTF314010.

Miscellaneous databases

PROiQ8CC21.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042298.
CleanExiMM_TTC19.
ExpressionAtlasiQ8CC21. baseline and differential.
GenevisibleiQ8CC21. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC19_MOUSE
AccessioniPrimary (citable) accession number: Q8CC21
Secondary accession number(s): Q5NCZ3
, Q5NCZ4, Q8K1X2, Q8R0G6, Q9CYS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.