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Protein

Codanin-1

Gene

Cdan1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a negative regulator of ASF1 in chromatin assembly.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Codanin-1
Gene namesi
Name:Cdan1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916218. Cdan1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endomembrane system Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal; embryos die before 7.5 days of gestation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000894402 – 1239Codanin-1Add BLAST1238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei70PhosphothreonineBy similarity1
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CC12.
PeptideAtlasiQ8CC12.
PRIDEiQ8CC12.

PTM databases

iPTMnetiQ8CC12.
PhosphoSitePlusiQ8CC12.

Expressioni

Tissue specificityi

Widely expressed in adult mice, the highest levels can be measured in erythropoietic cells.1 Publication

Developmental stagei

Expressed ubiquitously during early embryogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000027284.
ExpressionAtlasiQ8CC12. baseline and differential.
GenevisibleiQ8CC12. MM.

Interactioni

Subunit structurei

Interacts with ASF1A and ASF1B. Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106329.

Structurei

3D structure databases

ProteinModelPortaliQ8CC12.
SMRiQ8CC12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 213Interaction with ASF1A/BBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi748 – 751Poly-Leu4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHV. Eukaryota.
ENOG410XXWY. LUCA.
GeneTreeiENSGT00390000000491.
HOGENOMiHOG000111492.
HOVERGENiHBG107631.
InParanoidiQ8CC12.
KOiK19531.
OMAiLSKPKTC.
OrthoDBiEOG091G03X8.
PhylomeDBiQ8CC12.
TreeFamiTF328405.

Family and domain databases

InterProiIPR028171. Codanin-1_C.
[Graphical view]
PfamiPF15296. Codanin-1_C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CC12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVLESLLR EEVPVAAAVR WIARSTPSSE DSSEVAALSA LRPLRKEFVP
60 70 80 90 100
FLLNFLREQS SRVLPQGPST PAKTPVASAA LPARQGAPAR GGRGARSQLF
110 120 130 140 150
PAAEPLSAAA EAPLARRAGR RRGPGPGPSR ERGGRGSGAA EEGASGESPP
160 170 180 190 200
WAGGRKPKGS GSPGSPRLSL SDPPNLSNLE EFPPVGTVPP GSAGRTKPSR
210 220 230 240 250
RINPTPVSEE RSLSKPKTCF TSPPISCVPS SQPSTLDTSP WGLGLPPGCR
260 270 280 290 300
SLQEEREMLR KARTKQLQQS PTPASPIPES GSPVPSRTGN LTAEPADPAR
310 320 330 340 350
VSSRQRLELV ALIYSSCIAE NLVPNLFLEL FFVLQLLTAR RMVATKDSDL
360 370 380 390 400
ESSQGALDSL DTPLFRSIHD CVFFAVQVLE HQFQVLSYLD KGTLKLLAEN
410 420 430 440 450
ERLLCFSPAL QGRLRAAYEG SVAKVSLVIP PSAQAVSFQP ETDNRANFSS
460 470 480 490 500
DRAFHTFKKQ RDVFYEVLRE WEDHHEEPSW DFEKGLGSRI RAMMGQLSAA
510 520 530 540 550
CSHSHFVRLF QKQLLQMCQS PGGAGGSVLG EAPDVLNMLG ADKLGRLRQL
560 570 580 590 600
QERLIAPQSS GGPCPPPTFP GCQGFFRDFI MSASSFHFNQ HLMDSLSLKI
610 620 630 640 650
RELNGLRLPQ HEPGDEDGES DMDWQGERRQ FAVVLLSLRL LAKFLGFVAF
660 670 680 690 700
LPYRGHEPPP TRELQDSILA LRSQVPPVLD IRALLQQGLW ARRAVLTVPW
710 720 730 740 750
LVEFLSFADH IVPLLDYYRS VFTLLLRLHR SLVLSKENEG EMCFLNKLLL
760 770 780 790 800
LAVLGWLFQI PTVPEDLFFL EDGQVDAFEV TTTASEHGLD SVPVVDQQLL
810 820 830 840 850
YTCCPYIGEL RKLLASWVSG SSGRSGGFVR KITPTTTSSL GALPLQTSQG
860 870 880 890 900
LQAQLAEAFF HNQPPSLRRT VEFVAERIGS NCVKHIKATL VADLVHQAES
910 920 930 940 950
LLQEQLVARG QEGGDPAQLL ESLCSQLCPH GAQALTQGRE FCQRKSPTAV
960 970 980 990 1000
RALLPEETPA AVLSSAENIA VGLATEKACS WLSANITALI RREVKAAVSR
1010 1020 1030 1040 1050
MLRAQGPEPT ARVERRGCSR ACEHHAPLPS HLISEIKFHH CSLQDVLSLA
1060 1070 1080 1090 1100
AGPRDPEEGV SPEHLEQLLN QMGQSLRCRQ FLCPTAEQHL AKCSVELASL
1110 1120 1130 1140 1150
LVADQIPILG PPTQHRLERG HARRLLHMLL SLWKDDFQGP VPLQLLLSPR
1160 1170 1180 1190 1200
NVGLLADTRP REWDLLLFLL RELVEKDLMG HLEIEACLGR LNEAQWPGDF
1210 1220 1230
SEELSTLFRL FLAEPHLLEP QLRACELMQP NRGTVLAQS
Length:1,239
Mass (Da):135,883
Last modified:July 24, 2007 - v2
Checksum:i7A07DFAB1CBB7FB9
GO
Isoform 2 (identifier: Q8CC12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1044: Missing.

Show »
Length:1,232
Mass (Da):135,030
Checksum:i110402EDED275C4E
GO
Isoform 3 (identifier: Q8CC12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.

Show »
Length:898
Mass (Da):99,996
Checksum:iCD697786539D2F18
GO

Sequence cautioni

The sequence BAE34023 differs from that shown. Reason: Frameshift at position 106.Curated
The sequence CAM21399 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140A → P in BAE34023 (PubMed:19468303).Curated1
Sequence conflicti1220P → L in BAE34023 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0270991 – 341Missing in isoform 3. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_0271001038 – 1044Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034144 mRNA. Translation: BAC28605.1.
AK157271 mRNA. Translation: BAE34023.1. Frameshift.
AL935168 Genomic DNA. Translation: CAM21399.1. Sequence problems.
BC117555 mRNA. Translation: AAI17556.1.
CCDSiCCDS38212.1. [Q8CC12-1]
RefSeqiNP_081167.2. NM_026891.2. [Q8CC12-1]
UniGeneiMm.2289.

Genome annotation databases

EnsembliENSMUST00000110701; ENSMUSP00000106329; ENSMUSG00000027284. [Q8CC12-1]
GeneIDi68968.
KEGGimmu:68968.
UCSCiuc008lwu.1. mouse. [Q8CC12-1]
uc008lwv.1. mouse. [Q8CC12-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034144 mRNA. Translation: BAC28605.1.
AK157271 mRNA. Translation: BAE34023.1. Frameshift.
AL935168 Genomic DNA. Translation: CAM21399.1. Sequence problems.
BC117555 mRNA. Translation: AAI17556.1.
CCDSiCCDS38212.1. [Q8CC12-1]
RefSeqiNP_081167.2. NM_026891.2. [Q8CC12-1]
UniGeneiMm.2289.

3D structure databases

ProteinModelPortaliQ8CC12.
SMRiQ8CC12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106329.

PTM databases

iPTMnetiQ8CC12.
PhosphoSitePlusiQ8CC12.

Proteomic databases

PaxDbiQ8CC12.
PeptideAtlasiQ8CC12.
PRIDEiQ8CC12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110701; ENSMUSP00000106329; ENSMUSG00000027284. [Q8CC12-1]
GeneIDi68968.
KEGGimmu:68968.
UCSCiuc008lwu.1. mouse. [Q8CC12-1]
uc008lwv.1. mouse. [Q8CC12-2]

Organism-specific databases

CTDi146059.
MGIiMGI:1916218. Cdan1.

Phylogenomic databases

eggNOGiENOG410IGHV. Eukaryota.
ENOG410XXWY. LUCA.
GeneTreeiENSGT00390000000491.
HOGENOMiHOG000111492.
HOVERGENiHBG107631.
InParanoidiQ8CC12.
KOiK19531.
OMAiLSKPKTC.
OrthoDBiEOG091G03X8.
PhylomeDBiQ8CC12.
TreeFamiTF328405.

Miscellaneous databases

PROiQ8CC12.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027284.
ExpressionAtlasiQ8CC12. baseline and differential.
GenevisibleiQ8CC12. MM.

Family and domain databases

InterProiIPR028171. Codanin-1_C.
[Graphical view]
PfamiPF15296. Codanin-1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDAN1_MOUSE
AccessioniPrimary (citable) accession number: Q8CC12
Secondary accession number(s): A2AW10, Q149P8, Q3U032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.