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Protein

Dynactin subunit 4

Gene

Dctn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 4
Alternative name(s):
Dynactin subunit p62
Gene namesi
Name:Dctn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914915. Dctn4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 467466Dynactin subunit 4PRO_0000079824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei203 – 2031PhosphoserineBy similarity
Modified residuei414 – 4141PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8CBY8.
PaxDbiQ8CBY8.
PeptideAtlasiQ8CBY8.
PRIDEiQ8CBY8.

PTM databases

iPTMnetiQ8CBY8.
PhosphoSiteiQ8CBY8.
SwissPalmiQ8CBY8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024603.
CleanExiMM_DCTN4.
ExpressionAtlasiQ8CBY8. baseline and differential.
GenevisibleiQ8CBY8. MM.

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin (By similarity). Interacts with ATP7B, but not ATP7A, in a copper-dependent manner (By similarity). Interacts with ANK2; this interaction is required for localization at costameres.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212349. 14 interactions.
IntActiQ8CBY8. 17 interactions.
MINTiMINT-4127067.
STRINGi10090.ENSMUSP00000025505.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili152 – 17221Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the dynactin subunit 4 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3896. Eukaryota.
ENOG410ZCK8. LUCA.
GeneTreeiENSGT00390000006954.
HOGENOMiHOG000007947.
HOVERGENiHBG051324.
InParanoidiQ8CBY8.
KOiK10426.
OMAiPIRPMEE.
PhylomeDBiQ8CBY8.
TreeFamiTF105249.

Family and domain databases

InterProiIPR008603. DCTN4.
[Graphical view]
PANTHERiPTHR13034. PTHR13034. 1 hit.
PfamiPF05502. Dynactin_p62. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CBY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLLQSERV LYLVQGEKKV RAPLSQLYFC RYCSELRSLE CVSHEVDSHY
60 70 80 90 100
CPSCLENMPS AEAKLKKNRC ANCFDCPGCM HTLSTRATSI STQLPDDPAK
110 120 130 140 150
TTMKKAYYLA CGFCRWTSRD VGMADKSVAS GGWQEPENPH TQRMNKLIEY
160 170 180 190 200
YQQLAQKEKV ERDRKKLARR RNYMPLAFSQ HTIHVVDKYS LGTRLQRPRA
210 220 230 240 250
GASISTLAGL SLREGEDQKE VKIEPAQAVA EVEPLPEDYY TRPVNLTEVT
260 270 280 290 300
TLQQRLLQPD LQPVSASQLY PRHKHLLIKR SLRCRKCEHN LSKPEFNPTS
310 320 330 340 350
IKFKIQLVAV NYIPEVRIMS IPNLRYMKES QVLLTLTNPV ENLTHVTLLE
360 370 380 390 400
CDEGDPDNIN STAKVVVPPK ELILAGKDAA AEYDELAEPQ DFQDDPDIVA
410 420 430 440 450
FRKANKVGIF IKVTPQREEG EVTVCFKMKH DFKNLAAPIR PVEEGDQGTE
460
VIWLTQHVEL SFGPLLP
Length:467
Mass (Da):53,057
Last modified:March 1, 2003 - v1
Checksum:iEE026ABB13B62F9E
GO
Isoform 2 (identifier: Q8CBY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-186: Missing.

Show »
Length:460
Mass (Da):52,242
Checksum:iB9CC87B4D447082B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei180 – 1867Missing in isoform 2. 1 PublicationVSP_013573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016059 mRNA. Translation: BAB30095.1.
AK034292 mRNA. Translation: BAC28661.1.
BC006677 mRNA. Translation: AAH06677.1.
BC034725 mRNA. Translation: AAH34725.1.
CCDSiCCDS37832.1. [Q8CBY8-2]
RefSeqiNP_080578.1. NM_026302.3. [Q8CBY8-2]
XP_006526252.1. XM_006526189.2. [Q8CBY8-1]
UniGeneiMm.272801.

Genome annotation databases

EnsembliENSMUST00000025505; ENSMUSP00000025505; ENSMUSG00000024603. [Q8CBY8-2]
GeneIDi67665.
KEGGimmu:67665.
UCSCiuc008fak.1. mouse. [Q8CBY8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016059 mRNA. Translation: BAB30095.1.
AK034292 mRNA. Translation: BAC28661.1.
BC006677 mRNA. Translation: AAH06677.1.
BC034725 mRNA. Translation: AAH34725.1.
CCDSiCCDS37832.1. [Q8CBY8-2]
RefSeqiNP_080578.1. NM_026302.3. [Q8CBY8-2]
XP_006526252.1. XM_006526189.2. [Q8CBY8-1]
UniGeneiMm.272801.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212349. 14 interactions.
IntActiQ8CBY8. 17 interactions.
MINTiMINT-4127067.
STRINGi10090.ENSMUSP00000025505.

PTM databases

iPTMnetiQ8CBY8.
PhosphoSiteiQ8CBY8.
SwissPalmiQ8CBY8.

Proteomic databases

MaxQBiQ8CBY8.
PaxDbiQ8CBY8.
PeptideAtlasiQ8CBY8.
PRIDEiQ8CBY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025505; ENSMUSP00000025505; ENSMUSG00000024603. [Q8CBY8-2]
GeneIDi67665.
KEGGimmu:67665.
UCSCiuc008fak.1. mouse. [Q8CBY8-1]

Organism-specific databases

CTDi51164.
MGIiMGI:1914915. Dctn4.

Phylogenomic databases

eggNOGiKOG3896. Eukaryota.
ENOG410ZCK8. LUCA.
GeneTreeiENSGT00390000006954.
HOGENOMiHOG000007947.
HOVERGENiHBG051324.
InParanoidiQ8CBY8.
KOiK10426.
OMAiPIRPMEE.
PhylomeDBiQ8CBY8.
TreeFamiTF105249.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ8CBY8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024603.
CleanExiMM_DCTN4.
ExpressionAtlasiQ8CBY8. baseline and differential.
GenevisibleiQ8CBY8. MM.

Family and domain databases

InterProiIPR008603. DCTN4.
[Graphical view]
PANTHERiPTHR13034. PTHR13034. 1 hit.
PfamiPF05502. Dynactin_p62. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN4_MOUSE
AccessioniPrimary (citable) accession number: Q8CBY8
Secondary accession number(s): Q923A0, Q9D4X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.