Ezr

Functionⁱ

GO - Molecular functionⁱ

actin binding Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:EzrImported Synonyms:Vil2Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:98931. Ezr.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoskeleton Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q8CBU4.
PeptideAtlas More...PeptideAtlasⁱ	Q8CBU4.
PRIDEⁱ	Q8CBU4.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q8CBU4. MM.

Genevisibleⁱ

Q8CBU4. MM.

Interactionⁱ

GO - Molecular functionⁱ

actin binding Source: InterPro

Complete GO annotation...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CBU4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 130	FERMInterPro annotationAdd BLAST		130

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	137 – 297	Sequence analysisAdd BLAST		161
Coiled coilⁱ	359 – 386	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3529. Eukaryota. ENOG410XQFP. LUCA.
HOGENOMⁱ	HOG000007113.
HOVERGENⁱ	HBG002185.
KEGG Orthology (KO) More...KOⁱ	K08007.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473. FERM_B-lobe. 1 hit.
Gene3Dⁱ	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011259. ERM_C_dom. IPR000798. Ez/rad/moesin-like. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018980. FERM_PH-like_C. IPR008954. Moesin_tail. IPR011993. PH_dom-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00769. ERM. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit.
PRINTSⁱ	PR00661. ERMFAMILY.
SMARTⁱ	View protein in SMART SM01196. FERM_C. 1 hit.
SUPFAMⁱ	SSF47031. SSF47031. 1 hit. SSF48678. SSF48678. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00661. FERM_2. 1 hit. PS50057. FERM_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q8CBU4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
DQWEDRIQVW HAEHRGMLKD SAMLEYLKIA QDLEMYGINY FEIKNKKGTD 
        60         70         80         90        100
LWLGVDALGL NIYEKDDKLT PKIGFPWSEI RNISFNDKKF VIKPIDKKAP 
       110        120        130        140        150
DFVFYAPRLR INKRILQLCM GNHELYMRRR KPDTIEVQQM KAQAREEKHQ 
       160        170        180        190        200
KQLERQQLET EKKRRETVER EKEQMLREKE ELMLRLQDYE QKTKRAEKEL 
       210        220        230        240        250
SEQIEKALQL EEERRRAQEE AERLEADRMA ALRAKEELER QAQDQIKSQE 
       260        270        280        290        300
QLAAELAEYT AKIALLEEAR RRKEDEVEEW QHRAKEAQDD LVKTKEELHL 
       310        320        330        340        350
VMTAPPLPPP PVYEPVNYHV QEGLQDEGAE PMGYSAELSS EGILDDRNEE 
       360        370        380        390        400
KRITEAEKNE RVQRQLLTLS NELSQARDEN KRTHNDIIHN ENMRQGRDKY 
       410        420 
KTLRQIRQGN TKQRIDEFEA M

Length:421

Mass (Da):50,274

Last modified:March 1, 2003 - v1

Checksum:ⁱE8D6C0D03F6E7497

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK035271 mRNA. Translation: BAC29009.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033536.2. NM_009510.2.
UniGeneⁱ	Mm.277812.

Genome annotation databases

GeneIDⁱ	22350.
KEGGⁱ	mmu:22350.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK035271 mRNA. Translation: BAC29009.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033536.2. NM_009510.2.
UniGeneⁱ	Mm.277812.

3D structure databases

ProteinModelPortalⁱ	Q8CBU4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q8CBU4.
PeptideAtlas More...PeptideAtlasⁱ	Q8CBU4.
PRIDEⁱ	Q8CBU4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	22350.
KEGGⁱ	mmu:22350.

Organism-specific databases

CTDⁱ	7430.
MGIⁱ	MGI:98931. Ezr.

Phylogenomic databases

eggNOGⁱ	KOG3529. Eukaryota. ENOG410XQFP. LUCA.
HOGENOMⁱ	HOG000007113.
HOVERGENⁱ	HBG002185.
KEGG Orthology (KO) More...KOⁱ	K08007.

Miscellaneous databases

ChiTaRSⁱ	Ezr. mouse.
SOURCEⁱ	Search...

Gene expression databases

Genevisibleⁱ	Q8CBU4. MM.

Genevisibleⁱ

Q8CBU4. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473. FERM_B-lobe. 1 hit.
Gene3Dⁱ	1.20.80.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011259. ERM_C_dom. IPR000798. Ez/rad/moesin-like. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR019747. FERM_CS. IPR000299. FERM_domain. IPR018980. FERM_PH-like_C. IPR008954. Moesin_tail. IPR011993. PH_dom-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00769. ERM. 1 hit. PF09380. FERM_C. 1 hit. PF00373. FERM_M. 1 hit.
PRINTSⁱ	PR00661. ERMFAMILY.
SMARTⁱ	View protein in SMART SM01196. FERM_C. 1 hit.
SUPFAMⁱ	SSF47031. SSF47031. 1 hit. SSF48678. SSF48678. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00661. FERM_2. 1 hit. PS50057. FERM_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8CBU4_MOUSE
Accessionⁱ	Q8CBU4Primary (citable) accession number: Q8CBU4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 1, 2003
	Last sequence update:	March 1, 2003
	Last modified:	July 5, 2017
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q8CBU4 (Q8CBU4_MOUSE)

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Putative uncharacterized protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ