UniProtKB - Q8CBR1 (ILDR1_MOUSE)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Immunoglobulin-like domain-containing receptor 1
Gene
Ildr1
Organism
Mus musculus (Mouse)
Status
Functioni
Putative membrane receptor.By similarity
GO - Molecular functioni
- high-density lipoprotein particle receptor activity Source: MGI
- identical protein binding Source: MGI
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: MGI
- positive regulation of peptide hormone secretion Source: MGI
- protein homooligomerization Source: MGI
Keywordsi
Molecular function | Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin-like domain-containing receptor 1 |
Gene namesi | Name:Ildr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2146574. Ildr1. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 166 | ExtracellularSequence analysisAdd BLAST | 144 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 537 | CytoplasmicSequence analysisAdd BLAST | 350 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000245305 | 23 – 537 | Immunoglobulin-like domain-containing receptor 1Add BLAST | 515 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 144 | PROSITE-ProRule annotation | ||
Modified residuei | 490 | PhosphoserineCombined sources | 1 | |
Modified residuei | 492 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | Q8CBR1. |
PRIDEi | Q8CBR1. |
PTM databases
iPTMneti | Q8CBR1. |
PhosphoSitePlusi | Q8CBR1. |
Expressioni
Tissue specificityi
Expressed in the vestibule and in hair cells and supporting cells of the cochlea.1 Publication
Developmental stagei
Expressed early in development.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000022900. |
CleanExi | MM_ILDR1. |
Genevisiblei | Q8CBR1. MM. |
Interactioni
Subunit structurei
Homooligomer.By similarity
GO - Molecular functioni
- identical protein binding Source: MGI
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 161 | Ig-like V-typeAdd BLAST | 139 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 187 – 211 | Cys-richAdd BLAST | 25 | |
Compositional biasi | 434 – 489 | Arg-richAdd BLAST | 56 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IFI2. Eukaryota. ENOG4110276. LUCA. |
GeneTreei | ENSGT00430000030906. |
HOGENOMi | HOG000294105. |
HOVERGENi | HBG060497. |
InParanoidi | Q8CBR1. |
OMAi | WPEEKPP. |
OrthoDBi | EOG091G0875. |
PhylomeDBi | Q8CBR1. |
TreeFami | TF330877. |
Family and domain databases
InterProi | View protein in InterPro IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR003599. Ig_sub. IPR008664. LISCH7. |
Pfami | View protein in Pfam PF05624. LSR. 1 hit. |
SMARTi | View protein in SMART SM00409. IG. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 2 hits. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CBR1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGCGLLAAGL LLFTWLPAGC LSLLVTVQHT ERYVTLFASV TLKCDYTTSA
60 70 80 90 100
QLQDVVVTWR FKSFCKDPIF DYFSASYQAA LSLGQDPSND CSDNQREVRI
110 120 130 140 150
VAQRRGQSEP VLGVDYRQRK ITIQNRADLV INEVMWWDHG VYYCTIEAPG
160 170 180 190 200
DTSGDPDKEV KLIVLHWLTV IFIILGALLL LLLIGVCWCQ CCPQYCCCYI
210 220 230 240 250
RCPCCPTRCC CPEEALARHR YMKQVQALGP QMMEKPLYWG ADRSSQVSSY
260 270 280 290 300
AMNPLLQRDL SLQSSLPQMP MTQMAAHPPV ANGVLEYLEK ELRNLNPAQP
310 320 330 340 350
LPADLRAKSG HPCSMLSSLG SAEVVERRVI HLPPLIRDPP SSRTSNPSHQ
360 370 380 390 400
QRLNAVSSRH CDLSERPRQR HHSDFLRELQ DQGMRPWAPG RGELDPHWSG
410 420 430 440 450
RHHRSRPSES SMPWSDWDSL SECPSSSEAP WPPRRPEPRE GAQRRERRRH
460 470 480 490 500
RSYSPPLPSG PSSWSSEEEK ESLPRNWGAQ RRHHHRRRRS QSPNWPEEKP
510 520 530
PSYRSLDVTP GKNNRKKGNV ERRLERESSH SGRSVVI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | V → L in BAC29604 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 71 | D → G in BAC29081 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019688 | 215 – 258 | Missing in isoform 3. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_019689 | 512 – 516 | KNNRK → ERELP in isoform 2. 2 Publications | 5 | |
Alternative sequenceiVSP_019690 | 517 – 537 | Missing in isoform 2. 2 PublicationsAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK035504 mRNA. Translation: BAC29081.1. AK036844 mRNA. Translation: BAC29604.1. BC010485 mRNA. Translation: AAH10485.1. BC057644 mRNA. Translation: AAH57644.1. |
CCDSi | CCDS49841.1. [Q8CBR1-2] CCDS70718.1. [Q8CBR1-1] CCDS70719.1. [Q8CBR1-3] |
RefSeqi | NP_001272717.1. NM_001285788.1. [Q8CBR1-1] NP_001272720.1. NM_001285791.1. [Q8CBR1-3] NP_598870.1. NM_134109.2. [Q8CBR1-2] |
UniGenei | Mm.17807. |
Genome annotation databases
Ensembli | ENSMUST00000023617; ENSMUSP00000023617; ENSMUSG00000022900. [Q8CBR1-1] ENSMUST00000089618; ENSMUSP00000087045; ENSMUSG00000022900. [Q8CBR1-3] ENSMUST00000119464; ENSMUSP00000112539; ENSMUSG00000022900. [Q8CBR1-2] |
GeneIDi | 106347. |
KEGGi | mmu:106347. |
UCSCi | uc007zcs.2. mouse. [Q8CBR1-2] uc007zct.2. mouse. [Q8CBR1-1] uc007zcu.2. mouse. [Q8CBR1-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | ILDR1_MOUSE | |
Accessioni | Q8CBR1Primary (citable) accession number: Q8CBR1 Secondary accession number(s): Q6PFB3, Q8CB39, Q91VS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | July 11, 2006 | |
Last modified: | March 28, 2018 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |