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UniProtKB - Q8CBR1 (ILDR1_MOUSE)

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Protein

Immunoglobulin-like domain-containing receptor 1

Gene

Ildr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative membrane receptor.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI
  • positive regulation of peptide hormone secretion Source: MGI
  • protein homooligomerization Source: MGI
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin-like domain-containing receptor 1
Gene namesi
Name:Ildr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146574. Ildr1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 166ExtracellularSequence analysisAdd BLAST144
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 537CytoplasmicSequence analysisAdd BLAST350

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000024530523 – 537Immunoglobulin-like domain-containing receptor 1Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 144PROSITE-ProRule annotation
Modified residuei490PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ8CBR1.
PRIDEiQ8CBR1.

PTM databases

iPTMnetiQ8CBR1.
PhosphoSitePlusiQ8CBR1.

Expressioni

Tissue specificityi

Expressed in the vestibule and in hair cells and supporting cells of the cochlea.1 Publication

Developmental stagei

Expressed early in development.1 Publication

Gene expression databases

BgeeiENSMUSG00000022900.
CleanExiMM_ILDR1.
GenevisibleiQ8CBR1. MM.

Interactioni

Subunit structurei

Homooligomer.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Structurei

3D structure databases

ProteinModelPortaliQ8CBR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 161Ig-like V-typeAdd BLAST139

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 211Cys-richAdd BLAST25
Compositional biasi434 – 489Arg-richAdd BLAST56

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. LISCH7 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI2. Eukaryota.
ENOG4110276. LUCA.
GeneTreeiENSGT00430000030906.
HOGENOMiHOG000294105.
HOVERGENiHBG060497.
InParanoidiQ8CBR1.
OMAiWPEEKPP.
OrthoDBiEOG091G0875.
PhylomeDBiQ8CBR1.
TreeFamiTF330877.

Family and domain databases

InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR003599. Ig_sub.
IPR008664. LISCH7.
PfamiView protein in Pfam
PF05624. LSR. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CBR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCGLLAAGL LLFTWLPAGC LSLLVTVQHT ERYVTLFASV TLKCDYTTSA 
        60         70         80         90        100
QLQDVVVTWR FKSFCKDPIF DYFSASYQAA LSLGQDPSND CSDNQREVRI 
       110        120        130        140        150
VAQRRGQSEP VLGVDYRQRK ITIQNRADLV INEVMWWDHG VYYCTIEAPG 
       160        170        180        190        200
DTSGDPDKEV KLIVLHWLTV IFIILGALLL LLLIGVCWCQ CCPQYCCCYI 
       210        220        230        240        250
RCPCCPTRCC CPEEALARHR YMKQVQALGP QMMEKPLYWG ADRSSQVSSY 
       260        270        280        290        300
AMNPLLQRDL SLQSSLPQMP MTQMAAHPPV ANGVLEYLEK ELRNLNPAQP 
       310        320        330        340        350
LPADLRAKSG HPCSMLSSLG SAEVVERRVI HLPPLIRDPP SSRTSNPSHQ 
       360        370        380        390        400
QRLNAVSSRH CDLSERPRQR HHSDFLRELQ DQGMRPWAPG RGELDPHWSG 
       410        420        430        440        450
RHHRSRPSES SMPWSDWDSL SECPSSSEAP WPPRRPEPRE GAQRRERRRH 
       460        470        480        490        500
RSYSPPLPSG PSSWSSEEEK ESLPRNWGAQ RRHHHRRRRS QSPNWPEEKP 
       510        520        530 
PSYRSLDVTP GKNNRKKGNV ERRLERESSH SGRSVVI
Length:537
Mass (Da):61,277
Last modified:July 11, 2006 - v2
Checksum:i7757BFBD6188A16A
GO
Isoform 2 (identifier: Q8CBR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-516: KNNRK → ERELP
     517-537: Missing.

Show »
Length:516
Mass (Da):58,883
Checksum:iF0345FFE45552C59
GO
Isoform 3 (identifier: Q8CBR1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.

Show »
Length:493
Mass (Da):56,186
Checksum:i10D0640F1646C4EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25V → L in BAC29604 (PubMed:16141072).Curated1
Sequence conflicti71D → G in BAC29081 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019688215 – 258Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_019689512 – 516KNNRK → ERELP in isoform 2. 2 Publications5
Alternative sequenceiVSP_019690517 – 537Missing in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035504 mRNA. Translation: BAC29081.1.
AK036844 mRNA. Translation: BAC29604.1.
BC010485 mRNA. Translation: AAH10485.1.
BC057644 mRNA. Translation: AAH57644.1.
CCDSiCCDS49841.1. [Q8CBR1-2]
CCDS70718.1. [Q8CBR1-1]
CCDS70719.1. [Q8CBR1-3]
RefSeqiNP_001272717.1. NM_001285788.1. [Q8CBR1-1]
NP_001272720.1. NM_001285791.1. [Q8CBR1-3]
NP_598870.1. NM_134109.2. [Q8CBR1-2]
UniGeneiMm.17807.

Genome annotation databases

EnsembliENSMUST00000023617; ENSMUSP00000023617; ENSMUSG00000022900. [Q8CBR1-1]
ENSMUST00000089618; ENSMUSP00000087045; ENSMUSG00000022900. [Q8CBR1-3]
ENSMUST00000119464; ENSMUSP00000112539; ENSMUSG00000022900. [Q8CBR1-2]
GeneIDi106347.
KEGGimmu:106347.
UCSCiuc007zcs.2. mouse. [Q8CBR1-2]
uc007zct.2. mouse. [Q8CBR1-1]
uc007zcu.2. mouse. [Q8CBR1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiILDR1_MOUSE
AccessioniPrimary (citable) accession number: Q8CBR1
Secondary accession number(s): Q6PFB3, Q8CB39, Q91VS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome