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Protein

Immunoglobulin-like domain-containing receptor 1

Gene

Ildr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative membrane receptor.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI
  • positive regulation of peptide hormone secretion Source: MGI
  • protein homooligomerization Source: MGI

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin-like domain-containing receptor 1
Gene namesi
Name:Ildr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146574 Ildr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 166ExtracellularSequence analysisAdd BLAST144
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 537CytoplasmicSequence analysisAdd BLAST350

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000024530523 – 537Immunoglobulin-like domain-containing receptor 1Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 144PROSITE-ProRule annotation
Modified residuei490PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ8CBR1
PRIDEiQ8CBR1

PTM databases

iPTMnetiQ8CBR1
PhosphoSitePlusiQ8CBR1

Expressioni

Tissue specificityi

Expressed in the vestibule and in hair cells and supporting cells of the cochlea.1 Publication

Developmental stagei

Expressed early in development.1 Publication

Gene expression databases

BgeeiENSMUSG00000022900
CleanExiMM_ILDR1
GenevisibleiQ8CBR1 MM

Interactioni

Subunit structurei

Homooligomer.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8CBR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 161Ig-like V-typeAdd BLAST139

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 211Cys-richAdd BLAST25
Compositional biasi434 – 489Arg-richAdd BLAST56

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI2 Eukaryota
ENOG4110276 LUCA
GeneTreeiENSGT00430000030906
HOGENOMiHOG000294105
HOVERGENiHBG060497
InParanoidiQ8CBR1
OMAiWPEEKPP
OrthoDBiEOG091G0875
PhylomeDBiQ8CBR1
TreeFamiTF330877

Family and domain databases

InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR003599 Ig_sub
IPR008664 LISCH7
PfamiView protein in Pfam
PF05624 LSR, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CBR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCGLLAAGL LLFTWLPAGC LSLLVTVQHT ERYVTLFASV TLKCDYTTSA
60 70 80 90 100
QLQDVVVTWR FKSFCKDPIF DYFSASYQAA LSLGQDPSND CSDNQREVRI
110 120 130 140 150
VAQRRGQSEP VLGVDYRQRK ITIQNRADLV INEVMWWDHG VYYCTIEAPG
160 170 180 190 200
DTSGDPDKEV KLIVLHWLTV IFIILGALLL LLLIGVCWCQ CCPQYCCCYI
210 220 230 240 250
RCPCCPTRCC CPEEALARHR YMKQVQALGP QMMEKPLYWG ADRSSQVSSY
260 270 280 290 300
AMNPLLQRDL SLQSSLPQMP MTQMAAHPPV ANGVLEYLEK ELRNLNPAQP
310 320 330 340 350
LPADLRAKSG HPCSMLSSLG SAEVVERRVI HLPPLIRDPP SSRTSNPSHQ
360 370 380 390 400
QRLNAVSSRH CDLSERPRQR HHSDFLRELQ DQGMRPWAPG RGELDPHWSG
410 420 430 440 450
RHHRSRPSES SMPWSDWDSL SECPSSSEAP WPPRRPEPRE GAQRRERRRH
460 470 480 490 500
RSYSPPLPSG PSSWSSEEEK ESLPRNWGAQ RRHHHRRRRS QSPNWPEEKP
510 520 530
PSYRSLDVTP GKNNRKKGNV ERRLERESSH SGRSVVI
Length:537
Mass (Da):61,277
Last modified:July 11, 2006 - v2
Checksum:i7757BFBD6188A16A
GO
Isoform 2 (identifier: Q8CBR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-516: KNNRK → ERELP
     517-537: Missing.

Show »
Length:516
Mass (Da):58,883
Checksum:iF0345FFE45552C59
GO
Isoform 3 (identifier: Q8CBR1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.

Show »
Length:493
Mass (Da):56,186
Checksum:i10D0640F1646C4EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25V → L in BAC29604 (PubMed:16141072).Curated1
Sequence conflicti71D → G in BAC29081 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019688215 – 258Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_019689512 – 516KNNRK → ERELP in isoform 2. 2 Publications5
Alternative sequenceiVSP_019690517 – 537Missing in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035504 mRNA Translation: BAC29081.1
AK036844 mRNA Translation: BAC29604.1
BC010485 mRNA Translation: AAH10485.1
BC057644 mRNA Translation: AAH57644.1
CCDSiCCDS49841.1 [Q8CBR1-2]
CCDS70718.1 [Q8CBR1-1]
CCDS70719.1 [Q8CBR1-3]
RefSeqiNP_001272717.1, NM_001285788.1 [Q8CBR1-1]
NP_001272720.1, NM_001285791.1 [Q8CBR1-3]
NP_598870.1, NM_134109.2 [Q8CBR1-2]
UniGeneiMm.17807

Genome annotation databases

EnsembliENSMUST00000023617; ENSMUSP00000023617; ENSMUSG00000022900 [Q8CBR1-1]
ENSMUST00000089618; ENSMUSP00000087045; ENSMUSG00000022900 [Q8CBR1-3]
ENSMUST00000119464; ENSMUSP00000112539; ENSMUSG00000022900 [Q8CBR1-2]
GeneIDi106347
KEGGimmu:106347
UCSCiuc007zcs.2 mouse [Q8CBR1-2]
uc007zct.2 mouse [Q8CBR1-1]
uc007zcu.2 mouse [Q8CBR1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiILDR1_MOUSE
AccessioniPrimary (citable) accession number: Q8CBR1
Secondary accession number(s): Q6PFB3, Q8CB39, Q91VS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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