Immunoglobulin-like domain-containing receptor 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• high-density lipoprotein particle receptor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 23863714

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cellular response to leukemia inhibitory factor Source: MGI <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 20439489
• positive regulation of peptide hormone secretion Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 23863714

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• integral component of membrane Source: UniProtKB-KW
• plasma membrane Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 23863714
• tricellular tight junction Source: CACAO <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 25822906

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MGCGLLAAGL LLFTWLPAGC LSLLVTVQHT ERYVTLFASV TLKCDYTTSA 
        60         70         80         90        100
QLQDVVVTWR FKSFCKDPIF DYFSASYQAA LSLGQDPSND CSDNQREVRI 
       110        120        130        140        150
VAQRRGQSEP VLGVDYRQRK ITIQNRADLV INEVMWWDHG VYYCTIEAPG 
       160        170        180        190        200
DTSGDPDKEV KLIVLHWLTV IFIILGALLL LLLIGVCWCQ CCPQYCCCYI 
       210        220        230        240        250
RCPCCPTRCC CPEEALARHR YMKQVQALGP QMMEKPLYWG ADRSSQVSSY 
       260        270        280        290        300
AMNPLLQRDL SLQSSLPQMP MTQMAAHPPV ANGVLEYLEK ELRNLNPAQP 
       310        320        330        340        350
LPADLRAKSG HPCSMLSSLG SAEVVERRVI HLPPLIRDPP SSRTSNPSHQ 
       360        370        380        390        400
QRLNAVSSRH CDLSERPRQR HHSDFLRELQ DQGMRPWAPG RGELDPHWSG 
       410        420        430        440        450
RHHRSRPSES SMPWSDWDSL SECPSSSEAP WPPRRPEPRE GAQRRERRRH 
       460        470        480        490        500
RSYSPPLPSG PSSWSSEEEK ESLPRNWGAQ RRHHHRRRRS QSPNWPEEKP 
       510        520        530 
PSYRSLDVTP GKNNRKKGNV ERRLERESSH SGRSVVI            

        10         20         30         40         50
MGCGLLAAGL LLFTWLPAGC LSLLVTVQHT ERYVTLFASV TLKCDYTTSA 
        60         70         80         90        100
QLQDVVVTWR FKSFCKDPIF DYFSASYQAA LSLGQDPSND CSDNQREVRI 
       110        120        130        140        150
VAQRRGQSEP VLGVDYRQRK ITIQNRADLV INEVMWWDHG VYYCTIEAPG 
       160        170        180        190        200
DTSGDPDKEV KLIVLHWLTV IFIILGALLL LLLIGVCWCQ CCPQYCCCYI 
       210        220        230        240        250
RCPCCPTRCC CPEEALARHR YMKQVQALGP QMMEKPLYWG ADRSSQVSSY 
       260        270        280        290        300
AMNPLLQRDL SLQSSLPQMP MTQMAAHPPV ANGVLEYLEK ELRNLNPAQP 
       310        320        330        340        350
LPADLRAKSG HPCSMLSSLG SAEVVERRVI HLPPLIRDPP SSRTSNPSHQ 
       360        370        380        390        400
QRLNAVSSRH CDLSERPRQR HHSDFLRELQ DQGMRPWAPG RGELDPHWSG 
       410        420        430        440        450
RHHRSRPSES SMPWSDWDSL SECPSSSEAP WPPRRPEPRE GAQRRERRRH 
       460        470        480        490        500
RSYSPPLPSG PSSWSSEEEK ESLPRNWGAQ RRHHHRRRRS QSPNWPEEKP 
       510 
PSYRSLDVTP GERELP                                  

        10         20         30         40         50
MGCGLLAAGL LLFTWLPAGC LSLLVTVQHT ERYVTLFASV TLKCDYTTSA 
        60         70         80         90        100
QLQDVVVTWR FKSFCKDPIF DYFSASYQAA LSLGQDPSND CSDNQREVRI 
       110        120        130        140        150
VAQRRGQSEP VLGVDYRQRK ITIQNRADLV INEVMWWDHG VYYCTIEAPG 
       160        170        180        190        200
DTSGDPDKEV KLIVLHWLTV IFIILGALLL LLLIGVCWCQ CCPQYCCCYI 
       210        220        230        240        250
RCPCCPTRCC CPEEDLSLQS SLPQMPMTQM AAHPPVANGV LEYLEKELRN 
       260        270        280        290        300
LNPAQPLPAD LRAKSGHPCS MLSSLGSAEV VERRVIHLPP LIRDPPSSRT 
       310        320        330        340        350
SNPSHQQRLN AVSSRHCDLS ERPRQRHHSD FLRELQDQGM RPWAPGRGEL 
       360        370        380        390        400
DPHWSGRHHR SRPSESSMPW SDWDSLSECP SSSEAPWPPR RPEPREGAQR 
       410        420        430        440        450
RERRRHRSYS PPLPSGPSSW SSEEEKESLP RNWGAQRRHH HRRRRSQSPN 
       460        470        480        490 
WPEEKPPSYR SLDVTPGKNN RKKGNVERRL ERESSHSGRS VVI 

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families