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Protein

Immunoglobulin-like domain-containing receptor 1

Gene

Ildr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative membrane receptor.By similarity

GO - Molecular functioni

  • high-density lipoprotein particle receptor activity Source: MGI

GO - Biological processi

  • positive regulation of peptide hormone secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin-like domain-containing receptor 1
Gene namesi
Name:Ildr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146574. Ildr1.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 166144ExtracellularSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Topological domaini188 – 537350CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • tricellular tight junction Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 537515Immunoglobulin-like domain-containing receptor 1PRO_0000245305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 144PROSITE-ProRule annotation
Modified residuei490 – 4901PhosphoserineCombined sources
Modified residuei492 – 4921PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ8CBR1.
PRIDEiQ8CBR1.

PTM databases

iPTMnetiQ8CBR1.
PhosphoSiteiQ8CBR1.

Expressioni

Tissue specificityi

Expressed in the vestibule and in hair cells and supporting cells of the cochlea.1 Publication

Developmental stagei

Expressed early in development.1 Publication

Gene expression databases

BgeeiQ8CBR1.
CleanExiMM_ILDR1.
GenevisibleiQ8CBR1. MM.

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112539.

Structurei

3D structure databases

ProteinModelPortaliQ8CBR1.
SMRiQ8CBR1. Positions 118-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 161139Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 21125Cys-richAdd
BLAST
Compositional biasi434 – 48956Arg-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI2. Eukaryota.
ENOG4110276. LUCA.
GeneTreeiENSGT00430000030906.
HOGENOMiHOG000294105.
HOVERGENiHBG060497.
InParanoidiQ8CBR1.
OMAiWPEEKPP.
OrthoDBiEOG7FV3QT.
PhylomeDBiQ8CBR1.
TreeFamiTF330877.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR008664. LISCH7.
[Graphical view]
PfamiPF05624. LSR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CBR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCGLLAAGL LLFTWLPAGC LSLLVTVQHT ERYVTLFASV TLKCDYTTSA
60 70 80 90 100
QLQDVVVTWR FKSFCKDPIF DYFSASYQAA LSLGQDPSND CSDNQREVRI
110 120 130 140 150
VAQRRGQSEP VLGVDYRQRK ITIQNRADLV INEVMWWDHG VYYCTIEAPG
160 170 180 190 200
DTSGDPDKEV KLIVLHWLTV IFIILGALLL LLLIGVCWCQ CCPQYCCCYI
210 220 230 240 250
RCPCCPTRCC CPEEALARHR YMKQVQALGP QMMEKPLYWG ADRSSQVSSY
260 270 280 290 300
AMNPLLQRDL SLQSSLPQMP MTQMAAHPPV ANGVLEYLEK ELRNLNPAQP
310 320 330 340 350
LPADLRAKSG HPCSMLSSLG SAEVVERRVI HLPPLIRDPP SSRTSNPSHQ
360 370 380 390 400
QRLNAVSSRH CDLSERPRQR HHSDFLRELQ DQGMRPWAPG RGELDPHWSG
410 420 430 440 450
RHHRSRPSES SMPWSDWDSL SECPSSSEAP WPPRRPEPRE GAQRRERRRH
460 470 480 490 500
RSYSPPLPSG PSSWSSEEEK ESLPRNWGAQ RRHHHRRRRS QSPNWPEEKP
510 520 530
PSYRSLDVTP GKNNRKKGNV ERRLERESSH SGRSVVI
Length:537
Mass (Da):61,277
Last modified:July 11, 2006 - v2
Checksum:i7757BFBD6188A16A
GO
Isoform 2 (identifier: Q8CBR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-516: KNNRK → ERELP
     517-537: Missing.

Show »
Length:516
Mass (Da):58,883
Checksum:iF0345FFE45552C59
GO
Isoform 3 (identifier: Q8CBR1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-258: Missing.

Show »
Length:493
Mass (Da):56,186
Checksum:i10D0640F1646C4EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251V → L in BAC29604 (PubMed:16141072).Curated
Sequence conflicti71 – 711D → G in BAC29081 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei215 – 25844Missing in isoform 3. 1 PublicationVSP_019688Add
BLAST
Alternative sequencei512 – 5165KNNRK → ERELP in isoform 2. 2 PublicationsVSP_019689
Alternative sequencei517 – 53721Missing in isoform 2. 2 PublicationsVSP_019690Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035504 mRNA. Translation: BAC29081.1.
AK036844 mRNA. Translation: BAC29604.1.
BC010485 mRNA. Translation: AAH10485.1.
BC057644 mRNA. Translation: AAH57644.1.
CCDSiCCDS49841.1. [Q8CBR1-2]
CCDS70718.1. [Q8CBR1-1]
CCDS70719.1. [Q8CBR1-3]
RefSeqiNP_001272717.1. NM_001285788.1. [Q8CBR1-1]
NP_001272720.1. NM_001285791.1. [Q8CBR1-3]
NP_598870.1. NM_134109.2. [Q8CBR1-2]
UniGeneiMm.17807.

Genome annotation databases

EnsembliENSMUST00000023617; ENSMUSP00000023617; ENSMUSG00000022900. [Q8CBR1-1]
ENSMUST00000089618; ENSMUSP00000087045; ENSMUSG00000022900. [Q8CBR1-3]
ENSMUST00000119464; ENSMUSP00000112539; ENSMUSG00000022900. [Q8CBR1-2]
GeneIDi106347.
KEGGimmu:106347.
UCSCiuc007zcs.2. mouse. [Q8CBR1-2]
uc007zct.2. mouse. [Q8CBR1-1]
uc007zcu.2. mouse. [Q8CBR1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035504 mRNA. Translation: BAC29081.1.
AK036844 mRNA. Translation: BAC29604.1.
BC010485 mRNA. Translation: AAH10485.1.
BC057644 mRNA. Translation: AAH57644.1.
CCDSiCCDS49841.1. [Q8CBR1-2]
CCDS70718.1. [Q8CBR1-1]
CCDS70719.1. [Q8CBR1-3]
RefSeqiNP_001272717.1. NM_001285788.1. [Q8CBR1-1]
NP_001272720.1. NM_001285791.1. [Q8CBR1-3]
NP_598870.1. NM_134109.2. [Q8CBR1-2]
UniGeneiMm.17807.

3D structure databases

ProteinModelPortaliQ8CBR1.
SMRiQ8CBR1. Positions 118-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112539.

PTM databases

iPTMnetiQ8CBR1.
PhosphoSiteiQ8CBR1.

Proteomic databases

PaxDbiQ8CBR1.
PRIDEiQ8CBR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023617; ENSMUSP00000023617; ENSMUSG00000022900. [Q8CBR1-1]
ENSMUST00000089618; ENSMUSP00000087045; ENSMUSG00000022900. [Q8CBR1-3]
ENSMUST00000119464; ENSMUSP00000112539; ENSMUSG00000022900. [Q8CBR1-2]
GeneIDi106347.
KEGGimmu:106347.
UCSCiuc007zcs.2. mouse. [Q8CBR1-2]
uc007zct.2. mouse. [Q8CBR1-1]
uc007zcu.2. mouse. [Q8CBR1-3]

Organism-specific databases

CTDi286676.
MGIiMGI:2146574. Ildr1.

Phylogenomic databases

eggNOGiENOG410IFI2. Eukaryota.
ENOG4110276. LUCA.
GeneTreeiENSGT00430000030906.
HOGENOMiHOG000294105.
HOVERGENiHBG060497.
InParanoidiQ8CBR1.
OMAiWPEEKPP.
OrthoDBiEOG7FV3QT.
PhylomeDBiQ8CBR1.
TreeFamiTF330877.

Miscellaneous databases

PROiQ8CBR1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CBR1.
CleanExiMM_ILDR1.
GenevisibleiQ8CBR1. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR008664. LISCH7.
[Graphical view]
PfamiPF05624. LSR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Urinary bladder and Vagina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: FVB/N.
    Tissue: Mammary gland and Salivary gland.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490 AND SER-492, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.
  4. Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiILDR1_MOUSE
AccessioniPrimary (citable) accession number: Q8CBR1
Secondary accession number(s): Q6PFB3, Q8CB39, Q91VS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.