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Protein

Major facilitator superfamily domain-containing protein 6

Gene

Mfsd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

MHC class I receptor. Binds only to H-2 class I histocompatibility antigen, K-D alpha chain (H-2K(D)).1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Protein family/group databases

TCDBi2.A.1.65.6. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 6
Alternative name(s):
Macrophage MHC class I receptor 2
Gene namesi
Name:Mfsd6
Synonyms:Mmr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1922925. Mfsd6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei453 – 47321HelicalSequence analysisAdd
BLAST
Transmembranei482 – 50221HelicalSequence analysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence analysisAdd
BLAST
Transmembranei547 – 56721HelicalSequence analysisAdd
BLAST
Transmembranei582 – 60221HelicalSequence analysisAdd
BLAST
Transmembranei608 – 62821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775Major facilitator superfamily domain-containing protein 6PRO_0000321941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CBH5.
MaxQBiQ8CBH5.
PaxDbiQ8CBH5.
PRIDEiQ8CBH5.

PTM databases

iPTMnetiQ8CBH5.
PhosphoSiteiQ8CBH5.

Expressioni

Gene expression databases

BgeeiQ8CBH5.
CleanExiMM_2210010L05RIK.
ExpressionAtlasiQ8CBH5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8CBH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 27052Thr-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3762. Eukaryota.
ENOG410YMHR. LUCA.
GeneTreeiENSGT00530000063599.
HOGENOMiHOG000230724.
HOVERGENiHBG100740.
InParanoidiQ8CBH5.

Family and domain databases

InterProiIPR024989. MFS_assoc_dom.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF12832. MFS_1_like. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CBH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADDKVAIL TDDEEEQKRK YVLADPFNGI CREPEPPSNE TPSSTETSAI
60 70 80 90 100
PEEEIDWIEK HCVKVNNDLL ISKVFYFFFY SAYGSLYPLL PVYYKQLGMS
110 120 130 140 150
PSQSGLLVGI RYFIEFCSAP FWGVVADRFR KGKIVLLFSL LCWVLFNLGI
160 170 180 190 200
GFVKPATLRC LPKIPPTAHP TNVSHPVTVL PMNSSTVAFF STPPKLLQKR
210 220 230 240 250
DVQLSETEPN ISDIDLVSTA LTLTSEPTRR PQTEAITHPV TGLILNTSTV
260 270 280 290 300
TLPPTGNVTR ETTIAVVTTT KSLPSDQVTL VYDQQEVEAI FLIILVVVII
310 320 330 340 350
GEFFSASSVT IVDTVTLQYL GKHRDRYGLQ RMWGSLGWGL AMLSVGIGID
360 370 380 390 400
YTHIDVLIDG KGCKPPEYRN YQIVFIVFGV LMTMALIVAT QFRFRYNHFN
410 420 430 440 450
NSDGKGKEVE IPQVERDNST ESSEETPTAA THSQAFNFWD LIKLLCSVQY
460 470 480 490 500
GSVLFVAWFM GFGYGFVFTF LYWHLEDLNG TTTLFGVCSV LSHVSELTAY
510 520 530 540 550
FFSHKLIELI GHIRVLYIGL ACNTARYIYI SYLENAWTVL PMEVLQGVTH
560 570 580 590 600
AAIWAACISY LSAAVPPELR TSAQGILQGL HLGLGRGCGA MIGGVLVNYF
610 620 630 640 650
GAAATFRGIG MACLVILLLF ALIQWLAVPD EEEDKTMLAE RIPVPSSPVP
660 670 680 690 700
IATIDLVQQQ TEDVMPRVEA RLPPKKTKHQ EEQEDVNKPA WGVSSSPWVT
710 720 730 740 750
FVYALYQVKE LIQLTRESRA SEIQPLQVTL CWASVASAPL LPPCSSKHMG
760 770
NRKTGMLAKD ISGLRSLCHS VYQVA
Length:775
Mass (Da):86,076
Last modified:March 1, 2003 - v1
Checksum:iAD85C3E94AF135E9
GO
Isoform 2 (identifier: Q8CBH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     728-775: VTLCWASVAS...SLCHSVYQVA → GTSENREASP...QTQSSPAHPS

Show »
Length:774
Mass (Da):85,757
Checksum:i3D9E2F435511B44F
GO

Sequence cautioni

The sequence AAH17534.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC32900.1 differs from that shown. Reason: Frameshift at position 3. Curated
The sequence BAC32900.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF36946.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei728 – 77548VTLCW…VYQVA → GTSENREASPAGGAQRAPRE THSASPRNQPSPDTAASQTQ SSPAHPS in isoform 2. 1 PublicationVSP_031836Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035995 mRNA. Translation: BAC29272.1.
AK046866 mRNA. Translation: BAC32900.1. Sequence problems.
AB247936 mRNA. Translation: BAF36946.1. Different initiation.
BC017534 mRNA. Translation: AAH17534.1. Different initiation.
CCDSiCCDS14946.1. [Q8CBH5-1]
RefSeqiNP_835182.1. NM_178081.4. [Q8CBH5-1]
UniGeneiMm.491173.

Genome annotation databases

EnsembliENSMUST00000087701; ENSMUSP00000084991; ENSMUSG00000041439. [Q8CBH5-1]
GeneIDi98682.
KEGGimmu:98682.
UCSCiuc007aym.1. mouse. [Q8CBH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035995 mRNA. Translation: BAC29272.1.
AK046866 mRNA. Translation: BAC32900.1. Sequence problems.
AB247936 mRNA. Translation: BAF36946.1. Different initiation.
BC017534 mRNA. Translation: AAH17534.1. Different initiation.
CCDSiCCDS14946.1. [Q8CBH5-1]
RefSeqiNP_835182.1. NM_178081.4. [Q8CBH5-1]
UniGeneiMm.491173.

3D structure databases

ProteinModelPortaliQ8CBH5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.1.65.6. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8CBH5.
PhosphoSiteiQ8CBH5.

Proteomic databases

EPDiQ8CBH5.
MaxQBiQ8CBH5.
PaxDbiQ8CBH5.
PRIDEiQ8CBH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087701; ENSMUSP00000084991; ENSMUSG00000041439. [Q8CBH5-1]
GeneIDi98682.
KEGGimmu:98682.
UCSCiuc007aym.1. mouse. [Q8CBH5-1]

Organism-specific databases

CTDi54842.
MGIiMGI:1922925. Mfsd6.

Phylogenomic databases

eggNOGiKOG3762. Eukaryota.
ENOG410YMHR. LUCA.
GeneTreeiENSGT00530000063599.
HOGENOMiHOG000230724.
HOVERGENiHBG100740.
InParanoidiQ8CBH5.

Miscellaneous databases

ChiTaRSiMfsd6. mouse.
NextBioi353575.
PROiQ8CBH5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CBH5.
CleanExiMM_2210010L05RIK.
ExpressionAtlasiQ8CBH5. baseline and differential.

Family and domain databases

InterProiIPR024989. MFS_assoc_dom.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF12832. MFS_1_like. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Medulla oblongata.
  2. "Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice."
    Tashiro-Yamaji J., Kubota T., Yoshida R.
    Gene 384:1-8(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-775 (ISOFORM 1), FUNCTION.
    Strain: C57BL/6J.
    Tissue: Macrophage.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 183-775 (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-11, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiMFSD6_MOUSE
AccessioniPrimary (citable) accession number: Q8CBH5
Secondary accession number(s): Q8C8K4, Q8VIG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.