Reviewed,
UniProtKB/Swiss-Prot Q8CBF3 (EPHB1_MOUSE)
Last modified
February 9, 2010.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ephrin type-B receptor 1 EC=2.7.10.1 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 984 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system By similarity. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subunit structure | The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with EPHB6 and PRKCABP By similarity. |
| Subcellular location | Membrane; Single-pass type I membrane protein By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8CBF3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8CBF3-2) The sequence of this isoform differs from the canonical sequence as follows: 588-628: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | ||||||
| Chain | 18 – 984 | 967 | Ephrin type-B receptor 1 | PRO_0000260317 | |||||
Regions | |||||||||
| Topological domain | 18 – 540 | 523 | Extracellular Potential | ||||||
| Transmembrane | 541 – 563 | 23 | Potential | ||||||
| Topological domain | 564 – 984 | 421 | Cytoplasmic Potential | ||||||
| Domain | 323 – 424 | 102 | Fibronectin type-III 1 | ||||||
| Domain | 430 – 525 | 96 | Fibronectin type-III 2 | ||||||
| Domain | 619 – 882 | 264 | Protein kinase | ||||||
| Domain | 911 – 975 | 65 | SAM | ||||||
| Nucleotide binding | 625 – 633 | 9 | ATP By similarity | ||||||
| Motif | 982 – 984 | 3 | PDZ-binding Potential | ||||||
| Compositional bias | 183 – 319 | 137 | Cys-rich | ||||||
Sites | |||||||||
| Active site | 744 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 651 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 928 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
| Modified residue | 968 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 334 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 426 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 480 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 588 – 628 | 41 | Missing in isoform 2. | VSP_021595 | |||||
Experimental info | |||||||||
| Sequence conflict | 72 | 1 | L → Q in BAE22386. Ref.1 | ||||||
| Sequence conflict | 187 | 1 | L → P in BAE22386. Ref.1 | ||||||
| Sequence conflict | 194 | 1 | K → I in AAH57301. Ref.3 | ||||||
| Sequence conflict | 641 | 1 | P → Q in BAC29348. Ref.1 | ||||||
| Sequence conflict | 678 | 1 | P → R in AAH57301. Ref.3 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK036148 mRNA. Translation: BAC29320.1. AK036211 mRNA. Translation: BAC29348.1. AK135018 mRNA. Translation: BAE22386.1. CT025594 AC156635 Genomic DNA. Translation: CAM23741.1. BC057301 mRNA. Translation: AAH57301.1. |
| IPI | IPI00228309. IPI00808241. |
| RefSeq | NP_001161768.1. NP_775623.3. |
| UniGene | Mm.22897 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JPA based on UniProtKB P54763. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8CBF3. |
PTM databases | |
| PhosphoSite | Q8CBF3. |
Proteomic databases | |
| PRIDE | Q8CBF3. |
Genome annotation databases | |
| Ensembl | ENSMUST00000035129; ENSMUSP00000035129; ENSMUSG00000032537; Mus musculus. [Genome view] ENSMUST00000085169; ENSMUSP00000082261; ENSMUSG00000032537; Mus musculus. [Genome view] |
| GeneID | 270190. |
| KEGG | mmu:270190. |
| UCSC | uc009rfn.1. mouse. |
Organism-specific databases | |
| CTD | 270190. |
| MGI | MGI:1096337. Ephb1. |
Phylogenomic databases | |
| eggNOG | roNOG09683. |
| HOGENOM | HBG755340. |
| HOVERGEN | Q8CBF3. |
| InParanoid | Q8CBF3. |
| OMA | NSVACKA. |
| PhylomeDB | Q8CBF3. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.1. 244. |
Gene expression databases | |
| ArrayExpress | Q8CBF3. |
| Bgee | Q8CBF3. |
| CleanEx | MM_EPHB1. |
| Genevestigator | Q8CBF3. |
| GermOnline | ENSMUSG00000032537. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003962. FnIII_subd. IPR008979. Galactose-bd-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001660. SAM. IPR010993. SAM_homology. IPR013761. SAM_type. IPR021129. SAM_type1. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. IPR016257. Tyr_prot_kinase_ephrin_rcpt. IPR001426. Tyr_prot_kinase_rcpt_V_CS. [Graphical view] |
| Gene3D | G3DSA:2.60.40.30. FN_III-like. 2 hits. G3DSA:1.10.150.50. SAM_type. 1 hit. |
| PANTHER | PTHR23256. Tyr_prot_kinase. 1 hit. |
| Pfam | PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF00536. SAM_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF000666. TyrPK_ephrin_receptor. 1 hit. |
| PRINTS | PR00014. FNTYPEIII. |
| SMART | SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS01186. EGF_2. 1 hit. Uncertain. PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 393293. |
| SOURCE | Search... |
Entry information
| Entry name | EPHB1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8CBF3 Secondary accession number(s): B1B1C2 Q8CBE2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

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