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Protein

WD repeat-containing protein 37

Gene

Wdr37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 37
Gene namesi
Name:Wdr37
Synonyms:Kiaa0982
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920393. Wdr37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496WD repeat-containing protein 37PRO_0000051388Add
BLAST

Proteomic databases

MaxQBiQ8CBE3.
PaxDbiQ8CBE3.
PRIDEiQ8CBE3.

PTM databases

PhosphoSiteiQ8CBE3.

Expressioni

Gene expression databases

BgeeiQ8CBE3.
CleanExiMM_WDR37.
ExpressionAtlasiQ8CBE3. baseline and differential.
GenevestigatoriQ8CBE3.

Interactioni

Protein-protein interaction databases

BioGridi228908. 3 interactions.
IntActiQ8CBE3. 2 interactions.
MINTiMINT-4140335.

Structurei

3D structure databases

ProteinModelPortaliQ8CBE3.
SMRiQ8CBE3. Positions 98-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati154 – 19441WD 1Add
BLAST
Repeati197 – 23640WD 2Add
BLAST
Repeati281 – 32040WD 3Add
BLAST
Repeati323 – 36240WD 4Add
BLAST
Repeati367 – 40539WD 5Add
BLAST
Repeati408 – 44740WD 6Add
BLAST
Repeati454 – 49542WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00780000121967.
HOGENOMiHOG000013185.
HOVERGENiHBG057072.
InParanoidiQ8CBE3.
OMAiTGLPRDM.
OrthoDBiEOG77DJ5K.
PhylomeDBiQ8CBE3.
TreeFamiTF105876.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CBE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTESGSCST ARQAKQKRKS HSLSIRRTNS SEQERTGLPR EMLEGQDSKL
60 70 80 90 100
PSSVRSTLLE LFGQIEREFE NLYIENLELR REIDTLNERL AGEGQAIDGA
110 120 130 140 150
ELSKGQLKTK ASHSTSQLSQ KLKTTYKAST SKIVSSFKTT TSRAICQLVK
160 170 180 190 200
EYIGHRDGIW DVSVTRTQPI VLGTASADHT ALLWSIETGK CLVKYAGHVG
210 220 230 240 250
SVNSIKFHPS EQLALTASGD QTAHIWRYVV QLPTPQPVAD TSQQISGEDE
260 270 280 290 300
IECSDKDEPD IDGDVSSDCP TVRVPLTSLK SHQGVVIAAD WLVGGKQVVT
310 320 330 340 350
ASWDRTANLY DVETSELVHS LTGHDQELTH CCTHPTQRLV VTSSRDTTFR
360 370 380 390 400
LWDFRDPSIH SVNVFQGHTD TVTSAVFTVG DNVVSGSDDR TVKVWDLKNM
410 420 430 440 450
RSPIATIRTD SAINRINVCV GQKIIALPHD NRQVRLFDMS GVRLARLPRS
460 470 480 490
SRQGHRRMVC CSAWSEDHPI CNLFTCGFDR QAIGWNINIP ALLQEK
Length:496
Mass (Da):55,046
Last modified:March 1, 2003 - v1
Checksum:iD647D239E5F6EA08
GO

Sequence cautioni

The sequence BAC98064.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691F → L in BAC27934 (PubMed:16141072).Curated
Sequence conflicti139 – 1391T → I in AAH46236 (PubMed:15489334).Curated
Sequence conflicti224 – 2241H → N in BAC27934 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129254 mRNA. Translation: BAC98064.1. Different initiation.
AK032582 mRNA. Translation: BAC27934.1.
AK036203 mRNA. Translation: BAC29346.1.
BC046236 mRNA. Translation: AAH46236.1.
CCDSiCCDS26232.1.
RefSeqiNP_001034477.1. NM_001039388.2.
NP_766033.1. NM_172445.3.
XP_006516532.1. XM_006516469.2.
XP_006516533.1. XM_006516470.2.
UniGeneiMm.284654.

Genome annotation databases

EnsembliENSMUST00000021572; ENSMUSP00000021572; ENSMUSG00000021147.
ENSMUST00000054251; ENSMUSP00000062174; ENSMUSG00000021147.
GeneIDi207615.
KEGGimmu:207615.
UCSCiuc007pki.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129254 mRNA. Translation: BAC98064.1. Different initiation.
AK032582 mRNA. Translation: BAC27934.1.
AK036203 mRNA. Translation: BAC29346.1.
BC046236 mRNA. Translation: AAH46236.1.
CCDSiCCDS26232.1.
RefSeqiNP_001034477.1. NM_001039388.2.
NP_766033.1. NM_172445.3.
XP_006516532.1. XM_006516469.2.
XP_006516533.1. XM_006516470.2.
UniGeneiMm.284654.

3D structure databases

ProteinModelPortaliQ8CBE3.
SMRiQ8CBE3. Positions 98-488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228908. 3 interactions.
IntActiQ8CBE3. 2 interactions.
MINTiMINT-4140335.

PTM databases

PhosphoSiteiQ8CBE3.

Proteomic databases

MaxQBiQ8CBE3.
PaxDbiQ8CBE3.
PRIDEiQ8CBE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021572; ENSMUSP00000021572; ENSMUSG00000021147.
ENSMUST00000054251; ENSMUSP00000062174; ENSMUSG00000021147.
GeneIDi207615.
KEGGimmu:207615.
UCSCiuc007pki.1. mouse.

Organism-specific databases

CTDi22884.
MGIiMGI:1920393. Wdr37.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00780000121967.
HOGENOMiHOG000013185.
HOVERGENiHBG057072.
InParanoidiQ8CBE3.
OMAiTGLPRDM.
OrthoDBiEOG77DJ5K.
PhylomeDBiQ8CBE3.
TreeFamiTF105876.

Miscellaneous databases

ChiTaRSiWdr37. mouse.
NextBioi371979.
PROiQ8CBE3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CBE3.
CleanExiMM_WDR37.
ExpressionAtlasiQ8CBE3. baseline and differential.
GenevestigatoriQ8CBE3.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Olfactory bulb.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiWDR37_MOUSE
AccessioniPrimary (citable) accession number: Q8CBE3
Secondary accession number(s): Q80Y96, Q8CCL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.