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Protein

WD repeat-containing protein 37

Gene

Wdr37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 37
Gene namesi
Name:Wdr37
Synonyms:Kiaa0982
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920393. Wdr37.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513881 – 496WD repeat-containing protein 37Add BLAST496

Proteomic databases

EPDiQ8CBE3.
MaxQBiQ8CBE3.
PaxDbiQ8CBE3.
PeptideAtlasiQ8CBE3.
PRIDEiQ8CBE3.

PTM databases

iPTMnetiQ8CBE3.
PhosphoSitePlusiQ8CBE3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021147.
CleanExiMM_WDR37.
ExpressionAtlasiQ8CBE3. baseline and differential.
GenevisibleiQ8CBE3. MM.

Interactioni

Protein-protein interaction databases

BioGridi228908. 3 interactors.
IntActiQ8CBE3. 3 interactors.
MINTiMINT-4140335.
STRINGi10090.ENSMUSP00000021572.

Structurei

3D structure databases

ProteinModelPortaliQ8CBE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati154 – 194WD 1Add BLAST41
Repeati197 – 236WD 2Add BLAST40
Repeati281 – 320WD 3Add BLAST40
Repeati323 – 362WD 4Add BLAST40
Repeati367 – 405WD 5Add BLAST39
Repeati408 – 447WD 6Add BLAST40
Repeati454 – 495WD 7Add BLAST42

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0300. Eukaryota.
ENOG410XSES. LUCA.
GeneTreeiENSGT00780000121967.
HOGENOMiHOG000013185.
HOVERGENiHBG057072.
InParanoidiQ8CBE3.
OMAiWDFREAI.
OrthoDBiEOG091G06KJ.
PhylomeDBiQ8CBE3.
TreeFamiTF105876.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CBE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTESGSCST ARQAKQKRKS HSLSIRRTNS SEQERTGLPR EMLEGQDSKL
60 70 80 90 100
PSSVRSTLLE LFGQIEREFE NLYIENLELR REIDTLNERL AGEGQAIDGA
110 120 130 140 150
ELSKGQLKTK ASHSTSQLSQ KLKTTYKAST SKIVSSFKTT TSRAICQLVK
160 170 180 190 200
EYIGHRDGIW DVSVTRTQPI VLGTASADHT ALLWSIETGK CLVKYAGHVG
210 220 230 240 250
SVNSIKFHPS EQLALTASGD QTAHIWRYVV QLPTPQPVAD TSQQISGEDE
260 270 280 290 300
IECSDKDEPD IDGDVSSDCP TVRVPLTSLK SHQGVVIAAD WLVGGKQVVT
310 320 330 340 350
ASWDRTANLY DVETSELVHS LTGHDQELTH CCTHPTQRLV VTSSRDTTFR
360 370 380 390 400
LWDFRDPSIH SVNVFQGHTD TVTSAVFTVG DNVVSGSDDR TVKVWDLKNM
410 420 430 440 450
RSPIATIRTD SAINRINVCV GQKIIALPHD NRQVRLFDMS GVRLARLPRS
460 470 480 490
SRQGHRRMVC CSAWSEDHPI CNLFTCGFDR QAIGWNINIP ALLQEK
Length:496
Mass (Da):55,046
Last modified:March 1, 2003 - v1
Checksum:iD647D239E5F6EA08
GO

Sequence cautioni

The sequence BAC98064 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69F → L in BAC27934 (PubMed:16141072).Curated1
Sequence conflicti139T → I in AAH46236 (PubMed:15489334).Curated1
Sequence conflicti224H → N in BAC27934 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129254 mRNA. Translation: BAC98064.1. Different initiation.
AK032582 mRNA. Translation: BAC27934.1.
AK036203 mRNA. Translation: BAC29346.1.
BC046236 mRNA. Translation: AAH46236.1.
CCDSiCCDS26232.1.
RefSeqiNP_001034477.1. NM_001039388.2.
NP_766033.1. NM_172445.3.
XP_006516532.1. XM_006516469.3.
XP_006516533.1. XM_006516470.3.
UniGeneiMm.284654.

Genome annotation databases

EnsembliENSMUST00000021572; ENSMUSP00000021572; ENSMUSG00000021147.
ENSMUST00000054251; ENSMUSP00000062174; ENSMUSG00000021147.
GeneIDi207615.
KEGGimmu:207615.
UCSCiuc007pki.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129254 mRNA. Translation: BAC98064.1. Different initiation.
AK032582 mRNA. Translation: BAC27934.1.
AK036203 mRNA. Translation: BAC29346.1.
BC046236 mRNA. Translation: AAH46236.1.
CCDSiCCDS26232.1.
RefSeqiNP_001034477.1. NM_001039388.2.
NP_766033.1. NM_172445.3.
XP_006516532.1. XM_006516469.3.
XP_006516533.1. XM_006516470.3.
UniGeneiMm.284654.

3D structure databases

ProteinModelPortaliQ8CBE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228908. 3 interactors.
IntActiQ8CBE3. 3 interactors.
MINTiMINT-4140335.
STRINGi10090.ENSMUSP00000021572.

PTM databases

iPTMnetiQ8CBE3.
PhosphoSitePlusiQ8CBE3.

Proteomic databases

EPDiQ8CBE3.
MaxQBiQ8CBE3.
PaxDbiQ8CBE3.
PeptideAtlasiQ8CBE3.
PRIDEiQ8CBE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021572; ENSMUSP00000021572; ENSMUSG00000021147.
ENSMUST00000054251; ENSMUSP00000062174; ENSMUSG00000021147.
GeneIDi207615.
KEGGimmu:207615.
UCSCiuc007pki.2. mouse.

Organism-specific databases

CTDi22884.
MGIiMGI:1920393. Wdr37.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0300. Eukaryota.
ENOG410XSES. LUCA.
GeneTreeiENSGT00780000121967.
HOGENOMiHOG000013185.
HOVERGENiHBG057072.
InParanoidiQ8CBE3.
OMAiWDFREAI.
OrthoDBiEOG091G06KJ.
PhylomeDBiQ8CBE3.
TreeFamiTF105876.

Miscellaneous databases

ChiTaRSiWdr37. mouse.
PROiQ8CBE3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021147.
CleanExiMM_WDR37.
ExpressionAtlasiQ8CBE3. baseline and differential.
GenevisibleiQ8CBE3. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR37_MOUSE
AccessioniPrimary (citable) accession number: Q8CBE3
Secondary accession number(s): Q80Y96, Q8CCL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.