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Q8CBC4

- CNST_MOUSE

UniProt

Q8CBC4 - CNST_MOUSE

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Protein

Consortin

Gene

Cnst

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for targeting of connexins to the plasma membrane.By similarity

GO - Molecular functioni

  1. connexin binding Source: UniProtKB
  2. phosphatase binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of phosphatase activity Source: UniProtKB
  2. positive regulation of Golgi to plasma membrane protein transport Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Consortin
Gene namesi
Name:Cnst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2445141. Cnst.

Subcellular locationi

Cell membrane By similarity; Single-pass membrane protein By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Single-pass membrane protein By similarity. Cytoplasmic vesiclesecretory vesicle By similarity
Note: Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway (By similarity).By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
  3. protein complex Source: Ensembl
  4. trans-Golgi network Source: UniProtKB
  5. transport vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi558 – 5625DSDLL → NSDAA: Does not affect binding to connexins but results in their intracellular accumulation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711ConsortinPRO_0000288907Add
BLAST

Proteomic databases

MaxQBiQ8CBC4.
PaxDbiQ8CBC4.
PRIDEiQ8CBC4.

PTM databases

PhosphoSiteiQ8CBC4.

Expressioni

Gene expression databases

BgeeiQ8CBC4.
CleanExiMM_9630058J23RIK.
GenevestigatoriQ8CBC4.

Interactioni

Subunit structurei

Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gga1Q8R0H92EBI-2615407,EBI-2616212
Gga2Q6P5E62EBI-2615407,EBI-2616239
Gjb2P219942EBI-2615407,EBI-2616119From a different organism.

Protein-protein interaction databases

IntActiQ8CBC4. 9 interactions.
STRINGi10090.ENSMUSP00000048205.

Structurei

3D structure databases

ProteinModelPortaliQ8CBC4.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 650650CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini672 – 71140ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei651 – 67121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CNST family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG29134.
GeneTreeiENSGT00390000005861.
HOGENOMiHOG000111226.
HOVERGENiHBG098332.
InParanoidiQ8CBC4.
KOiK17581.
OMAiKHWIYLS.
OrthoDBiEOG708VZD.
PhylomeDBiQ8CBC4.
TreeFamiTF351172.

Family and domain databases

InterProiIPR028129. Consortin_C.
[Graphical view]
PfamiPF15281. Consortin_C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CBC4) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDSDPPTYS LQIEPQDGCH PGDSVERRVT RLPSVSDENE NQLAGDGPAG
60 70 80 90 100
LTTSEGAMGR ATVSEQDSLN NNESFPSSCE AAPTENAENT PSEGPKDDPP
110 120 130 140 150
SLGQDQKLPA KRSPRAKKSS PKSAPPGDAV PVMQTQNATS QAAGEEEAAG
160 170 180 190 200
VNANDPPKAP ALQPLFSLIR GEVAQMDSRA LPLFLHQVAE TYFQEEDYEK
210 220 230 240 250
AMKFIQLERL YHEQLLANLS AIQEQWETKW KAVQPRTVTP LRNSEKGFNG
260 270 280 290 300
EDFEQLAKIC TTHQDPLLSK LKTAPVEPSP ERKSLARAIM SEEAVGTEAA
310 320 330 340 350
AKEPEIETCP STDPSGDRHE EEPQESSPGC HQMEWQTASP ELPGTAGKDH
360 370 380 390 400
TEELPSSTNA TLDLHTQSLE TAGSRSGPAA ASNACKDSSC VPAPPTEDHC
410 420 430 440 450
GVARDPKVAP PSESVAEQKL STGDDGALPG LISEGKYSQA HRKELCLPLQ
460 470 480 490 500
DAFEALPRDQ PHSSEVAEPR QPDVTASDGK SAQSQAGLET GPESALCGDR
510 520 530 540 550
KACDVSTLCL EVCMAPEERR DSEDRVSKET EDYLHSLLER CLKDAEDSLS
560 570 580 590 600
YEDIQDDDSD LLQDLSPEEA SYSLQEDLPP DESTLSLDDL AKKIEIAEAI
610 620 630 640 650
PAEGLVSILK KRNDTVGSHP AQMQQKPAKR RVRFQEIDDN LEQDEVGGGS
660 670 680 690 700
CILLILLCIA TVFLSVGGTA LYCTLGNIES PVCTDFADNV DFYYTKLLQG
710
VAGLKHWVYL S
Length:711
Mass (Da):76,866
Last modified:March 1, 2003 - v1
Checksum:iB117F1FA8648E8EC
GO
Isoform 2 (identifier: Q8CBC4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-197: DAVPVMQTQN...VAETYFQEED → EAFRLSLLSF...PSLRHGGFAL
     198-711: Missing.

Show »
Length:201
Mass (Da):21,495
Checksum:iF439F01E6FF16D28
GO
Isoform 3 (identifier: Q8CBC4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-289: Missing.

Show »
Length:422
Mass (Da):45,414
Checksum:i63ECC182B66CFF30
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 289289Missing in isoform 3. 1 PublicationVSP_038657Add
BLAST
Alternative sequencei128 – 19770DAVPV…FQEED → EAFRLSLLSFNKNKHFFWCC SAAAPVAPLCGSCIPFVPAV TVYREITTCLVCFLYRPHHG VLTLPSLRHGGFAL in isoform 2. 1 PublicationVSP_025821Add
BLAST
Alternative sequencei198 – 711514Missing in isoform 2. 1 PublicationVSP_025822Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036332 mRNA. Translation: BAC29388.1.
AK040666 mRNA. Translation: BAC30660.1.
AK040899 mRNA. Translation: BAC30736.1.
AK146681 mRNA. Translation: BAE27356.1.
BC034107 mRNA. Translation: AAH34107.1.
BC054802 mRNA. Translation: AAH54802.1.
CCDSiCCDS15562.1. [Q8CBC4-1]
RefSeqiNP_666217.2. NM_146105.3. [Q8CBC4-1]
UniGeneiMm.87662.

Genome annotation databases

EnsembliENSMUST00000040706; ENSMUSP00000048205; ENSMUSG00000038949. [Q8CBC4-1]
GeneIDi226744.
KEGGimmu:226744.
UCSCiuc007dvm.1. mouse. [Q8CBC4-2]
uc007dvo.1. mouse. [Q8CBC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036332 mRNA. Translation: BAC29388.1 .
AK040666 mRNA. Translation: BAC30660.1 .
AK040899 mRNA. Translation: BAC30736.1 .
AK146681 mRNA. Translation: BAE27356.1 .
BC034107 mRNA. Translation: AAH34107.1 .
BC054802 mRNA. Translation: AAH54802.1 .
CCDSi CCDS15562.1. [Q8CBC4-1 ]
RefSeqi NP_666217.2. NM_146105.3. [Q8CBC4-1 ]
UniGenei Mm.87662.

3D structure databases

ProteinModelPortali Q8CBC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CBC4. 9 interactions.
STRINGi 10090.ENSMUSP00000048205.

PTM databases

PhosphoSitei Q8CBC4.

Proteomic databases

MaxQBi Q8CBC4.
PaxDbi Q8CBC4.
PRIDEi Q8CBC4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040706 ; ENSMUSP00000048205 ; ENSMUSG00000038949 . [Q8CBC4-1 ]
GeneIDi 226744.
KEGGi mmu:226744.
UCSCi uc007dvm.1. mouse. [Q8CBC4-2 ]
uc007dvo.1. mouse. [Q8CBC4-1 ]

Organism-specific databases

CTDi 163882.
MGIi MGI:2445141. Cnst.

Phylogenomic databases

eggNOGi NOG29134.
GeneTreei ENSGT00390000005861.
HOGENOMi HOG000111226.
HOVERGENi HBG098332.
InParanoidi Q8CBC4.
KOi K17581.
OMAi KHWIYLS.
OrthoDBi EOG708VZD.
PhylomeDBi Q8CBC4.
TreeFami TF351172.

Miscellaneous databases

ChiTaRSi CNST. mouse.
NextBioi 378309.
PROi Q8CBC4.
SOURCEi Search...

Gene expression databases

Bgeei Q8CBC4.
CleanExi MM_9630058J23RIK.
Genevestigatori Q8CBC4.

Family and domain databases

InterProi IPR028129. Consortin_C.
[Graphical view ]
Pfami PF15281. Consortin_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Amnion, Aorta, Cerebellum and Vein.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  3. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
    del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
    Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF ISOFORM 3, INTERACTION WITH GGA1; GGA2; GJA1; GJB1; GJB2; GJB3; GJB6 AND GJC1, MUTAGENESIS OF 558-562.

Entry informationi

Entry nameiCNST_MOUSE
AccessioniPrimary (citable) accession number: Q8CBC4
Secondary accession number(s): Q8BFS5, Q8K053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3