Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8CBC4

- CNST_MOUSE

UniProt

Q8CBC4 - CNST_MOUSE

Protein

Consortin

Gene

Cnst

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for targeting of connexins to the plasma membrane.By similarity

    GO - Molecular functioni

    1. connexin binding Source: UniProtKB
    2. phosphatase binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of phosphatase activity Source: UniProtKB
    2. positive regulation of Golgi to plasma membrane protein transport Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Consortin
    Gene namesi
    Name:Cnst
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2445141. Cnst.

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Single-pass membrane protein By similarity. Cytoplasmic vesiclesecretory vesicle By similarity
    Note: Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway By similarity.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB
    3. protein complex Source: Ensembl
    4. trans-Golgi network Source: UniProtKB
    5. transport vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi558 – 5625DSDLL → NSDAA: Does not affect binding to connexins but results in their intracellular accumulation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711ConsortinPRO_0000288907Add
    BLAST

    Proteomic databases

    PaxDbiQ8CBC4.
    PRIDEiQ8CBC4.

    PTM databases

    PhosphoSiteiQ8CBC4.

    Expressioni

    Gene expression databases

    BgeeiQ8CBC4.
    CleanExiMM_9630058J23RIK.
    GenevestigatoriQ8CBC4.

    Interactioni

    Subunit structurei

    Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Gga1Q8R0H92EBI-2615407,EBI-2616212
    Gga2Q6P5E62EBI-2615407,EBI-2616239
    Gjb2P219942EBI-2615407,EBI-2616119From a different organism.

    Protein-protein interaction databases

    IntActiQ8CBC4. 9 interactions.
    STRINGi10090.ENSMUSP00000048205.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CBC4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 650650CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini672 – 71140ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei651 – 67121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CNST family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG29134.
    GeneTreeiENSGT00390000005861.
    HOGENOMiHOG000111226.
    HOVERGENiHBG098332.
    InParanoidiQ8CBC4.
    KOiK17581.
    OMAiKHWIYLS.
    OrthoDBiEOG708VZD.
    PhylomeDBiQ8CBC4.
    TreeFamiTF351172.

    Family and domain databases

    InterProiIPR028129. Consortin_C.
    [Graphical view]
    PfamiPF15281. Consortin_C. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CBC4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDDSDPPTYS LQIEPQDGCH PGDSVERRVT RLPSVSDENE NQLAGDGPAG    50
    LTTSEGAMGR ATVSEQDSLN NNESFPSSCE AAPTENAENT PSEGPKDDPP 100
    SLGQDQKLPA KRSPRAKKSS PKSAPPGDAV PVMQTQNATS QAAGEEEAAG 150
    VNANDPPKAP ALQPLFSLIR GEVAQMDSRA LPLFLHQVAE TYFQEEDYEK 200
    AMKFIQLERL YHEQLLANLS AIQEQWETKW KAVQPRTVTP LRNSEKGFNG 250
    EDFEQLAKIC TTHQDPLLSK LKTAPVEPSP ERKSLARAIM SEEAVGTEAA 300
    AKEPEIETCP STDPSGDRHE EEPQESSPGC HQMEWQTASP ELPGTAGKDH 350
    TEELPSSTNA TLDLHTQSLE TAGSRSGPAA ASNACKDSSC VPAPPTEDHC 400
    GVARDPKVAP PSESVAEQKL STGDDGALPG LISEGKYSQA HRKELCLPLQ 450
    DAFEALPRDQ PHSSEVAEPR QPDVTASDGK SAQSQAGLET GPESALCGDR 500
    KACDVSTLCL EVCMAPEERR DSEDRVSKET EDYLHSLLER CLKDAEDSLS 550
    YEDIQDDDSD LLQDLSPEEA SYSLQEDLPP DESTLSLDDL AKKIEIAEAI 600
    PAEGLVSILK KRNDTVGSHP AQMQQKPAKR RVRFQEIDDN LEQDEVGGGS 650
    CILLILLCIA TVFLSVGGTA LYCTLGNIES PVCTDFADNV DFYYTKLLQG 700
    VAGLKHWVYL S 711
    Length:711
    Mass (Da):76,866
    Last modified:March 1, 2003 - v1
    Checksum:iB117F1FA8648E8EC
    GO
    Isoform 2 (identifier: Q8CBC4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         128-197: DAVPVMQTQN...VAETYFQEED → EAFRLSLLSF...PSLRHGGFAL
         198-711: Missing.

    Show »
    Length:201
    Mass (Da):21,495
    Checksum:iF439F01E6FF16D28
    GO
    Isoform 3 (identifier: Q8CBC4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-289: Missing.

    Show »
    Length:422
    Mass (Da):45,414
    Checksum:i63ECC182B66CFF30
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 289289Missing in isoform 3. 1 PublicationVSP_038657Add
    BLAST
    Alternative sequencei128 – 19770DAVPV…FQEED → EAFRLSLLSFNKNKHFFWCC SAAAPVAPLCGSCIPFVPAV TVYREITTCLVCFLYRPHHG VLTLPSLRHGGFAL in isoform 2. 1 PublicationVSP_025821Add
    BLAST
    Alternative sequencei198 – 711514Missing in isoform 2. 1 PublicationVSP_025822Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036332 mRNA. Translation: BAC29388.1.
    AK040666 mRNA. Translation: BAC30660.1.
    AK040899 mRNA. Translation: BAC30736.1.
    AK146681 mRNA. Translation: BAE27356.1.
    BC034107 mRNA. Translation: AAH34107.1.
    BC054802 mRNA. Translation: AAH54802.1.
    CCDSiCCDS15562.1. [Q8CBC4-1]
    RefSeqiNP_666217.2. NM_146105.3. [Q8CBC4-1]
    UniGeneiMm.87662.

    Genome annotation databases

    EnsembliENSMUST00000040706; ENSMUSP00000048205; ENSMUSG00000038949. [Q8CBC4-1]
    GeneIDi226744.
    KEGGimmu:226744.
    UCSCiuc007dvm.1. mouse. [Q8CBC4-2]
    uc007dvo.1. mouse. [Q8CBC4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036332 mRNA. Translation: BAC29388.1 .
    AK040666 mRNA. Translation: BAC30660.1 .
    AK040899 mRNA. Translation: BAC30736.1 .
    AK146681 mRNA. Translation: BAE27356.1 .
    BC034107 mRNA. Translation: AAH34107.1 .
    BC054802 mRNA. Translation: AAH54802.1 .
    CCDSi CCDS15562.1. [Q8CBC4-1 ]
    RefSeqi NP_666217.2. NM_146105.3. [Q8CBC4-1 ]
    UniGenei Mm.87662.

    3D structure databases

    ProteinModelPortali Q8CBC4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CBC4. 9 interactions.
    STRINGi 10090.ENSMUSP00000048205.

    PTM databases

    PhosphoSitei Q8CBC4.

    Proteomic databases

    PaxDbi Q8CBC4.
    PRIDEi Q8CBC4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040706 ; ENSMUSP00000048205 ; ENSMUSG00000038949 . [Q8CBC4-1 ]
    GeneIDi 226744.
    KEGGi mmu:226744.
    UCSCi uc007dvm.1. mouse. [Q8CBC4-2 ]
    uc007dvo.1. mouse. [Q8CBC4-1 ]

    Organism-specific databases

    CTDi 163882.
    MGIi MGI:2445141. Cnst.

    Phylogenomic databases

    eggNOGi NOG29134.
    GeneTreei ENSGT00390000005861.
    HOGENOMi HOG000111226.
    HOVERGENi HBG098332.
    InParanoidi Q8CBC4.
    KOi K17581.
    OMAi KHWIYLS.
    OrthoDBi EOG708VZD.
    PhylomeDBi Q8CBC4.
    TreeFami TF351172.

    Miscellaneous databases

    ChiTaRSi CNST. mouse.
    NextBioi 378309.
    PROi Q8CBC4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CBC4.
    CleanExi MM_9630058J23RIK.
    Genevestigatori Q8CBC4.

    Family and domain databases

    InterProi IPR028129. Consortin_C.
    [Graphical view ]
    Pfami PF15281. Consortin_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Amnion, Aorta, Cerebellum and Vein.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: C57BL/6.
      Tissue: Brain and Eye.
    3. "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."
      del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D., Chavrier P., Meda P., Petit C.
      Hum. Mol. Genet. 19:262-275(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF ISOFORM 3, INTERACTION WITH GGA1; GGA2; GJA1; GJB1; GJB2; GJB3; GJB6 AND GJC1, MUTAGENESIS OF 558-562.

    Entry informationi

    Entry nameiCNST_MOUSE
    AccessioniPrimary (citable) accession number: Q8CBC4
    Secondary accession number(s): Q8BFS5, Q8K053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3