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Protein

Ras association domain-containing protein 4

Gene

Rassf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 4
Gene namesi
Name:Rassf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2386853 Rassf4

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002403991 – 322Ras association domain-containing protein 4Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CB96
PeptideAtlasiQ8CB96
PRIDEiQ8CB96

PTM databases

iPTMnetiQ8CB96
PhosphoSitePlusiQ8CB96

Expressioni

Gene expression databases

BgeeiENSMUSG00000042129
ExpressionAtlasiQ8CB96 baseline and differential
GenevisibleiQ8CB96 MM

Interactioni

Subunit structurei

Interacts directly with activated KRAS in a GTP-dependent manner.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048267

Structurei

3D structure databases

ProteinModelPortaliQ8CB96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 264Ras-associatingPROSITE-ProRule annotationAdd BLAST90
Domaini271 – 318SARAHPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiKOG4239 Eukaryota
ENOG410Y2N1 LUCA
GeneTreeiENSGT00510000046426
HOGENOMiHOG000231738
HOVERGENiHBG054302
InParanoidiQ8CB96
KOiK09851
OMAiMFLMEAD
OrthoDBiEOG091G0BOA
PhylomeDBiQ8CB96
TreeFamiTF319243

Family and domain databases

InterProiView protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033622 RASSF4
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF4 PTHR22738:SF4, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CB96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEACSSSSH VPVSDSKYIL KSELLSLLKT YNCYHEGRSF QLRHREEEGT
60 70 80 90 100
LIIEGLLNIA WGLRRPIRLQ MQDDRERVHL PSATWVPERL SYLQKEASPQ
110 120 130 140 150
DSKVPTEEPG TQPANKAEVS GDSSGALEGE EEEVPQLMRT KSDASCIIQR
160 170 180 190 200
RSKSRAPSEA QKIRRHRFSI NGHFYNHKTS VFTPAYGSVT NVRVNSTMTT
210 220 230 240 250
QQVLTLLLNK FRVEDGPSEF ALYTVHESGE QTKLKDCEYP LISRILHGPC
260 270 280 290 300
EKIVKIFLME ADLSEEVPHD VAQYIKFEMP VLDSFVEKLK EEEEREIIKL
310 320
TMKFQALRLT MLQRLEQLVE AK
Length:322
Mass (Da):36,934
Last modified:March 1, 2003 - v1
Checksum:iC8CEE2610DDEFCC5
GO
Isoform 2 (identifier: Q8CB96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-322: Missing.

Show »
Length:303
Mass (Da):34,664
Checksum:i6E868DD20F300C2A
GO
Isoform 3 (identifier: Q8CB96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-276: TSVFTPAYGS...VPHDVAQYIK → VKSPSALSWA...IQHSSHSSIR
     277-322: Missing.

Show »
Length:216
Mass (Da):24,598
Checksum:iE75461E9D35D985E
GO

Sequence cautioni

The sequence BAE42308 differs from that shown. Reason: Frameshift at position 285.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153K → E in BAE42308 (PubMed:16141072).Curated1
Sequence conflicti291E → G in BAE37757 (PubMed:16141072).Curated1
Sequence conflicti295R → I in AAH60709 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019360179 – 276TSVFT…AQYIK → VKSPSALSWALKLRVQELFP STEERAPNIQHSSHSSIR in isoform 3. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_019361277 – 322Missing in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_019362304 – 322Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036528 mRNA Translation: BAC29463.1
AK160584 mRNA Translation: BAE35891.1
AK164357 mRNA Translation: BAE37757.1
AK170955 mRNA Translation: BAE42138.1
AK171198 mRNA Translation: BAE42308.1 Frameshift.
AK139284 mRNA Translation: BAE23943.1
BC023245 mRNA Translation: AAH23245.1
BC060709 mRNA Translation: AAH60709.1
CCDSiCCDS20460.1 [Q8CB96-1]
RefSeqiNP_835146.3, NM_178045.4 [Q8CB96-1]
UniGeneiMm.257931

Genome annotation databases

EnsembliENSMUST00000035842; ENSMUSP00000048267; ENSMUSG00000042129 [Q8CB96-1]
ENSMUST00000203029; ENSMUSP00000144786; ENSMUSG00000042129 [Q8CB96-2]
GeneIDi213391
KEGGimmu:213391
UCSCiuc009dkm.2 mouse [Q8CB96-1]
uc009dko.3 mouse [Q8CB96-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRASF4_MOUSE
AccessioniPrimary (citable) accession number: Q8CB96
Secondary accession number(s): Q3TBK1
, Q3TPH9, Q3TUT0, Q6P9L7, Q8CIM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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