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Protein

Transcription elongation factor B polypeptide 3

Gene

Tceb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-112387. Elongation arrest and recovery.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-MMU-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor B polypeptide 3
Alternative name(s):
Elongin 110 kDa subunit
Elongin-A
Short name:
EloA
RNA polymerase II transcription factor SIII subunit A1
SIII p110
Gene namesi
Name:Tceb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1351315. Tceb3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869611 – 773Transcription elongation factor B polypeptide 3Add BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei195PhosphoserineBy similarity1
Modified residuei309PhosphoserineCombined sources1
Modified residuei379PhosphoserineBy similarity1
Modified residuei390PhosphothreonineCombined sources1
Modified residuei430N6-acetyllysineCombined sources1
Modified residuei515PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CB77.
MaxQBiQ8CB77.
PaxDbiQ8CB77.
PeptideAtlasiQ8CB77.
PRIDEiQ8CB77.

PTM databases

iPTMnetiQ8CB77.
PhosphoSitePlusiQ8CB77.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028668.
GenevisibleiQ8CB77. MM.

Interactioni

Subunit structurei

Heterotrimer of an A (A1, A2 or A3), B and C subunit.By similarity

Protein-protein interaction databases

BioGridi205145. 3 interactors.
IntActiQ8CB77. 3 interactors.
MINTiMINT-4094290.
STRINGi10090.ENSMUSP00000030427.

Structurei

3D structure databases

ProteinModelPortaliQ8CB77.
SMRiQ8CB77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 79TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST76
Domaini565 – 609F-boxPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni521 – 680Activation domainBy similarityAdd BLAST160
Regioni549 – 558Interacting with Elongin BC complexBy similarity10

Domaini

The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ8CB77.
KOiK15076.
OMAiPHKVSHS.
OrthoDBiEOG091G0D2G.
TreeFamiTF317259.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS51319. TFIIS_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CB77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAESALQVV EKLQARLAAN PDPKKLLKYL KKLSILPITV DILVETGVGK
60 70 80 90 100
TVNSFRKHEQ VGNFARDLVA QWKKLVPVER NSEAEDQDFE KNNSRKRPRD
110 120 130 140 150
ALQREEELEG NYQESWKPSG SRSYSPEHRQ KKHKKLSEPE RPHKVAHSHE
160 170 180 190 200
KRDERKRCHK VSPPYSSDPE SSDYGHVQSP PPSSPHQMYT DLSRSPEEDQ
210 220 230 240 250
EPIISHQKPG KVHSNTFQDR LGVSHLGEQG KGAVSHHKQH RSSHKEKHPA
260 270 280 290 300
DAREDEKISA VSREKSHKAS SKEESRRLLS GDSAKEKLPS SVVKKDKDRE
310 320 330 340 350
GSSLKKKFSP ALDVASDNHF KKPKHKDSEK AKSDKNKQSV DGVDSGRGTG
360 370 380 390 400
DPLPKAKEKV PNHLKAQEGK VRTNADGKSA GPLHPKAEET DVDDEFERPT
410 420 430 440 450
MSFESYLSYD QPRKKKKKVV KTSSTALGEK GLKKKDSKST SKNLNSAQKL
460 470 480 490 500
PKVNENKSEK LQPAGAEPTR PRKVPTDVLP ALPDIPLPAI HANYRPLPSL
510 520 530 540 550
ELIPSFQPKR KAFSSPQEEE EAGFTGRRMN SKMQVYSGSK CAYLPKMMTL
560 570 580 590 600
HQQCIRVLKN NIDSIFEVGG VPYSVLEPVL ERCTPDQLYR IEECNHVLIE
610 620 630 640 650
ETDQLWKVHC HRDFKEERPE EYESWREMYL RLQDAREQRL RLLTNNIRSA
660 670 680 690 700
HANKPKGRQA KMAFVNSVAK PPRDVRRRQE KFGTGGAAVP EKVRIKPAPY
710 720 730 740 750
TTGSSHVPAS NSSSNFHSSP EELAYDGPST SSAHLAPVAS SSVSYDPRKP
760 770
AVKKIAPMMA KTIKAFKNRF SRR
Length:773
Mass (Da):87,161
Last modified:July 27, 2011 - v3
Checksum:i7F5B33C4B6E87561
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35I → V in BAA84994 (PubMed:10575222).Curated1
Sequence conflicti142P → R in BAA84994 (PubMed:10575222).Curated1
Sequence conflicti159H → Q in BAA84994 (PubMed:10575222).Curated1
Sequence conflicti236H → Q in BAA84994 (PubMed:10575222).Curated1
Sequence conflicti382P → L in BAA84994 (PubMed:10575222).Curated1
Sequence conflicti382P → L in AAH49885 (PubMed:15489334).Curated1
Sequence conflicti609H → P in BAA84994 (PubMed:10575222).Curated1
Sequence conflicti625 – 626WR → LE in BAA84994 (PubMed:10575222).Curated2
Sequence conflicti633 – 635QDA → SER in BAA84994 (PubMed:10575222).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025015 mRNA. Translation: BAA84994.1.
AK036592 mRNA. Translation: BAC29497.1.
AK145994 mRNA. Translation: BAE26815.1.
AK147088 mRNA. Translation: BAE27668.1.
AL672076 Genomic DNA. Translation: CAM15908.1.
CH466552 Genomic DNA. Translation: EDL29954.1.
BC049885 mRNA. Translation: AAH49885.1.
CCDSiCCDS18798.1.
RefSeqiNP_038764.2. NM_013736.4.
UniGeneiMm.27663.

Genome annotation databases

EnsembliENSMUST00000030427; ENSMUSP00000030427; ENSMUSG00000028668.
GeneIDi27224.
KEGGimmu:27224.
UCSCiuc008vhp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025015 mRNA. Translation: BAA84994.1.
AK036592 mRNA. Translation: BAC29497.1.
AK145994 mRNA. Translation: BAE26815.1.
AK147088 mRNA. Translation: BAE27668.1.
AL672076 Genomic DNA. Translation: CAM15908.1.
CH466552 Genomic DNA. Translation: EDL29954.1.
BC049885 mRNA. Translation: AAH49885.1.
CCDSiCCDS18798.1.
RefSeqiNP_038764.2. NM_013736.4.
UniGeneiMm.27663.

3D structure databases

ProteinModelPortaliQ8CB77.
SMRiQ8CB77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205145. 3 interactors.
IntActiQ8CB77. 3 interactors.
MINTiMINT-4094290.
STRINGi10090.ENSMUSP00000030427.

PTM databases

iPTMnetiQ8CB77.
PhosphoSitePlusiQ8CB77.

Proteomic databases

EPDiQ8CB77.
MaxQBiQ8CB77.
PaxDbiQ8CB77.
PeptideAtlasiQ8CB77.
PRIDEiQ8CB77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030427; ENSMUSP00000030427; ENSMUSG00000028668.
GeneIDi27224.
KEGGimmu:27224.
UCSCiuc008vhp.1. mouse.

Organism-specific databases

CTDi6924.
MGIiMGI:1351315. Tceb3.

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ8CB77.
KOiK15076.
OMAiPHKVSHS.
OrthoDBiEOG091G0D2G.
TreeFamiTF317259.

Enzyme and pathway databases

ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-112387. Elongation arrest and recovery.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-MMU-75955. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

PROiQ8CB77.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028668.
GenevisibleiQ8CB77. MM.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS51319. TFIIS_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOA1_MOUSE
AccessioniPrimary (citable) accession number: Q8CB77
Secondary accession number(s): Q3UI38, Q80VB2, Q9R0Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.