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Protein

Acetyl-CoA acetyltransferase, cytosolic

Gene

Acat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Acyl-thioester intermediateBy similarity1
Active sitei353Proton acceptorPROSITE-ProRule annotation1
Active sitei383Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-191273 Cholesterol biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase, cytosolic (EC:2.3.1.9)
Alternative name(s):
Cytosolic acetoacetyl-CoA thiolase
Gene namesi
Name:Acat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:87871 Acat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002064101 – 397Acetyl-CoA acetyltransferase, cytosolicAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei200N6-acetyllysineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei235N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8CAY6
MaxQBiQ8CAY6
PaxDbiQ8CAY6
PeptideAtlasiQ8CAY6
PRIDEiQ8CAY6

2D gel databases

REPRODUCTION-2DPAGEiQ8CAY6

PTM databases

iPTMnetiQ8CAY6
PhosphoSitePlusiQ8CAY6
SwissPalmiQ8CAY6

Expressioni

Gene expression databases

BgeeiENSMUSG00000023832
CleanExiMM_ACAT2
ExpressionAtlasiQ8CAY6 baseline and differential
GenevisibleiQ8CAY6 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi225610, 1 interactor
IntActiQ8CAY6, 2 interactors
MINTiQ8CAY6
STRINGi10090.ENSMUSP00000007005

Structurei

3D structure databases

ProteinModelPortaliQ8CAY6
SMRiQ8CAY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiKOG1391 Eukaryota
COG0183 LUCA
GeneTreeiENSGT00390000009412
HOGENOMiHOG000012238
HOVERGENiHBG003112
InParanoidiQ8CAY6
KOiK00626
OMAiICPSIAI
OrthoDBiEOG091G09C6
PhylomeDBiQ8CAY6
TreeFamiTF300650

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CAY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAGSDPVVI VSAARTAIGS FNGALSTVPV HEMGTTVIKE VLQRAKVAPE
60 70 80 90 100
EVSEVIFGHV LTAGCGQNPT RQASVGAGIP YSVPAWSCQM ICGSGLKAVC
110 120 130 140 150
LAAQSIAMGD STIVVAGGME NMSKAPHLTH LRTGVRMGEV PLADSILCDG
160 170 180 190 200
LTDAFHNYHM GITAENVAKK WQVSREAQDK VAVLSQNRAE HAQKAGHFDK
210 220 230 240 250
EIVPVLVSSR KGLTEVKIDE FPRHGSNLEA MGKLKPYFLT DGTGTVTPAN
260 270 280 290 300
ASGMNDGAAA VVLMKKTEAE RRMLKPLARI VSWSQAGVEP SVMGVGPIPA
310 320 330 340 350
IKQAVAKAGW SLEDVDLFEI NEAFAAVSAA IAKELGLNPE KVNIDGGAIA
360 370 380 390
LGHPLGASGC RILVTLLHTL ERVGGTRGVA ALCIGGGMGV AMCVQRG
Length:397
Mass (Da):41,298
Last modified:September 13, 2004 - v2
Checksum:iAABC2DF22F4EE930
GO

Sequence cautioni

The sequence BAB28763 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106I → L in AAH12496 (PubMed:15489334).Curated1
Sequence conflicti115 – 119VAGGM → CLTGK (PubMed:2055458).Curated5
Sequence conflicti125A → P in AAA76575 (PubMed:2055458).Curated1
Sequence conflicti191H → T in AAA76575 (PubMed:2055458).Curated1
Sequence conflicti230A → D in BAB28763 (PubMed:16141072).Curated1
Sequence conflicti233K → T in AAA76575 (PubMed:2055458).Curated1
Sequence conflicti262V → L in BAB28763 (PubMed:16141072).Curated1
Sequence conflicti266K → E in BAC29776 (PubMed:16141072).Curated1
Sequence conflicti340E → G in AAA76575 (PubMed:2055458).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013275 mRNA Translation: BAB28763.1 Different initiation.
AK037249 mRNA Translation: BAC29776.1
AK166813 mRNA Translation: BAE39040.1
AK167234 mRNA Translation: BAE39358.1
BC004823 mRNA Translation: AAH04823.2
BC012496 mRNA Translation: AAH12496.2
M35797 mRNA Translation: AAA76575.1
CCDSiCCDS37437.1
PIRiA53174
RefSeqiNP_033364.2, NM_009338.3
UniGeneiMm.439711

Genome annotation databases

EnsembliENSMUST00000007005; ENSMUSP00000007005; ENSMUSG00000023832
GeneIDi110460
KEGGimmu:110460
UCSCiuc008alp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTHIC_MOUSE
AccessioniPrimary (citable) accession number: Q8CAY6
Secondary accession number(s): Q3TJY7
, Q62292, Q96EB7, Q99K88, Q9CYV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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