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Q8CAY6

- THIC_MOUSE

UniProt

Q8CAY6 - THIC_MOUSE

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Protein
Acetyl-CoA acetyltransferase, cytosolic
Gene
Acat2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Acyl-thioester intermediate By similarity
Active sitei353 – 3531Proton acceptor By similarity
Active sitei383 – 3831Proton acceptor By similarity

GO - Molecular functioni

  1. acetyl-CoA C-acetyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase, cytosolic (EC:2.3.1.9)
Alternative name(s):
Cytosolic acetoacetyl-CoA thiolase
Gene namesi
Name:Acat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:87871. Acat2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Acetyl-CoA acetyltransferase, cytosolic
PRO_0000206410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei200 – 2001N6-acetyllysine By similarity
Modified residuei233 – 2331N6-acetyllysine By similarity
Modified residuei235 – 2351N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8CAY6.
PaxDbiQ8CAY6.
PRIDEiQ8CAY6.

2D gel databases

REPRODUCTION-2DPAGEQ8CAY6.

PTM databases

PhosphoSiteiQ8CAY6.

Expressioni

Gene expression databases

ArrayExpressiQ8CAY6.
BgeeiQ8CAY6.
CleanExiMM_ACAT2.
GenevestigatoriQ8CAY6.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

IntActiQ8CAY6. 2 interactions.
MINTiMINT-1864806.

Structurei

3D structure databases

ProteinModelPortaliQ8CAY6.
SMRiQ8CAY6. Positions 4-396.

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.

Phylogenomic databases

eggNOGiCOG0183.
GeneTreeiENSGT00390000009412.
HOGENOMiHOG000012238.
HOVERGENiHBG003112.
InParanoidiQ8CAY6.
KOiK00626.
OMAiKRCLSRA.
OrthoDBiEOG7JQBNG.
PhylomeDBiQ8CAY6.
TreeFamiTF300650.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CAY6-1 [UniParc]FASTAAdd to Basket

« Hide

MNAGSDPVVI VSAARTAIGS FNGALSTVPV HEMGTTVIKE VLQRAKVAPE    50
EVSEVIFGHV LTAGCGQNPT RQASVGAGIP YSVPAWSCQM ICGSGLKAVC 100
LAAQSIAMGD STIVVAGGME NMSKAPHLTH LRTGVRMGEV PLADSILCDG 150
LTDAFHNYHM GITAENVAKK WQVSREAQDK VAVLSQNRAE HAQKAGHFDK 200
EIVPVLVSSR KGLTEVKIDE FPRHGSNLEA MGKLKPYFLT DGTGTVTPAN 250
ASGMNDGAAA VVLMKKTEAE RRMLKPLARI VSWSQAGVEP SVMGVGPIPA 300
IKQAVAKAGW SLEDVDLFEI NEAFAAVSAA IAKELGLNPE KVNIDGGAIA 350
LGHPLGASGC RILVTLLHTL ERVGGTRGVA ALCIGGGMGV AMCVQRG 397
Length:397
Mass (Da):41,298
Last modified:September 13, 2004 - v2
Checksum:iAABC2DF22F4EE930
GO

Sequence cautioni

The sequence BAB28763.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061I → L in AAH12496. 1 Publication
Sequence conflicti115 – 1195VAGGM → CLTGK1 Publication
Sequence conflicti125 – 1251A → P in AAA76575. 1 Publication
Sequence conflicti191 – 1911H → T in AAA76575. 1 Publication
Sequence conflicti230 – 2301A → D in BAB28763. 1 Publication
Sequence conflicti233 – 2331K → T in AAA76575. 1 Publication
Sequence conflicti262 – 2621V → L in BAB28763. 1 Publication
Sequence conflicti266 – 2661K → E in BAC29776. 1 Publication
Sequence conflicti340 – 3401E → G in AAA76575. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013275 mRNA. Translation: BAB28763.1. Different initiation.
AK037249 mRNA. Translation: BAC29776.1.
AK166813 mRNA. Translation: BAE39040.1.
AK167234 mRNA. Translation: BAE39358.1.
BC004823 mRNA. Translation: AAH04823.2.
BC012496 mRNA. Translation: AAH12496.2.
M35797 mRNA. Translation: AAA76575.1.
CCDSiCCDS37437.1.
PIRiA53174.
RefSeqiNP_033364.2. NM_009338.3.
UniGeneiMm.439711.

Genome annotation databases

EnsembliENSMUST00000007005; ENSMUSP00000007005; ENSMUSG00000023832.
GeneIDi110460.
KEGGimmu:110460.
UCSCiuc008alp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013275 mRNA. Translation: BAB28763.1 . Different initiation.
AK037249 mRNA. Translation: BAC29776.1 .
AK166813 mRNA. Translation: BAE39040.1 .
AK167234 mRNA. Translation: BAE39358.1 .
BC004823 mRNA. Translation: AAH04823.2 .
BC012496 mRNA. Translation: AAH12496.2 .
M35797 mRNA. Translation: AAA76575.1 .
CCDSi CCDS37437.1.
PIRi A53174.
RefSeqi NP_033364.2. NM_009338.3.
UniGenei Mm.439711.

3D structure databases

ProteinModelPortali Q8CAY6.
SMRi Q8CAY6. Positions 4-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CAY6. 2 interactions.
MINTi MINT-1864806.

PTM databases

PhosphoSitei Q8CAY6.

2D gel databases

REPRODUCTION-2DPAGE Q8CAY6.

Proteomic databases

MaxQBi Q8CAY6.
PaxDbi Q8CAY6.
PRIDEi Q8CAY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007005 ; ENSMUSP00000007005 ; ENSMUSG00000023832 .
GeneIDi 110460.
KEGGi mmu:110460.
UCSCi uc008alp.1. mouse.

Organism-specific databases

CTDi 39.
MGIi MGI:87871. Acat2.

Phylogenomic databases

eggNOGi COG0183.
GeneTreei ENSGT00390000009412.
HOGENOMi HOG000012238.
HOVERGENi HBG003112.
InParanoidi Q8CAY6.
KOi K00626.
OMAi KRCLSRA.
OrthoDBi EOG7JQBNG.
PhylomeDBi Q8CAY6.
TreeFami TF300650.

Miscellaneous databases

NextBioi 364019.
PROi Q8CAY6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8CAY6.
Bgeei Q8CAY6.
CleanExi MM_ACAT2.
Genevestigatori Q8CAY6.

Family and domain databases

Gene3Di 3.40.47.10. 4 hits.
InterProi IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view ]
Pfami PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEi PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Blastocyst, Embryo and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Mammary gland and Retina.
  3. "Isolation and characterization of a cDNA clone corresponding to the mouse T-complex gene Tcp-1x."
    Dudley K., Shanahan F., Burtenshaw M., Evans E.P., Ruddy S., Lyon M.F.
    Genet. Res. 57:147-152(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 115-397.
    Strain: C57BL/6J.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 342-372, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiTHIC_MOUSE
AccessioniPrimary (citable) accession number: Q8CAY6
Secondary accession number(s): Q3TJY7
, Q62292, Q96EB7, Q99K88, Q9CYV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi