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Protein

Non-specific protein-tyrosine kinase

Gene

Itk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: MGI

GO - Biological processi

  1. innate immune response Source: GO_Central
  2. interferon-gamma production Source: MGI
  3. interleukin-4 production Source: MGI
  4. NK T cell differentiation Source: MGI
  5. peptidyl-tyrosine autophosphorylation Source: GO_Central
  6. regulation of cell proliferation Source: GO_Central
  7. transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific protein-tyrosine kinaseSAAS annotation (EC:2.7.10.2SAAS annotation)
Gene namesi
Name:ItkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96621. Itk.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8CAW3.
ExpressionAtlasiQ8CAW3. baseline and differential.
GenevestigatoriQ8CAW3.

Structurei

3D structure databases

ProteinModelPortaliQ8CAW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8CAW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YTVSVFTKAI ISENPCIKHY HIKETNDSPK RYYVAEKYVF DSIPLLIQYH
60 70 80 90 100
QYNGGGLVTR LRYPVCSWRQ KAPVTAGLRY GKWVIQPSEL TFVQEIGSGQ
110 120 130 140 150
FGLVHLGYWL NKDKVAIKTI QEGAMSEEDF IEEAEVMMKL SHPKLVQLYG
160 170 180 190 200
VCLEQAPICL VFEFMEHGCL SDYLRSQRGL FAAETLLGMC LDVCEGMAYL
210 220 230 240 250
EKACVIHRDL AARNCLVGEN QVIKVSDFGM TRFVLDDQYT SSTGTKFPVK
260 270 280 290 300
WASPEVFSFS RYSSKSDVWS FGVLMWEVFS EGKIPYENRS NSEVVEDIST
310 320 330 340
GFRLYKPRLA SCHVYQIMNH CWKEKPEDRP PFSQLLSQLA EIAEAGL
Length:347
Mass (Da):39,640
Last modified:February 28, 2003 - v1
Checksum:i2517B761AAB322AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037554 mRNA. Translation: BAC29830.1.
UniGeneiMm.339927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037554 mRNA. Translation: BAC29830.1.
UniGeneiMm.339927.

3D structure databases

ProteinModelPortaliQ8CAW3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96621. Itk.

Phylogenomic databases

HOVERGENiHBG008761.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ8CAW3.
ExpressionAtlasiQ8CAW3. baseline and differential.
GenevestigatoriQ8CAW3.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ8CAW3_MOUSE
AccessioniPrimary (citable) accession number: Q8CAW3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 28, 2003
Last sequence update: February 28, 2003
Last modified: March 3, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.