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Protein

Non-specific protein-tyrosine kinase

Gene

Itk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific protein-tyrosine kinaseSAAS annotation (EC:2.7.10.2SAAS annotation)
Gene namesi
Name:ItkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96621. Itk.

PTM / Processingi

Proteomic databases

PaxDbiQ8CAW3.

Structurei

3D structure databases

ProteinModelPortaliQ8CAW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 65SH2InterPro annotationAdd BLAST65
Domaini90 – 342Protein kinaseInterPro annotationAdd BLAST253

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00219. TyrKc. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8CAW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YTVSVFTKAI ISENPCIKHY HIKETNDSPK RYYVAEKYVF DSIPLLIQYH
60 70 80 90 100
QYNGGGLVTR LRYPVCSWRQ KAPVTAGLRY GKWVIQPSEL TFVQEIGSGQ
110 120 130 140 150
FGLVHLGYWL NKDKVAIKTI QEGAMSEEDF IEEAEVMMKL SHPKLVQLYG
160 170 180 190 200
VCLEQAPICL VFEFMEHGCL SDYLRSQRGL FAAETLLGMC LDVCEGMAYL
210 220 230 240 250
EKACVIHRDL AARNCLVGEN QVIKVSDFGM TRFVLDDQYT SSTGTKFPVK
260 270 280 290 300
WASPEVFSFS RYSSKSDVWS FGVLMWEVFS EGKIPYENRS NSEVVEDIST
310 320 330 340
GFRLYKPRLA SCHVYQIMNH CWKEKPEDRP PFSQLLSQLA EIAEAGL
Length:347
Mass (Da):39,640
Last modified:March 1, 2003 - v1
Checksum:i2517B761AAB322AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037554 mRNA. Translation: BAC29830.1.
UniGeneiMm.339927.

Similar proteinsi

Entry informationi

Entry nameiQ8CAW3_MOUSE
AccessioniPrimary (citable) accession number: Q8CAW3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)