Q8CAS9 (PARP9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly [ADP-ribose] polymerase 9
Short name=PARP-9
EC=2.4.2.30

Alternative name(s):
B aggressive lymphoma protein homolog

Gene names

Name:	Parp9
Synonyms:	Bal

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	866 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in inducing the expression of IFN-gamma-responsive genes By similarity.
Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Subunit structure	Interacts with DTX3L By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Nucleus By similarity. Note: Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L By similarity.
Tissue specificity	Highly expressed in the thymus and intestine. Ref.3
Developmental stage	Developmentally regulated. Expressed prominently in the developing thymus and the gut, and also weakly expressed in specific regions of the developing brain. Ref.3
Sequence similarities	Contains 2 Macro domains. Contains 1 PARP catalytic domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	NAD
Molecular function	Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8CAS9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q8CAS9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     17-52: Missing.

Isoform 3 (identifier: Q8CAS9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     679-866: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 866	866	Poly [ADP-ribose] polymerase 9		PRO_0000211340
Regions
	Domain	109 – 298	190	Macro 1
	Domain	313 – 492	180	Macro 2
	Domain	635 – 853	219	PARP catalytic
Amino acid modifications
	Modified residue	42	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	17 – 52	36	Missing in isoform 2.		VSP_008506
	Alternative sequence	679 – 866	188	Missing in isoform 3.		VSP_008507

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 10, 2003. Version 2. Checksum: 790AF1968F6C035D	FASTA	866	96,659
	10 20 30 40 50 60 MAYYMDTWAA APAERPGMIA SLSLSFKKAF AELFPQRRRG HSEGDYPPLR GSANNSLEEH 70 80 90 100 110 120 YRWQIPIKHN VFEILKSNES QLCEVLQNKF GCISTLSCPT LAGSSSPAQR VFRRTLIPGI 130 140 150 160 170 180 ELSVWKDDLT RHVVDAVVNA ANENLLHGSG LAGSLVKTGG FEIQEESKRI IANVGKISVG 190 200 210 220 230 240 GIAITGAGRL PCHLIIHAVG PRWTVTNSQT AIELLKFAIR NILDYVTKYD LRIKTVAIPA 250 260 270 280 290 300 LSSGIFQFPL DLCTSIILET IRLYFQDKQM FGNLREIHLV SNEDPTVASF KSASESILGR 310 320 330 340 350 360 DLSSWGGPET DPASTMTLRI GRGLTLQIVQ GCIEMQTTDV IVNSGYMQDF KSGRVAQSIL 370 380 390 400 410 420 RQAGVEMEKE LDKVNLSTDY QEVWVTKGFK LSCQYVFHVA WHSQINKYQI LKDAMKSCLE 430 440 450 460 470 480 KCLKPDINSI SFPALGTGLM DLKKSTAAQI MFEEVFAFAK EHKEKTLTVK IVIFPVDVET 490 500 510 520 530 540 YKIFYAEMTK RSNELNLSGN SGALALQWSS GEQRRGGLEA GSPAINLMGV KVGEMCEAQE 550 560 570 580 590 600 WIERLLVSLD HHIIENNHIL YLGKKEHDVL SELQTSTRVS ISETVSPRTA TLEIKGPQAD 610 620 630 640 650 660 LIDAVMRIEC MLCDVQEEVA GKREKNLWSL SGQGTNQQEK LDKMEESYTF QRYPASLTQE 670 680 690 700 710 720 LQDRKKQFEK CGLWVVQVEQ IDNKVLLAAF QEKKKMMEER TPKGSGSQRL FQQVPHQFCN 730 740 750 760 770 780 TVCRVGFHRM YSTSYNPVYG AGIYFTKSLK NLADKVKKTS STDKLIYVFE AEVLTGSFCQ 790 800 810 820 830 840 GNSSNIIPPP LSPGALDVND SVVDNVSSPE TIVVFNGMQA MPLYLWTCTQ DRTFSQHPMW 850 860 SQGYSSGPGM VSSLQSWEWV LNGSSV
	Isoform 2 [UniParc]. Checksum: 779197039E99D012	FASTA	830	92,669
	10 20 30 40 50 60 MAYYMDTWAA APAERPANNS LEEHYRWQIP IKHNVFEILK SNESQLCEVL QNKFGCISTL 70 80 90 100 110 120 SCPTLAGSSS PAQRVFRRTL IPGIELSVWK DDLTRHVVDA VVNAANENLL HGSGLAGSLV 130 140 150 160 170 180 KTGGFEIQEE SKRIIANVGK ISVGGIAITG AGRLPCHLII HAVGPRWTVT NSQTAIELLK 190 200 210 220 230 240 FAIRNILDYV TKYDLRIKTV AIPALSSGIF QFPLDLCTSI ILETIRLYFQ DKQMFGNLRE 250 260 270 280 290 300 IHLVSNEDPT VASFKSASES ILGRDLSSWG GPETDPASTM TLRIGRGLTL QIVQGCIEMQ 310 320 330 340 350 360 TTDVIVNSGY MQDFKSGRVA QSILRQAGVE MEKELDKVNL STDYQEVWVT KGFKLSCQYV 370 380 390 400 410 420 FHVAWHSQIN KYQILKDAMK SCLEKCLKPD INSISFPALG TGLMDLKKST AAQIMFEEVF 430 440 450 460 470 480 AFAKEHKEKT LTVKIVIFPV DVETYKIFYA EMTKRSNELN LSGNSGALAL QWSSGEQRRG 490 500 510 520 530 540 GLEAGSPAIN LMGVKVGEMC EAQEWIERLL VSLDHHIIEN NHILYLGKKE HDVLSELQTS 550 560 570 580 590 600 TRVSISETVS PRTATLEIKG PQADLIDAVM RIECMLCDVQ EEVAGKREKN LWSLSGQGTN 610 620 630 640 650 660 QQEKLDKMEE SYTFQRYPAS LTQELQDRKK QFEKCGLWVV QVEQIDNKVL LAAFQEKKKM 670 680 690 700 710 720 MEERTPKGSG SQRLFQQVPH QFCNTVCRVG FHRMYSTSYN PVYGAGIYFT KSLKNLADKV 730 740 750 760 770 780 KKTSSTDKLI YVFEAEVLTG SFCQGNSSNI IPPPLSPGAL DVNDSVVDNV SSPETIVVFN 790 800 810 820 830 GMQAMPLYLW TCTQDRTFSQ HPMWSQGYSS GPGMVSSLQS WEWVLNGSSV
	Isoform 3 [UniParc]. Checksum: 19EBC4E623A9C48B	FASTA	678	75,739
	10 20 30 40 50 60 MAYYMDTWAA APAERPGMIA SLSLSFKKAF AELFPQRRRG HSEGDYPPLR GSANNSLEEH 70 80 90 100 110 120 YRWQIPIKHN VFEILKSNES QLCEVLQNKF GCISTLSCPT LAGSSSPAQR VFRRTLIPGI 130 140 150 160 170 180 ELSVWKDDLT RHVVDAVVNA ANENLLHGSG LAGSLVKTGG FEIQEESKRI IANVGKISVG 190 200 210 220 230 240 GIAITGAGRL PCHLIIHAVG PRWTVTNSQT AIELLKFAIR NILDYVTKYD LRIKTVAIPA 250 260 270 280 290 300 LSSGIFQFPL DLCTSIILET IRLYFQDKQM FGNLREIHLV SNEDPTVASF KSASESILGR 310 320 330 340 350 360 DLSSWGGPET DPASTMTLRI GRGLTLQIVQ GCIEMQTTDV IVNSGYMQDF KSGRVAQSIL 370 380 390 400 410 420 RQAGVEMEKE LDKVNLSTDY QEVWVTKGFK LSCQYVFHVA WHSQINKYQI LKDAMKSCLE 430 440 450 460 470 480 KCLKPDINSI SFPALGTGLM DLKKSTAAQI MFEEVFAFAK EHKEKTLTVK IVIFPVDVET 490 500 510 520 530 540 YKIFYAEMTK RSNELNLSGN SGALALQWSS GEQRRGGLEA GSPAINLMGV KVGEMCEAQE 550 560 570 580 590 600 WIERLLVSLD HHIIENNHIL YLGKKEHDVL SELQTSTRVS ISETVSPRTA TLEIKGPQAD 610 620 630 640 650 660 LIDAVMRIEC MLCDVQEEVA GKREKNLWSL SGQGTNQQEK LDKMEESYTF QRYPASLTQE 670 LQDRKKQFEK CGLWVVQV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: C57BL/6J. Tissue: Liver and Thymus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6. Tissue: Eye and Mammary tumor.
[3]	"The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues." Hakme A., Huber A., Dolle P., Schreiber V. Dev. Dyn. 237:209-215(2008) [PubMed: 18069692] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[4]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK037903 mRNA. Translation: BAC29897.1. AK050032 mRNA. Translation: BAC34040.1. BC003281 mRNA. Translation: AAH03281.1. BC070466 mRNA. Translation: AAH70466.1.
IPI	IPI00116859. IPI00228181. IPI00377563.
RefSeq	NP_084529.1. NM_030253.3.
UniGene	Mm.49074.
3D structure databases
ProteinModelPortal	Q8CAS9.
SMR	Q8CAS9. Positions 111-298, 310-493, 651-830.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CAS9.
PTM databases
PhosphoSite	Q8CAS9.
Proteomic databases
PRIDE	Q8CAS9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000114877; ENSMUSP00000110527; ENSMUSG00000022906. ENSMUST00000114878; ENSMUSP00000110528; ENSMUSG00000022906. ENSMUST00000114880; ENSMUSP00000110530; ENSMUSG00000022906.
GeneID	80285.
KEGG	mmu:80285.
UCSC	uc007zbx.1. mouse. uc007zby.1. mouse.
Organism-specific databases
CTD	83666.
MGI	MGI:1933117. Parp9.
Phylogenomic databases
GeneTree	ENSGT00600000084200.
HOGENOM	HBG282503.
HOVERGEN	HBG045406.
InParanoid	Q8CAS9.
OMA	SSGIFQF.
Gene expression databases
ArrayExpress	Q8CAS9.
Bgee	Q8CAS9.
CleanEx	MM_PARP9.
Genevestigator	Q8CAS9.
GermOnline	ENSMUSG00000022906. Mus musculus.
Family and domain databases
InterPro	IPR002589. A1pp. IPR012317. Poly(ADP-ribose)pol_cat_dom. [Graphical view]
KO	K15260.
Pfam	PF01661. Macro. 2 hits. [Graphical view]
SMART	SM00506. A1pp. 2 hits. [Graphical view]
PROSITE	PS51154. MACRO. 2 hits. PS51059. PARP_CATALYTIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

PARP9_MOUSE

Accession

Primary (citable) accession number: Q8CAS9
Secondary accession number(s): Q6IRT6, Q99LF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 10, 2003
Last modified:	January 25, 2012
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program