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Protein
Submitted name:

Insulin-like growth factor I

Gene

Igf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor IImported
Gene namesi
Name:Igf1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:96432 Igf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_501410733633 – 165Sequence analysisAdd BLAST133

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ8CAR0

Expressioni

Gene expression databases

BgeeiENSMUSG00000020053

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056668

Structurei

3D structure databases

SMRiQ8CAR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 93IlGFInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T Eukaryota
ENOG4111MIV LUCA
GeneTreeiENSGT00530000063856
HOGENOMiHOG000233362
HOVERGENiHBG006137
OrthoDBiEOG091G0H56
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR022341 IGF-I
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 2 hits
PRINTSiPR02002 INSLNLIKEGF
PR02005 INSLNLIKEGF1
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CAR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPAIKIHI MSSSHLFYLA LCLLTFTSST TAGPETLCGA ELVDALQFVC
60 70 80 90 100
GPRGFYFNKP TGYGSSIRRA PQTGIVDECC FRSCDLRRLE MYCAPLKPTK
110 120 130 140 150
AARSIRAQRH TDMPKTQKSP SLSTNKKTKL QRRRKGEPKT HPEGEQEEVT
160
EATRKIRGPR EKRLG
Length:165
Mass (Da):18,473
Last modified:March 1, 2003 - v1
Checksum:i2CE0D3DA981C93F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125082 Genomic DNA No translation available.
AC139754 Genomic DNA No translation available.
AK038119 mRNA Translation: BAC29934.1
RefSeqiNP_001104744.1, NM_001111274.1
NP_001104746.1, NM_001111276.1
UniGeneiMm.268521

Genome annotation databases

EnsembliENSMUST00000062862; ENSMUSP00000056668; ENSMUSG00000020053
GeneIDi16000
UCSCiuc007gqx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ8CAR0_MOUSE
AccessioniPrimary (citable) accession number: Q8CAR0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health