Q8CAR0 (Q8CAR0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Insulin-like growth factor I Ensembl ENSMUSP00000056668

Gene names

Name:

Igf1 Ensembl ENSMUSP00000056668 MGI 96432

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted By similarity RuleBase RU000406.
Sequence similarities	Belongs to the insulin family. RuleBase RU000406

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS022353
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Type I pneumocyte differentiation Inferred from mutant phenotype PubMed 16691571. Source: MGI Type II pneumocyte differentiation Inferred from mutant phenotype PubMed 16691571. Source: MGI blood vessel remodeling Inferred from mutant phenotype PubMed 16691571. Source: MGI bone mineralization involved in bone maturation Inferred from electronic annotation. Source: Compara branching morphogenesis of an epithelial tube Inferred from mutant phenotype PubMed 15059953. Source: MGI cell development Inferred from mutant phenotype PubMed 10465256. Source: MGI chondroitin sulfate proteoglycan biosynthetic process Inferred from direct assay PubMed 17644814. Source: MGI exocrine pancreas development Inferred from mutant phenotype PubMed 12101187. Source: MGI glial cell differentiation Inferred from mutant phenotype PubMed 12574418. Source: MGI inner ear development Inferred from direct assay PubMed 21795542. Source: MGI insulin-like growth factor receptor signaling pathway Inferred from direct assay PubMed 12805218. Source: MGI lung alveolus development Inferred from mutant phenotype PubMed 16691571. Source: MGI lung lobe morphogenesis Inferred from mutant phenotype PubMed 16691571. Source: MGI lung vasculature development Inferred from mutant phenotype PubMed 16691571. Source: MGI mammary gland development Inferred from mutant phenotype PubMed 15059953. Source: MGI multicellular organism growth Inferred from direct assay PubMed 12865332. Source: MGI muscle hypertrophy Inferred from electronic annotation. Source: Compara myoblast differentiation Inferred from electronic annotation. Source: Compara myoblast proliferation Inferred from electronic annotation. Source: Compara myotube cell development Inferred from electronic annotation. Source: Compara negative regulation of ERK1 and ERK2 cascade Inferred from genetic interaction PubMed 16691571. Source: MGI negative regulation of androgen receptor signaling pathway Inferred from mutant phenotype PubMed 18827067. Source: MGI negative regulation of apoptotic process Inferred from direct assay PubMed 12904469. Source: MGI negative regulation of cell proliferation Inferred from mutant phenotype PubMed 16691571. Source: MGI negative regulation of smooth muscle cell apoptotic process Inferred from electronic annotation. Source: Compara phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: Compara positive regulation of DNA binding Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of Ras protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of activated T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of calcineurin-NFAT signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle hypertrophy Inferred from electronic annotation. Source: Compara positive regulation of cerebellar granule cell precursor proliferation Inferred from direct assay PubMed 10027293. Source: MGI positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of glucose import Inferred from electronic annotation. Source: Compara positive regulation of glycogen biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of glycolysis Inferred from electronic annotation. Source: Compara positive regulation of insulin-like growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara positive regulation of myoblast proliferation Inferred from mutant phenotype PubMed 21406500. Source: MGI positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara positive regulation of protein import into nucleus, translocation Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from direct assay PubMed 19208758. Source: MGI positive regulation of smooth muscle cell migration Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 15322112PubMed 17644814. Source: MGI positive regulation of tyrosine phosphorylation of Stat5 protein Inferred from electronic annotation. Source: Compara prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Inferred from mutant phenotype PubMed 10218945. Source: MGI prostate gland growth Inferred from direct assay PubMed 17138659. Source: MGI prostate gland stromal morphogenesis Inferred from mutant phenotype PubMed 17138659. Source: MGI regulation of establishment or maintenance of cell polarity Inferred from direct assay PubMed 7848824. Source: MGI regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara regulation of protein phosphorylation Inferred from direct assay PubMed 19744960. Source: MGI satellite cell maintenance involved in skeletal muscle regeneration Inferred from electronic annotation. Source: Compara water homeostasis Inferred from genetic interaction PubMed 7510770. Source: MGI
Cellular_component	extracellular space Inferred from direct assay PubMed 17693256PubMed 7510770PubMed 9630227. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8CAR0 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2CE0D3DA981C93F8	FASTA	165	18,473
	10 20 30 40 50 60 MTAPAIKIHI MSSSHLFYLA LCLLTFTSST TAGPETLCGA ELVDALQFVC GPRGFYFNKP 70 80 90 100 110 120 TGYGSSIRRA PQTGIVDECC FRSCDLRRLE MYCAPLKPTK AARSIRAQRH TDMPKTQKSP 130 140 150 160 SLSTNKKTKL QRRRKGEPKT HPEGEQEEVT EATRKIRGPR EKRLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC29934.1. Tissue: Thymus EMBL BAC29934.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC29934.1. Tissue: Thymus EMBL BAC29934.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC29934.1. Tissue: Thymus EMBL BAC29934.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC29934.1. Tissue: Thymus EMBL BAC29934.1.
[5]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC29934.1. Tissue: Thymus EMBL BAC29934.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC29934.1. Tissue: Thymus EMBL BAC29934.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC29934.1. Tissue: Thymus EMBL BAC29934.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC29934.1. Tissue: Thymus EMBL BAC29934.1.
[9]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000056668.
[10]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000056668.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC125082 Genomic DNA. No translation available. AC139754 Genomic DNA. No translation available. AK038119 mRNA. Translation: BAC29934.1.
IPI	IPI00228152.
RefSeq	NP_001104744.1. NM_001111274.1. NP_001104746.1. NM_001111276.1. NP_908941.1. NM_184052.3.
UniGene	Mm.268521.
3D structure databases
HSSP	HSSP built from PDB template 1GZZ based on UniProtKB P01343.
SMR	Q8CAR0. Positions 34-95.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000062862; ENSMUSP00000056668; ENSMUSG00000020053.
GeneID	16000.
KEGG	mmu:16000.
UCSC	uc007gqx.2. mouse.
Organism-specific databases
CTD	3479.
MGI	MGI:96432. Igf1.
Phylogenomic databases
GeneTree	ENSGT00530000063856.
HOGENOM	HOG000233362.
HOVERGEN	HBG006137.
InParanoid	Q8CAR0.
KO	K05459.
Gene expression databases
Genevestigator	Q8CAR0.
Family and domain databases
Gene3D	1.10.100.10. 1 hit.
InterPro	IPR022341. IGF-I. IPR016179. Insulin-like. IPR022350. Insulin-like_growth_factor. IPR022353. Insulin_CS. IPR022352. Insulin_family. [Graphical view]
Pfam	PF00049. Insulin. 2 hits. [Graphical view]
PRINTS	PR02002. INSLNLIKEGF. PR02005. INSLNLIKEGF1. PR00276. INSULINFAMLY.
SMART	SM00078. IlGF. 1 hit. [Graphical view]
SUPFAM	SSF56994. Insulin-like. 1 hit.
PROSITE	PS00262. INSULIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IGF1. mouse.
NextBio	288784.
SOURCE	Search...

Entry information

Entry name

Q8CAR0_MOUSE

Accession

Primary (citable) accession number: Q8CAR0

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)