Q8CAM5 (RAB36_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-36

Gene names

Name:

Rab36

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein transport. Probably involved in vesicular traffic By similarity.
Subcellular location	Golgi apparatus membrane; Lipid-anchor.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Ras-related protein Rab-36		PRO_0000315237
Regions
	Nucleotide binding	64 – 71	8	GTP By similarity
	Nucleotide binding	112 – 116	5	GTP By similarity
	Nucleotide binding	171 – 174	4	GTP By similarity
	Motif	86 – 94	9	Effector region By similarity
Amino acid modifications
	Lipidation	266	1	S-geranylgeranyl cysteine Potential
	Lipidation	267	1	S-geranylgeranyl cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8CAM5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: E1D4B36A4BA598F0	FASTA	267	29,776
	10 20 30 40 50 60 MRSSWTPLGP PVSQDRIITS FPKWYTPDAC LQLKEHFHSR VSTACQHRNT GTAGLRLSKV 70 80 90 100 110 120 VVVGDLYVGK TSLIHRLCKN VFDHDYKATI GVDFEIERFE IAGIPYSLQI WDTAGQEKFK 130 140 150 160 170 180 CIASAYYRGA QVIITAFDLT DVQTLEHTRQ WLEDVLRENE AGSCFIFLVG TKKDLLSGAA 190 200 210 220 230 240 CEQAEAEAVH LANEMQAEYW SVSAKTGENV KAFFSRVAAL AFEQSVLQDL EKRPSTQSQV 250 260 GDGDGDLIRI EVPKTQENKR PPGLGCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity." Itoh T., Satoh M., Kanno E., Fukuda M. Genes Cells 11:1023-1037(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Corpora quadrigemina, Eye and Hypothalamus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB232632 mRNA. Translation: BAF02894.1. AK038445 mRNA. Translation: BAC30001.1. AK046113 mRNA. Translation: BAE20653.1. AK142025 mRNA. Translation: BAE24917.1. BC119094 mRNA. Translation: AAI19095.1. BC119098 mRNA. Translation: AAI19099.1.
IPI	IPI00228122.
RefSeq	NP_084057.1. NM_029781.3.
UniGene	Mm.133593.
3D structure databases
HSSP	HSSP built from PDB template 1Z22 based on UniProtKB P35288.
ProteinModelPortal	Q8CAM5.
SMR	Q8CAM5. Positions 57-237.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000101062.
PTM databases
PhosphoSite	Q8CAM5.
Proteomic databases
PaxDb	Q8CAM5.
PRIDE	Q8CAM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020391; ENSMUSP00000020391; ENSMUSG00000020175. ENSMUST00000146440; ENSMUSP00000121693; ENSMUSG00000020175. ENSMUST00000147802; ENSMUSP00000119399; ENSMUSG00000020175.
GeneID	76877.
KEGG	mmu:76877.
UCSC	uc007fpx.1. mouse.
Organism-specific databases
CTD	9609.
MGI	MGI:1924127. Rab36.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00600000084435.
HOGENOM	HOG000233970.
HOVERGEN	HBG106693.
InParanoid	Q8CAM5.
KO	K07922.
OMA	PEACLQF.
Gene expression databases
ArrayExpress	Q8CAM5.
Bgee	Q8CAM5.
CleanEx	MM_RAB36.
Genevestigator	Q8CAM5.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	345985.
SOURCE	Search...

Entry information

Entry name

RAB36_MOUSE

Accession

Primary (citable) accession number: Q8CAM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program