Reviewed, UniProtKB/Swiss-Prot Q8CAL5 (GPC5_MOUSE)

Names and origin

Protein names

Recommended name:
    Glypican-5
Cleaved into the following chain:
    1- Recommended name:
            Secreted glypican-5

Gene names

Name:

Gpc5

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cell surface proteoglycan that bears heparan sulfate By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side By similarity. Secreted glypican-5: Secreted › extracellular space By similarity.
Sequence similarities	Belongs to the glypican family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Domain	Signal
PTM	GPI-anchor Glycoprotein Heparan sulfate Lipoprotein Proteoglycan
Gene Ontology (GO)
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proteinaceous extracellular matrix Inferred from electronic annotation. Source: InterPro
Molecular function	heparan sulfate proteoglycan binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – ?		Glypican-5		PRO_0000012321
	Chain	25 – ?		Secreted glypican-5		PRO_0000333850
	Propeptide	? – 572		Removed in mature form Potential		PRO_0000012322
Amino acid modifications
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	237	1	N-linked (GlcNAc...) Potential
	Glycosylation	486	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	493	1	N-linked (GlcNAc...) Potential
	Glycosylation	495	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	507	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	509	1	O-linked (Xyl...) (glycosaminoglycan) Potential
	Glycosylation	527	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8CAL5-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1935E2B9B77ECB61	FASTA	572	63,792
	10 20 30 40 50 60 MDARTWRLGW RCLLLLALLG STRSEGVESC EEVRKLFQWR LGGAVKGLPE APRAGPDLQV 70 80 90 100 110 120 CLSKNPTCCT RKMEERYQIA ARQDLQQVLQ TSSSTLKLLI SRNAAAFQET LETLIRQAEN 130 140 150 160 170 180 YTSILFCNTY RNMALEAAAS IQEFFTDVGL YLFGADVNPE EFVNRFFDSL FPLVYNHLIN 190 200 210 220 230 240 PGVTDSSLQY SECIRMARQD VSPFGNIPKR VMGQMGRSLL PGRTFLQALN LGIEVINTTD 250 260 270 280 290 300 HIHFSKECSR ALLKMQYCPH CQSLMLSKPC MGYCLNVIRG CLAHMTELNP HWHAYIRSLE 310 320 330 340 350 360 ELSDAMHGTY DVEHVLLNFH LLVNDAVLQA HLNGQKLLDQ VNTICGHPVR TPTQSPRCTF 370 380 390 400 410 420 DPSKEKHGMK ISARNGEETL ANRRKEFINS LRLHGSFYGG LADQLCVNEL AAPEGRPCWN 430 440 450 460 470 480 GEEIVKSYAQ RVVGNGIKAQ SANPEVRVRG TDPVVNQIID KLKHVIQLLR GRSPKPNKWE 490 500 510 520 530 540 LLQPGSGGGM LENSSGDCDD EDGCGGSGSG EVKRTLKITN WMPDSMNFSD VKQVHRADHG 550 560 570 STLDTTSTGC ASGTESMALP LMGTLMFLPW LW

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Hypothalamus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK038547 mRNA. Translation: BAC30037.1. BC115712 mRNA. Translation: AAI15713.1.
IPI	IPI00228115.
RefSeq	NP_780709.1.
UniGene	Mm.320791
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8CAL5.
Genome annotation databases
Ensembl	ENSMUST00000022707; ENSMUSP00000022707; ENSMUSG00000022112; Mus musculus. [Genome view]
GeneID	103978.
KEGG	mmu:103978.
UCSC	uc007uyi.1. mouse.
Organism-specific databases
CTD	103978.
MGI	MGI:1194894. Gpc5.
Phylogenomic databases
HOGENOM	HBG402880.
HOVERGEN	Q8CAL5.
InParanoid	Q8CAL5.
OMA	VQEFFTD.
OrthoDB	EOG9VX4R6.
PhylomeDB	Q8CAL5.
Gene expression databases
ArrayExpress	Q8CAL5.
Bgee	Q8CAL5.
CleanEx	MM_GPC5.
Genevestigator	Q8CAL5.
GermOnline	ENSMUSG00000022112. Mus musculus.
Family and domain databases
InterPro	IPR001863. Glypican. IPR015501. Glypican-3. IPR019803. Glypican_CS. [Graphical view]
PANTHER	PTHR10822. Glypican. 1 hit. PTHR10822:SF4. GPC3. 1 hit.
Pfam	PF01153. Glypican. 1 hit. [Graphical view]
PROSITE	PS01207. GLYPICAN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	356285.
SOURCE	Search...

Entry information

Entry name

GPC5_MOUSE

Accession

Primary (citable) accession number: Q8CAL5
Secondary accession number(s): Q14BN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)