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Protein

Glypican-5

Gene

Gpc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-5362798. Release of Hh-Np from the secreting cell.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-5
Cleaved into the following chain:
Gene namesi
Name:Gpc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1194894. Gpc5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 572Removed in mature formSequence analysisPRO_0000012322
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – ?Glypican-5PRO_0000012321
Chaini25 – ?Secreted glypican-5PRO_0000333850

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence analysis
Glycosylationi486 – 4861O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence analysis
Glycosylationi495 – 4951O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi507 – 5071O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi509 – 5091O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

MaxQBiQ8CAL5.
PaxDbiQ8CAL5.
PRIDEiQ8CAL5.

PTM databases

iPTMnetiQ8CAL5.
PhosphoSiteiQ8CAL5.

Expressioni

Gene expression databases

BgeeiQ8CAL5.
CleanExiMM_GPC5.
ExpressionAtlasiQ8CAL5. baseline and differential.
GenevisibleiQ8CAL5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8CAL5. 1 interaction.
MINTiMINT-4096527.
STRINGi10090.ENSMUSP00000022707.

Structurei

3D structure databases

ProteinModelPortaliQ8CAL5.
SMRiQ8CAL5. Positions 29-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiQ8CAL5.
KOiK08111.
PhylomeDBiQ8CAL5.

Family and domain databases

InterProiIPR001863. Glypican.
IPR031188. Glypican-5.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF12. PTHR10822:SF12. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CAL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDARTWRLGW RCLLLLALLG STRSEGVESC EEVRKLFQWR LGGAVKGLPE
60 70 80 90 100
APRAGPDLQV CLSKNPTCCT RKMEERYQIA ARQDLQQVLQ TSSSTLKLLI
110 120 130 140 150
SRNAAAFQET LETLIRQAEN YTSILFCNTY RNMALEAAAS IQEFFTDVGL
160 170 180 190 200
YLFGADVNPE EFVNRFFDSL FPLVYNHLIN PGVTDSSLQY SECIRMARQD
210 220 230 240 250
VSPFGNIPKR VMGQMGRSLL PGRTFLQALN LGIEVINTTD HIHFSKECSR
260 270 280 290 300
ALLKMQYCPH CQSLMLSKPC MGYCLNVIRG CLAHMTELNP HWHAYIRSLE
310 320 330 340 350
ELSDAMHGTY DVEHVLLNFH LLVNDAVLQA HLNGQKLLDQ VNTICGHPVR
360 370 380 390 400
TPTQSPRCTF DPSKEKHGMK ISARNGEETL ANRRKEFINS LRLHGSFYGG
410 420 430 440 450
LADQLCVNEL AAPEGRPCWN GEEIVKSYAQ RVVGNGIKAQ SANPEVRVRG
460 470 480 490 500
TDPVVNQIID KLKHVIQLLR GRSPKPNKWE LLQPGSGGGM LENSSGDCDD
510 520 530 540 550
EDGCGGSGSG EVKRTLKITN WMPDSMNFSD VKQVHRADHG STLDTTSTGC
560 570
ASGTESMALP LMGTLMFLPW LW
Length:572
Mass (Da):63,792
Last modified:March 1, 2003 - v1
Checksum:i1935E2B9B77ECB61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038547 mRNA. Translation: BAC30037.1.
BC115712 mRNA. Translation: AAI15713.1.
CCDSiCCDS27329.1.
RefSeqiNP_780709.1. NM_175500.4.
UniGeneiMm.320791.

Genome annotation databases

EnsembliENSMUST00000022707; ENSMUSP00000022707; ENSMUSG00000022112.
GeneIDi103978.
KEGGimmu:103978.
UCSCiuc007uyi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038547 mRNA. Translation: BAC30037.1.
BC115712 mRNA. Translation: AAI15713.1.
CCDSiCCDS27329.1.
RefSeqiNP_780709.1. NM_175500.4.
UniGeneiMm.320791.

3D structure databases

ProteinModelPortaliQ8CAL5.
SMRiQ8CAL5. Positions 29-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CAL5. 1 interaction.
MINTiMINT-4096527.
STRINGi10090.ENSMUSP00000022707.

PTM databases

iPTMnetiQ8CAL5.
PhosphoSiteiQ8CAL5.

Proteomic databases

MaxQBiQ8CAL5.
PaxDbiQ8CAL5.
PRIDEiQ8CAL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022707; ENSMUSP00000022707; ENSMUSG00000022112.
GeneIDi103978.
KEGGimmu:103978.
UCSCiuc007uyi.2. mouse.

Organism-specific databases

CTDi2262.
MGIiMGI:1194894. Gpc5.

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
GeneTreeiENSGT00550000074430.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiQ8CAL5.
KOiK08111.
PhylomeDBiQ8CAL5.

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-5362798. Release of Hh-Np from the secreting cell.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

PROiQ8CAL5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CAL5.
CleanExiMM_GPC5.
ExpressionAtlasiQ8CAL5. baseline and differential.
GenevisibleiQ8CAL5. MM.

Family and domain databases

InterProiIPR001863. Glypican.
IPR031188. Glypican-5.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF12. PTHR10822:SF12. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPC5_MOUSE
AccessioniPrimary (citable) accession number: Q8CAL5
Secondary accession number(s): Q14BN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.