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Protein

Glypican-5

Gene

Gpc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-5362798 Release of Hh-Np from the secreting cell
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-5
Cleaved into the following chain:
Gene namesi
Name:Gpc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1194894 Gpc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000012322? – 572Removed in mature formSequence analysis
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001232125 – ?Glypican-5
ChainiPRO_000033385025 – ?Secreted glypican-5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi495O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi507O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi509O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi527N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Proteoglycan

Proteomic databases

MaxQBiQ8CAL5
PaxDbiQ8CAL5
PRIDEiQ8CAL5

PTM databases

iPTMnetiQ8CAL5
PhosphoSitePlusiQ8CAL5

Expressioni

Gene expression databases

BgeeiENSMUSG00000022112
CleanExiMM_GPC5
ExpressionAtlasiQ8CAL5 baseline and differential
GenevisibleiQ8CAL5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CAL5, 1 interactor
MINTiQ8CAL5
STRINGi10090.ENSMUSP00000022707

Structurei

3D structure databases

ProteinModelPortaliQ8CAL5
SMRiQ8CAL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821 Eukaryota
ENOG410XST2 LUCA
GeneTreeiENSGT00550000074430
HOGENOMiHOG000049177
HOVERGENiHBG005896
InParanoidiQ8CAL5
KOiK08111
PhylomeDBiQ8CAL5

Family and domain databases

InterProiView protein in InterPro
IPR001863 Glypican
IPR031188 Glypican-5
IPR019803 Glypican_CS
PANTHERiPTHR10822 PTHR10822, 1 hit
PTHR10822:SF12 PTHR10822:SF12, 1 hit
PfamiView protein in Pfam
PF01153 Glypican, 1 hit
PROSITEiView protein in PROSITE
PS01207 GLYPICAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CAL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDARTWRLGW RCLLLLALLG STRSEGVESC EEVRKLFQWR LGGAVKGLPE
60 70 80 90 100
APRAGPDLQV CLSKNPTCCT RKMEERYQIA ARQDLQQVLQ TSSSTLKLLI
110 120 130 140 150
SRNAAAFQET LETLIRQAEN YTSILFCNTY RNMALEAAAS IQEFFTDVGL
160 170 180 190 200
YLFGADVNPE EFVNRFFDSL FPLVYNHLIN PGVTDSSLQY SECIRMARQD
210 220 230 240 250
VSPFGNIPKR VMGQMGRSLL PGRTFLQALN LGIEVINTTD HIHFSKECSR
260 270 280 290 300
ALLKMQYCPH CQSLMLSKPC MGYCLNVIRG CLAHMTELNP HWHAYIRSLE
310 320 330 340 350
ELSDAMHGTY DVEHVLLNFH LLVNDAVLQA HLNGQKLLDQ VNTICGHPVR
360 370 380 390 400
TPTQSPRCTF DPSKEKHGMK ISARNGEETL ANRRKEFINS LRLHGSFYGG
410 420 430 440 450
LADQLCVNEL AAPEGRPCWN GEEIVKSYAQ RVVGNGIKAQ SANPEVRVRG
460 470 480 490 500
TDPVVNQIID KLKHVIQLLR GRSPKPNKWE LLQPGSGGGM LENSSGDCDD
510 520 530 540 550
EDGCGGSGSG EVKRTLKITN WMPDSMNFSD VKQVHRADHG STLDTTSTGC
560 570
ASGTESMALP LMGTLMFLPW LW
Length:572
Mass (Da):63,792
Last modified:March 1, 2003 - v1
Checksum:i1935E2B9B77ECB61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038547 mRNA Translation: BAC30037.1
BC115712 mRNA Translation: AAI15713.1
CCDSiCCDS27329.1
RefSeqiNP_780709.1, NM_175500.4
UniGeneiMm.320791

Genome annotation databases

EnsembliENSMUST00000022707; ENSMUSP00000022707; ENSMUSG00000022112
GeneIDi103978
KEGGimmu:103978
UCSCiuc007uyi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGPC5_MOUSE
AccessioniPrimary (citable) accession number: Q8CAL5
Secondary accession number(s): Q14BN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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