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Protein

Putative transferase CAF17 homolog, mitochondrial

Gene

Iba57

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transferase CAF17 homolog, mitochondrial (EC:2.1.-.-)
Alternative name(s):
Iron-sulfur cluster assembly factor homolog
Gene namesi
Name:Iba57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3041174. Iba57.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 94MitochondrionSequence analysisAdd BLAST94
ChainiPRO_000027863495 – 358Putative transferase CAF17 homolog, mitochondrialAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222N6-acetyllysineCombined sources1
Modified residuei311N6-acetyllysine; alternateCombined sources1
Modified residuei311N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8CAK1.
MaxQBiQ8CAK1.
PaxDbiQ8CAK1.
PeptideAtlasiQ8CAK1.
PRIDEiQ8CAK1.

PTM databases

iPTMnetiQ8CAK1.
PhosphoSitePlusiQ8CAK1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049287.
CleanExiMM_A230051G13RIK.
ExpressionAtlasiQ8CAK1. baseline and differential.
GenevisibleiQ8CAK1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8CAK1. 1 interactor.
MINTiMINT-4114889.
STRINGi10090.ENSMUSP00000049823.

Structurei

3D structure databases

ProteinModelPortaliQ8CAK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family. CAF17 subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2929. Eukaryota.
COG0354. LUCA.
GeneTreeiENSGT00390000006465.
HOVERGENiHBG080951.
InParanoidiQ8CAK1.
OMAiYAHFLNK.
OrthoDBiEOG091G0JGU.
PhylomeDBiQ8CAK1.
TreeFamiTF105983.

Family and domain databases

InterProiIPR013977. GCV_T_C.
IPR017703. YgfZ/GcvT_CS.
[Graphical view]
PfamiPF08669. GCV_T_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03317. ygfZ_signature. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CAK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVALLRGA AVGRRSPAWH WRLSGTASHC LARGFGLLGS NPADGVAWTC
60 70 80 90 100
FRLDGRALVR VRGPDAAPFL LGLSTNELPL SGPPTGAAQP SARAAYAHFL
110 120 130 140 150
NVQGRTLYDV ILYGLPECTE GAPSFLLECD SSVLGALQKH LSMYKIRRKV
160 170 180 190 200
TVEPSPELHV WAVLPCVPQT SETAPLEERV EGTTMLIRDP RTARMGWRLL
210 220 230 240 250
TQDDGPALVP RGQLGDLQDY HKYRYQQGIP EGVCDLPPGM ALPLESNLVF
260 270 280 290 300
MNGVSFTKGC YIGQELTART HHTGVIRKRL FPVKLEGPLP ASGVSPGAIV
310 320 330 340 350
TVTATGQAAG KFRAGQGHVG LALLRSETIK GPLHIKTSES QLVAVTAVVP

DWWPTAAK
Length:358
Mass (Da):38,399
Last modified:March 1, 2003 - v1
Checksum:i20DA23B0F14A764C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267T → A in BAE43049 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038625 mRNA. Translation: BAC30069.1.
AK133203 mRNA. Translation: BAE21556.1.
AK172525 mRNA. Translation: BAE43049.1.
AL645854 Genomic DNA. Translation: CAM17098.1.
BC094909 mRNA. Translation: AAH94909.1.
CCDSiCCDS24758.1.
RefSeqiNP_776146.1. NM_173785.6.
UniGeneiMm.266175.
Mm.487361.

Genome annotation databases

EnsembliENSMUST00000054523; ENSMUSP00000049823; ENSMUSG00000049287.
GeneIDi216792.
KEGGimmu:216792.
UCSCiuc007jdd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038625 mRNA. Translation: BAC30069.1.
AK133203 mRNA. Translation: BAE21556.1.
AK172525 mRNA. Translation: BAE43049.1.
AL645854 Genomic DNA. Translation: CAM17098.1.
BC094909 mRNA. Translation: AAH94909.1.
CCDSiCCDS24758.1.
RefSeqiNP_776146.1. NM_173785.6.
UniGeneiMm.266175.
Mm.487361.

3D structure databases

ProteinModelPortaliQ8CAK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CAK1. 1 interactor.
MINTiMINT-4114889.
STRINGi10090.ENSMUSP00000049823.

PTM databases

iPTMnetiQ8CAK1.
PhosphoSitePlusiQ8CAK1.

Proteomic databases

EPDiQ8CAK1.
MaxQBiQ8CAK1.
PaxDbiQ8CAK1.
PeptideAtlasiQ8CAK1.
PRIDEiQ8CAK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054523; ENSMUSP00000049823; ENSMUSG00000049287.
GeneIDi216792.
KEGGimmu:216792.
UCSCiuc007jdd.2. mouse.

Organism-specific databases

CTDi200205.
MGIiMGI:3041174. Iba57.

Phylogenomic databases

eggNOGiKOG2929. Eukaryota.
COG0354. LUCA.
GeneTreeiENSGT00390000006465.
HOVERGENiHBG080951.
InParanoidiQ8CAK1.
OMAiYAHFLNK.
OrthoDBiEOG091G0JGU.
PhylomeDBiQ8CAK1.
TreeFamiTF105983.

Miscellaneous databases

PROiQ8CAK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049287.
CleanExiMM_A230051G13RIK.
ExpressionAtlasiQ8CAK1. baseline and differential.
GenevisibleiQ8CAK1. MM.

Family and domain databases

InterProiIPR013977. GCV_T_C.
IPR017703. YgfZ/GcvT_CS.
[Graphical view]
PfamiPF08669. GCV_T_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03317. ygfZ_signature. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAF17_MOUSE
AccessioniPrimary (citable) accession number: Q8CAK1
Secondary accession number(s): Q3T9H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.