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Protein
Submitted name:

Putative uncharacterized protein

Gene

Ercc5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. bubble DNA binding Source: MGI
  2. double-stranded DNA binding Source: MGI
  3. endodeoxyribonuclease activity Source: MGI
  4. protein homodimerization activity Source: MGI
  5. protein N-terminus binding Source: MGI
  6. single-stranded DNA binding Source: MGI

GO - Biological processi

  1. determination of adult lifespan Source: MGI
  2. DNA catabolic process, endonucleolytic Source: MGI
  3. DNA repair Source: MGI
  4. multicellular organism growth Source: MGI
  5. negative regulation of apoptotic process Source: MGI
  6. nucleotide-excision repair Source: MGI
  7. nucleotide-excision repair, DNA incision, 3'-to lesion Source: MGI
  8. response to UV Source: MGI
  9. response to UV-C Source: MGI
  10. transcription-coupled nucleotide-excision repair Source: MGI
  11. UV protection Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Ercc5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103582. Ercc5.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament cytoskeleton Source: MGI
  2. nucleoplasm Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8CAG2.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG054810.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR029060. PIN_domain-like.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERiPTHR11081:SF1. PTHR11081:SF1. 1 hit.
PfamiPF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00066. XRODRMPGMNTG.
SMARTiSM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.
PROSITEiPS00841. XPG_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8CAG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVQGLWKLL ECSGHRVSPE ALEGKVLAVD ISIWLNQALK GVRDSHGNVI
60 70 80 90 100
ENAHLLTLFH RLCKLLFFRI RPIFVFDGDA PLLKKQTLAK RRQRKDSASI
110 120 130 140 150
DSRKTTEKLL KTFLKRQALK TAFRSSRHEA PPSLTQVQRQ DDIYVLPPLP
160 170 180 190 200
EEEKHSSEEE DEKQWQARMD QKQALQEEFF HNPQAIDIES EDFSSLPPEV
210 220 230 240 250
KHEILTDMKE FTKRRRTLFE AMPESVIMPC MLIPVLWRQR QKDLHNFKAS
260 270
MFYIVISWLA WATYWKTVST RTTA
Length:274
Mass (Da):32,039
Last modified:October 11, 2005 - v2
Checksum:i7325E60AEEBCB37C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei274 – 2741Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038822 mRNA. Translation: BAC30139.2.
UniGeneiMm.2213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038822 mRNA. Translation: BAC30139.2.
UniGeneiMm.2213.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103582. Ercc5.

Phylogenomic databases

HOVERGENiHBG054810.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8CAG2.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR029060. PIN_domain-like.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERiPTHR11081:SF1. PTHR11081:SF1. 1 hit.
PfamiPF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00066. XRODRMPGMNTG.
SMARTiSM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.
PROSITEiPS00841. XPG_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HypothalamusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HypothalamusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HypothalamusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HypothalamusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HypothalamusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HypothalamusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HypothalamusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HypothalamusImported.

Entry informationi

Entry nameiQ8CAG2_MOUSE
AccessioniPrimary (citable) accession number: Q8CAG2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.