ID   Q8CAF8_MOUSE            Unreviewed;       748 AA.
AC   Q8CAF8;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 110.
DE   RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
DE   Flags: Fragment;
GN   Name=Gabbr1 {ECO:0000313|MGI:MGI:1860139};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC30149.1};
RN   [1] {ECO:0000313|EMBL:BAC30149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30149.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30149.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAC30149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30149.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30149.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAC30149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30149.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30149.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAC30149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30149.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30149.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAC30149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30149.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30149.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:BAC30149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30149.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30149.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [7] {ECO:0000313|EMBL:BAC30149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30149.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30149.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAC30149.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30149.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30149.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC       receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR   EMBL; AK038844; BAC30149.1; -; mRNA.
DR   AlphaFoldDB; Q8CAF8; -.
DR   PeptideAtlas; Q8CAF8; -.
DR   AGR; MGI:1860139; -.
DR   MGI; MGI:1860139; Gabbr1.
DR   ChiTaRS; Gabbr1; mouse.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR   CDD; cd15291; 7tmC_GABA-B-R1; 1.
DR   CDD; cd06366; PBP1_GABAb_receptor; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR002455; GPCR3_GABA-B.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR002456; GPCR_3_GABA_rcpt_B1.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR   PANTHER; PTHR10519:SF76; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   PRINTS; PR01177; GABAB1RECPTR.
DR   PRINTS; PR01176; GABABRECEPTR.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        378..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        495..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        555..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        595..613
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        619..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          385..663
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          654..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          696..748
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        654..671
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        714..728
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAC30149.1"
SQ   SEQUENCE   748 AA;  84777 MW;  991B3DB1749A8614 CRC64;
     IHHDSKCDPG QATKYLYELL YNDPIKIILM PGCSSVSTLV AEAARMWNLI VLSYGSSSPA
     LSNRQRFPTF FRTHPSATLH NPTRVKLFEK WGWKKIATIQ QTTEVFTSTL DDLEERVKEA
     GIEITFRQSF FSDPAVPVKN LKRQDARIIV GLFYETEARK VFCEVYKERL FGKKYVWFLI
     GWYADNWFKT YDPSINCTVE EMTEAVEGHI TTEIVMLNPA NTRSISNMTS QEFVEKLTKR
     LKRHPEETGG FQEAPLAYDA IWALALALNK TSGGGGRSGV RLEDFNYNNQ TITDQIYRAM
     NSSSFEGVSG HVVFDASGSR MAWTLIEQLQ GGSYKKIGYY DSTKDDLSWS KTDKWIGGSP
     PADQTLVIKT FRFLSQKLFI SVSVLSSLGI VLAVVCLSFN IYNSHVRYIQ NSQPNLNNLT
     AVGCSLALAA VFPLGLDGYH IGRSQFPFVC QARLWLLGLG FSLGYGSMFT KIWWVHTVFT
     KKEEKKEWRK TLEPWKLYAT VGLLVGMDIL TLAIWQIVDP LHRTIETFAK EEPKEDIDVS
     ILPQLEHCSS KKMNTWLGIF YGYKGLLLLL GIFLAYETKS VSTEKINDHR AVGMAIYNVA
     VLCLITAPVT MILSSQQDAA FAFASLAIVF SSYITLVVLF VPKMRRLITR GEWQSEAQDT
     MKTGSSTNNN EEEKSRLLEK ENRELEKIIA EKEERVSELR HQLQSRQQIR SRRHPPTPPD
     PSGGLPRGPS EPPDRLSCDG SRVHLLYK
//