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Protein

Gigaxonin

Gene

Gan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
GigaxoninImported
Gene namesi
Name:GanImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1890619. Gan.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Mice have a relatively normal life span. However, they display deterioration in motor function with onset varying from 6 to 10 months as well as abnormalities in non-neuronal tissues. The prominent pathological features include limb weakness, muscular atrophy, axonal degeneration, neurofilament accumulation, an abnormal microtubule network, mitochondrial swelling and thinned myelin sheaths.2 Publications

Keywords - Diseasei

Neurodegeneration

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597GigaxoninPRO_0000358592Add
BLAST

Post-translational modificationi

Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8CA72.
PaxDbiQ8CA72.
PeptideAtlasiQ8CA72.
PRIDEiQ8CA72.

PTM databases

iPTMnetiQ8CA72.
PhosphoSiteiQ8CA72.

Expressioni

Tissue specificityi

Expressed in brain, heart and muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000052557.
ExpressionAtlasiQ8CA72. baseline and differential.
GenevisibleiQ8CA72. MM.

Interactioni

Subunit structurei

Interacts with TBCB. Interacts with CUL3. Part of a complex that contains CUL3, RBX1 and GAN. Interacts (via BTB domain) with UBA1 (By similarity). Interacts (via Kelch domains) with MAP1B (via C-terminus) and MAP1S (via C-terminus).By similarity2 Publications

Protein-protein interaction databases

IntActiQ8CA72. 1 interaction.
STRINGi10090.ENSMUSP00000070168.

Structurei

3D structure databases

ProteinModelPortaliQ8CA72.
SMRiQ8CA72. Positions 3-247, 268-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9970BTBPROSITE-ProRule annotationAdd
BLAST
Domaini134 – 236103BACKSequence analysisAdd
BLAST
Repeati274 – 32653Kelch 1Sequence analysisAdd
BLAST
Repeati327 – 37448Kelch 2Sequence analysisAdd
BLAST
Repeati376 – 42146Kelch 3Sequence analysisAdd
BLAST
Repeati422 – 46847Kelch 4Sequence analysisAdd
BLAST
Repeati470 – 52253Kelch 5Sequence analysisAdd
BLAST
Repeati528 – 57447Kelch 6Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 BACK (BTB/Kelch associated) domain.Sequence analysis
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Sequence analysis

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000290709.
HOVERGENiHBG005802.
InParanoidiQ8CA72.
KOiK10453.
OMAiWIELAPM.
OrthoDBiEOG091G0FDQ.
PhylomeDBiQ8CA72.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030579. KLHL16.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF232. PTHR24412:SF232. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CA72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGSAVSDP QHAARLLRAL SSFREEARFC DAHLVLDGEE IPVQKNILAA
60 70 80 90 100
ASPYIRTKLN YNPPKDDGST YKIELEGISV MVMREILDYI FSGQIRLNED
110 120 130 140 150
TIQDVVQAAD LLLLTDLKTL CCEFLEGCIA AENCIGIRDF ALHYCLHHVH
160 170 180 190 200
YLATEYLETH FRDVSSTEEF LELSPQKLKE VISLEKLNVG NERYVFEAVI
210 220 230 240 250
RWIAHDVEMR KVHMKDVMSA LWVSGLDSSY LREQMLNEPL VREIVKECSN
260 270 280 290 300
IPLSQPQQGE AMLASFKPRG YSECIVTIGG EERVSRKPTA AMRCMCPLYD
310 320 330 340 350
PNRQLWIELA PLSMPRINHG VLSAEGFLFV LGGQDENKQT LSSGEKYDPD
360 370 380 390 400
ANTWTALPPM HEARHNFGIV EIDGMLYILG GEDGDRELIS MECYDIYSKT
410 420 430 440 450
WTKQPDLTMV RKIGCYAAMK KKIYAMGGGS YGKLFESVEC YDPRTQQWTA
460 470 480 490 500
ICPLKERRFG AVACGVAMEL YVFGGVRSRE DIQGSEMVTC KSEFYHDEFK
510 520 530 540 550
RWIYLNDQNL CIPASSSFVY GAVPIGASIY VIGDLDTGTN YDYVREFKRS
560 570 580 590
TGTWHHTKPL LPSDLRRTGC AALRIANCKL FRLQLQQGLF RIRVHSP
Length:597
Mass (Da):67,671
Last modified:December 16, 2008 - v2
Checksum:i6A7DE61945B64F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121116 mRNA. No translation available.
AK039455 mRNA. Translation: BAC30353.1.
BC112432 mRNA. Translation: AAI12433.1.
CCDSiCCDS40490.1.
RefSeqiNP_001074620.1. NM_001081151.1.
UniGeneiMm.132992.

Genome annotation databases

EnsembliENSMUST00000064488; ENSMUSP00000070168; ENSMUSG00000052557.
GeneIDi209239.
KEGGimmu:209239.
UCSCiuc009nox.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121116 mRNA. No translation available.
AK039455 mRNA. Translation: BAC30353.1.
BC112432 mRNA. Translation: AAI12433.1.
CCDSiCCDS40490.1.
RefSeqiNP_001074620.1. NM_001081151.1.
UniGeneiMm.132992.

3D structure databases

ProteinModelPortaliQ8CA72.
SMRiQ8CA72. Positions 3-247, 268-554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CA72. 1 interaction.
STRINGi10090.ENSMUSP00000070168.

PTM databases

iPTMnetiQ8CA72.
PhosphoSiteiQ8CA72.

Proteomic databases

MaxQBiQ8CA72.
PaxDbiQ8CA72.
PeptideAtlasiQ8CA72.
PRIDEiQ8CA72.

Protocols and materials databases

DNASUi209239.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064488; ENSMUSP00000070168; ENSMUSG00000052557.
GeneIDi209239.
KEGGimmu:209239.
UCSCiuc009nox.1. mouse.

Organism-specific databases

CTDi8139.
MGIiMGI:1890619. Gan.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000290709.
HOVERGENiHBG005802.
InParanoidiQ8CA72.
KOiK10453.
OMAiWIELAPM.
OrthoDBiEOG091G0FDQ.
PhylomeDBiQ8CA72.
TreeFamiTF329218.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8CA72.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052557.
ExpressionAtlasiQ8CA72. baseline and differential.
GenevisibleiQ8CA72. MM.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030579. KLHL16.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF232. PTHR24412:SF232. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAN_MOUSE
AccessioniPrimary (citable) accession number: Q8CA72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.