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Protein

Thymic stromal cotransporter protein

Gene

Slc46a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a transporter.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of T cell apoptotic process Source: MGI
  • regulation of T cell differentiation Source: MGI
  • T cell homeostasis Source: MGI
  • thymus development Source: MGI
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thymic stromal cotransporter protein
Alternative name(s):
Solute carrier family 46 member 2
Gene namesi
Name:Slc46a2
Synonyms:Tscot
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1353616. Slc46a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 8036ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini102 – 1109CytoplasmicSequence analysis
Transmembranei111 – 13121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini132 – 1409ExtracellularSequence analysis
Transmembranei141 – 16121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini162 – 17413CytoplasmicSequence analysisAdd
BLAST
Transmembranei175 – 19521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini196 – 20712ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini229 – 28153CytoplasmicSequence analysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 32119ExtracellularSequence analysisAdd
BLAST
Transmembranei322 – 34221Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini343 – 3486CytoplasmicSequence analysis
Transmembranei349 – 36921Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini370 – 3712ExtracellularSequence analysis
Transmembranei372 – 39221Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini393 – 40715CytoplasmicSequence analysisAdd
BLAST
Transmembranei408 – 42821Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini429 – 44113ExtracellularSequence analysisAdd
BLAST
Transmembranei442 – 46221Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini463 – 47917CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Thymic stromal cotransporter proteinPRO_0000065660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CA03.
PRIDEiQ8CA03.

PTM databases

PhosphoSiteiQ8CA03.

Expressioni

Tissue specificityi

Expressed on cortical epithelial cells in the thymus. Mainly expressed in the thymic cortex and is highly enriched in SCID thymus. Also expressed in lymph nodes, heart, fetal liver, brain, spleen, intestine and kidney, but not in adult liver, skin, skeletal muscle and lung.2 Publications

Developmental stagei

Highly expressed during fetal thymus development and decreases after day 16.1 Publication

Gene expression databases

BgeeiQ8CA03.
CleanExiMM_SLC46A2.
GenevisibleiQ8CA03. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030081.

Structurei

3D structure databases

ProteinModelPortaliQ8CA03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISYW. Eukaryota.
ENOG410YS8M. LUCA.
GeneTreeiENSGT00530000063076.
HOGENOMiHOG000231710.
HOVERGENiHBG054696.
InParanoidiQ8CA03.
KOiK14614.
OMAiYAVGHPP.
OrthoDBiEOG7DNNVC.
PhylomeDBiQ8CA03.
TreeFamiTF315701.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CA03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGGTCPWS SRLSGFRVRT WIEPVVASTQ VAGSLYDAGL LLVVKESFKS
60 70 80 90 100
EAGGSSNYSA NQSLVEYQED QQQKAISNFN IIYNLVLGLT PLLSAYGLGW
110 120 130 140 150
LSDRYHRKIS ICTAMLGFLL SRIGLLLKVM LDWPVEVMYG AAALNGLCGS
160 170 180 190 200
FSAYWSGVMA LGSLGCSEGR RSVRLILIDL VLGLAGFSGS MASGHLFKQI
210 220 230 240 250
VGHSAQGLLL TACSVGCAAF ALFYSLFVLK VPESKPNKVH PTVDTVSGMM
260 270 280 290 300
GTYRTLDPDQ QDKQNVPRNP RTPGKGKSSQ REVVALLFVG AIIYDLAAVG
310 320 330 340 350
TVDVMALFVL KEPLHWNQVQ LGYGMASGYI IFITSFLGVL VFSRCFRDTT
360 370 380 390 400
MIIIGMLSFG SGALLLAFVK ETYMFYIARA IMLFALIPIT TIRSAMSKLI
410 420 430 440 450
KDSSYGKIFV ILQLCLTLTG VVTSTIYNKI YQLTLDKFIG TCFVLSSFLS
460 470
FLAIVPIGVV AYKQVPRSQQ GECAEKQRS
Length:479
Mass (Da):52,083
Last modified:February 1, 2005 - v2
Checksum:iEC8BEF1E446A5CFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941S → T in BAB30710 (PubMed:16141072).Curated
Sequence conflicti274 – 2741G → R (PubMed:10706709).Curated
Sequence conflicti274 – 2741G → R (PubMed:10978518).Curated
Sequence conflicti465 – 4651V → I in BAC30504 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148145 mRNA. Translation: AAF73110.1.
AF242559 Genomic DNA. Translation: AAK28344.1.
AK017363 mRNA. Translation: BAB30710.1.
AK040063 mRNA. Translation: BAC30504.1.
AL831738 Genomic DNA. Translation: CAM24715.1.
CCDSiCCDS18227.1.
RefSeqiNP_066395.3. NM_021053.4.
UniGeneiMm.284433.

Genome annotation databases

EnsembliENSMUST00000030081; ENSMUSP00000030081; ENSMUSG00000028386.
GeneIDi30936.
KEGGimmu:30936.
UCSCiuc008taf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148145 mRNA. Translation: AAF73110.1.
AF242559 Genomic DNA. Translation: AAK28344.1.
AK017363 mRNA. Translation: BAB30710.1.
AK040063 mRNA. Translation: BAC30504.1.
AL831738 Genomic DNA. Translation: CAM24715.1.
CCDSiCCDS18227.1.
RefSeqiNP_066395.3. NM_021053.4.
UniGeneiMm.284433.

3D structure databases

ProteinModelPortaliQ8CA03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030081.

PTM databases

PhosphoSiteiQ8CA03.

Proteomic databases

PaxDbiQ8CA03.
PRIDEiQ8CA03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030081; ENSMUSP00000030081; ENSMUSG00000028386.
GeneIDi30936.
KEGGimmu:30936.
UCSCiuc008taf.2. mouse.

Organism-specific databases

CTDi57864.
MGIiMGI:1353616. Slc46a2.

Phylogenomic databases

eggNOGiENOG410ISYW. Eukaryota.
ENOG410YS8M. LUCA.
GeneTreeiENSGT00530000063076.
HOGENOMiHOG000231710.
HOVERGENiHBG054696.
InParanoidiQ8CA03.
KOiK14614.
OMAiYAVGHPP.
OrthoDBiEOG7DNNVC.
PhylomeDBiQ8CA03.
TreeFamiTF315701.

Miscellaneous databases

NextBioi307362.
PROiQ8CA03.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CA03.
CleanExiMM_SLC46A2.
GenevisibleiQ8CA03. MM.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A putative 12 transmembrane domain cotransporter expressed in thymic cortical epithelial cells."
    Kim M.G., Flomerfelt F.A., Lee K.-N., Chen C., Schwartz R.H.
    J. Immunol. 164:3185-3192(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Thymus.
  2. "Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology."
    Chen C., Kim M.G., Lyu M.S., Kozak C.A., Schwartz R.H., Flomerfelt F.A.
    Biochim. Biophys. Acta 1493:159-169(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTSCOT_MOUSE
AccessioniPrimary (citable) accession number: Q8CA03
Secondary accession number(s): A2ANT4, Q9D3J2, Q9JLQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 11, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.