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Protein

Carabin

Gene

Tbc1d10c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei135 – 1351Arginine fingerBy similarity
Sitei176 – 1761Glutamine fingerBy similarity

GO - Molecular functioni

GO - Biological processi

  • activation of GTPase activity Source: GO_Central
  • negative regulation of B cell activation Source: MGI
  • negative regulation of ERK1 and ERK2 cascade Source: MGI
  • negative regulation of NFAT protein import into nucleus Source: MGI
  • regulation of vesicle fusion Source: GO_Central
  • retrograde transport, endosome to Golgi Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Carabin
Alternative name(s):
TBC1 domain family member 10C
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1922072. Tbc1d10c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444CarabinPRO_0000284468Add
BLAST

Proteomic databases

PaxDbiQ8C9V1.
PRIDEiQ8C9V1.

PTM databases

iPTMnetiQ8C9V1.
PhosphoSiteiQ8C9V1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040247.
CleanExiMM_TBC1D10C.
GenevisibleiQ8C9V1. MM.

Interactioni

Subunit structurei

Interacts with both calcineurin and HRAS.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042660.

Structurei

3D structure databases

ProteinModelPortaliQ8C9V1.
SMRiQ8C9V1. Positions 36-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 278189Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni404 – 44441Interaction with calcineurinBy similarityAdd
BLAST

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00760000119202.
HOGENOMiHOG000007561.
HOVERGENiHBG070028.
InParanoidiQ8C9V1.
KOiK19944.
OMAiMSQVHSV.
OrthoDBiEOG091G07CB.
PhylomeDBiQ8C9V1.
TreeFamiTF313293.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C9V1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQALGEDLL SELQDDSSSL GSDSELSGPS PYRQADRYGF IGGNSGELRL
60 70 80 90 100
CQPSADLIRQ REMKWVEMTL HWEKTMSRRY KKVKIQCRKG IPSALRARCW
110 120 130 140 150
PLLCGARMCQ KNNPGTYQEL AAAPGDPQWM ETIGRDLHRQ FPLHEMFVSP
160 170 180 190 200
QGHGQQGLLQ VLKAYTLYRP EQGYCQAQGP VAAVLLMHLP PEEAFWCLVQ
210 220 230 240 250
ICEVYLPGYY GPHMEAVQLD AEVFMALLRR QLPRVYKHLQ QVGVGPLLYL
260 270 280 290 300
PEWFLCLFTR SLPFPTVLRI WDAFLSEGAK VLFRVGLTLM RLALGTVEQR
310 320 330 340 350
TACPGLLETL GALRAIPPTQ LQEEVFMSQV HSVTLSERVL QQEIRIQLAQ
360 370 380 390 400
LSKSLPGPAP LPQARLPGAQ AIFESQQLAG VRESTKPEIP RIVVQPPEEP
410 420 430 440
KPPRRKPQTR GKTFHGLLIR ARGPPIEGPS RSQRGSASFL DTRF
Length:444
Mass (Da):49,930
Last modified:March 1, 2003 - v1
Checksum:iC142EC1491874B7C
GO
Isoform 2 (identifier: Q8C9V1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-231: Missing.

Show »
Length:427
Mass (Da):47,959
Checksum:iF53043BA0EA13265
GO
Isoform 3 (identifier: Q8C9V1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:382
Mass (Da):43,260
Checksum:iB7CA117C58E405C6
GO
Isoform 4 (identifier: Q8C9V1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-180: QQGLLQVLKAYTLYRPEQGYCQAQGP → RGCCRFSRPTPCTGQSRDTARLRDL
     181-444: Missing.

Show »
Length:179
Mass (Da):20,257
Checksum:iEAAD5554BE5AEDCD
GO

Sequence cautioni

The sequence BAD21427 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6262Missing in isoform 3. 1 PublicationVSP_024536Add
BLAST
Alternative sequencei155 – 18026QQGLL…QAQGP → RGCCRFSRPTPCTGQSRDTA RLRDL in isoform 4. 1 PublicationVSP_024537Add
BLAST
Alternative sequencei181 – 444264Missing in isoform 4. 1 PublicationVSP_024539Add
BLAST
Alternative sequencei215 – 23117Missing in isoform 2. 1 PublicationVSP_024538Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131177 mRNA. Translation: BAD21427.1. Different initiation.
AK038366 mRNA. Translation: BAE20537.1.
AK040487 mRNA. Translation: BAC30605.1.
AK075803 mRNA. Translation: BAC35971.1.
AK088119 mRNA. Translation: BAC40158.1.
AK146426 mRNA. Translation: BAE27160.1.
CCDSiCCDS37885.1. [Q8C9V1-1]
RefSeqiNP_848765.2. NM_178650.3. [Q8C9V1-1]
XP_006531689.1. XM_006531626.2. [Q8C9V1-1]
XP_006531690.1. XM_006531627.2. [Q8C9V1-1]
XP_006544947.1. XM_006544884.2. [Q8C9V1-1]
XP_006544948.1. XM_006544885.2. [Q8C9V1-1]
UniGeneiMm.288312.

Genome annotation databases

EnsembliENSMUST00000045864; ENSMUSP00000042660; ENSMUSG00000040247. [Q8C9V1-1]
ENSMUST00000181228; ENSMUSP00000137980; ENSMUSG00000097708. [Q8C9V1-1]
GeneIDi108995.
KEGGimmu:108995.
UCSCiuc008fze.1. mouse. [Q8C9V1-1]
uc012bgh.1. mouse. [Q8C9V1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131177 mRNA. Translation: BAD21427.1. Different initiation.
AK038366 mRNA. Translation: BAE20537.1.
AK040487 mRNA. Translation: BAC30605.1.
AK075803 mRNA. Translation: BAC35971.1.
AK088119 mRNA. Translation: BAC40158.1.
AK146426 mRNA. Translation: BAE27160.1.
CCDSiCCDS37885.1. [Q8C9V1-1]
RefSeqiNP_848765.2. NM_178650.3. [Q8C9V1-1]
XP_006531689.1. XM_006531626.2. [Q8C9V1-1]
XP_006531690.1. XM_006531627.2. [Q8C9V1-1]
XP_006544947.1. XM_006544884.2. [Q8C9V1-1]
XP_006544948.1. XM_006544885.2. [Q8C9V1-1]
UniGeneiMm.288312.

3D structure databases

ProteinModelPortaliQ8C9V1.
SMRiQ8C9V1. Positions 36-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042660.

PTM databases

iPTMnetiQ8C9V1.
PhosphoSiteiQ8C9V1.

Proteomic databases

PaxDbiQ8C9V1.
PRIDEiQ8C9V1.

Protocols and materials databases

DNASUi108995.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045864; ENSMUSP00000042660; ENSMUSG00000040247. [Q8C9V1-1]
ENSMUST00000181228; ENSMUSP00000137980; ENSMUSG00000097708. [Q8C9V1-1]
GeneIDi108995.
KEGGimmu:108995.
UCSCiuc008fze.1. mouse. [Q8C9V1-1]
uc012bgh.1. mouse. [Q8C9V1-2]

Organism-specific databases

CTDi374403.
MGIiMGI:1922072. Tbc1d10c.

Phylogenomic databases

eggNOGiKOG2221. Eukaryota.
ENOG410XPSR. LUCA.
GeneTreeiENSGT00760000119202.
HOGENOMiHOG000007561.
HOVERGENiHBG070028.
InParanoidiQ8C9V1.
KOiK19944.
OMAiMSQVHSV.
OrthoDBiEOG091G07CB.
PhylomeDBiQ8C9V1.
TreeFamiTF313293.

Miscellaneous databases

ChiTaRSiTbc1d10c. mouse.
PROiQ8C9V1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040247.
CleanExiMM_TBC1D10C.
GenevisibleiQ8C9V1. MM.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTB10C_MOUSE
AccessioniPrimary (citable) accession number: Q8C9V1
Secondary accession number(s): Q3V3L7
, Q6KAN0, Q8C2R6, Q8C6F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.