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Q8C9K1

- Q8C9K1_MOUSE

UniProt

Q8C9K1 - Q8C9K1_MOUSE

Protein
Submitted name:

Kit ligand

Gene

Kitl

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. protein binding Source: MGI
    3. stem cell factor receptor binding Source: MGI

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. ectopic germ cell programmed cell death Source: MGI
    3. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    4. germ cell development Source: MGI
    5. negative regulation of apoptotic process Source: MGI
    6. negative regulation of mast cell apoptotic process Source: MGI
    7. neural crest cell migration Source: MGI
    8. positive regulation of cell proliferation Source: MGI
    9. positive regulation of MAP kinase activity Source: MGI
    10. positive regulation of mast cell proliferation Source: MGI
    11. positive regulation of melanocyte differentiation Source: MGI
    12. positive regulation of myeloid leukocyte differentiation Source: MGI
    13. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
    14. positive regulation of Ras protein signal transduction Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Kit ligandImported
    Gene namesi
    Name:KitlImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:96974. Kitl.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. integral component of membrane Source: MGI
    3. plasma membrane Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ8C9K1.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000018272.
    HOVERGENiHBG060088.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003452. SCF.
    [Graphical view]
    PANTHERiPTHR11574. PTHR11574. 1 hit.
    PfamiPF02404. SCF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q8C9K1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKTQVSRAR PGGARKLSKK IAPGAPGSPA RSGTGNQAMW GCALPTWIIT    50
    CIYLQLLLFN PLVKTKEICG NPVTDNVKDI TKLVANLPND YMITLNYVAG 100
    MDVLPSHCWL RDMVIQLSLS LTTLLDKFSN ISEGLSNYSI IDKLGKIVDD 150
    LVLCMEENAP 160
    Length:160
    Mass (Da):17,493
    Last modified:March 1, 2003 - v1
    Checksum:iB12AC581346AAE6D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei160 – 1601Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC159910 Genomic DNA. No translation available.
    AK041961 mRNA. Translation: BAC31113.1.
    UniGeneiMm.45124.

    Genome annotation databases

    EnsembliENSMUST00000130190; ENSMUSP00000123360; ENSMUSG00000019966.
    UCSCiuc007gxr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC159910 Genomic DNA. No translation available.
    AK041961 mRNA. Translation: BAC31113.1 .
    UniGenei Mm.45124.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000130190 ; ENSMUSP00000123360 ; ENSMUSG00000019966 .
    UCSCi uc007gxr.1. mouse.

    Organism-specific databases

    MGIi MGI:96974. Kitl.

    Phylogenomic databases

    GeneTreei ENSGT00390000018272.
    HOVERGENi HBG060088.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8C9K1.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003452. SCF.
    [Graphical view ]
    PANTHERi PTHR11574. PTHR11574. 1 hit.
    Pfami PF02404. SCF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    10. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8C9K1_MOUSE
    AccessioniPrimary (citable) accession number: Q8C9K1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3