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Q8C9K1

- Q8C9K1_MOUSE

UniProt

Q8C9K1 - Q8C9K1_MOUSE

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Protein
Submitted name:

Kit ligand

Gene

Kitl

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. stem cell factor receptor binding Source: MGI

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. ectopic germ cell programmed cell death Source: MGI
  3. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  4. germ cell development Source: MGI
  5. negative regulation of apoptotic process Source: MGI
  6. negative regulation of mast cell apoptotic process Source: MGI
  7. neural crest cell migration Source: MGI
  8. positive regulation of cell proliferation Source: MGI
  9. positive regulation of MAP kinase activity Source: MGI
  10. positive regulation of mast cell proliferation Source: MGI
  11. positive regulation of melanocyte differentiation Source: MGI
  12. positive regulation of myeloid leukocyte differentiation Source: MGI
  13. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  14. positive regulation of Ras protein signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Kit ligandImported
Gene namesi
Name:KitlImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:96974. Kitl.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. integral component of membrane Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8C9K1.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018272.
HOVERGENiHBG060088.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003452. SCF.
[Graphical view]
PANTHERiPTHR11574. PTHR11574. 1 hit.
PfamiPF02404. SCF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8C9K1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKTQVSRAR PGGARKLSKK IAPGAPGSPA RSGTGNQAMW GCALPTWIIT
60 70 80 90 100
CIYLQLLLFN PLVKTKEICG NPVTDNVKDI TKLVANLPND YMITLNYVAG
110 120 130 140 150
MDVLPSHCWL RDMVIQLSLS LTTLLDKFSN ISEGLSNYSI IDKLGKIVDD
160
LVLCMEENAP
Length:160
Mass (Da):17,493
Last modified:March 1, 2003 - v1
Checksum:iB12AC581346AAE6D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei160 – 1601Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC159910 Genomic DNA. No translation available.
AK041961 mRNA. Translation: BAC31113.1.
UniGeneiMm.45124.

Genome annotation databases

EnsembliENSMUST00000130190; ENSMUSP00000123360; ENSMUSG00000019966.
UCSCiuc007gxr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC159910 Genomic DNA. No translation available.
AK041961 mRNA. Translation: BAC31113.1 .
UniGenei Mm.45124.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000130190 ; ENSMUSP00000123360 ; ENSMUSG00000019966 .
UCSCi uc007gxr.1. mouse.

Organism-specific databases

MGIi MGI:96974. Kitl.

Phylogenomic databases

GeneTreei ENSGT00390000018272.
HOVERGENi HBG060088.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q8C9K1.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003452. SCF.
[Graphical view ]
PANTHERi PTHR11574. PTHR11574. 1 hit.
Pfami PF02404. SCF. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8C9K1_MOUSE
AccessioniPrimary (citable) accession number: Q8C9K1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3