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Protein

Striatin-interacting proteins 2

Gene

Strip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).By similarity

Caution

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-interacting proteins 2
Alternative name(s):
Protein FAM40B
Gene namesi
Name:Strip2
Synonyms:Fam40b, Kiaa1170, Stripb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444363 Strip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870231 – 844Striatin-interacting proteins 2Add BLAST844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei328PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8C9H6
PRIDEiQ8C9H6

PTM databases

iPTMnetiQ8C9H6
PhosphoSitePlusiQ8C9H6

Expressioni

Gene expression databases

BgeeiENSMUSG00000039629
ExpressionAtlasiQ8C9H6 baseline and differential
GenevisibleiQ8C9H6 MM

Interactioni

Subunit structurei

Component of striatin-interacting phosphatase and kinase (STRIPAK) complex. Interacts with CTTNBP2NL (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8C9H6 1 interactor.
STRINGi10090.ENSMUSP00000036477

Structurei

3D structure databases

ProteinModelPortaliQ8C9H6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STRIP family.Curated

Phylogenomic databases

eggNOGiKOG3680 Eukaryota
ENOG410XRAB LUCA
GeneTreeiENSGT00400000022095
HOGENOMiHOG000252963
HOVERGENiHBG081506
InParanoidiQ8C9H6
OMAiRRYDKPQ
OrthoDBiEOG091G02GC
PhylomeDBiQ8C9H6
TreeFamiTF314205

Family and domain databases

InterProiView protein in InterPro
IPR021819 Far11/STRP_C
IPR012486 Far11/STRP_N
PfamiView protein in Pfam
PF11882 DUF3402, 2 hits
PF07923 N1221, 1 hit
SMARTiView protein in SMART
SM01293 DUF3402, 1 hit
SM01292 N1221, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C9H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDPAAPGPA GSPANDNGNG NGNGNGNGNG GKGKPAVPKG RETFRNQRRE
60 70 80 90 100
SEGSVDCPTL EFEYGDSDGH AAELSELYSY TENLEFTTNR KCFEEDFRTQ
110 120 130 140 150
VQDTKEWLEL EEDAQKTYVM GLLDRLEVVS REKRLKVARA VLYLAQGTFG
160 170 180 190 200
ECDSEVDVLH WSRYNCFLLY QMGTFSAFLE LLHMEIDNSQ ASSSALRKPA
210 220 230 240 250
VSIADSTELR VLLSVMYLMV ENIRLEREID PCGWRTARET FRTELSFSTH
260 270 280 290 300
NEEPFALLLF SMVTKFCSGL APHFPIKKVL LLLWKVVMFT LGGFEHLQAL
310 320 330 340 350
KIQKRAELGL PPLAEDSIQV VKSMRAASPP SYTLDLGESQ LAPPPSKLRG
360 370 380 390 400
RRGSRRQLLT KQDSLDIYNE RDLFKTEEPA TEEEEESAAD GERTLDGELD
410 420 430 440 450
LLEQDPLVPP PPSQTPLSTD RVAFPKGLPW APKVRQKDIE HFLEMSRNKF
460 470 480 490 500
IGFTLGQDTD TLVGLPRPIH ESVKTLKQHK YISIADIQIK NEEELEKCPL
510 520 530 540 550
SLGEEVVPET PSEILYQGML YSLPQYMIAL LKILLAAAPT SKAKTDSINI
560 570 580 590 600
LADVLPEEMP VTVLQSMKLG IDVNRHKEII VKSISALLLL LLKHFKLNHI
610 620 630 640 650
YQFEYVSQHL VFANCIPLIL KFFNQNILSY ITAKNSISVL DYPCCTIQDL
660 670 680 690 700
PELTTESLEA GDNSQFCWRN LFSCINLLRL LNKLTKWKHS RTMMLVVFKS
710 720 730 740 750
APILKRALKV KQAMLQLYVL KLLKIQTKYL GRQWRKSNMK TMSAIYQKVR
760 770 780 790 800
HRMNDDWAYG NDIDARPWDF QAEECTLRAN IEAFNSRRYD KPQDSEFSPV
810 820 830 840
DNCLQSVLGQ RLDLPEDFHY SYELWLEREV FSQPICWEEL LQNH
Length:844
Mass (Da):96,294
Last modified:March 1, 2003 - v1
Checksum:i78E4D64476A7B097
GO
Isoform 2 (identifier: Q8C9H6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     659-662: EAGD → GLSV
     663-844: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):74,343
Checksum:iC4E179876A6B0E11
GO
Isoform 3 (identifier: Q8C9H6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     694-721: Missing.

Note: No experimental confirmation available.
Show »
Length:816
Mass (Da):93,082
Checksum:iABC28DB876D6423F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47Q → L in BAC65741 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019001659 – 662EAGD → GLSV in isoform 2. 1 Publication4
Alternative sequenceiVSP_019002663 – 844Missing in isoform 2. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_014870694 – 721Missing in isoform 3. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042073 mRNA Translation: BAC31154.1
AK163706 mRNA Translation: BAE37467.1
AK122459 mRNA Translation: BAC65741.1
CCDSiCCDS19967.1 [Q8C9H6-1]
CCDS85025.1 [Q8C9H6-3]
RefSeqiNP_001032829.1, NM_001037740.1 [Q8C9H6-3]
NP_796178.2, NM_177204.3 [Q8C9H6-1]
UniGeneiMm.56097

Genome annotation databases

EnsembliENSMUST00000046028; ENSMUSP00000036477; ENSMUSG00000039629 [Q8C9H6-1]
ENSMUST00000151738; ENSMUSP00000119506; ENSMUSG00000039629 [Q8C9H6-3]
GeneIDi320609
KEGGimmu:320609
UCSCiuc009bem.1 mouse [Q8C9H6-1]
uc009beo.1 mouse [Q8C9H6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTRP2_MOUSE
AccessioniPrimary (citable) accession number: Q8C9H6
Secondary accession number(s): Q3TQB7, Q80TI6, Q8C7A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome