Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Striatin-interacting proteins 2

Gene

Strip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-interacting proteins 2
Alternative name(s):
Protein FAM40B
Gene namesi
Name:Strip2
Synonyms:Fam40b, Kiaa1170, Stripb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444363. Strip2.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Enriched in lamellipodia.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 844844Striatin-interacting proteins 2PRO_0000187023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei328 – 3281PhosphoserineCombined sources
Modified residuei339 – 3391PhosphoserineCombined sources
Modified residuei364 – 3641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C9H6.
PaxDbiQ8C9H6.
PRIDEiQ8C9H6.

PTM databases

iPTMnetiQ8C9H6.
PhosphoSiteiQ8C9H6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039629.
ExpressionAtlasiQ8C9H6. baseline and differential.
GenevisibleiQ8C9H6. MM.

Interactioni

Subunit structurei

Component of striatin-interacting phosphatase and kinase (STRIPAK) complex. Interacts with CTTNBP2NL (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8C9H6. 1 interaction.
STRINGi10090.ENSMUSP00000036477.

Structurei

3D structure databases

ProteinModelPortaliQ8C9H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STRIP family.Curated

Phylogenomic databases

eggNOGiKOG3680. Eukaryota.
ENOG410XRAB. LUCA.
GeneTreeiENSGT00400000022095.
HOGENOMiHOG000252963.
HOVERGENiHBG081506.
InParanoidiQ8C9H6.
OMAiMYLLVEN.
OrthoDBiEOG091G02GC.
PhylomeDBiQ8C9H6.
TreeFamiTF314205.

Family and domain databases

InterProiIPR021819. DUF3402.
IPR012486. N1221.
[Graphical view]
PfamiPF11882. DUF3402. 2 hits.
PF07923. N1221. 1 hit.
[Graphical view]
SMARTiSM01293. DUF3402. 1 hit.
SM01292. N1221. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C9H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDPAAPGPA GSPANDNGNG NGNGNGNGNG GKGKPAVPKG RETFRNQRRE
60 70 80 90 100
SEGSVDCPTL EFEYGDSDGH AAELSELYSY TENLEFTTNR KCFEEDFRTQ
110 120 130 140 150
VQDTKEWLEL EEDAQKTYVM GLLDRLEVVS REKRLKVARA VLYLAQGTFG
160 170 180 190 200
ECDSEVDVLH WSRYNCFLLY QMGTFSAFLE LLHMEIDNSQ ASSSALRKPA
210 220 230 240 250
VSIADSTELR VLLSVMYLMV ENIRLEREID PCGWRTARET FRTELSFSTH
260 270 280 290 300
NEEPFALLLF SMVTKFCSGL APHFPIKKVL LLLWKVVMFT LGGFEHLQAL
310 320 330 340 350
KIQKRAELGL PPLAEDSIQV VKSMRAASPP SYTLDLGESQ LAPPPSKLRG
360 370 380 390 400
RRGSRRQLLT KQDSLDIYNE RDLFKTEEPA TEEEEESAAD GERTLDGELD
410 420 430 440 450
LLEQDPLVPP PPSQTPLSTD RVAFPKGLPW APKVRQKDIE HFLEMSRNKF
460 470 480 490 500
IGFTLGQDTD TLVGLPRPIH ESVKTLKQHK YISIADIQIK NEEELEKCPL
510 520 530 540 550
SLGEEVVPET PSEILYQGML YSLPQYMIAL LKILLAAAPT SKAKTDSINI
560 570 580 590 600
LADVLPEEMP VTVLQSMKLG IDVNRHKEII VKSISALLLL LLKHFKLNHI
610 620 630 640 650
YQFEYVSQHL VFANCIPLIL KFFNQNILSY ITAKNSISVL DYPCCTIQDL
660 670 680 690 700
PELTTESLEA GDNSQFCWRN LFSCINLLRL LNKLTKWKHS RTMMLVVFKS
710 720 730 740 750
APILKRALKV KQAMLQLYVL KLLKIQTKYL GRQWRKSNMK TMSAIYQKVR
760 770 780 790 800
HRMNDDWAYG NDIDARPWDF QAEECTLRAN IEAFNSRRYD KPQDSEFSPV
810 820 830 840
DNCLQSVLGQ RLDLPEDFHY SYELWLEREV FSQPICWEEL LQNH
Length:844
Mass (Da):96,294
Last modified:March 1, 2003 - v1
Checksum:i78E4D64476A7B097
GO
Isoform 2 (identifier: Q8C9H6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     659-662: EAGD → GLSV
     663-844: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):74,343
Checksum:iC4E179876A6B0E11
GO
Isoform 3 (identifier: Q8C9H6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     694-721: Missing.

Note: No experimental confirmation available.
Show »
Length:816
Mass (Da):93,082
Checksum:iABC28DB876D6423F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471Q → L in BAC65741 (PubMed:12693553).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei659 – 6624EAGD → GLSV in isoform 2. 1 PublicationVSP_019001
Alternative sequencei663 – 844182Missing in isoform 2. 1 PublicationVSP_019002Add
BLAST
Alternative sequencei694 – 72128Missing in isoform 3. 1 PublicationVSP_014870Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042073 mRNA. Translation: BAC31154.1.
AK163706 mRNA. Translation: BAE37467.1.
AK122459 mRNA. Translation: BAC65741.1.
CCDSiCCDS19967.1. [Q8C9H6-1]
RefSeqiNP_001032829.1. NM_001037740.1. [Q8C9H6-3]
NP_796178.2. NM_177204.3. [Q8C9H6-1]
UniGeneiMm.56097.

Genome annotation databases

EnsembliENSMUST00000046028; ENSMUSP00000036477; ENSMUSG00000039629. [Q8C9H6-1]
ENSMUST00000151738; ENSMUSP00000119506; ENSMUSG00000039629. [Q8C9H6-3]
GeneIDi320609.
KEGGimmu:320609.
UCSCiuc009bem.1. mouse. [Q8C9H6-1]
uc009beo.1. mouse. [Q8C9H6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042073 mRNA. Translation: BAC31154.1.
AK163706 mRNA. Translation: BAE37467.1.
AK122459 mRNA. Translation: BAC65741.1.
CCDSiCCDS19967.1. [Q8C9H6-1]
RefSeqiNP_001032829.1. NM_001037740.1. [Q8C9H6-3]
NP_796178.2. NM_177204.3. [Q8C9H6-1]
UniGeneiMm.56097.

3D structure databases

ProteinModelPortaliQ8C9H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C9H6. 1 interaction.
STRINGi10090.ENSMUSP00000036477.

PTM databases

iPTMnetiQ8C9H6.
PhosphoSiteiQ8C9H6.

Proteomic databases

MaxQBiQ8C9H6.
PaxDbiQ8C9H6.
PRIDEiQ8C9H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046028; ENSMUSP00000036477; ENSMUSG00000039629. [Q8C9H6-1]
ENSMUST00000151738; ENSMUSP00000119506; ENSMUSG00000039629. [Q8C9H6-3]
GeneIDi320609.
KEGGimmu:320609.
UCSCiuc009bem.1. mouse. [Q8C9H6-1]
uc009beo.1. mouse. [Q8C9H6-3]

Organism-specific databases

CTDi57464.
MGIiMGI:2444363. Strip2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3680. Eukaryota.
ENOG410XRAB. LUCA.
GeneTreeiENSGT00400000022095.
HOGENOMiHOG000252963.
HOVERGENiHBG081506.
InParanoidiQ8C9H6.
OMAiMYLLVEN.
OrthoDBiEOG091G02GC.
PhylomeDBiQ8C9H6.
TreeFamiTF314205.

Miscellaneous databases

PROiQ8C9H6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039629.
ExpressionAtlasiQ8C9H6. baseline and differential.
GenevisibleiQ8C9H6. MM.

Family and domain databases

InterProiIPR021819. DUF3402.
IPR012486. N1221.
[Graphical view]
PfamiPF11882. DUF3402. 2 hits.
PF07923. N1221. 1 hit.
[Graphical view]
SMARTiSM01293. DUF3402. 1 hit.
SM01292. N1221. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTRP2_MOUSE
AccessioniPrimary (citable) accession number: Q8C9H6
Secondary accession number(s): Q3TQB7, Q80TI6, Q8C7A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.