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Protein

Hepatocyte growth factor

Gene

Hgf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.UniRule annotation

GO - Molecular functioni

  1. chemoattractant activity Source: MGI
  2. identical protein binding Source: MGI
  3. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. cell chemotaxis Source: MGI
  3. cell morphogenesis Source: MGI
  4. cell proliferation Source: MGI
  5. cellular response to hepatocyte growth factor stimulus Source: MGI
  6. hepatocyte growth factor receptor signaling pathway Source: MGI
  7. liver development Source: MGI
  8. myoblast proliferation Source: MGI
  9. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  10. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  11. negative regulation of hydrogen peroxide-mediated programmed cell death Source: MGI
  12. negative regulation of release of cytochrome c from mitochondria Source: MGI
  13. positive chemotaxis Source: MGI
  14. positive regulation of cell migration Source: MGI
  15. positive regulation of DNA biosynthetic process Source: MGI
  16. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  17. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  18. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotation, Serine protease homologUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factorUniRule annotation
Alternative name(s):
Hepatopoietin-AUniRule annotation
Scatter factorUniRule annotation
Gene namesi
Name:HgfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96079. Hgf.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8C9G5.

Interactioni

Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030683.

Structurei

3D structure databases

ProteinModelPortaliQ8C9G5.
SMRiQ8C9G5. Positions 39-210, 496-725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation
Contains peptidase S1 domain.SAAS annotation
Contains peptidase Sdomain.SAAS annotation

Keywords - Domaini

KringleSAAS annotation

Phylogenomic databases

HOVERGENiHBG004381.
KOiK05460.

Family and domain databases

InterProiIPR027284. Hepatocyte_GF.
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF500183. Hepatocyte_GF. 1 hit.
PIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C9G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT
60 70 80 90 100
LTKEDPLLKI KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY
110 120 130 140 150
PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC
160 170 180 190 200
QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE
210 220 230 240 250
VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER
260 270 280 290 300
YPDKGFDDNY CRNPDGKPRP WCYTLDPDTT WEYCAIKTCA HSAVNETDVP
310 320 330 340 350
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL
360 370 380 390 400
RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY
410 420 430 440 450
MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLNKNY CRNPDDDAHG
460 470 480 490 500
PWCYTGNPLI PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLRVVNGI
510 520 530 540 550
PTQTTVGWMV SLKYRNKHIC GGSLIKESWV ITARQCFPAR NKDLKDYEAW
560 570 580 590 600
LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI
610 620 630 640 650
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ
660 670 680 690 700
GKVTLNESEL CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC
710 720
AIPNRPVIFV RVAYYAKWIH KVILTYKL
Length:728
Mass (Da):82,991
Last modified:March 1, 2003 - v1
Checksum:i8D5258DF3BCF3545
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042121 mRNA. Translation: BAC31175.1.
RefSeqiNP_001276387.1. NM_001289458.1.
NP_001276388.1. NM_001289459.1.
NP_034557.3. NM_010427.5.
UniGeneiMm.267078.

Genome annotation databases

GeneIDi15234.
KEGGimmu:15234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042121 mRNA. Translation: BAC31175.1.
RefSeqiNP_001276387.1. NM_001289458.1.
NP_001276388.1. NM_001289459.1.
NP_034557.3. NM_010427.5.
UniGeneiMm.267078.

3D structure databases

ProteinModelPortaliQ8C9G5.
SMRiQ8C9G5. Positions 39-210, 496-725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15234.
KEGGimmu:15234.

Organism-specific databases

CTDi3082.
MGIiMGI:96079. Hgf.

Phylogenomic databases

HOVERGENiHBG004381.
KOiK05460.

Miscellaneous databases

NextBioi287831.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8C9G5.

Family and domain databases

InterProiIPR027284. Hepatocyte_GF.
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF500183. Hepatocyte_GF. 1 hit.
PIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ8C9G5_MOUSE
AccessioniPrimary (citable) accession number: Q8C9G5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.