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Q8C9G5

- Q8C9G5_MOUSE

UniProt

Q8C9G5 - Q8C9G5_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Hgf

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. cell morphogenesis Source: MGI
    3. cell proliferation Source: MGI
    4. hepatocyte growth factor receptor signaling pathway Source: MGI
    5. liver development Source: MGI
    6. myoblast proliferation Source: MGI
    7. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    8. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI

    Keywords - Molecular functioni

    Serine protease homologUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:HgfImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96079. Hgf.

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8C9G5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000030683.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8C9G5.
    SMRiQ8C9G5. Positions 39-210, 496-725.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S1 family.UniRule annotation
    Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation
    Contains peptidase S1 domain.SAAS annotation
    Contains peptidase Sdomain.SAAS annotation

    Keywords - Domaini

    KringleSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG004381.
    InParanoidiQ8C9G5.
    KOiK05460.

    Family and domain databases

    Gene3Di2.40.20.10. 4 hits.
    InterProiIPR024174. HGF_MST1.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00051. Kringle. 4 hits.
    PF00024. PAN_1. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001152. HGF_MST1. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00130. KR. 4 hits.
    SM00473. PAN_AP. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 4 hits.
    PROSITEiPS00021. KRINGLE_1. 4 hits.
    PS50070. KRINGLE_2. 4 hits.
    PS50948. PAN. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8C9G5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT    50
    LTKEDPLLKI KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY 100
    PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC 150
    QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE 200
    VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER 250
    YPDKGFDDNY CRNPDGKPRP WCYTLDPDTT WEYCAIKTCA HSAVNETDVP 300
    METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL 350
    RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY 400
    MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLNKNY CRNPDDDAHG 450
    PWCYTGNPLI PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLRVVNGI 500
    PTQTTVGWMV SLKYRNKHIC GGSLIKESWV ITARQCFPAR NKDLKDYEAW 550
    LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI 600
    DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ 650
    GKVTLNESEL CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC 700
    AIPNRPVIFV RVAYYAKWIH KVILTYKL 728
    Length:728
    Mass (Da):82,991
    Last modified:March 1, 2003 - v1
    Checksum:i8D5258DF3BCF3545
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042121 mRNA. Translation: BAC31175.1.
    RefSeqiNP_001276387.1. NM_001289458.1.
    NP_001276388.1. NM_001289459.1.
    NP_034557.3. NM_010427.5.
    UniGeneiMm.267078.

    Genome annotation databases

    GeneIDi15234.
    KEGGimmu:15234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042121 mRNA. Translation: BAC31175.1 .
    RefSeqi NP_001276387.1. NM_001289458.1.
    NP_001276388.1. NM_001289459.1.
    NP_034557.3. NM_010427.5.
    UniGenei Mm.267078.

    3D structure databases

    ProteinModelPortali Q8C9G5.
    SMRi Q8C9G5. Positions 39-210, 496-725.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000030683.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15234.
    KEGGi mmu:15234.

    Organism-specific databases

    CTDi 3082.
    MGIi MGI:96079. Hgf.

    Phylogenomic databases

    HOVERGENi HBG004381.
    InParanoidi Q8C9G5.
    KOi K05460.

    Miscellaneous databases

    NextBioi 287831.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8C9G5.

    Family and domain databases

    Gene3Di 2.40.20.10. 4 hits.
    InterProi IPR024174. HGF_MST1.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00051. Kringle. 4 hits.
    PF00024. PAN_1. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001152. HGF_MST1. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00130. KR. 4 hits.
    SM00473. PAN_AP. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 4 hits.
    PROSITEi PS00021. KRINGLE_1. 4 hits.
    PS50070. KRINGLE_2. 4 hits.
    PS50948. PAN. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.

    Entry informationi

    Entry nameiQ8C9G5_MOUSE
    AccessioniPrimary (citable) accession number: Q8C9G5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)