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Protein

Hepatocyte growth factor

Gene

Hgf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorUniRule annotation, Serine protease homologUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factorUniRule annotation
Alternative name(s):
Hepatopoietin-AUniRule annotation
Scatter factorUniRule annotation
Gene namesi
Name:HgfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96079. Hgf.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_500430736733 – 728Hepatocyte growth factorSequence analysisAdd BLAST696

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi212 ↔ 289PROSITE-ProRule annotation
Disulfide bondi233 ↔ 272PROSITE-ProRule annotation
Disulfide bondi261 ↔ 284PROSITE-ProRule annotation
Disulfide bondi327 ↔ 366PROSITE-ProRule annotation
Disulfide bondi355 ↔ 378PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ8C9G5.

Expressioni

Gene expression databases

GenevisibleiQ8C9G5. MM.

Interactioni

Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8C9G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 124AppleInterPro annotationAdd BLAST87
Domaini128 – 207KringleInterPro annotationAdd BLAST80
Domaini211 – 289KringleInterPro annotationAdd BLAST79
Domaini305 – 384KringleInterPro annotationAdd BLAST80
Domaini391 – 470KringleInterPro annotationAdd BLAST80
Domaini496 – 724Peptidase S1InterPro annotationAdd BLAST229

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
HOVERGENiHBG004381.
KOiK05460.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR027284. Hepatocyte_GF.
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
PfamiView protein in Pfam
PF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF500183. Hepatocyte_GF. 1 hit.
PIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiView protein in PROSITE
PS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8C9G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT
60 70 80 90 100
LTKEDPLLKI KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY
110 120 130 140 150
PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC
160 170 180 190 200
QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE
210 220 230 240 250
VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER
260 270 280 290 300
YPDKGFDDNY CRNPDGKPRP WCYTLDPDTT WEYCAIKTCA HSAVNETDVP
310 320 330 340 350
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL
360 370 380 390 400
RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY
410 420 430 440 450
MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLNKNY CRNPDDDAHG
460 470 480 490 500
PWCYTGNPLI PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLRVVNGI
510 520 530 540 550
PTQTTVGWMV SLKYRNKHIC GGSLIKESWV ITARQCFPAR NKDLKDYEAW
560 570 580 590 600
LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI
610 620 630 640 650
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ
660 670 680 690 700
GKVTLNESEL CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC
710 720
AIPNRPVIFV RVAYYAKWIH KVILTYKL
Length:728
Mass (Da):82,991
Last modified:March 1, 2003 - v1
Checksum:i8D5258DF3BCF3545
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042121 mRNA. Translation: BAC31175.1.
RefSeqiNP_001276387.1. NM_001289458.1.
NP_001276388.1. NM_001289459.1.
NP_034557.3. NM_010427.5.
UniGeneiMm.267078.

Genome annotation databases

GeneIDi15234.
KEGGimmu:15234.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ8C9G5_MOUSE
AccessioniPrimary (citable) accession number: Q8C9G5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 5, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation