Q8C9B9 (DIDO1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Death-inducer obliterator 1
Short name=DIO-1

Alternative name(s):
Death-associated transcription factor 1
Short name=DATF-1

Gene names

Name:	Dido1
Synonyms:	Datf1, Dio1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2256 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative transcription factor, weakly pro-apoptotic when overexpressed.
Subcellular location	Cytoplasm. Nucleus. Note: Translocates to the nucleus after pro-apoptotic stimuli.
Tissue specificity	Ubiquitous. Expressed at intermediate levels.
Induction	Up-regulated during apoptosis.
Sequence similarities	Contains 1 PHD-type zinc finger. Contains 1 TFIIS central domain.
Sequence caution	The sequence AAH44755.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC28053.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC97927.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from direct assay Ref.1. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Traceable author statement Ref.1. Source: MGI nucleoplasm Traceable author statement. Source: Reactome
Molecular function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8C9B9-1)

Also known as: Dido3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8C9B9-2)

Also known as: Dido1;

The sequence of this isoform differs from the canonical sequence as follows:
     529-614: SMKDDRRVED...LSGTSARQAG → CTYHPKAGFP...AISYFSFRPW
     615-2256: Missing.

Isoform 3 (identifier: Q8C9B9-3)

Also known as: Dido2;

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1183: LESPRPN → KHPVSGR
     1184-2256: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2256

2256

Death-inducer obliterator 1

PRO_0000059325

Regions

Domain

667 – 787

121

TFIIS central

Zinc finger

265 – 319

55

PHD-type

Motif

162 – 170

9

Nuclear localization signal Potential

Motif

182 – 190

9

Nuclear localization signal Potential

Amino acid modifications

Modified residue

1

1

N-acetylmethionine By similarity

Modified residue

8

1

Phosphoserine Ref.9

Modified residue

148

1

Phosphothreonine Ref.9

Modified residue

149

1

Phosphoserine By similarity

Modified residue

151

1

Phosphoserine By similarity

Modified residue

522

1

Phosphoserine By similarity

Modified residue

647

1

Phosphoserine By similarity

Modified residue

674

1

Phosphoserine By similarity

Modified residue

802

1

Phosphoserine Ref.8 Ref.9

Modified residue

806

1

Phosphoserine By similarity

Modified residue

1016

1

Phosphoserine By similarity

Modified residue

1027

1

Phosphoserine By similarity

Modified residue

1035

1

Phosphoserine By similarity

Modified residue

1243

1

Phosphoserine By similarity

Modified residue

1256

1

Phosphoserine Ref.9

Modified residue

1305

1

Phosphothreonine By similarity

Modified residue

1307

1

Phosphoserine By similarity

Modified residue

1463

1

Phosphoserine By similarity

Modified residue

1726

1

Phosphoserine By similarity

Natural variations

Alternative sequence

529 – 614

86

SMKDD…ARQAG → CTYHPKAGFPGPSHHLGGCL GLSRTRVLGVLVLIVASSSL PARSRYQDASGPQVFLPSLW SLSGWFLKSCVGLMLEAISY FSFRPW in isoform 2.

VSP_012363

Alternative sequence

615 – 2256

1642

Missing in isoform 2.

VSP_012364

Alternative sequence

1177 – 1183

7

LESPRPN → KHPVSGR in isoform 3.

VSP_026606

Alternative sequence

1184 – 2256

1073

Missing in isoform 3.

VSP_026607

Experimental info

Sequence conflict

45

1

V → A in CAB48401. Ref.1

Sequence conflict

331

1

D → N in CAB48401. Ref.1

Sequence conflict

353

1

V → I in BAC31270. Ref.4

Sequence conflict

436

1

P → K in AAH29110. Ref.6

Sequence conflict

688

1

D → Y in AAR84049. Ref.2

Sequence conflict

688

1

D → Y in AAR84050. Ref.2

Sequence conflict

718

1

Y → F in AAR84049. Ref.2

Sequence conflict

718

1

Y → F in AAR84050. Ref.2

Sequence conflict

1739

1

P → L in AAR84050. Ref.2

Sequence conflict

2046

1

Q → H in AAR84050. Ref.2

Sequence conflict

2049

1

K → T in AAR84050. Ref.2

Sequence conflict

2054

1

E → K in AAR84050. Ref.2

Sequence conflict

2058

1

A → P in AAR84050. Ref.2

Sequence conflict

2118

1

Q → L in BAC28053. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

2256

Helix Strand Turn

Details...

Beta strand

279 – 281

3

Beta strand

283 – 285

3

Beta strand

288 – 290

3

Helix

291 – 294

4

Helix

298 – 307

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Dido3) [UniParc]. Last modified July 10, 2007. Version 4. Checksum: CB4F6F6D3FE53747	FASTA	2,256	247,176
	10 20 30 40 50 60 MDDKGHLSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDTEVDPSEQ QPQQHNLSLR 70 80 90 100 110 120 RSGRQPKRTE RVEEFLTTVR RRGKKNVPVS LEDSSEPTSS TVTDVETASE GSVESSSEIR 130 140 150 160 170 180 SGPVSDSLGK EHPASSEKAK GGEEEEDTSD SDSDGLTLKE LQNRLRRKRE QEPVERSLRG 190 200 210 220 230 240 SQNRLRKKRR EEDSAETGSV QIGSAEQDRP LCKQEPEASQ GPVSQSETDD IENQLEGKAT 250 260 270 280 290 300 QGNTEENPRE AGKPKPECEV YDPNALYCIC RQPHNNRFMI CCDRCEEWFH GDCVGISEAR 310 320 330 340 350 360 GRLLERNGED YICPNCTILQ VQDETNGSAT DEQDSGCRSV GADGTDCTSI GTVEQKSGED 370 380 390 400 410 420 QGIKGRIEKA ANPSGKKKLK IFQPVVEAPG APKCIGPGCS SVAQPDSVYC SNDCILKHAA 430 440 450 460 470 480 ATMRFLSSGK EQKTKPKEKV KTKPEKFSLP KCSVQVGIKI SSVHKRLASE KRENPVKKVM 490 500 510 520 530 540 LASRSETSGK EAACESSTPS WASDHNYNAV KPEKPEKPTA LSPTLLSKSM KDDRRVEDRT 550 560 570 580 590 600 MAAVTIPKKA LPSASLVGRQ TSPRNLVPKK LPPYSNMAGA KPAIKKLPSG FKGTIPKRPW 610 620 630 640 650 660 PSATLSGTSA RQAGPTPMTA ASKKLPGSAA VVGVTRKPMS ANVPAASPAP GRLGPVSPAP 670 680 690 700 710 720 SQPNSQIRQN IRRSLKEILW KRVNDSDDLI MTENEVGKIA LHIEKEMFNL FQVTDNRYKS 730 740 750 760 770 780 KYRSIMFNLK DPKNQGLFHR VLREEISLAK LVRMKPEELV SKELSMWTEK PTKSVIESRT 790 800 810 820 830 840 KLLNESKKNT TKPETIPDME DSPPVSDSEE QQESVRAAPE KSAAPLLDVF SSMLKDTTSQ 850 860 870 880 890 900 HRAHLFDLNC KICTGQVPSS EDEPAPKKQK LSASSKKEDF KPRHDSSPPN AVPNTADEGI 910 920 930 940 950 960 ADTLPENASE PDPESTSSLN QERKCFPESP GDSHPEPSSL GGLSPSSASG GSGVVTTVTM 970 980 990 1000 1010 1020 SGRDPRTALS GSCTVTASMA AHLDNSQASE TKLDMIKPAL TSAVVPKSIL AKPSSSPDPR 1030 1040 1050 1060 1070 1080 YLSVPPSPSI SESRSPPEGD TTLFLSRLNT IWKGFINMQS VAKFVTKAYP VSGCLDYLSE 1090 1100 1110 1120 1130 1140 DLPDTIHIGG RIAPKTVWDY VGKLKSSVSK ELCLIRFHPA TEEEEVAYIS LYSYFSSRGR 1150 1160 1170 1180 1190 1200 FGVVANNNRH VKDLYLIPLS AKDPVPSKLL PFEGPGLESP RPNIILGLVI CQKVKRPSSA 1210 1220 1230 1240 1250 1260 GELDKTDEKR TRLQQEELET SVYPKVTAAL PSEKKPPKYS VHSIDTAATS TTPPGSPPPP 1270 1280 1290 1300 1310 1320 PPLPEPPVLK ILSSLKPGST STVTAPTTAA ITTTASPVTA ATSKTASPLE HILQTLFGKK 1330 1340 1350 1360 1370 1380 KSFEPSGKES VGSTLSPHQD SKAKGEDTMS AAPLLDPIVQ QFGQFSKDKA LEEEEEDDRP 1390 1400 1410 1420 1430 1440 YDPEEEYNPD RAFHTLLAEP GRPHDVQSVS ETAEREEVAY DPEDETILEE AKVTIDDLPN 1450 1460 1470 1480 1490 1500 RMCMKVSATE RPADFTTDAS SASLVEQQKM LEELNKQIEE QKRQLEEQEE ALRQQRAAVG 1510 1520 1530 1540 1550 1560 VSMAHFSVSD ALMSPPPKSS LGKTELFSQE QQAPDPSQGA PNTNHNLDSR QSRDPRQARR 1570 1580 1590 1600 1610 1620 LAAENTENES LPRAPTGSTP GPQGTLPARE TPAGTAVVQG PGLAAEAKES MAVPWAPGEN 1630 1640 1650 1660 1670 1680 AVLRPEHDIQ KCEHPGNPVS LPLDTSHLPT AGDGAARPAP PRRVLLPTPP STTFPPSFPL 1690 1700 1710 1720 1730 1740 QPKAQNFSSG SREPFSGPTF MSQETSLGSS QYEDPRGAQS AGKNDSPVAD MEDSREPQPR 1750 1760 1770 1780 1790 1800 PGESTTSFPQ PGQRGGGPQP QFPGQREPAP RTFGMSGHHG PSFPGPRGPV PPYSEENLVP 1810 1820 1830 1840 1850 1860 NSDGPRGPPP ARFGAQKPPI PSLFSGQHGP PPYGDNRGLS PSYLGGPRGG APAQFEDRKD 1870 1880 1890 1900 1910 1920 PHGEKREFQD TPYNEMTGAP AQCEGPDQAQ FMGNRAPFQF GGQRRPLLTQ MKGPRGGPPP 1930 1940 1950 1960 1970 1980 SQFGAQRGPP PGHFVGPRGP HPSQFENSRG THPGQFEGAR GQAPGFMPGP RGIQPQQFEE 1990 2000 2010 2020 2030 2040 QRVNSPPRFA GQRASAPLPY GGPRGPAPFP EKNEQPPSRF HFQGPSSQPV KPPPRPLLEL 2050 2060 2070 2080 2090 2100 PSHPPQHRKD RWDEAGPATA LPSSAGPGQG HEADGQWATS EFREGKGHEY RSPAFEGRQR 2110 2120 2130 2140 2150 2160 ERFEAGSKEK PLDEPEAQGL ESRQGRAFED RRRERERGRN WSRERDWERS RDWDRHREWD 2170 2180 2190 2200 2210 2220 KGRDRSSNRD RERDNDRAKE WDRSRERSRN RDRDRERRRD RDRSRSRDRD RDRERARDRD 2230 2240 2250 RDRGRDRKDR SKSRESPRDQ KPEARTSEGG PAAAQA
	Isoform 2 (Dido1) [UniParc]. Checksum: 15A20A74BAEBC9E9	FASTA	614	67,395
	10 20 30 40 50 60 MDDKGHLSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDTEVDPSEQ QPQQHNLSLR 70 80 90 100 110 120 RSGRQPKRTE RVEEFLTTVR RRGKKNVPVS LEDSSEPTSS TVTDVETASE GSVESSSEIR 130 140 150 160 170 180 SGPVSDSLGK EHPASSEKAK GGEEEEDTSD SDSDGLTLKE LQNRLRRKRE QEPVERSLRG 190 200 210 220 230 240 SQNRLRKKRR EEDSAETGSV QIGSAEQDRP LCKQEPEASQ GPVSQSETDD IENQLEGKAT 250 260 270 280 290 300 QGNTEENPRE AGKPKPECEV YDPNALYCIC RQPHNNRFMI CCDRCEEWFH GDCVGISEAR 310 320 330 340 350 360 GRLLERNGED YICPNCTILQ VQDETNGSAT DEQDSGCRSV GADGTDCTSI GTVEQKSGED 370 380 390 400 410 420 QGIKGRIEKA ANPSGKKKLK IFQPVVEAPG APKCIGPGCS SVAQPDSVYC SNDCILKHAA 430 440 450 460 470 480 ATMRFLSSGK EQKTKPKEKV KTKPEKFSLP KCSVQVGIKI SSVHKRLASE KRENPVKKVM 490 500 510 520 530 540 LASRSETSGK EAACESSTPS WASDHNYNAV KPEKPEKPTA LSPTLLSKCT YHPKAGFPGP 550 560 570 580 590 600 SHHLGGCLGL SRTRVLGVLV LIVASSSLPA RSRYQDASGP QVFLPSLWSL SGWFLKSCVG 610 LMLEAISYFS FRPW
	Isoform 3 (Dido2) [UniParc]. Checksum: 5D808FD9C763F72D	FASTA	1,183	129,171
	10 20 30 40 50 60 MDDKGHLSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDTEVDPSEQ QPQQHNLSLR 70 80 90 100 110 120 RSGRQPKRTE RVEEFLTTVR RRGKKNVPVS LEDSSEPTSS TVTDVETASE GSVESSSEIR 130 140 150 160 170 180 SGPVSDSLGK EHPASSEKAK GGEEEEDTSD SDSDGLTLKE LQNRLRRKRE QEPVERSLRG 190 200 210 220 230 240 SQNRLRKKRR EEDSAETGSV QIGSAEQDRP LCKQEPEASQ GPVSQSETDD IENQLEGKAT 250 260 270 280 290 300 QGNTEENPRE AGKPKPECEV YDPNALYCIC RQPHNNRFMI CCDRCEEWFH GDCVGISEAR 310 320 330 340 350 360 GRLLERNGED YICPNCTILQ VQDETNGSAT DEQDSGCRSV GADGTDCTSI GTVEQKSGED 370 380 390 400 410 420 QGIKGRIEKA ANPSGKKKLK IFQPVVEAPG APKCIGPGCS SVAQPDSVYC SNDCILKHAA 430 440 450 460 470 480 ATMRFLSSGK EQKTKPKEKV KTKPEKFSLP KCSVQVGIKI SSVHKRLASE KRENPVKKVM 490 500 510 520 530 540 LASRSETSGK EAACESSTPS WASDHNYNAV KPEKPEKPTA LSPTLLSKSM KDDRRVEDRT 550 560 570 580 590 600 MAAVTIPKKA LPSASLVGRQ TSPRNLVPKK LPPYSNMAGA KPAIKKLPSG FKGTIPKRPW 610 620 630 640 650 660 PSATLSGTSA RQAGPTPMTA ASKKLPGSAA VVGVTRKPMS ANVPAASPAP GRLGPVSPAP 670 680 690 700 710 720 SQPNSQIRQN IRRSLKEILW KRVNDSDDLI MTENEVGKIA LHIEKEMFNL FQVTDNRYKS 730 740 750 760 770 780 KYRSIMFNLK DPKNQGLFHR VLREEISLAK LVRMKPEELV SKELSMWTEK PTKSVIESRT 790 800 810 820 830 840 KLLNESKKNT TKPETIPDME DSPPVSDSEE QQESVRAAPE KSAAPLLDVF SSMLKDTTSQ 850 860 870 880 890 900 HRAHLFDLNC KICTGQVPSS EDEPAPKKQK LSASSKKEDF KPRHDSSPPN AVPNTADEGI 910 920 930 940 950 960 ADTLPENASE PDPESTSSLN QERKCFPESP GDSHPEPSSL GGLSPSSASG GSGVVTTVTM 970 980 990 1000 1010 1020 SGRDPRTALS GSCTVTASMA AHLDNSQASE TKLDMIKPAL TSAVVPKSIL AKPSSSPDPR 1030 1040 1050 1060 1070 1080 YLSVPPSPSI SESRSPPEGD TTLFLSRLNT IWKGFINMQS VAKFVTKAYP VSGCLDYLSE 1090 1100 1110 1120 1130 1140 DLPDTIHIGG RIAPKTVWDY VGKLKSSVSK ELCLIRFHPA TEEEEVAYIS LYSYFSSRGR 1150 1160 1170 1180 FGVVANNNRH VKDLYLIPLS AKDPVPSKLL PFEGPGKHPV SGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DIO-1 is a novel gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development." Garcia-Domingo D., Leonardo E., Grandien A., Martinez P., Albar J.P., Izpisua-Belmonte J.-C., Martinez-A C. Proc. Natl. Acad. Sci. U.S.A. 96:7992-7997(1999) [PubMed: 10393935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION. Tissue: Pre-B cell.
[2]	"Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms." Futterer A., Campanero M.R., Leonardo E., Criado L.M., Flores J.M., Hernandez J.M., San Miguel J.F., Martinez-A C. J. Clin. Invest. 115:2351-2362(2005) [PubMed: 16127461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed: 14621295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1484-2256 (ISOFORM 1). Strain: C57BL/6J. Tissue: Embryo, Thymus and Wolffian duct.
[5]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: C57BL/6J and FVB/N. Tissue: Brain, Mammary gland and Mammary tumor.
[7]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 540-548 AND 699-705, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[8]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-802, MASS SPECTROMETRY. Tissue: Liver.
[9]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 19367708] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8; THR-148; SER-802 AND SER-1256, MASS SPECTROMETRY. Tissue: Melanoma.
[10]	"Solution structure of PHD domain in death inducer-obliterator 1(DIO-1)." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 257-319.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ238332 mRNA. Translation: CAB48401.1.
AY425951 mRNA. Translation: AAR84049.1.
AY425952 mRNA. Translation: AAR84050.1.
AK129117 mRNA. Translation: BAC97927.1. Different initiation.
AK032843 mRNA. Translation: BAC28053.1. Different initiation.
AK042474 mRNA. Translation: BAC31270.1.
AK044919 mRNA. Translation: BAC32141.1.
AL732560 Genomic DNA. Translation: CAM27684.1.
AL732560 Genomic DNA. Translation: CAM27685.1.
AL732560 Genomic DNA. Translation: CAM27686.1.
AL732560 Genomic DNA. Translation: CAM27687.1.
BC029110 mRNA. Translation: AAH29110.1.
BC044755 mRNA. Translation: AAH44755.1. Different initiation.
BC096662 mRNA. Translation: AAH96662.1.
BC138712 mRNA. Translation: AAI38713.1.
BC138713 mRNA. Translation: AAI38714.1.

IPI

IPI00227469.
IPI00453851.
IPI00828403.

RefSeq

NP_035935.2. NM_011805.2.
NP_780760.2. NM_175551.3.
NP_808520.2. NM_177852.3.

UniGene

Mm.253836.
Mm.485484.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WEM	NMR	-	A	257-319	[»]

ProteinModelPortal

Q8C9B9.

SMR

Q8C9B9. Positions 257-319, 665-771.

ModBase

Search...

Protein-protein interaction databases

STRING

Q8C9B9.

PTM databases

PhosphoSite

Q8C9B9.

Proteomic databases

PRIDE

Q8C9B9.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000037764; ENSMUSP00000048315; ENSMUSG00000038914.
ENSMUST00000087517; ENSMUSP00000084794; ENSMUSG00000038914.
ENSMUST00000103055; ENSMUSP00000099344; ENSMUSG00000038914.
ENSMUST00000103056; ENSMUSP00000099345; ENSMUSG00000038914.
ENSMUST00000103057; ENSMUSP00000099346; ENSMUSG00000038914.
ENSMUST00000130986; ENSMUSP00000119689; ENSMUSG00000038914.

GeneID

23856.

KEGG

mmu:23856.

UCSC

uc008ojq.1. mouse.
uc008ojr.1. mouse.
uc008oju.1. mouse.

Organism-specific databases

CTD

11083.

MGI

MGI:1344352. Dido1.

Phylogenomic databases

eggNOG

roNOG06980.

GeneTree

ENSGT00530000063844.

HOVERGEN

HBG060199.

InParanoid

Q8C9B9.

OMA

PPGHFVG.

Enzyme and pathway databases

Reactome

REACT_75800. Meiotic Synapsis (mouse).

Gene expression databases

ArrayExpress

Q8C9B9.

Bgee

Q8C9B9.

CleanEx

MM_DIDO1.
MM_DIO1.

Genevestigator

Q8C9B9.

Family and domain databases

InterPro

IPR012921. SPOC_C.
IPR003618. TFIIS_cen_dom.
IPR017890. TFS2M.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Gene3D

G3DSA:1.10.472.30. TFIIS_centre. 1 hit.
G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.

Pfam

PF00628. PHD. 1 hit.
PF07744. SPOC. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]

SMART

SM00249. PHD. 1 hit.
SM00510. TFS2M. 1 hit.
[Graphical view]

SUPFAM

SSF57903. FYVE_PHD_ZnF. 1 hit.
SSF46942. TFIIS_centre. 1 hit.

PROSITE

PS51321. TFIIS_CENTRAL. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

303557.

SOURCE

Search...

Entry information

Entry name

DIDO1_MOUSE

Accession

Primary (citable) accession number: Q8C9B9
Secondary accession number(s): A2AJ47 , A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8CHR5, Q9WV00

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	July 10, 2007
Last modified:	November 16, 2011
This is version 96 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program