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Protein

Zinc finger protein ZXDC

Gene

Zxdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri209 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri239 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri329 – 353C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri359 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri389 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri419 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri452 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZXDC
Gene namesi
Name:Zxdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1933108. Zxdc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002928041 – 858Zinc finger protein ZXDCAdd BLAST858

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki661Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylated at Lys-661 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8C8V1.
PRIDEiQ8C8V1.

PTM databases

PhosphoSitePlusiQ8C8V1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034430.
CleanExiMM_ZXDC.
ExpressionAtlasiQ8C8V1. baseline and differential.
GenevisibleiQ8C8V1. MM.

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDB and CIITA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074619.

Structurei

3D structure databases

ProteinModelPortaliQ8C8V1.
SMRiQ8C8V1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZXD family.Curated
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri209 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri239 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri329 – 353C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri359 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri389 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri419 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri452 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123023.
HOVERGENiHBG002277.
InParanoidiQ8C8V1.
OMAiTKPFACP.
OrthoDBiEOG091G037W.
PhylomeDBiQ8C8V1.
TreeFamiTF330996.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C8V1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLPAVLAAP ATRGDQHGGG PSRLRRGAGP SLGAGPGRRR LLLLRGPEDG
60 70 80 90 100
GPGPRPEEAP GPSPPPPEDG GDSFVVLLEV PRAADTHGQE EAEPDSGASP
110 120 130 140 150
TEQVPAAAPG AALAGTVTIH NQDLLVRFDR GVFTLAAAPA PAAPSLHPAT
160 170 180 190 200
TPGLEPSSAA ASRRGPVAAS AGSPAYRCPE PQCALSFAKK HQLKVHLLTH
210 220 230 240 250
GSLQGRRPFK CPLDGCGWAF TTSYKLKRHL QSHDKLRPFS CPVGGCGKKF
260 270 280 290 300
TTVYNLKAHM KGHEQESLFK CEVCAERFPT HAKLNSHQRS HFEPERPYKC
310 320 330 340 350
DFPGCEKTFI TVSALFSHNR AHFREQELFS CSFPGCNKQY DKACRLKIHL
360 370 380 390 400
RSHTGERPFI CDSDSCGWTF TSMSKLLRHK RKHDDDRRFT CPVEGCGKSF
410 420 430 440 450
TRAEHLKGHS ITHLGTKPFE CPVEGCCARF SARSSLYIHS KKHLQDVGTP
460 470 480 490 500
KSRCPVSSCN RLFTSKHSMK AHVVRQHSRR QDLVPQLEAP SSLTPSSELS
510 520 530 540 550
SPGQSELTNI DLAALFSDTP ANSSSSTAGS DEALNSGILT IDVTSVSSSL
560 570 580 590 600
GGNLPTNNNS LGPMDPLVLV AHGDMPPSLD SPLVLGTSAT VLQPGSFSAD
610 620 630 640 650
DSQAMSTGAV GCLVALPVRN LNQDSPALTP SNNLTAPGTT PTSSDTTQET
660 670 680 690 700
GSVPDLLVPI KVEQDLSPVP DVVQGQKESH GPSQSVLSSS TERPGAQKDS
710 720 730 740 750
ELSAGTGSLY LESGGSARTD YRAIQLVKKK KQKGTGSDEG ASDSAHRKVK
760 770 780 790 800
GGTINPPHVH SGQHSCFCGT LMVPSGGLTV PAPAAGLQCV QIPVLQDDPS
810 820 830 840 850
GEGGLPLGLS PQRSAFHPYF TVDLPVYVLQ EVLPAPGGFA GLETAQVPGS

TINLRDLE
Length:858
Mass (Da):90,755
Last modified:March 1, 2003 - v1
Checksum:iA7B31AFE64907C3B
GO
Isoform 2 (identifier: Q8C8V1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     712-712: E → V
     713-858: Missing.

Show »
Length:712
Mass (Da):75,647
Checksum:i4AE84A5E999223C5
GO
Isoform 3 (identifier: Q8C8V1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-512: SELTNIDL → RKWGLSKN
     513-858: Missing.

Note: No experimental confirmation available.
Show »
Length:512
Mass (Da):55,723
Checksum:i9197279E9EA609A7
GO
Isoform 4 (identifier: Q8C8V1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-363: ERPFICDS → MSCSVHLM
     364-858: Missing.

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):38,909
Checksum:i3C55853A64055511
GO

Sequence cautioni

The sequence AAH03332 differs from that shown. Reason: Frameshift at position 672.Curated
The sequence BAC31967 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC33082 differs from that shown. Reason: Frameshift at position 108.Curated
The sequence BAC38113 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154L → Q in BAE24766 (PubMed:16141072).Curated1
Sequence conflicti576P → R in BAC38113 (PubMed:16141072).Curated1
Sequence conflicti608G → V in BAC37873 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026439356 – 363ERPFICDS → MSCSVHLM in isoform 4. 1 Publication8
Alternative sequenceiVSP_026440364 – 858Missing in isoform 4. 1 PublicationAdd BLAST495
Alternative sequenceiVSP_026441505 – 512SELTNIDL → RKWGLSKN in isoform 3. 1 Publication8
Alternative sequenceiVSP_026442513 – 858Missing in isoform 3. 1 PublicationAdd BLAST346
Alternative sequenceiVSP_026443712E → V in isoform 2. 2 Publications1
Alternative sequenceiVSP_026444713 – 858Missing in isoform 2. 2 PublicationsAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044429 mRNA. Translation: BAC31914.1.
AK044529 mRNA. Translation: BAC31967.1. Different initiation.
AK047538 mRNA. Translation: BAC33082.1. Frameshift.
AK080307 mRNA. Translation: BAC37873.1.
AK081005 mRNA. Translation: BAC38113.1. Different initiation.
AK141613 mRNA. Translation: BAE24766.1.
AK169517 mRNA. Translation: BAE41206.1.
BC003332 mRNA. Translation: AAH03332.1. Frameshift.
CCDSiCCDS20358.1. [Q8C8V1-1]
CCDS51848.1. [Q8C8V1-2]
RefSeqiNP_084536.2. NM_030260.3. [Q8C8V1-2]
NP_766590.1. NM_173002.3. [Q8C8V1-1]
UniGeneiMm.100116.
Mm.473652.

Genome annotation databases

EnsembliENSMUST00000045740; ENSMUSP00000036329; ENSMUSG00000034430. [Q8C8V1-3]
ENSMUST00000075117; ENSMUSP00000074619; ENSMUSG00000034430. [Q8C8V1-1]
ENSMUST00000113539; ENSMUSP00000109167; ENSMUSG00000034430. [Q8C8V1-2]
GeneIDi80292.
KEGGimmu:80292.
UCSCiuc009cxf.2. mouse. [Q8C8V1-1]
uc012eoy.1. mouse. [Q8C8V1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044429 mRNA. Translation: BAC31914.1.
AK044529 mRNA. Translation: BAC31967.1. Different initiation.
AK047538 mRNA. Translation: BAC33082.1. Frameshift.
AK080307 mRNA. Translation: BAC37873.1.
AK081005 mRNA. Translation: BAC38113.1. Different initiation.
AK141613 mRNA. Translation: BAE24766.1.
AK169517 mRNA. Translation: BAE41206.1.
BC003332 mRNA. Translation: AAH03332.1. Frameshift.
CCDSiCCDS20358.1. [Q8C8V1-1]
CCDS51848.1. [Q8C8V1-2]
RefSeqiNP_084536.2. NM_030260.3. [Q8C8V1-2]
NP_766590.1. NM_173002.3. [Q8C8V1-1]
UniGeneiMm.100116.
Mm.473652.

3D structure databases

ProteinModelPortaliQ8C8V1.
SMRiQ8C8V1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074619.

PTM databases

PhosphoSitePlusiQ8C8V1.

Proteomic databases

PaxDbiQ8C8V1.
PRIDEiQ8C8V1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045740; ENSMUSP00000036329; ENSMUSG00000034430. [Q8C8V1-3]
ENSMUST00000075117; ENSMUSP00000074619; ENSMUSG00000034430. [Q8C8V1-1]
ENSMUST00000113539; ENSMUSP00000109167; ENSMUSG00000034430. [Q8C8V1-2]
GeneIDi80292.
KEGGimmu:80292.
UCSCiuc009cxf.2. mouse. [Q8C8V1-1]
uc012eoy.1. mouse. [Q8C8V1-2]

Organism-specific databases

CTDi79364.
MGIiMGI:1933108. Zxdc.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123023.
HOVERGENiHBG002277.
InParanoidiQ8C8V1.
OMAiTKPFACP.
OrthoDBiEOG091G037W.
PhylomeDBiQ8C8V1.
TreeFamiTF330996.

Miscellaneous databases

PROiQ8C8V1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034430.
CleanExiMM_ZXDC.
ExpressionAtlasiQ8C8V1. baseline and differential.
GenevisibleiQ8C8V1. MM.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZXDC_MOUSE
AccessioniPrimary (citable) accession number: Q8C8V1
Secondary accession number(s): Q3TEP2
, Q3URC2, Q8C4U7, Q8C4Z9, Q8C8C2, Q8C8T1, Q99J65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.