Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Liprin-beta-1

Gene

Ppfibp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-beta-1
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1
Short name:
PTPRF-interacting protein-binding protein 1
Gene namesi
Name:Ppfibp1
Synonyms:Kiaa1230
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914783. Ppfibp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910351 – 969Liprin-beta-1Add BLAST969

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineBy similarity1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei40PhosphoserineCombined sources1
Modified residuei291N6-acetyllysineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei435PhosphoserineBy similarity1
Modified residuei500PhosphoserineBy similarity1
Modified residuei538PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei757PhosphoserineCombined sources1
Modified residuei957PhosphoserineBy similarity1
Modified residuei959PhosphoserineBy similarity1
Modified residuei961PhosphoserineCombined sources1
Modified residuei963PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8C8U0.
PaxDbiQ8C8U0.
PeptideAtlasiQ8C8U0.
PRIDEiQ8C8U0.

PTM databases

iPTMnetiQ8C8U0.
PhosphoSitePlusiQ8C8U0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016487.
ExpressionAtlasiQ8C8U0. baseline and differential.
GenevisibleiQ8C8U0. MM.

Interactioni

Subunit structurei

Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8C8U0. 2 interactors.
MINTiMINT-4100442.
STRINGi10090.ENSMUSP00000107250.

Structurei

Secondary structure

1969
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi603 – 605Combined sources3
Helixi608 – 617Combined sources10
Turni618 – 620Combined sources3
Helixi624 – 627Combined sources4
Turni628 – 630Combined sources3
Helixi635 – 639Combined sources5
Helixi642 – 648Combined sources7
Helixi654 – 669Combined sources16
Helixi675 – 677Combined sources3
Helixi680 – 690Combined sources11
Helixi693 – 695Combined sources3
Helixi696 – 702Combined sources7
Helixi706 – 710Combined sources5
Helixi714 – 719Combined sources6
Helixi725 – 740Combined sources16
Turni741 – 743Combined sources3
Beta strandi747 – 749Combined sources3
Helixi755 – 757Combined sources3
Helixi760 – 765Combined sources6
Helixi768 – 777Combined sources10
Turni781 – 783Combined sources3
Helixi784 – 787Combined sources4
Helixi794 – 799Combined sources6
Helixi805 – 811Combined sources7
Helixi819 – 833Combined sources15
Helixi835 – 844Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TADX-ray2.90C/D593-853[»]
ProteinModelPortaliQ8C8U0.
SMRiQ8C8U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini606 – 670SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini678 – 741SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini763 – 835SAM 3PROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili99 – 310Sequence analysisAdd BLAST212

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4 (By similarity).By similarity

Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated
Contains 3 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1899. Eukaryota.
ENOG410XSFF. LUCA.
GeneTreeiENSGT00760000119138.
HOGENOMiHOG000082535.
HOVERGENiHBG052331.
InParanoidiQ8C8U0.
OMAiVPEEFHT.
OrthoDBiEOG091G01OJ.
PhylomeDBiQ8C8U0.
TreeFamiTF314207.

Family and domain databases

Gene3Di1.10.150.50. 3 hits.
InterProiIPR029515. Liprin.
IPR030437. PPFIBP1.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR12587. PTHR12587. 1 hit.
PTHR12587:SF16. PTHR12587:SF16. 1 hit.
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiPS50105. SAM_DOMAIN. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8C8U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH
60 70 80 90 100
LVEDLRGLLE MMETDEKEGL RCQIPDSTAE VLIEWLQNQM TNGHLPGNGD
110 120 130 140 150
VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKLNA
160 170 180 190 200
TEEMLQQELL SRTSLETQKL ELMAEISNLK LKLTAVEKDR LDYEDRFRDT
210 220 230 240 250
EGLIQEINDL RLKVNEMDGE RLQYEKKLKS TKDELASLKE QLEEKECEVK
260 270 280 290 300
RLQERLVCKA KGEGIEVLDR DIEVQKMKKA VESLMAANEE KERKIEDLRQ
310 320 330 340 350
CLSRYRKMQD PAVLAQGQDS ECEGLFHSSS ISTLLDAQGF SDLERSTSST
360 370 380 390 400
PGMGSPSRDL LHTSAPEEFH TSVLQASIPS LLPPSVDVDT CEKPKLPTKP
410 420 430 440 450
ETSFEEGDGR AILGAAAEVS LSDGVSTSSL QKSSSLGNLK KEASDGTDKA
460 470 480 490 500
PTDSRTFGTL PPKVPGHEAS VDDNPFGTRK ARSSFGRGFF KIKSGKRTAS
510 520 530 540 550
APNLAETEKE TAEHLNLAGT SRSKGSQGTS PFPMSPPSPD SRKKSRGIMR
560 570 580 590 600
LFGKLRRSQS TTFNPDDMSE PEFKRGGTRA TAGPRLGWSR DLGQSNSDLD
610 620 630 640 650
MPFAKWTKEQ VCSWLAEQGL GSYLSSGKHW IISGQTLLQA SQQDLEKELG
660 670 680 690 700
IKHSLHRKKL QLALQALGSE EETNYGKLDF NWVTRWLDDI GLPQYKTQFD
710 720 730 740 750
EGRVDGRMLH YMTVDDLLSL KVVSVLHHLS IKRAIQVLRI NNFEPNCLRR
760 770 780 790 800
RPSDENSITP SEVQQWTNHR VMEWLRSVDL AEYAPNLRGS GVHGGLMVLE
810 820 830 840 850
PRFNVETMAQ LLNIPPNKTL LRRHLATHFN LLIGAEAQHQ KRDAMELPDY
860 870 880 890 900
VLLTATAKVK PKKLTFSNFG NLRKKKHEDG EEYVCPMELG QASGSSQKGF
910 920 930 940 950
RPGLDMRLYE EDDLDRLEQM EDSEGTVRQI GAFSEGINNL THMLKEDDMF
960
KDFAARSPSA SITDEDSNV
Note: No experimental confirmation available.
Length:969
Mass (Da):108,540
Last modified:December 7, 2004 - v3
Checksum:i7322E25285DDF499
GO
Isoform 2 (identifier: Q8C8U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.

Note: No experimental confirmation available.
Show »
Length:693
Mass (Da):76,921
Checksum:iDA531714968AEC25
GO
Isoform 3 (identifier: Q8C8U0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-271: D → DENIKKKLKEKN

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):109,894
Checksum:i867A8633F7167EAA
GO

Sequence cautioni

The sequence BAD32411 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti360L → P in BAD32411 (PubMed:15489334).Curated1
Sequence conflicti389D → E (PubMed:16141072).Curated1
Sequence conflicti389D → E (PubMed:15489334).Curated1
Sequence conflicti817 – 874NKTLL…GNLRK → CQQHLHLPLTVLFLYIFLNT CIYTVYRKQNLYFVTQGSKD HIKMKKPQYFNDHIPADS in BAC31950 (PubMed:16141072).CuratedAdd BLAST58
Sequence conflicti875 – 969Missing (PubMed:16141072).CuratedAdd BLAST95

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0120951 – 276Missing in isoform 2. 1 PublicationAdd BLAST276
Alternative sequenceiVSP_012096271D → DENIKKKLKEKN in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044496 mRNA. Translation: BAC31950.1.
AK014559 mRNA. Translation: BAB29428.1.
AK173133 mRNA. Translation: BAD32411.1. Different initiation.
BC049862 mRNA. Translation: AAH49862.1.
BC058176 mRNA. Translation: AAH58176.1.
BC072603 mRNA. Translation: AAH72603.1.
CCDSiCCDS39715.1. [Q8C8U0-1]
CCDS51958.1. [Q8C8U0-3]
RefSeqiNP_001163904.1. NM_001170433.1. [Q8C8U0-3]
NP_080497.1. NM_026221.2. [Q8C8U0-1]
XP_017177208.1. XM_017321719.1. [Q8C8U0-1]
UniGeneiMm.103382.

Genome annotation databases

EnsembliENSMUST00000016631; ENSMUSP00000016631; ENSMUSG00000016487. [Q8C8U0-1]
ENSMUST00000111623; ENSMUSP00000107250; ENSMUSG00000016487. [Q8C8U0-3]
GeneIDi67533.
KEGGimmu:67533.
UCSCiuc009esm.2. mouse. [Q8C8U0-1]
uc009esn.2. mouse. [Q8C8U0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044496 mRNA. Translation: BAC31950.1.
AK014559 mRNA. Translation: BAB29428.1.
AK173133 mRNA. Translation: BAD32411.1. Different initiation.
BC049862 mRNA. Translation: AAH49862.1.
BC058176 mRNA. Translation: AAH58176.1.
BC072603 mRNA. Translation: AAH72603.1.
CCDSiCCDS39715.1. [Q8C8U0-1]
CCDS51958.1. [Q8C8U0-3]
RefSeqiNP_001163904.1. NM_001170433.1. [Q8C8U0-3]
NP_080497.1. NM_026221.2. [Q8C8U0-1]
XP_017177208.1. XM_017321719.1. [Q8C8U0-1]
UniGeneiMm.103382.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TADX-ray2.90C/D593-853[»]
ProteinModelPortaliQ8C8U0.
SMRiQ8C8U0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C8U0. 2 interactors.
MINTiMINT-4100442.
STRINGi10090.ENSMUSP00000107250.

PTM databases

iPTMnetiQ8C8U0.
PhosphoSitePlusiQ8C8U0.

Proteomic databases

EPDiQ8C8U0.
PaxDbiQ8C8U0.
PeptideAtlasiQ8C8U0.
PRIDEiQ8C8U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016631; ENSMUSP00000016631; ENSMUSG00000016487. [Q8C8U0-1]
ENSMUST00000111623; ENSMUSP00000107250; ENSMUSG00000016487. [Q8C8U0-3]
GeneIDi67533.
KEGGimmu:67533.
UCSCiuc009esm.2. mouse. [Q8C8U0-1]
uc009esn.2. mouse. [Q8C8U0-3]

Organism-specific databases

CTDi8496.
MGIiMGI:1914783. Ppfibp1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1899. Eukaryota.
ENOG410XSFF. LUCA.
GeneTreeiENSGT00760000119138.
HOGENOMiHOG000082535.
HOVERGENiHBG052331.
InParanoidiQ8C8U0.
OMAiVPEEFHT.
OrthoDBiEOG091G01OJ.
PhylomeDBiQ8C8U0.
TreeFamiTF314207.

Miscellaneous databases

PROiQ8C8U0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016487.
ExpressionAtlasiQ8C8U0. baseline and differential.
GenevisibleiQ8C8U0. MM.

Family and domain databases

Gene3Di1.10.150.50. 3 hits.
InterProiIPR029515. Liprin.
IPR030437. PPFIBP1.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR12587. PTHR12587. 1 hit.
PTHR12587:SF16. PTHR12587:SF16. 1 hit.
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiPS50105. SAM_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPB1_MOUSE
AccessioniPrimary (citable) accession number: Q8C8U0
Secondary accession number(s): Q69ZN5
, Q6GQV3, Q80VB4, Q9CUT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.