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Protein

Protein ELFN1

Gene

Elfn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses. Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
  • synapse organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ELFN1
Alternative name(s):
Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1
Protein phosphatase 1 regulatory subunit 28
Gene namesi
Name:Elfn1
Synonyms:Ppp1r28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442479. Elfn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 418393ExtracellularSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Topological domaini440 – 828389CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • dendrite Source: UniProtKB
  • excitatory synapse Source: UniProtKB
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 828803Protein ELFN1PRO_0000343739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence analysis
Modified residuei460 – 4601PhosphoserineBy similarity
Modified residuei646 – 6461PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8C8T7.
PaxDbiQ8C8T7.
PRIDEiQ8C8T7.

PTM databases

iPTMnetiQ8C8T7.
PhosphoSiteiQ8C8T7.

Expressioni

Tissue specificityi

Selectively expressed in perialvear somatostatin (Sst)-containing interneurons.1 Publication

Gene expression databases

BgeeiENSMUSG00000048988.
GenevisibleiQ8C8T7. MM.

Interactioni

Subunit structurei

Interacts with PPP1CA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053869.

Structurei

3D structure databases

ProteinModelPortaliQ8C8T7.
SMRiQ8C8T7. Positions 54-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 8222LRR 1Add
BLAST
Repeati85 – 10622LRR 2Add
BLAST
Repeati109 – 13022LRR 3Add
BLAST
Repeati133 – 15422LRR 4Add
BLAST
Repeati157 – 17822LRR 5Add
BLAST
Domaini190 – 25364LRRCTAdd
BLAST
Domaini312 – 39988Fibronectin type-IIIAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi263 – 28826Pro-richAdd
BLAST
Compositional biasi709 – 72416Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.Curated
Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHCP. Eukaryota.
ENOG4110NB3. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000112354.
HOVERGENiHBG056941.
InParanoidiQ8C8T7.
KOiK17567.
OMAiYHNLSYS.
OrthoDBiEOG091G01RI.
PhylomeDBiQ8C8T7.
TreeFamiTF332887.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C8T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGHGWGTAW VLVAAATLLH AGGLAQGDCW LIEGDKGFVW LAICSQNQPP
60 70 80 90 100
YEAIPQQINN TIVDLRLNEN RIRSVQYASL SRFGNLTYLN LTKNEIGYIE
110 120 130 140 150
DGAFSGQFNL QVLQLGYNRL RNLTEGMLRG LSKLEYLYLQ ANLIEVVMAS
160 170 180 190 200
AFWECPNIVN IDLSMNRIQQ LGSGTFAGLT KLSVCEIYSN PFYCSCELLG
210 220 230 240 250
FLRWLAAFTN ATQTHDRVQC ESPPVYAGYF LLGQGRHGHQ RSILSKLQSV
260 270 280 290 300
CTEGSYTAEV LGPPRPVPGR SQPGHSPPPP PPEPSDMPCA DDECFSGDGT
310 320 330 340 350
TPLVILTTLV PQTEARPSMK VKQLTQNSAT IMVQLPSPFN RMYTLEQYNN
360 370 380 390 400
SKSFTVSKLT QPQEEIRLTN LYTLTNYTYC VVSTSSGTHH NHTCLTICLP
410 420 430 440 450
KPPSPPGPVP SPSTATHYIM TILGCLFGMV LVLGAVYYCL RKRRRQEEKH
460 470 480 490 500
KKAVAAAAGS LKKTIIELKY GPEIEAPGLA PLTQGPLLGP EAVTRIPYLP
510 520 530 540 550
AATSDVEQYK LVESSETPKA TKGNYIEVRT GEPQERRGCE LSRPGEPQSS
560 570 580 590 600
VAEISTIAKE VDRVNQIINN CIDALKSEST SFQGAKSGAV SAAEPQLVLL
610 620 630 640 650
SEPLASKHSF LSPVYKDAFG HGGLQRHHSV EAAPGPPRAS TSSSGSARSP
660 670 680 690 700
RTFRAEATGT HKAPATETKY IEKSSPVPET ILTVTPAATV LRAEADKSRQ
710 720 730 740 750
YGEHRHSYPG SHPAEPPAPP PPPPTHEGLG GRKASILEPL TRPRPRDLVY
760 770 780 790 800
SQLSPQYHNL SYSSSPEYTC RASPSIWERL RLSRRRHKDD AEFMAAGHAL
810 820
RKKVQFAKDE DLHDILDYWK GVSAQHKS
Length:828
Mass (Da):90,815
Last modified:March 1, 2003 - v1
Checksum:iD07E6734C156E03D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044511 mRNA. Translation: BAC31957.1.
BC059029 mRNA. Translation: AAH59029.1.
CCDSiCCDS19816.1.
RefSeqiNP_780731.1. NM_175522.3.
XP_006504764.1. XM_006504701.2.
XP_006504765.1. XM_006504702.2.
XP_006504766.1. XM_006504703.2.
XP_006504767.1. XM_006504704.2.
UniGeneiMm.237102.

Genome annotation databases

EnsembliENSMUST00000050519; ENSMUSP00000053869; ENSMUSG00000048988.
GeneIDi243312.
KEGGimmu:243312.
UCSCiuc009ahi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044511 mRNA. Translation: BAC31957.1.
BC059029 mRNA. Translation: AAH59029.1.
CCDSiCCDS19816.1.
RefSeqiNP_780731.1. NM_175522.3.
XP_006504764.1. XM_006504701.2.
XP_006504765.1. XM_006504702.2.
XP_006504766.1. XM_006504703.2.
XP_006504767.1. XM_006504704.2.
UniGeneiMm.237102.

3D structure databases

ProteinModelPortaliQ8C8T7.
SMRiQ8C8T7. Positions 54-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053869.

PTM databases

iPTMnetiQ8C8T7.
PhosphoSiteiQ8C8T7.

Proteomic databases

MaxQBiQ8C8T7.
PaxDbiQ8C8T7.
PRIDEiQ8C8T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050519; ENSMUSP00000053869; ENSMUSG00000048988.
GeneIDi243312.
KEGGimmu:243312.
UCSCiuc009ahi.2. mouse.

Organism-specific databases

CTDi392617.
MGIiMGI:2442479. Elfn1.

Phylogenomic databases

eggNOGiENOG410IHCP. Eukaryota.
ENOG4110NB3. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000112354.
HOVERGENiHBG056941.
InParanoidiQ8C8T7.
KOiK17567.
OMAiYHNLSYS.
OrthoDBiEOG091G01RI.
PhylomeDBiQ8C8T7.
TreeFamiTF332887.

Miscellaneous databases

ChiTaRSiElfn1. mouse.
PROiQ8C8T7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048988.
GenevisibleiQ8C8T7. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELFN1_MOUSE
AccessioniPrimary (citable) accession number: Q8C8T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.