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Protein
Submitted name:

Putative uncharacterized protein

Gene

Itpr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium channel inhibitor activity Source: MGI
  2. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: MGI
  3. phosphatidylinositol binding Source: MGI

GO - Biological processi

  1. calcium ion transport Source: MGI
  2. endoplasmic reticulum calcium ion homeostasis Source: MGI
  3. inositol phosphate-mediated signaling Source: GOC
  4. negative regulation of calcium-mediated signaling Source: MGI
  5. post-embryonic development Source: MGI
  6. response to hypoxia Source: MGI
  7. voluntary musculoskeletal movement Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Itpr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96623. Itpr1.

Subcellular locationi

GO - Cellular componenti

  1. calcineurin complex Source: MGI
  2. cytoplasm Source: MGI
  3. endoplasmic reticulum Source: MGI
  4. endoplasmic reticulum membrane Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. membrane Source: MGI
  7. nuclear envelope Source: MGI
  8. nuclear inner membrane Source: MGI
  9. nucleolus Source: MGI
  10. platelet dense granule membrane Source: MGI
  11. platelet dense tubular network Source: MGI
  12. postsynaptic density Source: MGI
  13. protein complex Source: MGI
  14. sarcoplasmic reticulum Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ8C8N0.
ExpressionAtlasiQ8C8N0. baseline and differential.
GenevestigatoriQ8C8N0.

Family & Domainsi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOVERGENiHBG106626.
KOiK04958.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8C8N0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
NLLVAFFYPF KGVRGGTLEP HWSGLLWTAM LISLAIVIAL PKPHGIRALI
60 70 80 90 100
ASTILRLIFS VGLQPTLFLL GAFNVCNKII FLMSFVGNCG TFTRGYRAMV
110 120 130 140 150
LDVEFLYHLL YLLICAMGLF VHEFFYSLLL FDLVYREETL LNVIKSVTRN
160 170 180 190 200
GRSIILTAVL ALILVYLFSI VGYLFFKDDF ILEVDRLPNE TAVPETGESL
210 220 230 240 250
ANDFLYSDVC RVETGENCTS PAPKEELLPA EETEQDKEHT CETLLMCIVT
260 270 280 290 300
VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV IIIVLNLIFG
310 320 330 340 350
VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKEEHN
360 370 380 390 400
MWHYLCFIVL VKVKDSTEYT GPESYVAEMI RERNLDWFPR MRAMSLVSSD
410 420 430 440 450
SEGEQNELRN LQEKLESTMK LVTNLSGQLS ELKDQMTEQR KQKQRIGLLG
460
HPPHMNVNPQ QPA
Length:463
Mass (Da):52,762
Last modified:March 1, 2003 - v1
Checksum:iB517A935952DEA3F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044776 mRNA. Translation: BAC32085.1.
RefSeqiNP_034715.3. NM_010585.5.
UniGeneiMm.227912.

Genome annotation databases

GeneIDi16438.
KEGGimmu:16438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044776 mRNA. Translation: BAC32085.1.
RefSeqiNP_034715.3. NM_010585.5.
UniGeneiMm.227912.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16438.
KEGGimmu:16438.

Organism-specific databases

CTDi3708.
MGIiMGI:96623. Itpr1.

Phylogenomic databases

HOVERGENiHBG106626.
KOiK04958.

Miscellaneous databases

ChiTaRSiItpr1. mouse.
NextBioi289681.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C8N0.
ExpressionAtlasiQ8C8N0. baseline and differential.
GenevestigatoriQ8C8N0.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.

Entry informationi

Entry nameiQ8C8N0_MOUSE
AccessioniPrimary (citable) accession number: Q8C8N0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.