UniProtKB - Q8C8M3 (Q8C8M3_MOUSE)
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Protein
Signal transducer and activator of transcription
Gene
Stat1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA binding transcription factor activity Source: InterPro
- signal transducer activity Source: UniProtKB-UniRule
GO - Biological processi
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | ActivatorUniRule annotation, DNA-bindingUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcriptionUniRule annotation |
Gene namesi | Name:Stat1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:103063. Stat1. |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinUniRule annotationProteomic databases
PRIDEi | Q8C8M3. |
PTM databases
SwissPalmi | Q8C8M3. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 579 – 676 | SH2InterPro annotationAdd BLAST | 98 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 139 – 166 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 263 – 290 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the transcription factor STAT family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG3667. Eukaryota. ENOG410XPN8. LUCA. |
HOGENOMi | HOG000220792. |
HOVERGENi | HBG055669. |
KOi | K11220. |
Family and domain databases
CDDi | cd10372. SH2_STAT1. 1 hit. |
Gene3Di | 1.10.532.10. 1 hit. 1.10.8.1200. 1 hit. 2.60.40.630. 1 hit. 3.30.505.10. 1 hit. |
InterProi | View protein in InterPro IPR008967. p53-like_TF_DNA-bd. IPR000980. SH2. IPR036860. SH2_dom_sf. IPR001217. STAT. IPR038295. STAT1_C_sf. IPR035859. STAT1_SH2. IPR022752. STAT1_TAZ2-bd_C. IPR036535. STAT_N_sf. IPR013800. STAT_TF_alpha. IPR015988. STAT_TF_coiled-coil. IPR013801. STAT_TF_DNA-bd. IPR012345. STAT_TF_DNA-bd_N. IPR013799. STAT_TF_prot_interaction. |
PANTHERi | PTHR11801. PTHR11801. 1 hit. |
Pfami | View protein in Pfam PF00017. SH2. 1 hit. PF12162. STAT1_TAZ2bind. 1 hit. PF01017. STAT_alpha. 1 hit. PF02864. STAT_bind. 1 hit. PF02865. STAT_int. 1 hit. |
SMARTi | View protein in SMART SM00964. STAT_int. 1 hit. |
SUPFAMi | SSF47655. SSF47655. 1 hit. SSF48092. SSF48092. 1 hit. SSF49417. SSF49417. 1 hit. SSF55550. SSF55550. 1 hit. |
PROSITEi | View protein in PROSITE PS50001. SH2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8C8M3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQWFELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAAYDV
60 70 80 90 100
SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPVQ
110 120 130 140 150
MSMIIYNCLK EERKILENAQ RFNQAQEGNI QNTVMLDKQK ELDSKVRNVK
160 170 180 190 200
DQVMCIEQEI KTLEELQDEY DFKCKTSQNR EGEANGVAKS DQKQEQLLLH
210 220 230 240 250
KMFLMLDNKR KEIIHKIREL LNSIELTQNT LINDELVEWK RRQQSACIGG
260 270 280 290 300
PPNACLDQLQ SWFTIVAETL QQIRQQLKKL EELEQKFTYE PDPITKNKQV
310 320 330 340 350
LSDRTFLLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK
360 370 380 390 400
LQELNYNLKV KVSFDKDVNY IYTVKGFRKF NILGTHTKVM NMEESTNGSL
410 420 430 440 450
AAEFRHLQLK EQKNAGNRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLEV
460 470 480 490 500
FVPFQTTSLP VVVISNVSQL PSGWASILWY NMLVTEPRNL SFFLNPPCAW
510 520 530 540 550
WSQLSEVLSW QFSSVTKRGL NADQLSMLGE KLLGPNAGPD GLIPWTRFCK
560 570 580 590 600
ENINDKNFSF WPWIDTILEL IKKHLLCLWN DGCIMGFISK ERERALLKDQ
610 620 630 640 650
QPGTFLLRFS ESSREGAITF TWVERSQNGG EPDFHAVEPY TKKELSAVTF
660 670 680 690 700
PDIIRNYKVM AAENIPENPL KYLYPNIDKD HAFGKYYSRP KEAPEPMELD
710 720 730 740 750
DPKRTGYIKT ELISVSEVHP SRLQTTDNLL PMSPEEFDEM SRIVGPEFDS
MMSTV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK046517 mRNA. Translation: BAC32766.1. |
RefSeqi | NP_001192242.1. NM_001205313.1. |
UniGenei | Mm.277406. Mm.487336. |
Genome annotation databases
GeneIDi | 20846. |
KEGGi | mmu:20846. |
Similar proteinsi
Entry informationi
Entry namei | Q8C8M3_MOUSE | |
Accessioni | Q8C8M3Primary (citable) accession number: Q8C8M3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | March 28, 2018 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |