Stat1

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
signal transducer activity Source: UniProtKB-UniRule
transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-KW

Keywordsⁱ

Molecular function	ActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological process	Transcription, Transcription regulationUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Signal transducer and activator of transcriptionUniRule annotation
Gene namesⁱ	Name:Stat1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:103063. Stat1.

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU046415

Nucleus
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU046415

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell
nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingⁱ

Keywords - PTMⁱ

PhosphoproteinUniRule annotation

Proteomic databases

PaxDbⁱ	Q8C8M3.
PRIDEⁱ	Q8C8M3.

PTM databases

SwissPalmⁱ	Q8C8M3.

SwissPalmⁱ

Q8C8M3.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q8C8M3. MM.

Genevisibleⁱ

Q8C8M3. MM.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8C8M3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	579 – 676	SH2InterPro annotationAdd BLAST		98

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	139 – 166	Sequence analysisAdd BLAST		28
Coiled coilⁱ	263 – 290	Sequence analysisAdd BLAST		28

Sequence similaritiesⁱ

Belongs to the transcription factor STAT family.UniRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3667. Eukaryota. ENOG410XPN8. LUCA.
HOGENOMⁱ	HOG000220792.
HOVERGENⁱ	HBG055669.
KEGG Orthology (KO) More...KOⁱ	K11220.

Family and domain databases

Gene3Dⁱ	1.10.532.10. 1 hit. 2.60.40.630. 1 hit. 3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR008967. p53-like_TF_DNA-bd. IPR000980. SH2. IPR001217. STAT. IPR022752. STAT1_TAZ2-bd_C. IPR013800. STAT_TF_alpha. IPR015988. STAT_TF_coiled-coil. IPR013801. STAT_TF_DNA-bd. IPR012345. STAT_TF_DNA-bd_sub. IPR013799. STAT_TF_prot_interaction.
PANTHERⁱ	PTHR11801. PTHR11801. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017. SH2. 1 hit. PF12162. STAT1_TAZ2bind. 1 hit. PF01017. STAT_alpha. 1 hit. PF02864. STAT_bind. 1 hit. PF02865. STAT_int. 1 hit.
SMARTⁱ	View protein in SMART SM00964. STAT_int. 1 hit.
SUPFAMⁱ	SSF47655. SSF47655. 1 hit. SSF48092. SSF48092. 1 hit. SSF49417. SSF49417. 1 hit. SSF55550. SSF55550. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50001. SH2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8C8M3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQWFELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAAYDV 
        60         70         80         90        100
SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPVQ 
       110        120        130        140        150
MSMIIYNCLK EERKILENAQ RFNQAQEGNI QNTVMLDKQK ELDSKVRNVK 
       160        170        180        190        200
DQVMCIEQEI KTLEELQDEY DFKCKTSQNR EGEANGVAKS DQKQEQLLLH 
       210        220        230        240        250
KMFLMLDNKR KEIIHKIREL LNSIELTQNT LINDELVEWK RRQQSACIGG 
       260        270        280        290        300
PPNACLDQLQ SWFTIVAETL QQIRQQLKKL EELEQKFTYE PDPITKNKQV 
       310        320        330        340        350
LSDRTFLLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK 
       360        370        380        390        400
LQELNYNLKV KVSFDKDVNY IYTVKGFRKF NILGTHTKVM NMEESTNGSL 
       410        420        430        440        450
AAEFRHLQLK EQKNAGNRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLEV 
       460        470        480        490        500
FVPFQTTSLP VVVISNVSQL PSGWASILWY NMLVTEPRNL SFFLNPPCAW 
       510        520        530        540        550
WSQLSEVLSW QFSSVTKRGL NADQLSMLGE KLLGPNAGPD GLIPWTRFCK 
       560        570        580        590        600
ENINDKNFSF WPWIDTILEL IKKHLLCLWN DGCIMGFISK ERERALLKDQ 
       610        620        630        640        650
QPGTFLLRFS ESSREGAITF TWVERSQNGG EPDFHAVEPY TKKELSAVTF 
       660        670        680        690        700
PDIIRNYKVM AAENIPENPL KYLYPNIDKD HAFGKYYSRP KEAPEPMELD 
       710        720        730        740        750
DPKRTGYIKT ELISVSEVHP SRLQTTDNLL PMSPEEFDEM SRIVGPEFDS 

MMSTV

Length:755

Mass (Da):88,101

Last modified:March 1, 2003 - v1

Checksum:ⁱ9A06C9F7EAA7099A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK046517 mRNA. Translation: BAC32766.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001192242.1. NM_001205313.1.
UniGeneⁱ	Mm.277406. Mm.487336.

Genome annotation databases

GeneIDⁱ	20846.
KEGGⁱ	mmu:20846.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK046517 mRNA. Translation: BAC32766.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001192242.1. NM_001205313.1.
UniGeneⁱ	Mm.277406. Mm.487336.

3D structure databases

ProteinModelPortalⁱ	Q8C8M3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

SwissPalmⁱ	Q8C8M3.

SwissPalmⁱ

Q8C8M3.

Proteomic databases

PaxDbⁱ	Q8C8M3.
PRIDEⁱ	Q8C8M3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	20846.
KEGGⁱ	mmu:20846.

Organism-specific databases

CTDⁱ	6772.
MGIⁱ	MGI:103063. Stat1.

Phylogenomic databases

eggNOGⁱ	KOG3667. Eukaryota. ENOG410XPN8. LUCA.
HOGENOMⁱ	HOG000220792.
HOVERGENⁱ	HBG055669.
KEGG Orthology (KO) More...KOⁱ	K11220.

Miscellaneous databases

ChiTaRSⁱ	Stat1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Genevisibleⁱ	Q8C8M3. MM.

Genevisibleⁱ

Q8C8M3. MM.

Family and domain databases

Gene3Dⁱ	1.10.532.10. 1 hit. 2.60.40.630. 1 hit. 3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR008967. p53-like_TF_DNA-bd. IPR000980. SH2. IPR001217. STAT. IPR022752. STAT1_TAZ2-bd_C. IPR013800. STAT_TF_alpha. IPR015988. STAT_TF_coiled-coil. IPR013801. STAT_TF_DNA-bd. IPR012345. STAT_TF_DNA-bd_sub. IPR013799. STAT_TF_prot_interaction.
PANTHERⁱ	PTHR11801. PTHR11801. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017. SH2. 1 hit. PF12162. STAT1_TAZ2bind. 1 hit. PF01017. STAT_alpha. 1 hit. PF02864. STAT_bind. 1 hit. PF02865. STAT_int. 1 hit.
SMARTⁱ	View protein in SMART SM00964. STAT_int. 1 hit.
SUPFAMⁱ	SSF47655. SSF47655. 1 hit. SSF48092. SSF48092. 1 hit. SSF49417. SSF49417. 1 hit. SSF55550. SSF55550. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50001. SH2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8C8M3_MOUSE
Accessionⁱ	Q8C8M3Primary (citable) accession number: Q8C8M3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 1, 2003
	Last sequence update:	March 1, 2003
	Last modified:	July 5, 2017
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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Supporting data

UniProtKB - Q8C8M3 (Q8C8M3_MOUSE)

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Signal transducer and activator of transcription

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ