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Protein

Receptor-transporting protein 1

Gene

Rtp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 1
Gene namesi
Name:Rtp1
Synonyms:Gm604
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2685450. Rtp1.

Subcellular locationi

  • Cell membrane 1 Publication; Single-pass type III membrane protein 1 Publication

  • Note: Effective cell surface expression depends upon interaction with olfactory receptors.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 238CytoplasmicSequence analysisAdd BLAST238
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 263ExtracellularSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001819901 – 263Receptor-transporting protein 1Add BLAST263

Proteomic databases

PaxDbiQ8C8C1.
PRIDEiQ8C8C1.

PTM databases

PhosphoSitePlusiQ8C8C1.

Expressioni

Tissue specificityi

Predominantly expressed in olfactory and vomeronasal organs, in mature olfactory sensory neurons.1 Publication

Gene expression databases

BgeeiENSMUSG00000033383.
CleanExiMM_RTP1.
ExpressionAtlasiQ8C8C1. baseline and differential.

Interactioni

Subunit structurei

Interacts with olfactory receptors.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043416.

Structurei

3D structure databases

ProteinModelPortaliQ8C8C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE69. Eukaryota.
ENOG41119VJ. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000060180.
HOVERGENiHBG079158.
InParanoidiQ8C8C1.
OMAiTDETMCK.
OrthoDBiEOG091G0DS4.
PhylomeDBiQ8C8C1.
TreeFamiTF333246.

Family and domain databases

InterProiIPR026096. R-trans_p.
IPR026692. RTP1.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF19. PTHR14402:SF19. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C8C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIFRPWRLR CPALHLPSFP TFSIKCSLPP LPTDEDMCKS VTTGEWKKVF
60 70 80 90 100
YEKMEEVKPA DSWDFIIDPN LKHNVLAPGW KQYLELHASG RFHCSWCWHT
110 120 130 140 150
WQSPHVVILF HMYLDKAQRA GSVRMRVFKQ LCYECGTARL DESSMLEENI
160 170 180 190 200
ESLVDNLITS LREQCYGERG GHYRIHVASR QDNRRHRGEF CEACQEGIVH
210 220 230 240 250
WKPSEKLLEE EATTYTFSRA PSPTKPQAET GSGCNFCSIP WCLFWATVLM
260
LIIYLQFSFR TSV
Length:263
Mass (Da):30,732
Last modified:March 1, 2003 - v1
Checksum:iBA12E392354F33D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562225 mRNA. Translation: AAT70670.1.
AK047543 mRNA. Translation: BAC33083.1.
CCDSiCCDS28078.1.
RefSeqiNP_001004151.1. NM_001004151.2.
UniGeneiMm.208751.

Genome annotation databases

EnsembliENSMUST00000038730; ENSMUSP00000043416; ENSMUSG00000033383.
GeneIDi239766.
KEGGimmu:239766.
UCSCiuc007ytq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562225 mRNA. Translation: AAT70670.1.
AK047543 mRNA. Translation: BAC33083.1.
CCDSiCCDS28078.1.
RefSeqiNP_001004151.1. NM_001004151.2.
UniGeneiMm.208751.

3D structure databases

ProteinModelPortaliQ8C8C1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043416.

PTM databases

PhosphoSitePlusiQ8C8C1.

Proteomic databases

PaxDbiQ8C8C1.
PRIDEiQ8C8C1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038730; ENSMUSP00000043416; ENSMUSG00000033383.
GeneIDi239766.
KEGGimmu:239766.
UCSCiuc007ytq.1. mouse.

Organism-specific databases

CTDi132112.
MGIiMGI:2685450. Rtp1.

Phylogenomic databases

eggNOGiENOG410IE69. Eukaryota.
ENOG41119VJ. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000060180.
HOVERGENiHBG079158.
InParanoidiQ8C8C1.
OMAiTDETMCK.
OrthoDBiEOG091G0DS4.
PhylomeDBiQ8C8C1.
TreeFamiTF333246.

Miscellaneous databases

PROiQ8C8C1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033383.
CleanExiMM_RTP1.
ExpressionAtlasiQ8C8C1. baseline and differential.

Family and domain databases

InterProiIPR026096. R-trans_p.
IPR026692. RTP1.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF19. PTHR14402:SF19. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTP1_MOUSE
AccessioniPrimary (citable) accession number: Q8C8C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.