Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor suppressor candidate 5 homolog

Gene

Tusc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in fat metabolism.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 5 homolog
Alternative name(s):
Dispanin subfamily B member 1
Short name:
DSPB1
Gene namesi
Name:Tusc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3029307. Tusc5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 102102ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST
Topological domaini124 – 15027CytoplasmicSequence analysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST
Topological domaini172 – 1732ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Tumor suppressor candidate 5 homologPRO_0000263640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineBy similarity
Modified residuei43 – 431PhosphoserineBy similarity
Modified residuei45 – 451PhosphoserineBy similarity
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei85 – 851PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C838.
PaxDbiQ8C838.
PeptideAtlasiQ8C838.
PRIDEiQ8C838.

PTM databases

iPTMnetiQ8C838.
PhosphoSiteiQ8C838.
SwissPalmiQ8C838.

Expressioni

Gene expression databases

BgeeiQ8C838.
CleanExiMM_TUSC5.
GenevisibleiQ8C838. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061634.

Structurei

3D structure databases

ProteinModelPortaliQ8C838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYHE. Eukaryota.
ENOG4111PC3. LUCA.
GeneTreeiENSGT00530000063980.
HOGENOMiHOG000261613.
HOVERGENiHBG094099.
InParanoidiQ8C838.
OMAiMSRSSMQ.
OrthoDBiEOG7QK0FC.
PhylomeDBiQ8C838.
TreeFamiTF333012.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8C838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPAQPPLQ DPGSTSPLEL PEMEKLLTKV ENKDDQALNL SKSLSGALDL
60 70 80 90 100
EQNGHSLPFK VISEGHRQPS LSGSPSRVSS RRASSVITTS YAQDQEAPKD
110 120 130 140 150
YLVLAIASCF CPVWPLNLIP LIFSIMSRSS VQQGDLDGAR RLGRLARLLS
160 170
ITFIILGIVI IIVAVTVNFT VPK
Length:173
Mass (Da):18,719
Last modified:March 1, 2003 - v1
Checksum:iA57DA2E8C27BBE53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048522 mRNA. Translation: BAC33359.1.
AK158395 mRNA. Translation: BAE34485.1.
BX000359 Genomic DNA. Translation: CAI25287.1.
BC119801 mRNA. Translation: AAI19802.1.
BC122875 mRNA. Translation: AAI22876.1.
CCDSiCCDS25069.1.
RefSeqiNP_808377.1. NM_177709.3.
UniGeneiMm.127006.

Genome annotation databases

EnsembliENSMUST00000062024; ENSMUSP00000061634; ENSMUSG00000046275.
GeneIDi237858.
KEGGimmu:237858.
UCSCiuc007kfy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048522 mRNA. Translation: BAC33359.1.
AK158395 mRNA. Translation: BAE34485.1.
BX000359 Genomic DNA. Translation: CAI25287.1.
BC119801 mRNA. Translation: AAI19802.1.
BC122875 mRNA. Translation: AAI22876.1.
CCDSiCCDS25069.1.
RefSeqiNP_808377.1. NM_177709.3.
UniGeneiMm.127006.

3D structure databases

ProteinModelPortaliQ8C838.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061634.

PTM databases

iPTMnetiQ8C838.
PhosphoSiteiQ8C838.
SwissPalmiQ8C838.

Proteomic databases

MaxQBiQ8C838.
PaxDbiQ8C838.
PeptideAtlasiQ8C838.
PRIDEiQ8C838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062024; ENSMUSP00000061634; ENSMUSG00000046275.
GeneIDi237858.
KEGGimmu:237858.
UCSCiuc007kfy.2. mouse.

Organism-specific databases

CTDi286753.
MGIiMGI:3029307. Tusc5.

Phylogenomic databases

eggNOGiENOG410IYHE. Eukaryota.
ENOG4111PC3. LUCA.
GeneTreeiENSGT00530000063980.
HOGENOMiHOG000261613.
HOVERGENiHBG094099.
InParanoidiQ8C838.
OMAiMSRSSMQ.
OrthoDBiEOG7QK0FC.
PhylomeDBiQ8C838.
TreeFamiTF333012.

Miscellaneous databases

PROiQ8C838.
SOURCEiSearch...

Gene expression databases

BgeeiQ8C838.
CleanExiMM_TUSC5.
GenevisibleiQ8C838. MM.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Inner ear.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue.
  5. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
    Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
    PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiTUSC5_MOUSE
AccessioniPrimary (citable) accession number: Q8C838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.