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Protein

Tumor suppressor candidate 5 homolog

Gene

Tusc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in fat metabolism.By similarity

GO - Biological processi

  • cellular response to insulin stimulus Source: MGI
  • endosome to plasma membrane protein transport Source: MGI
  • glucose import in response to insulin stimulus Source: MGI
  • plasma membrane fusion Source: MGI
  • protein localization to plasma membrane Source: MGI
  • response to biotic stimulus Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 5 homolog
Alternative name(s):
Dispanin subfamily B member 1
Short name:
DSPB1
Gene namesi
Name:Tusc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3029307 Tusc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 102ExtracellularSequence analysisAdd BLAST102
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 150CytoplasmicSequence analysisAdd BLAST27
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 173ExtracellularSequence analysis2

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636401 – 173Tumor suppressor candidate 5 homologAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei85PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8C838
PaxDbiQ8C838
PeptideAtlasiQ8C838
PRIDEiQ8C838

PTM databases

iPTMnetiQ8C838
PhosphoSitePlusiQ8C838
SwissPalmiQ8C838

Expressioni

Gene expression databases

BgeeiENSMUSG00000046275
CleanExiMM_TUSC5
GenevisibleiQ8C838 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061634

Structurei

3D structure databases

ProteinModelPortaliQ8C838
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYHE Eukaryota
ENOG4111PC3 LUCA
GeneTreeiENSGT00530000063980
HOGENOMiHOG000261613
HOVERGENiHBG094099
InParanoidiQ8C838
OMAiMSRSSMQ
OrthoDBiEOG091G0JH3
PhylomeDBiQ8C838
TreeFamiTF333012

Family and domain databases

InterProiView protein in InterPro
IPR007593 CD225/Dispanin_fam
PfamiView protein in Pfam
PF04505 CD225, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPAQPPLQ DPGSTSPLEL PEMEKLLTKV ENKDDQALNL SKSLSGALDL
60 70 80 90 100
EQNGHSLPFK VISEGHRQPS LSGSPSRVSS RRASSVITTS YAQDQEAPKD
110 120 130 140 150
YLVLAIASCF CPVWPLNLIP LIFSIMSRSS VQQGDLDGAR RLGRLARLLS
160 170
ITFIILGIVI IIVAVTVNFT VPK
Length:173
Mass (Da):18,719
Last modified:March 1, 2003 - v1
Checksum:iA57DA2E8C27BBE53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048522 mRNA Translation: BAC33359.1
AK158395 mRNA Translation: BAE34485.1
BX000359 Genomic DNA No translation available.
BC119801 mRNA Translation: AAI19802.1
BC122875 mRNA Translation: AAI22876.1
CCDSiCCDS25069.1
RefSeqiNP_808377.1, NM_177709.3
UniGeneiMm.127006

Genome annotation databases

EnsembliENSMUST00000062024; ENSMUSP00000061634; ENSMUSG00000046275
GeneIDi237858
KEGGimmu:237858
UCSCiuc007kfy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTUSC5_MOUSE
AccessioniPrimary (citable) accession number: Q8C838
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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